Proteintech

SLC27A2 Polyclonal Antibody

SLC27A2 Antibody in Immunocytochemistry (ICC/IF)

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SLC27A2 Antibody (14048-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 14048-1-AP (SLC27A2 antibody) at dilution of 1:25 and Alexa Fluor 594-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

SLC27A2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SLC27A2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

14048-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 27 publications 27 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 4 publications 4 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SLC27A2 Fusion Protein Ag5217 (208-567 aa encoded by BC057770)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: ESWRSEVTF STPALYIYTS GTTGATLALR TKFSASQFWD DCRKYNVTVI QYIGELLRYL CNSPQKPNDR DHKVRLALGN GLRGDVWRQF VKRFGDICIY EFYAATEGNI GFMNYARKVG AVGRVNYLQK KIITYDLIKY DVEKDEPVRD ENGYCVRVPK GEVGLLVCKI TQLTPFNGYA GAKAQTEKKK LRDVFKKGDL YFNSGDLLMV DHENFIYFHD RVGDTFRWKG ENVATTEVAD TVGLVDFVQE VNVYGVHVPD HEGRIGMASI KMKENHEFDG KKLFQHIADY LPSYARPRFL RIQDTIEITG TFKHRKMTLV EEGFNPAVIK DALYFLDDTA KMYVPMTEDI YNAISAKTLK L (208-567 aa encoded by BC057770)

Target Information

The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Fatty acid transport protein inhibition sensitizes breast and ovarian cancers to oncolytic virus therapy via lipid modulation of the tumor microenvironment.

Frontiers in immunology

Surendran A,Jamalkhah M,Poutou J,Birtch R,Lawson C,Dave J,Crupi MJF,Mayer J,Taylor V,Petryk J,de Souza CT,Moodie N,Billingsley JL,Austin B,Cormack N,Blamey N,Rezaei R,McCloskey CW,Fekete EEF,Birdi HK,Neault S,Jamieson TR,Wylie B,Tucker S,Azad T,Vanderhyden B,Tai LH,Bell JC,Ilkow CS

Tue Mar 28 00:00:00 EDT 2023

FATP2 regulates non-small cell lung cancer by mediating lipid metabolism through ACSL1.

Tissue & cell

Chen Y,Zhao Y,Deng Y,Yang Y,Xu L,Fu J

Thu Jun 01 00:00:00 EDT 2023

FATP2 regulates non-small cell lung cancer by mediating lipid metabolism through ACSL1.

Tissue & cell

Chen Y,Zhao Y,Deng Y,Yang Y,Xu L,Fu J

Thu Jun 01 00:00:00 EDT 2023

Icariin Alleviates Nonalcoholic Fatty Liver Disease in Polycystic Ovary Syndrome by Improving Liver Fatty Acid Oxidation and Inhibiting Lipid Accumulation.

Molecules (Basel, Switzerland)

Hai Y,Zuo L,Wang M,Zhang R,Wang M,Ren L,Yang C,Wang J

Thu Jan 05 00:00:00 EST 2023

A novel therapy for hepatic cholestasis treatment-the combination of rosiglitazone and fenofibrate.

European journal of pharmacology

Chen Y,Yang S,Liu L,Yang X,Duan Y,Zhang S,Han J

Thu Jan 05 00:00:00 EST 2023

Adipose lipolysis is important for ethanol to induce fatty liver in the National Institute on Alcohol Abuse and Alcoholism murine model of chronic and binge ethanol feeding.

Hepatology (Baltimore, Md.)

Mathur M,Yeh YT,Arya RK,Jiang L,Pornour M,Chen W,Ma Y,Gao B,He L,Ying Z,Xue B,Shi H,Choi Y,Yu L

Mon May 01 00:00:00 EDT 2023

Letter to the editor: Adipose lipolysis is important for ethanol to induce fatty liver in the NIAAA murine model of chronic and binge ethanol feeding.

Hepatology (Baltimore, Md.)

Luo W,Wang Y,Li Y,Zhang T

Mon May 01 00:00:00 EDT 2023

SLC27A2 mediates FAO in colorectal cancer through nongenic crosstalk regulation of the PPARs pathway.

BMC cancer

Shang K,Ma N,Che J,Li H,Hu J,Sun H,Cao B

Tue Apr 11 00:00:00 EDT 2023

Monounsaturated fatty acid-enriched olive oil exacerbates chronic alcohol-induced hepatic steatosis and liver injury in C57BL/6J mice.

