Product References
Pan-Phosphodiesterase Inhibitors Attenuate TGF-β-Induced Pro-Fibrotic Phenotype in Alveolar Epithelial Type II Cells by Downregulating Smad-2 Phosphorylation.
Pharmaceuticals (Basel, Switzerland)
Wójcik-Pszczoła K,Chłoń-Rzepa G,Jankowska A,Ferreira B,Koczurkiewicz-Adamczyk P,Pękala E,Wyska E,Pociecha K,Gosens R
Published figure using SMAD2 polyclonal antibody (Product # 51-1300) in Western Blot
Wed Mar 30 00:00:00 EDT 2022
LINC02381 aggravates breast cancer through the miR-1271-5p/FN1 axis to activate PI3K/AKT pathway.
Molecular carcinogenesis
Huang S,Huang P,Wu H,Wang S,Liu G
51-1300 was used in ChIP Assay, ELISA, Immunohistochemistry (Paraffin), Western Blot to conclude that LINC02381 exerts carcinogenic effects in BC by the miR-1271-5p/FN1 axis to activate PI3K/AKT pathway.
Tue Mar 01 00:00:00 EST 2022
Heat Shock Protein 90 Involvement in the Development of Idiopathic Epiretinal Membranes.
Investigative ophthalmology & visual science
Tosi GM,Regoli M,Altera A,Galvagni F,Arcuri C,Bacci T,Elia I,Realini G,Orlandini M,Bertelli E
51-1300 was used in Immunohistochemistry (Frozen) to characterize cells of idiopathic epiretinal membranes (iERMs).
Wed Jul 01 00:00:00 EDT 2020
Deletion of Akt1 Promotes Kidney Fibrosis in a Murine Model of Unilateral Ureteral Obstruction.
BioMed research international
Kim IY,Lee MY,Park MW,Seong EY,Lee DW,Lee SB,Bae SS,Kim SS,Song SH
51-1300 was used in Western Blotting to show renal fibrosis can be promoted by Akt1 deletion by induction of the TGFβ1/STAT3 pathway.
Fri May 07 00:00:00 EDT 2021
A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling.
International journal of molecular sciences
Wójcik-Pszczoła K,Chłoń-Rzepa G,Jankowska A,Ślusarczyk M,Ferdek PE,Kusiak AA,Świerczek A,Pociecha K,Koczurkiewicz-Adamczyk P,Wyska E,Pękala E,Gosens R
51-1300 was used in Western Blotting to investigate the effect of selected derivatives (832-a pan-PDE inhibitor, 869-a TRPA1 modulator, and 145-a pan-PDE inhibitor and a weak TRPA1 modulator) on cellular responses related to airway remodeling using MRC-5 human lung fibroblasts.
Wed Jun 03 00:00:00 EDT 2020
A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling.
International journal of molecular sciences
Wójcik-Pszczoła K,Chłoń-Rzepa G,Jankowska A,Ślusarczyk M,Ferdek PE,Kusiak AA,Świerczek A,Pociecha K,Koczurkiewicz-Adamczyk P,Wyska E,Pękala E,Gosens R
51-1300 was used in Western Blotting to investigate the effect of selected derivatives (832-a pan-PDE inhibitor, 869-a TRPA1 modulator, and 145-a pan-PDE inhibitor and a weak TRPA1 modulator) on cellular responses related to airway remodeling using MRC-5 human lung fibroblasts.
Wed Jun 03 00:00:00 EDT 2020
The neovascularization effect of dedifferentiated fat cells.
Scientific reports
Watanabe H,Goto S,Kato R,Komiyama S,Nagaoka Y,Kazama T,Yamamoto C,Li Y,Konuma N,Hagikura K,Matsumoto T
Published figure using SMAD2 polyclonal antibody (Product # 51-1300) in Western Blot
Mon Jun 08 00:00:00 EDT 2020
The neovascularization effect of dedifferentiated fat cells.
Scientific reports
Watanabe H,Goto S,Kato R,Komiyama S,Nagaoka Y,Kazama T,Yamamoto C,Li Y,Konuma N,Hagikura K,Matsumoto T
Published figure using SMAD2 polyclonal antibody (Product # 51-1300) in Western Blot
Mon Jun 08 00:00:00 EDT 2020
NG2 glia regulate brain innate immunity via TGF-β2/TGFBR2 axis.
BMC medicine
Zhang SZ,Wang QQ,Yang QQ,Gu HY,Yin YQ,Li YD,Hou JC,Chen R,Sun QQ,Sun YF,Hu G,Zhou JW
Published figure using SMAD2 polyclonal antibody (Product # 51-1300) in Western Blot
Fri Nov 15 00:00:00 EST 2019
Inhibition of TGF-β1 Signaling by IL-15: A Novel Role for IL-15 in the Control of Renal Epithelial-Mesenchymal Transition: IL-15 Counteracts TGF-β1-Induced EMT in Renal Fibrosis.
