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FIGURE: 1 / 1
SLC28A2 Antibody (PA5-90922) in WB
Western blot analysis of SLC28A2 in extracts of various cell lines. Samples were incubated with SLC28A2 Polyclonal antibody (Product # PA5-90922) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.
Product Details
PA5-90922
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 350-450 of human SLC28A2 (NP_0042032)
Conjugate
Form
Liquid
Concentration
0.42 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2806292
Product Specific Information
Immunogen sequence: GAFIAFGVDA SSLISASVMA APCALASSKL AYPEVEESKF KSEEGVKLPR GKERNVLEAA SNGAVDAIGL ATNVAANLIA FLAVLAFINA ALSWLGELVD I; Positive Samples: HepG2, 293T, HT-29, BxPC-3, Mouse heart, Mouse spleen, Rat liver, Rat heart; Cellular Location: Membrane, Multi-pass membrane protein
Target Information
The concentrative nucleoside transporter (CNT) family comprises three members: CNT1, CNT2 and CNT3. CNT2 participates in the absorption and disposition of endogenous nucleosides and mediates the first step of nucleotide biosynthesis. CNT2 levels are highly dependent on insulin (but not glucose) concentration, and the protein is under the control of the Adenosine 1 receptor. CNT family members are imperative in the response of cells to a variety of anticancer and antiviral nucleoside analogs, as the CNT proteins modulate their entry into target tissues. Increasing evidence also suggests that CNT2 may have a role in energy metabolism because activation of CNT2 relies on the opening of ATP-sensitive K+ channels.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CNT 2; CNT-2; Concentrative nucleoside transporter 2; Na(+)/nucleoside cotransporter 2; purine-selective Na+ nucleoside cotransporter; rCNT2; Sodium-coupled nucleoside transporter 2; Sodium/nucleoside cotransporter 2; Sodium/purine nucleoside co-transporter; Sodium/purine nucleoside cotransporter; solute carrier family 28 (concentrative nucleoside transporter), member 2; solute carrier family 28 (sodium-coupled nucleoside transporter), member 2; Solute carrier family 28 member 2; solute carrier family 28, member 2; SPNT
Gene Aliases: 2010208B10Rik; B430217P18; BB152493; CNT2; HCNT2; HsT17153; SLC28A2; Spnt; SPNT1
UniProt ID: (Human) O43868, (Mouse) O88627, (Rat) Q62773
Entrez Gene ID: (Human) 9153, (Mouse) 269346, (Rat) 60423
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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