Food & function

Guo R,Chen L,Zhu J,Li J,Ding Q,Chang K,Han Q,Li S

Mon Feb 06 00:00:00 EST 2023

Andrographolide ameliorates hepatic steatosis by suppressing FATP2-mediated fatty acid uptake in mice with nonalcoholic fatty liver disease.

Journal of natural medicines

Ran LS,Wu YZ,Gan YW,Wang HL,Wu LJ,Zheng CM,Ming Y,Xiong R,Li YL,Lei SH,Wang X,Lao XQ,Zhang HM,Wang L,Chen C,Zhao CY

Sun Jan 01 00:00:00 EST 2023

Andrographolide ameliorates hepatic steatosis by suppressing FATP2-mediated fatty acid uptake in mice with nonalcoholic fatty liver disease.

Journal of natural medicines

Ran LS,Wu YZ,Gan YW,Wang HL,Wu LJ,Zheng CM,Ming Y,Xiong R,Li YL,Lei SH,Wang X,Lao XQ,Zhang HM,Wang L,Chen C,Zhao CY

Sun Jan 01 00:00:00 EST 2023

Andrographolide ameliorates hepatic steatosis by suppressing FATP2-mediated fatty acid uptake in mice with nonalcoholic fatty liver disease.

Journal of natural medicines

Ran LS,Wu YZ,Gan YW,Wang HL,Wu LJ,Zheng CM,Ming Y,Xiong R,Li YL,Lei SH,Wang X,Lao XQ,Zhang HM,Wang L,Chen C,Zhao CY

Sun Jan 01 00:00:00 EST 2023

Andrographolide ameliorates hepatic steatosis by suppressing FATP2-mediated fatty acid uptake in mice with nonalcoholic fatty liver disease.

Journal of natural medicines

Ran LS,Wu YZ,Gan YW,Wang HL,Wu LJ,Zheng CM,Ming Y,Xiong R,Li YL,Lei SH,Wang X,Lao XQ,Zhang HM,Wang L,Chen C,Zhao CY

Sun Jan 01 00:00:00 EST 2023

Dynamic cellular changes in acute kidney injury caused by different ischemia time.

iScience

Shan D,Wang YY,Chang Y,Cui H,Tao M,Sheng Y,Kang H,Jia P,Song J

Fri May 19 00:00:00 EDT 2023

Ameliorative Effect of Ethanolic Echinacea purpurea against Hyperthyroidism-Induced Oxidative Stress via AMRK and PPAR Signal Pathway Using Transcriptomics and Network Pharmacology Analysis.

International journal of molecular sciences

Zhu Y,Zhang J,Wang C,Zheng T,Di S,Wang Y,Fei W,Liang W,Wang L

Thu Dec 22 00:00:00 EST 2022

DNA 6mA Demethylase ALKBH1 Orchestrates Fatty Acid Metabolism and Suppresses Diet-Induced Hepatic Steatosis.

Cellular and molecular gastroenterology and hepatology

Luo L,Liu Y,Nizigiyimana P,Ye M,Xiao Y,Guo Q,Su T,Luo X,Huang Y,Zhou H

Tue Nov 22 00:00:00 EST 2022

B-cell lymphoma 6 alleviates nonalcoholic fatty liver disease in mice through suppression of fatty acid transporter CD36.

Cell death & disease

Zhang H,Li Y,Zhang C,Huang K,Zhao J,Le S,Jiang L,Liu H,Yang P,Xiao X,Yu J,Wu J,Ye P,Xia J

Mon Apr 18 00:00:00 EDT 2022

Ionic Liquid-Based Extraction System for In-Depth Analysis of Membrane Protein Complexes.

Analytical chemistry

Chu H,Zhao Q,Liu J,Yang K,Wang Y,Liu J,Zhang K,Zhao B,He H,Zheng Y,Zhong S,Liang Z,Zhang L,Zhang Y

Tue Jan 18 00:00:00 EST 2022

Dietary camellia seed oil attenuates liver injury in mice chronically exposed to alcohol.

Frontiers in nutrition

Guo R,Zhu J,Chen L,Li J,Ding Q,Han Q,Zheng W,Li S

Wed Nov 02 00:00:00 EDT 2022

Beneficial effects of bempedoic acid treatment in polycystic kidney disease cells and mice.