International journal of cell biology
Devocelle A,Lecru L,François H,Desterke C,Gallerne C,Eid P,Estelle O,Azzarone B,Giron-Michel J
51-1300 was used in Western Blot to analyse whether human chronic inflammatory nephropathies evolving towards fibrosis could be also characterized by a weak intrarenal IL-15 expression and if IL-15 could inhibit epithelial-mesenchymal transition (EMT) and excess matrix deposition in human renal proximal tubular epithelial cells (RPTEC).
Wed Sep 30 00:00:00 EDT 2020
KLF10 Gene Expression Modulates Fibrosis in Dystrophic Skeletal Muscle.
The American journal of pathology
DiMario JX
51-1300 was used in Western Blotting to study the effect of loss of KLF10 gene expression in wild type and dystrophic skeletal muscle.
Tue May 01 00:00:00 EDT 2018
TGF-β induces Smad2 Phosphorylation, ARE Induction, and Trophoblast Differentiation.
International journal of stem cells
Albers RE,Selesniemi K,Natale DRC,Brown TL
51-1300 was used in Western Blotting to identify an important regulatory signalling pathway in SM10 progenitor cells that is involved in labyrinthine trophoblast differentiation.
Wed May 30 00:00:00 EDT 2018
TGF-β induces Smad2 Phosphorylation, ARE Induction, and Trophoblast Differentiation.
International journal of stem cells
Albers RE,Selesniemi K,Natale DRC,Brown TL
51-1300 was used in Western Blotting to identify an important regulatory signalling pathway in SM10 progenitor cells that is involved in labyrinthine trophoblast differentiation.
Wed May 30 00:00:00 EDT 2018
Acinar-to-Ductal Metaplasia Induced by Transforming Growth Factor Beta Facilitates KRASG12D-driven Pancreatic Tumorigenesis.
Cellular and molecular gastroenterology and hepatology
Chuvin N,Vincent DF,Pommier RM,Alcaraz LB,Gout J,Caligaris C,Yacoub K,Cardot V,Roger E,Kaniewski B,Martel S,Cintas C,Goddard-Léon S,Colombe A,Valantin J,Gadot N,Servoz E,Morton J,Goddard I,Couvelard A,Rebours V,Guillermet J,Sansom OJ,Treilleux I,Valcourt U,Sentis S,Dubus P,Bartholin L
Published figure using SMAD2 polyclonal antibody (Product # 51-1300) in Western Blot
Fri Sep 01 00:00:00 EDT 2017
Silencing Med12 Gene Reduces Proliferation of Human Leiomyoma Cells Mediated via Wnt/β-Catenin Signaling Pathway.
Endocrinology
Al-Hendy A,Laknaur A,Diamond MP,Ismail N,Boyer TG,Halder SK
Published figure using SMAD2 polyclonal antibody (Product # 51-1300) in Western Blot
Wed Mar 01 00:00:00 EST 2017
MicroRNA-30b controls endothelial cell capillary morphogenesis through regulation of transforming growth factor beta 2.
PloS one
Howe GA,Kazda K,Addison CL
51-1300 was used in Western Blotting to support that the regulation of miR-30b by vascular endothelial growth factor in human umbilical vein endothelial cells is important for capillary morphogenesis.
Thu Nov 02 00:00:00 EDT 2017
MicroRNA-30b controls endothelial cell capillary morphogenesis through regulation of transforming growth factor beta 2.
PloS one
Howe GA,Kazda K,Addison CL
51-1300 was used in Western Blotting to support that the regulation of miR-30b by vascular endothelial growth factor in human umbilical vein endothelial cells is important for capillary morphogenesis.
Thu Nov 02 00:00:00 EDT 2017
FGFR1 is critical for the anti-endothelial mesenchymal transition effect of N-acetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway.
Cell death & disease
Li J,Shi S,Srivastava SP,Kitada M,Nagai T,Nitta K,Kohno M,Kanasaki K,Koya D
51-1300 was used in Western Blot to elucidate the role of the AcSDKP-FGFR1-MAP4K4 axis in combating endothelial-to-mesenchymal transition-associated fibrotic disorders.
Thu Aug 03 00:00:00 EDT 2017
Response to Nodal morphogen gradient is determined by the kinetics of target gene induction.
eLife
Dubrulle J,Jordan BM,Akhmetova L,Farrell JA,Kim SH,Solnica-Krezel L,Schier AF
Published figure using SMAD2 polyclonal antibody (Product # 51-1300) in ChIP assay
Tue Apr 14 00:00:00 EDT 2015
An integrated genomic approach identifies persistent tumor suppressive effects of transforming growth factor-β in human breast cancer.
