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Invitrogen
SLC26A5 Polyclonal Antibody
Product Details
PA5-42533
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Guinea pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the middle region of human SLC26A5
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2608418
Product Specific Information
Peptide sequence: FSVTISMAKT LANKHGYQVD GNQELIALGL CNSIGSLFQT FSISCSLSRS
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Target Information
SLC26A5 is a member of the SLC26A/SulP transporter family. SLC26A5 is specifically expressed in outer hair cells (OHCs) of the cochlea and is essential in auditory processing. Intracellular anions are thought to act as extrinsic voltage sensors, which bind to this protein and trigger the conformational changes required for rapid length changes in OHCs. Mutations in its gene have been associated with non-syndromic hearing loss.This gene is a member of the SLC26A/SulP transporter family. It encodes a protein that is specifically expressed in outer hair cells (OHCs) of the cochlea and is essential in auditory processing. Intracellular anions are thought to act as extrinsic voltage sensors, which bind to this protein and trigger the conformational changes required for rapid length changes in OHCs. Mutations in this gene have been associated with non-syndromic hearing loss. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MGC118886; MGC118887; MGC118888; MGC118889; Prestin; prestin (motor protein); solute carrier family 26 (anion exchanger), member 5; Solute carrier family 26 member 5
Gene Aliases: DFNB61; PRES; SLC26A5
UniProt ID: (Human) P58743
Entrez Gene ID: (Human) 375611
chloride channel activity
transcription factor binding
secondary active sulfate transmembrane transporter activity
bicarbonate transmembrane transporter activity
sulfate transmembrane transporter activity
anion:anion antiporter activity
oxalate transmembrane transporter activity
spectrin binding
protein homodimerization activity
transporter
response to ischemia
sensory perception of sound
regulation of cell shape
response to salicylic acid
response to auditory stimulus
bicarbonate transport
fructose transport
oxalate transport
negative regulation of ion transmembrane transport
response to potassium ion
regulation of membrane potential
response to drug
positive regulation of cell size
protein tetramerization
regulation of intracellular pH
cochlea development
response to thyroid hormone
response to salt
sulfate transmembrane transport
chloride transmembrane transport
positive regulation of cell motility
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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