Invitrogen

SLC7A11 Polyclonal Antibody

SLC7A11 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SLC7A11 Antibody (PA1-16893) in IHC (P)

Immunohistochemical analysis of SLC7A11 in the absorptive epithelia of small intestinal villi. Samples were incubated in SLC7A11 polyclonal antibody (Product # PA1-16893).

SLC7A11 Antibody in Immunohistochemistry (IHC)

SLC7A11 Antibody in Western Blot, Immunoprecipitation (WB, IP)

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Product Details

PA1-16893

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

5 µg/mL

Immunocytochemistry (ICC/IF)

1:100-1:1,000

Flow Cytometry (Flow)

2-3 µg/mL

View 1 publication 1 publication

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide between amino acid 1-50 of the human XCT protein.

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2286208

Product Specific Information

This antibody is not recommended for Immunoprecipitation.

Permeablization is recommended prior to performing Flow analysis.

Suggested positive control: antigen standard for SLC7A11 (transient overexpression lysate), human stomach protein or stomach tissue lysate.

Target Information

SLC7A11 (also known as XCT) is a member of a hetromeric, sodium-independent, anionic amino acid transport system. It is highly specific for cysteine and glutamate. SLC7A11 is a mediator of Kaposi sarcoma-associated herpes virus fusion and entry into cells. Increased expression of this protein in primary gliomas is associated with neuronal cell death.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Cottonseed oil alleviates ischemic stroke injury by inhibiting ferroptosis.

Brain and behavior

Sun M,Liu M,Li Q,Zhang X,Liu S,Yang H,Yang L,Tian J,Mi W,Ma Y

Published figure using SLC7A11 polyclonal antibody (Product # PA1-16893) in Western Blot

Sun Oct 01 00:00:00 EDT 2023

miR-16-5p Regulates Ferroptosis by Targeting SLC7A11 in Adriamycin-Induced Ferroptosis in Cardiomyocytes.

Journal of inflammation research

Chen Y,Deng Y,Chen L,Huang Z,Yan Y,Huang Z

Published figure using SLC7A11 polyclonal antibody (Product # PA1-16893) in Western Blot

Tue Feb 20 00:00:00 EST 2024

Slc7a11 stimulates glutathione synthesis to preserve fatty acid metabolism in primary hepatocytes.

Redox report : communications in free radical research

Liu Y,Wu K,Fu Y,Li W,Zhao XY

Published figure using SLC7A11 polyclonal antibody (Product # PA1-16893) in Western Blot

Fri Dec 01 00:00:00 EST 2023

Transcriptome Profiles of IncRNA and mRNA Highlight the Role of Ferroptosis in Chronic Neuropathic Pain With Memory Impairment.

Frontiers in cell and developmental biology

Tang Y,Liu C,Zhu T,Chen H,Sun Y,Zhang X,Zhao Q,Wu J,Fei X,Ye S,Chen C

Published figure using SLC7A11 polyclonal antibody (Product # PA1-16893) in Western Blot

Sat Jul 16 00:00:00 EDT 2022

TRIM26 Induces Ferroptosis to Inhibit Hepatic Stellate Cell Activation and Mitigate Liver Fibrosis Through Mediating SLC7A11 Ubiquitination.

Frontiers in cell and developmental biology

Zhu Y,Zhang C,Huang M,Lin J,Fan X,Ni T

PA1-16893 was used in Immunoprecipitation to find that TRIM26 was downregulated in fibrotic liver tissues.

Wed Apr 21 00:00:00 EDT 2021

TRIM26 Induces Ferroptosis to Inhibit Hepatic Stellate Cell Activation and Mitigate Liver Fibrosis Through Mediating SLC7A11 Ubiquitination.

Frontiers in cell and developmental biology

Zhu Y,Zhang C,Huang M,Lin J,Fan X,Ni T

PA1-16893 was used in Immunoprecipitation to find that TRIM26 was downregulated in fibrotic liver tissues.

Wed Apr 21 00:00:00 EDT 2021

Overexpression of Cystine/Glutamate Antiporter xCT Correlates with Nutrient Flexibility and ZEB1 Expression in Highly Clonogenic Glioblastoma Stem-like Cells (GSCs).

Cancers

Koch K,Hartmann R,Suwala AK,Rios DH,Kamp MA,Sabel M,Steiger HJ,Willbold D,Sharma A,Kahlert UD,Maciaczyk J

PA1-16893 was used in Western Blot to study the metabolic dependencies of glioblastoma stem-like cells with high-resolution proton nuclear magnetic resonance spectroscopy.

Mon Nov 29 00:00:00 EST 2021

Overexpression of Cystine/Glutamate Antiporter xCT Correlates with Nutrient Flexibility and ZEB1 Expression in Highly Clonogenic Glioblastoma Stem-like Cells (GSCs).

Cancers

Koch K,Hartmann R,Suwala AK,Rios DH,Kamp MA,Sabel M,Steiger HJ,Willbold D,Sharma A,Kahlert UD,Maciaczyk J

PA1-16893 was used in Western Blot to study the metabolic dependencies of glioblastoma stem-like cells with high-resolution proton nuclear magnetic resonance spectroscopy.