Breast cancer research : BCR
Sato M,Kadota M,Tang B,Yang HH,Yang YA,Shan M,Weng J,Welsh MA,Flanders KC,Nagano Y,Michalowski AM,Clifford RJ,Lee MP,Wakefield LM
51-1300 was used in western blot to evaluate a genomic strategy for the evaluation of transforming growth factor-beta in breast cancer.
Mon Jun 02 00:00:00 EDT 2014
Brightfield proximity ligation assay reveals both canonical and mixed transforming growth factor-β/bone morphogenetic protein Smad signaling complexes in tissue sections.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Flanders KC,Heger CD,Conway C,Tang B,Sato M,Dengler SL,Goldsmith PK,Hewitt SM,Wakefield LM
Published figure using SMAD2 polyclonal antibody (Product # 51-1300) in Immunohistochemistry
Mon Dec 01 00:00:00 EST 2014
Brightfield proximity ligation assay reveals both canonical and mixed transforming growth factor-β/bone morphogenetic protein Smad signaling complexes in tissue sections.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Flanders KC,Heger CD,Conway C,Tang B,Sato M,Dengler SL,Goldsmith PK,Hewitt SM,Wakefield LM
Published figure using SMAD2 polyclonal antibody (Product # 51-1300) in Immunohistochemistry
Mon Dec 01 00:00:00 EST 2014
TGF-β induction of FGF-2 expression in stromal cells requires integrated smad3 and MAPK pathways.
American journal of clinical and experimental urology
Strand DW,Liang YY,Yang F,Barron DA,Ressler SJ,Schauer IG,Feng XH,Rowley DR
51-1300 was used in western blot to determine how TGF-beta1-induced FGF-2 expression is regulated in prostate stromal fibroblasts and mouse embryo fibroblasts null for Smad2 and Smad3
Thu Nov 06 00:00:00 EST 2014
Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis.
Nature medicine
Han G,Bian L,Li F,Cotrim A,Wang D,Lu J,Deng Y,Bird G,Sowers A,Mitchell JB,Gutkind JS,Zhao R,Raben D,ten Dijke P,Refaeli Y,Zhang Q,Wang XJ
Published figure using SMAD2 polyclonal antibody (Product # 51-1300) in ChIP assay
Mon Apr 01 00:00:00 EDT 2013
Cycloheximide inhibits follicle-stimulating hormone β subunit transcription by blocking de novo synthesis of the labile activin type II receptor in gonadotrope cells.
Cellular signalling
Rejon CA,Ho CC,Wang Y,Zhou X,Bernard DJ,Hébert TE
51-1300 was used in western blot to demonstrate that cycloheximide produces inhibin-like effects in gonadotropes by preventing de novo synthesis of ACVR2.
Sat Jun 01 00:00:00 EDT 2013
Expression of Wnt and TGF-β pathway components and key adrenal transcription factors in adrenocortical tumors: association to carcinoma aggressiveness.
Pathology, research and practice
Parviainen H,Schrade A,Kiiveri S,Prunskaite-Hyyryläinen R,Haglund C,Vainio S,Wilson DB,Arola J,Heikinheimo M
51-1300 was used in immunohistochemistry to study the expression and prognostic value of Wnt and TGF-? pathway components and key adrenal transcription factors in adrenocortical tumors
Thu Aug 01 00:00:00 EDT 2013
Transforming growth factor-β3 (TGF-β3) knock-in ameliorates inflammation due to TGF-β1 deficiency while promoting glucose tolerance.
The Journal of biological chemistry
Hall BE,Wankhade UD,Konkel JE,Cherukuri K,Nagineni CN,Flanders KC,Arany PR,Chen W,Rane SG,Kulkarni AB
51-1300 was used in western blot to evaluate the role of transforming growth factor-beta3 in inflammation and glucose tolerance
Fri Nov 01 00:00:00 EDT 2013
Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of β-catenin.
Gastroenterology
Freeman TJ,Smith JJ,Chen X,Washington MK,Roland JT,Means AL,Eschrich SA,Yeatman TJ,Deane NG,Beauchamp RD
51-1300 was used in western blot to study the effects of Smad4 loss on the levels of β-catenin messenger RNA and Wnt signaling.
Thu Mar 01 00:00:00 EST 2012
Biological responses to TGF-β in the mammary epithelium show a complex dependency on Smad3 gene dosage with important implications for tumor progression.
Molecular cancer research : MCR
Kohn EA,Yang YA,Du Z,Nagano Y,Van Schyndle CM,Herrmann MA,Heldman M,Chen JQ,Stuelten CH,Flanders KC,Wakefield LM
Published figure using SMAD2 polyclonal antibody (Product # 51-1300) in Western Blot
Mon Oct 01 00:00:00 EDT 2012
Transforming growth factor β inhibits bone morphogenetic protein-induced transcription through novel phosphorylated Smad1/5-Smad3 complexes.
