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Product Details
PA5-62358
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SLC34A1. Recombinant protein control fragment (Product #RP-98434).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2647456
Product Specific Information
Immunogen sequence: PLPVPGGHVM RGTAFAYVPS PQVLHRIPGT SAYAFPSLGP VALAEHTCPC GEVLERHEPL PAKLALEEEQ KPESRLVPKL RQA
Highest antigen sequence identity to the following orthologs: Mouse - 72%, Rat - 73%.
Target Information
Renal tubular reabsorption of phosphate is critical to the maintenance of phosphate homeostasis in mammals. The brush-border membrane Na+/Pi cotransport systems in proximal tubules play a major role in this process. The renal Na(+)/P(i) cotransporter NPT2 is expressed in the brush border membrane (BBM) of proximal tubular cells. NPT2 gene expression is crucial for PTH effects on renal P(i) handling. However, renal expression of the sodium/phosphate cotransporter gene, NPT2, is not required for regulation of renal 1 alpha-hydroxylase by phosphate. NPT2 is an integral membrane protein expressed in kidney and lung. The gene encoding human NPT1 maps to chromosome 6q21.3-p23, while the gene encoding human NPT2 maps to chromosome 5q35.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Na(+)-dependent phosphate cotransporter 2A; Na(+)/Pi cotransporter 2A; Na+-phosphate cotransporter type II; naPi-2a; NaPi-3; renal sodium-dependent phosphate transporter; Sodium-dependent phosphate transport protein 2A; Sodium-phosphate transport protein 2A; sodium/phosphate co-transporter; Sodium/phosphate cotransporter 2A; solute carrier family 17 (sodium phosphate), member 2; solute carrier family 34 (sodium phosphate), member 1; solute carrier family 34 (type II sodium/phosphate cotransporter), member 1; Solute carrier family 34 member 1
Gene Aliases: FRTS2; HCINF2; NAPI-3; NPHLOP1; NPT2; NPTIIa; SLC11; SLC17A2; SLC34A1
UniProt ID: (Human) Q06495
Entrez Gene ID: (Human) 6569
ossification
kidney development
phosphate ion transport
glycoprotein metabolic process
response to lead ion
cellular phosphate ion homeostasis
response to magnesium ion
response to estradiol
response to vitamin A
phosphate ion transmembrane transport
sodium ion transmembrane transport
response to potassium ion
indole metabolic process
response to drug
cellular protein metabolic process
sodium-dependent phosphate transport
positive regulation of membrane potential
response to cadmium ion
response to mercury ion
protein homooligomerization
phosphate ion homeostasis
response to growth hormone
cellular response to metal ion
cellular response to parathyroid hormone stimulus
tricarboxylic acid metabolic process
cellular response to staurosporine
response to thyroid hormone
dentinogenesis
gentamycin metabolic process
arsenate ion transmembrane transport
positive regulation of sodium-dependent phosphate transport
positive regulation of phosphate transmembrane transport
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