Mon Nov 29 00:00:00 EST 2021

Mitochondrial fusion supports increased oxidative phosphorylation during cell proliferation.

eLife

Yao CH,Wang R,Wang Y,Kung CP,Weber JD,Patti GJ

PA1-16893 was used in Western Blotting to reveal that cell proliferation requires increased OXPHOS as supported by mitochondrial fusion.

Tue Jan 29 00:00:00 EST 2019

Mitochondrial fusion supports increased oxidative phosphorylation during cell proliferation.

eLife

Yao CH,Wang R,Wang Y,Kung CP,Weber JD,Patti GJ

PA1-16893 was used in Western Blotting to reveal that cell proliferation requires increased OXPHOS as supported by mitochondrial fusion.

Tue Jan 29 00:00:00 EST 2019

Glutamate Signaling in Hepatic Stellate Cells Drives Alcoholic Steatosis.

Cell metabolism

Choi WM,Kim HH,Kim MH,Cinar R,Yi HS,Eun HS,Kim SH,Choi YJ,Lee YS,Kim SY,Seo W,Lee JH,Shim YR,Kim YE,Yang K,Ryu T,Hwang JH,Lee CH,Choi HS,Gao B,Kim W,Kim SK,Kunos G,Jeong WI

PA1-16893 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to investigate hepatocyte cannabinoid receptor-1 in alcoholic liver disease and lipogenesis.

Tue Nov 05 00:00:00 EST 2019

Participation of xCT in melanoma cell proliferation in vitro and tumorigenesis in vivo.

Oncogenesis

Shin SS,Jeong BS,Wall BA,Li J,Shan NL,Wen Y,Goydos JS,Chen S

PA1-16893 was used in Western Blotting to show that xCT may be utilised as a marker to monitor patients undergoing riluzole-based chemotherapies.

Wed Nov 14 00:00:00 EST 2018

Participation of xCT in melanoma cell proliferation in vitro and tumorigenesis in vivo.

Oncogenesis

Shin SS,Jeong BS,Wall BA,Li J,Shan NL,Wen Y,Goydos JS,Chen S

PA1-16893 was used in Western Blotting to show that xCT may be utilised as a marker to monitor patients undergoing riluzole-based chemotherapies.

Wed Nov 14 00:00:00 EST 2018

Participation of xCT in melanoma cell proliferation in vitro and tumorigenesis in vivo.

Oncogenesis

Shin SS,Jeong BS,Wall BA,Li J,Shan NL,Wen Y,Goydos JS,Chen S

PA1-16893 was used in Western Blotting to show that xCT may be utilised as a marker to monitor patients undergoing riluzole-based chemotherapies.

Wed Nov 14 00:00:00 EST 2018

Comparative analysis of antibodies to xCT (Slc7a11): Forewarned is forearmed.

The Journal of comparative neurology

Van Liefferinge J,Bentea E,Demuyser T,Albertini G,Follin-Arbelet V,Holmseth S,Merckx E,Sato H,Aerts JL,Smolders I,Arckens L,Danbolt NC,Massie A

PA1-16893 was used in western blot to analyze antibodies to xCT (Slc7a11) comparatively

Fri Apr 01 00:00:00 EDT 2016

Comparative analysis of antibodies to xCT (Slc7a11): Forewarned is forearmed.

The Journal of comparative neurology

Van Liefferinge J,Bentea E,Demuyser T,Albertini G,Follin-Arbelet V,Holmseth S,Merckx E,Sato H,Aerts JL,Smolders I,Arckens L,Danbolt NC,Massie A

PA1-16893 was used in western blot to analyze antibodies to xCT (Slc7a11) comparatively

Fri Apr 01 00:00:00 EDT 2016

Reduced expression of miRNA-27a modulates cisplatin resistance in bladder cancer by targeting the cystine/glutamate exchanger SLC7A11.

Clinical cancer research : an official journal of the American Association for Cancer Research

Drayton RM,Dudziec E,Peter S,Bertz S,Hartmann A,Bryant HE,Catto JW

PA1-16893 was used in immunohistochemistry to study the role of SLC7A11 in the mechanism by which miRNA-27a expression levels modulate bladder cancer cisplatin resistance

Tue Apr 01 00:00:00 EDT 2014

Bioinformatics

Protein Aliases: Amino acid transport system xc-; Calcium channel blocker resistance protein CCBR1; cysteine/glutamate transporter; Cystine/glutamate transporter; sodium independent anionic amino acid transport system; solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11; solute carrier family 7 (cationic amino acid transporter, y+ system), member 11; Solute carrier family 7 member 11; solute carrier family 7, (cationic amino acid transporter, y+ system) member 11; Subtle gray protein; xCT

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Gene Aliases: 9930009M05Rik; AI451155; CCBR1; SLC7A11; sut; xCT

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UniProt ID: (Human) Q9UPY5, (Mouse) Q9WTR6

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Entrez Gene ID: (Human) 23657, (Mouse) 26570, (Rat) 310392

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Function(s)

protein binding cystine:glutamate antiporter activity amino acid transmembrane transporter activity molecular_function transporter

Process(es)

amino acid transmembrane transport amino acid transport response to oxidative stress brain development response to toxic substance response to nicotine leukocyte migration lens fiber cell differentiation platelet aggregation L-glutamate transmembrane transport transport neutral amino acid transport modified amino acid transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SLC7A11 Polyclonal Antibody

SLC7A11 Antibody (PA1-16893) in IHC (P)

Product Details

PA1-16893

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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