Molecular and cellular biology
Grönroos E,Kingston IJ,Ramachandran A,Randall RA,Vizán P,Hill CS
Published figure using SMAD2 polyclonal antibody (Product # 51-1300) in Immunoprecipitation
Sun Jul 01 00:00:00 EDT 2012
Transforming growth factor β inhibits bone morphogenetic protein-induced transcription through novel phosphorylated Smad1/5-Smad3 complexes.
Molecular and cellular biology
Grönroos E,Kingston IJ,Ramachandran A,Randall RA,Vizán P,Hill CS
Published figure using SMAD2 polyclonal antibody (Product # 51-1300) in Immunoprecipitation
Sun Jul 01 00:00:00 EDT 2012
Targeted inhibition of β-catenin/CBP signaling ameliorates renal interstitial fibrosis.
Journal of the American Society of Nephrology : JASN
Hao S,He W,Li Y,Ding H,Hou Y,Nie J,Hou FF,Kahn M,Liu Y
51-1300 was used in western blot to assess the effects of β-catenin modulation on tubular epithelial-mesenchymal transition.
Thu Sep 01 00:00:00 EDT 2011
Regulation of extra-embryonic endoderm stem cell differentiation by Nodal and Cripto signaling.
Development (Cambridge, England)
Kruithof-de Julio M,Alvarez MJ,Galli A,Chu J,Price SM,Califano A,Shen MM
Published figure using SMAD2 polyclonal antibody (Product # 51-1300) in Western Blot
Thu Sep 01 00:00:00 EDT 2011
Distinctive mechanism for sustained TGF-β signaling and growth inhibition: MEK1 activation-dependent stabilization of type II TGF-β receptors.
Molecular cancer research : MCR
Chen G,Ghosh P,Longo DL
51-1300 was used in western blot to report a novel mechanism by which cells become resistant to TGF-beta-mediated growth suppression
Sat Jan 01 00:00:00 EST 2011
IL-13 induces connective tissue growth factor in rat hepatic stellate cells via TGF-β-independent Smad signaling.
Journal of immunology (Baltimore, Md. : 1950)
Liu Y,Meyer C,Müller A,Herweck F,Li Q,Müllenbach R,Mertens PR,Dooley S,Weng HL
Thu Sep 01 00:00:00 EDT 2011
Reduction of transforming growth factor-beta type II receptor is caused by the enhanced ubiquitin-dependent degradation in human renal cell carcinoma.
International journal of cancer
Fukasawa H,Yamamoto T,Fujigaki Y,Misaki T,Ohashi N,Takayama T,Suzuki S,Mugiya S,Oda T,Uchida C,Kitagawa K,Hattori T,Hayashi H,Ozono S,Kitagawa M,Hishida A
51-1300 was used in western blot to study transforming growth factor-beta signaling in renal cell carcinoma
Fri Oct 01 00:00:00 EDT 2010
Conditional overexpression of TGF-beta1 disrupts mouse salivary gland development and function.
Laboratory investigation; a journal of technical methods and pathology
Hall BE,Zheng C,Swaim WD,Cho A,Nagineni CN,Eckhaus MA,Flanders KC,Ambudkar IS,Baum BJ,Kulkarni AB
51-1300 was used in western blot to investigate the role of TGF-beta1 in the salivary gland
Thu Apr 01 00:00:00 EDT 2010
SKI promotes Smad3 linker phosphorylations associated with the tumor-promoting trait of TGFbeta.
Cell cycle (Georgetown, Tex.)
Lin Q,Chen D,Timchenko NA,Medrano EE
51-1300 was used in western blot to discuss how SKI-mediated processes in melanoma cells
Sat May 01 00:00:00 EDT 2010
Activin A regulates porcine follicle-stimulating hormone beta-subunit transcription via cooperative actions of SMADs and FOXL2.
Endocrinology
Lamba P,Wang Y,Tran S,Ouspenskaia T,Libasci V,Hébert TE,Miller GJ,Bernard DJ
51-1300 was used in western blot to demonstrate that SMAD and FOXL2 form a complex that activates transcription.
Mon Nov 01 00:00:00 EDT 2010
Autocrine transforming growth factor-{beta}1 activation mediated by integrin {alpha}V{beta}3 regulates transcriptional expression of laminin-332 in Madin-Darby canine kidney epithelial cells.
Molecular biology of the cell
Moyano JV,Greciano PG,Buschmann MM,Koch M,Matlin KS
51-1300 was used in western blot to examine production and localization of LM-332 in epithelial cells
Mon Nov 01 00:00:00 EDT 2010
Plasminogen activator inhibitor-1 is a transcriptional target of the canonical pathway of Wnt/beta-catenin signaling.