Frontiers in molecular biosciences

Hallows KR,Li H,Saitta B,Sepehr S,Huang P,Pham J,Wang J,Mancino V,Chung EJ,Pinkosky SL,Pastor-Soler NM

Tue Dec 20 00:00:00 EST 2022

Sperm acquire epididymis-derived proteins through epididymosomes.

Human reproduction (Oxford, England)

Barrachina F,Battistone MA,Castillo J,Mallofré C,Jodar M,Breton S,Oliva R

Fri Apr 01 00:00:00 EDT 2022

Fatty acid transport protein 2 interacts with ceramide synthase 2 to promote ceramide synthesis.

The Journal of biological chemistry

Kim JL,Mestre B,Malitsky S,Itkin M,Kupervaser M,Futerman AH

Fri Apr 01 00:00:00 EDT 2022

Fatty acid transport protein 2 interacts with ceramide synthase 2 to promote ceramide synthesis.

The Journal of biological chemistry

Kim JL,Mestre B,Malitsky S,Itkin M,Kupervaser M,Futerman AH

Fri Apr 01 00:00:00 EDT 2022

Dendrobium officinale Regulates Fatty Acid Metabolism to Ameliorate Liver Lipid Accumulation in NAFLD Mice.

Evidence-based complementary and alternative medicine : eCAM

Lei SS,Zhang NY,Zhou FC,He X,Wang HY,Li LZ,Zheng X,Dong YJ,Luo R,Li B,Jin HY,Yu QX,Lv GY,Chen SH

Tue Jun 15 00:00:00 EDT 2021

Multi-Omics Analysis of Fatty Acid Metabolism in Thyroid Carcinoma.

Frontiers in oncology

Lu J,Zhang Y,Sun M,Ding C,Zhang L,Kong Y,Cai M,Miccoli P,Ma C,Yue X

Fri Apr 29 00:00:00 EDT 2022

Multi-Omics Analysis of Fatty Acid Metabolism in Thyroid Carcinoma.

Frontiers in oncology

Lu J,Zhang Y,Sun M,Ding C,Zhang L,Kong Y,Cai M,Miccoli P,Ma C,Yue X

Fri Apr 29 00:00:00 EDT 2022

Celastrol inhibits intestinal lipid absorption by reprofiling the gut microbiota to attenuate high-fat diet-induced obesity.

iScience

Hua H,Zhang Y,Zhao F,Chen K,Wu T,Liu Q,Huang S,Zhang A,Jia Z

Fri Feb 19 00:00:00 EST 2021

MicroRNA-20a-5p Ameliorates Non-alcoholic Fatty Liver Disease via Inhibiting the Expression of CD36.

Frontiers in cell and developmental biology

Wang X,Ma Y,Yang LY,Zhao D

Tue Dec 22 00:00:00 EST 2020

A novel bile acid analog, A17, ameliorated non-alcoholic steatohepatitis in high-fat diet-fed hamsters.

Toxicology and applied pharmacology

Wang Y,Zhu Y,Niu J,Deng Q,Guo S,Jiang H,Peng Z,Xue Y,Peng H,Xuan L,Pan G

Thu Oct 01 00:00:00 EDT 2020

Hypertensive Rats Treated Chronically With N^ω-Nitro-L-Arginine Methyl Ester (L-NAME) Induced Disorder of Hepatic Fatty Acid Metabolism and Intestinal Pathophysiology.

Frontiers in pharmacology

Li B,He X,Lei SS,Zhou FC,Zhang NY,Chen YH,Wang YZ,Su J,Yu JJ,Li LZ,Zheng X,Luo R,Kołodyńska D,Xiong S,Lv GY,Chen SH

Mon Sep 28 00:00:00 EDT 2020

Hypertensive Rats Treated Chronically With N^ω-Nitro-L-Arginine Methyl Ester (L-NAME) Induced Disorder of Hepatic Fatty Acid Metabolism and Intestinal Pathophysiology.

Frontiers in pharmacology

Li B,He X,Lei SS,Zhou FC,Zhang NY,Chen YH,Wang YZ,Su J,Yu JJ,Li LZ,Zheng X,Luo R,Kołodyńska D,Xiong S,Lv GY,Chen SH

Mon Sep 28 00:00:00 EDT 2020

Orphan nuclear receptor NR4A1 suppresses hyperhomocysteinemia-induced hepatic steatosis in vitro and in vivo.

