Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 7
Immunogen sequence: MEKASGRQSI ALSTVETGTV NLGLELMEKE VEPEGSKRTD AQGHSLGDGL GPSTYQRRSR WPFSKARSFC KTHASLFKK
Highest antigen sequence identity to the following orthologs: Mouse - 51%, Rat - 51%.
The concentrative nucleoside transporter (CNT) family comprises three members: CNT1, CNT2 and CNT3. CNT2 participates in the absorption and disposition of endogenous nucleosides and mediates the first step of nucleotide biosynthesis. CNT2 levels are highly dependent on insulin (but not glucose) concentration, and the protein is under the control of the Adenosine 1 receptor. CNT family members are imperative in the response of cells to a variety of anticancer and antiviral nucleoside analogs, as the CNT proteins modulate their entry into target tissues. Increasing evidence also suggests that CNT2 may have a role in energy metabolism because activation of CNT2 relies on the opening of ATP-sensitive K+ channels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CNT 2; CNT-2; Concentrative nucleoside transporter 2; Na(+)/nucleoside cotransporter 2; Sodium-coupled nucleoside transporter 2; Sodium/nucleoside cotransporter 2; Sodium/purine nucleoside co-transporter; solute carrier family 28 (concentrative nucleoside transporter), member 2; solute carrier family 28 (sodium-coupled nucleoside transporter), member 2; Solute carrier family 28 member 2; SPNT
Gene Aliases: CNT2; HCNT2; HsT17153; SLC28A2; SPNT1
UniProt ID: (Human) O43868
Entrez Gene ID: (Human) 9153
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