The Journal of biological chemistry
He W,Tan R,Dai C,Li Y,Wang D,Hao S,Kahn M,Liu Y
Published figure using SMAD2 polyclonal antibody (Product # 51-1300) in Western Blot
Fri Aug 06 00:00:00 EDT 2010
Plasminogen activator inhibitor-1 is a transcriptional target of the canonical pathway of Wnt/beta-catenin signaling.
The Journal of biological chemistry
He W,Tan R,Dai C,Li Y,Wang D,Hao S,Kahn M,Liu Y
Published figure using SMAD2 polyclonal antibody (Product # 51-1300) in Western Blot
Fri Aug 06 00:00:00 EDT 2010
Plasminogen activator inhibitor-1 is a transcriptional target of the canonical pathway of Wnt/beta-catenin signaling.
The Journal of biological chemistry
He W,Tan R,Dai C,Li Y,Wang D,Hao S,Kahn M,Liu Y
Published figure using SMAD2 polyclonal antibody (Product # 51-1300) in Western Blot
Fri Aug 06 00:00:00 EDT 2010
Foxa1 functions as a pioneer transcription factor at transposable elements to activate Afp during differentiation of embryonic stem cells.
The Journal of biological chemistry
Taube JH,Allton K,Duncan SA,Shen L,Barton MC
Published figure using SMAD2 polyclonal antibody (Product # 51-1300) in Western Blot
Fri May 21 00:00:00 EDT 2010
Foxa1 functions as a pioneer transcription factor at transposable elements to activate Afp during differentiation of embryonic stem cells.
The Journal of biological chemistry
Taube JH,Allton K,Duncan SA,Shen L,Barton MC
Published figure using SMAD2 polyclonal antibody (Product # 51-1300) in Western Blot
Fri May 21 00:00:00 EDT 2010
Induction of ΔNp63 by the newly identified keratinocyte-specific transforming growth factor β Signaling Pathway with Smad2 and IκB Kinase α in squamous cell carcinoma.
Neoplasia (New York, N.Y.)
Fukunishi N,Katoh I,Tomimori Y,Tsukinoki K,Hata R,Nakao A,Ikawa Y,Kurata S
Published figure using SMAD2 polyclonal antibody (Product # 51-1300) in ChIP assay
Wed Dec 01 00:00:00 EST 2010
Measuring the absolute abundance of the Smad transcription factors using quantitative immunoblotting.
Methods in molecular biology (Clifton, N.J.)
Clarke DC,Liu X
51-1300 was used in western blot to establish an immunoblotting method to determine the number of Smad transcription factor molecules per cell
Tue Dec 28 00:00:00 EST 2010
Analysis of ligand-dependent nuclear accumulation of Smads in TGF-beta signaling.
Methods in molecular biology (Clifton, N.J.)
Chapnick DA,Liu X
51-1300 was used in Immunocytochemistry-immunoflourescence to develop live cell imaging and immunofluorescence methods for tracking Smad subcellular localisation in response to TGF-beta and leptomycin B treatment.
Tue Dec 28 00:00:00 EST 2010
Nox-2 is a modulator of fibrogenesis in kidney allografts.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Djamali A,Vidyasagar A,Adulla M,Hullett D,Reese S
51-1300 was used in western blot to investigate the role of NADPH oxidase in the pathogenesis of kidney allograft tubulointerstitial fibrosis
Thu Jan 01 00:00:00 EST 2009
A positive role for Myc in TGFbeta-induced Snail transcription and epithelial-to-mesenchymal transition.
Oncogene
Smith AP,Verrecchia A,Fagà G,Doni M,Perna D,Martinato F,Guccione E,Amati B
51-1300 was used in ChIP assay and western blot to elucidate the role of Myc in the TGFbeta response
Thu Jan 22 00:00:00 EST 2009
Activins regulate 17beta-hydroxysteroid dehydrogenase type I transcription in murine gonadotrope cells.
The Journal of endocrinology
Bak B,Carpio L,Kipp JL,Lamba P,Wang Y,Ge RS,Hardy MP,Mayo KE,Bernard DJ
51-1300 was used in Chromatin immunoprecipitation to demonstrate that activin A rapidly regulates 17beta-hydroxysteroid dehydrogenase type I transcription in gonadotrope and granulosa cells and may thereby regulate local 17beta-estradiol synthesis.
Wed Apr 01 00:00:00 EDT 2009
SKI knockdown inhibits human melanoma tumor growth in vivo.
Pigment cell & melanoma research
Chen D,Lin Q,Box N,Roop D,Ishii S,Matsuzaki K,Fan T,Hornyak TJ,Reed JA,Stavnezer E,Timchenko NA,Medrano EE
51-1300 was used in Western Blotting to demonstrate that SKI knockdown in human melanoma cells results in minimal orthotopic tumour xenograft nodules that display low mitotic rate and prominent apoptosis.
Tue Dec 01 00:00:00 EST 2009
BMP7 and SHH regulate Pax2 in mouse retinal astrocytes by relieving TLX repression.