FEBS letters

Liang H,Xie X,Song X,Huang M,Su T,Chang X,Liang B,Huang D

Wed May 01 00:00:00 EDT 2019

Rapid affinity purification of intracellular organelles using a twin strep tag.

Journal of cell science

Xiong J,He J,Xie WP,Hinojosa E,Ambati CSR,Putluri N,Kim HE,Zhu MX,Du G

Fri Dec 13 00:00:00 EST 2019

Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.

EMBO reports

Zhang Y,Li C,Hu C,Wu Q,Cai Y,Xing S,Lu H,Wang L,Huang D,Sun L,Li T,He X,Zhong X,Wang J,Gao P,Smith ZJ,Jia W,Zhang H

Fri Oct 04 00:00:00 EDT 2019

Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity.

Archives of toxicology

Cheng L,Ge M,Lan Z,Ma Z,Chi W,Kuang W,Sun K,Zhao X,Liu Y,Feng Y,Huang Y,Luo M,Li L,Zhang B,Hu X,Xu L,Liu X,Huo Y,Deng H,Yang J,Xi Q,Zhang Y,Siegenthaler JA,Chen L

Mon Jan 01 00:00:00 EST 2018

Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity.

Archives of toxicology

Cheng L,Ge M,Lan Z,Ma Z,Chi W,Kuang W,Sun K,Zhao X,Liu Y,Feng Y,Huang Y,Luo M,Li L,Zhang B,Hu X,Xu L,Liu X,Huo Y,Deng H,Yang J,Xi Q,Zhang Y,Siegenthaler JA,Chen L

Mon Jan 01 00:00:00 EST 2018

Hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol-induced liver injury in mice.

Scientific reports

Zhang W,Zhong W,Sun Q,Sun X,Zhou Z

Mon Aug 21 00:00:00 EDT 2017

Hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol-induced liver injury in mice.

Scientific reports

Zhang W,Zhong W,Sun Q,Sun X,Zhou Z

Mon Aug 21 00:00:00 EDT 2017

Real-Time Tracking of BODIPY-C12 Long-Chain Fatty Acid in Human Term Placenta Reveals Unique Lipid Dynamics in Cytotrophoblast Cells.

PloS one

Kolahi K,Louey S,Varlamov O,Thornburg K

Tue Feb 21 00:00:00 EST 2017

Real-Time Tracking of BODIPY-C12 Long-Chain Fatty Acid in Human Term Placenta Reveals Unique Lipid Dynamics in Cytotrophoblast Cells.

PloS one

Kolahi K,Louey S,Varlamov O,Thornburg K

Tue Feb 21 00:00:00 EST 2017

Bioinformatics

Protein Aliases: Arachidonate--CoA ligase; FATP-2; Fatty acid transport protein 2; Fatty-acid-coenzyme A ligase, very long-chain 1; Long-chain fatty acid transport protein 2; Long-chain-fatty-acid--CoA ligase; Phytanate--CoA ligase; Slc27a2; solute carrier family 27 (fatty acid transporter), member 2; solute carrier family 27 (fatty acid transporter), member 32; Solute carrier family 27 member 2; THCA-CoA ligase; ve; Very long-chain acyl-CoA synthetase; very long-chain acyl-Coenzyme A dehydrogenase synthase; very long-chain fatty-acid-coenzyme A ligase 1; Very long-chain-fatty-acid-CoA ligase; very-long-chain acyl-CoA synthetase; VLACS; VLCS

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Gene Aliases: ACSVL1; FACVL1; FATP2; hFACVL1; HsT17226; SLC27A2; Vlac; VLACS; VLCS

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UniProt ID: (Human) O14975, (Rat) P97524, (Mouse) O35488

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Entrez Gene ID: (Human) 11001, (Rat) 65192, (Mouse) 26458

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Function(s)

Process(es)

fatty acid alpha-oxidation long-chain fatty acid metabolic process fatty acid beta-oxidation bile acid biosynthetic process fatty acid transport very long-chain fatty acid catabolic process long-chain fatty acid import methyl-branched fatty acid metabolic process very long-chain fatty acid metabolic process lipid metabolic process fatty acid metabolic process metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SLC27A2 Polyclonal Antibody

SLC27A2 Antibody (14048-1-AP) in ICC/IF

Product Details

14048-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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