Developmental biology
Sehgal R,Sheibani N,Rhodes SJ,Belecky Adams TL
Sat Aug 15 00:00:00 EDT 2009
Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage.
Gastroenterology
Dooley S,Hamzavi J,Ciuclan L,Godoy P,Ilkavets I,Ehnert S,Ueberham E,Gebhardt R,Kanzler S,Geier A,Breitkopf K,Weng H,Mertens PR
51-1300 was used in Western Blotting to show that hepatocytes undergo transforming growth factor (TGF)-beta-dependent epithelial-to-mesenchymal transition-like phenotypic changes and actively participate in fibrogenesis.
Fri Aug 01 00:00:00 EDT 2008
Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus encoded EBNA1 contributes to the growth and survival of Hodgkin lymphoma cells.
Blood
Flavell JR,Baumforth KR,Wood VH,Davies GL,Wei W,Reynolds GM,Morgan S,Boyce A,Kelly GL,Young LS,Murray PG
51-1300 was used in Western Blotting to demonstrate that PTPRK is a functional tumour suppressor in Hodgkin lymphoma cells.
Tue Jan 01 00:00:00 EST 2008
The role of caveolin-1 in pulmonary matrix remodeling and mechanical properties.
American journal of physiology. Lung cellular and molecular physiology
Le Saux O,Teeters K,Miyasato S,Choi J,Nakamatsu G,Richardson JA,Starcher B,Davis EC,Tam EK,Jourdan-Le Saux C
Published figure using SMAD2 polyclonal antibody (Product # 51-1300) in Western Blot
Mon Dec 01 00:00:00 EST 2008
Smad ubiquitination regulatory factor-2 in the fibrotic kidney: regulation, target specificity, and functional implication.
American journal of physiology. Renal physiology
Tan R,He W,Lin X,Kiss LP,Liu Y
51-1300 was used in Western Blotting to demonstrate that Smurf2 is up-regulated specifically in renal tubules of the fibrotic kidney, which is likely mediated by TGF-Β1.
Thu May 01 00:00:00 EDT 2008
Smad ubiquitination regulatory factor-2 in the fibrotic kidney: regulation, target specificity, and functional implication.
American journal of physiology. Renal physiology
Tan R,He W,Lin X,Kiss LP,Liu Y
51-1300 was used in Western Blotting to demonstrate that Smurf2 is up-regulated specifically in renal tubules of the fibrotic kidney, which is likely mediated by TGF-Β1.
Thu May 01 00:00:00 EDT 2008
TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs.
Developmental dynamics : an official publication of the American Association of Anatomists
Alejandre-Alcázar MA,Michiels-Corsten M,Vicencio AG,Reiss I,Ryu J,de Krijger RR,Haddad GG,Tibboel D,Seeger W,Eickelberg O,Morty RE
Published figure using SMAD2 polyclonal antibody (Product # 51-1300) in Western Blot
Tue Jan 01 00:00:00 EST 2008
Generation of mice with conditionally activated transforming growth factor beta signaling through the TbetaRI/ALK5 receptor.
Genesis (New York, N.Y. : 2000)
Bartholin L,Cyprian FS,Vincent D,Garcia CN,Martel S,Horvat B,Berthet C,Goddard-Léon S,Treilleux I,Rimokh R,Marie JC
51-1300 was used in western blot to generate and characterize LSL-TbetaRI(CA) transgenic mice
Mon Dec 01 00:00:00 EST 2008
Down-regulation of caveolin-1, an inhibitor of transforming growth factor-beta signaling, in acute allergen-induced airway remodeling.
The Journal of biological chemistry
Le Saux CJ,Teeters K,Miyasato SK,Hoffmann PR,Bollt O,Douet V,Shohet RV,Broide DH,Tam EK
51-1300 was used in western blot to report that IL-4 modulates TGF-beta signaling
Fri Feb 29 00:00:00 EST 2008
Smad signaling pathway is a pivotal component of tissue inhibitor of metalloproteinases-3 regulation by transforming growth factor beta in human chondrocytes.
Biochimica et biophysica acta
Qureshi HY,Ricci G,Zafarullah M
51-1300 was used in ChIP assay and western blot to determine the roles of Smads in TGF-beta1 induction of the TIMP-3 gene
Mon Sep 01 00:00:00 EDT 2008
Profibrogenic transforming growth factor-beta/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes.
Hepatology (Baltimore, Md.)
Weng HL,Ciuclan L,Liu Y,Hamzavi J,Godoy P,Gaitantzi H,Kanzler S,Heuchel R,Ueberham U,Gebhardt R,Breitkopf K,Dooley S
Published figure using SMAD2 polyclonal antibody (Product # 51-1300) in Western Blot
Mon Oct 01 00:00:00 EDT 2007
Localization of TGF-beta signaling intermediates Smad2, 3, 4, and 7 in developing and mature human and mouse kidney.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Banas MC,Parks WT,Hudkins KL,Banas B,Holdren M,Iyoda M,Wietecha TA,Kowalewska J,Liu G,Alpers CE
51-1300 was used in Immunohistochemistry to demonstrate expression of the TGF-beta-receptor-activated Smad2 and Smad3, the common mediator Smad4, and the inhibitory Smad7 in the developing human fetal kidney.
Thu Mar 01 00:00:00 EST 2007
Localization of TGF-beta signaling intermediates Smad2, 3, 4, and 7 in developing and mature human and mouse kidney.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Banas MC,Parks WT,Hudkins KL,Banas B,Holdren M,Iyoda M,Wietecha TA,Kowalewska J,Liu G,Alpers CE
51-1300 was used in Immunohistochemistry to demonstrate expression of the TGF-beta-receptor-activated Smad2 and Smad3, the common mediator Smad4, and the inhibitory Smad7 in the developing human fetal kidney.
Thu Mar 01 00:00:00 EST 2007
Requirement for the dynein light chain km23-1 in a Smad2-dependent transforming growth factor-beta signaling pathway.
The Journal of biological chemistry
Jin Q,Ding W,Mulder KM
51-1300 was used in immunocytochemistry to report that a dynein light chain is required for the Smad2-dependent TGFbeta signaling pathway
Fri Jun 29 00:00:00 EDT 2007
Requirement for the dynein light chain km23-1 in a Smad2-dependent transforming growth factor-beta signaling pathway.
The Journal of biological chemistry
Jin Q,Ding W,Mulder KM
51-1300 was used in immunocytochemistry to report that a dynein light chain is required for the Smad2-dependent TGFbeta signaling pathway
Fri Jun 29 00:00:00 EDT 2007
Requirement for the dynein light chain km23-1 in a Smad2-dependent transforming growth factor-beta signaling pathway.
The Journal of biological chemistry
Jin Q,Ding W,Mulder KM
51-1300 was used in immunocytochemistry to report that a dynein light chain is required for the Smad2-dependent TGFbeta signaling pathway
Fri Jun 29 00:00:00 EDT 2007
LMO4 can interact with Smad proteins and modulate transforming growth factor-beta signaling in epithelial cells.
Oncogene
Lu Z,Lam KS,Wang N,Xu X,Cortes M,Andersen B
51-1300 was used in immunoprecipitation to study the involvement of LMO4 in mesenchymal-epithelial signaling
Thu May 11 00:00:00 EDT 2006
Cutting edge: deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Wohlfert EA,Gorelik L,Mittler R,Flavell RA,Clark RB
51-1300 was used in western blot to report that Cbl-b plays an integral role in T cell TGF-beta signaling
Wed Feb 01 00:00:00 EST 2006
The mechanism of nuclear export of Smad3 involves exportin 4 and Ran.
Molecular and cellular biology
Kurisaki A,Kurisaki K,Kowanetz M,Sugino H,Yoneda Y,Heldin CH,Moustakas A
Wed Feb 01 00:00:00 EST 2006
TGFbeta protein processing and activity through TCR triggering of primary CD8+ T regulatory cells.
Journal of immunology (Baltimore, Md. : 1950)
Ménoret A,Myers LM,Lee SJ,Mittler RS,Rossi RJ,Vella AT
51-1300 was used in ChIP Assay, ELISA, Immunohistochemistry (Paraffin), Western Blot to investigate TGFbeta activity due to mouse CD8 regulatory T cells.
Wed Nov 01 00:00:00 EST 2006
Activin A mediates growth inhibition and cell cycle arrest through Smads in human breast cancer cells.
Cancer research
Burdette JE,Jeruss JS,Kurley SJ,Lee EJ,Woodruff TK
51-1300 was used in western blot to determine the role of activin A in the growth regulation of breast cancer cells
Thu Sep 01 00:00:00 EDT 2005
Inactivation of TGF-beta signaling in hepatocytes results in an increased proliferative response after partial hepatectomy.
Oncogene
Romero-Gallo J,Sozmen EG,Chytil A,Russell WE,Whitehead R,Parks WT,Holdren MS,Her MF,Gautam S,Magnuson M,Moses HL,Grady WM
Thu Apr 21 00:00:00 EDT 2005
Smad7 abrogates transforming growth factor-beta1-mediated growth inhibition in COLO-357 cells through functional inactivation of the retinoblastoma protein.
The Journal of biological chemistry
Boyer Arnold N,Korc M
Fri Jun 10 00:00:00 EDT 2005
Smad7 abrogates transforming growth factor-beta1-mediated growth inhibition in COLO-357 cells through functional inactivation of the retinoblastoma protein.
The Journal of biological chemistry
Boyer Arnold N,Korc M
Fri Jun 10 00:00:00 EDT 2005
Smad7 abrogates transforming growth factor-beta1-mediated growth inhibition in COLO-357 cells through functional inactivation of the retinoblastoma protein.
The Journal of biological chemistry
Boyer Arnold N,Korc M
Fri Jun 10 00:00:00 EDT 2005
Smad-binding defective mutant of transforming growth factor beta type I receptor enhances tumorigenesis but suppresses metastasis of breast cancer cell lines.
Cancer research
Tian F,Byfield SD,Parks WT,Stuelten CH,Nemani D,Zhang YE,Roberts AB
Thu Jul 01 00:00:00 EDT 2004
Smad-binding defective mutant of transforming growth factor beta type I receptor enhances tumorigenesis but suppresses metastasis of breast cancer cell lines.
Cancer research
Tian F,Byfield SD,Parks WT,Stuelten CH,Nemani D,Zhang YE,Roberts AB
Thu Jul 01 00:00:00 EDT 2004
Smad expression in human atherosclerotic lesions: evidence for impaired TGF-beta/Smad signaling in smooth muscle cells of fibrofatty lesions.
Arteriosclerosis, thrombosis, and vascular biology
Kalinina N,Agrotis A,Antropova Y,Ilyinskaya O,Smirnov V,Tararak E,Bobik A
51-1300 was used in Western Blotting to define the actions of Transforming growth factor-beta (TGF-beta) during lesion progression in humans by examining the expression of Smads in relation to TGF-beta-mediated responses.
Sun Aug 01 00:00:00 EDT 2004
Involvement of c-Src kinase in the regulation of TGF-beta1-induced apoptosis.
Oncogene
Park SS,Eom YW,Kim EH,Lee JH,Min DS,Kim S,Kim SJ,Choi KS
51-1300 was used in western blot to investigate the involvement of c-Src in the regulation of TGF-beta1-induced apoptosis
Thu Aug 19 00:00:00 EDT 2004
Signaling "cross-talk" between TGF-beta1 and ECM signals in chondrocytic cells.
Cellular signalling
Schneiderbauer MM,Dutton CM,Scully SP
51-1300 was used in western blot to elucidate how the integrin pathway regulates downstream effectors of the TGF-beta1 pathway in chondrocytic cell signaling
Fri Oct 01 00:00:00 EDT 2004
BMP and activin receptor expression in lens development.
Molecular vision
de Iongh RU,Chen Y,Kokkinos MI,McAvoy JW
51-1300 was used in western blot to assess the spatio-temporal expression patterns of activin receptors, BMP receptors, and the phosphorylated forms of Smad1 and Smad2 during lens development
Mon Aug 23 00:00:00 EDT 2004
Cellular response to hypoxia involves signaling via Smad proteins.
Blood
Zhang H,Akman HO,Smith EL,Zhao J,Murphy-Ullrich JE,Batuman OA
Sat Mar 15 00:00:00 EST 2003
Cellular response to hypoxia involves signaling via Smad proteins.
Blood
Zhang H,Akman HO,Smith EL,Zhao J,Murphy-Ullrich JE,Batuman OA
Sat Mar 15 00:00:00 EST 2003
Cellular response to hypoxia involves signaling via Smad proteins.
Blood
Zhang H,Akman HO,Smith EL,Zhao J,Murphy-Ullrich JE,Batuman OA
Sat Mar 15 00:00:00 EST 2003
Cellular response to hypoxia involves signaling via Smad proteins.
Blood
Zhang H,Akman HO,Smith EL,Zhao J,Murphy-Ullrich JE,Batuman OA
Sat Mar 15 00:00:00 EST 2003
Reduction in Smad2/3 signaling enhances tumorigenesis but suppresses metastasis of breast cancer cell lines.
Cancer research
Tian F,DaCosta Byfield S,Parks WT,Yoo S,Felici A,Tang B,Piek E,Wakefield LM,Roberts AB
Mon Dec 01 00:00:00 EST 2003
Reduction in Smad2/3 signaling enhances tumorigenesis but suppresses metastasis of breast cancer cell lines.
Cancer research
Tian F,DaCosta Byfield S,Parks WT,Yoo S,Felici A,Tang B,Piek E,Wakefield LM,Roberts AB
Mon Dec 01 00:00:00 EST 2003
Development and application of fully functional epitope-tagged forms of transforming growth factor-beta.
Journal of immunological methods
Wolfraim LA,Alkemade GM,Alex B,Sharpe S,Parks WT,Letterio JJ
51-1300 was used in western blot to develop functional epitope-tagged TGF-beta proteins.
Thu Aug 01 00:00:00 EDT 2002
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.jpg?time=20220826?time=20220826 "SMAD2 Antibody (51-1300) in WB")
.jpg?time=20220826?time=20220826 "SMAD2 Antibody (51-1300) in WB")
