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Product Details
H00006608-M08
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
3B1
Immunogen
SMO (NP_005622, 56 a.a. approximately 155 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: GPPPPLSHCG RAAPCEPLRY NVCLGSVLPY GATSTLLAGD SDSQEEAHGK LVLWSGLRNA PRCWAVIQPL LCAVYMPKCE NDRVELPSRT LCQATRGPCA
Target Information
Smoothened drosophila homolog (SMOH) is a serpentine protein belonging to the G-protein coupled receptor Fz/Smo family with 787 aa, seven transmembrane G protein-coupled receptors with 4 glycosylation sites and a putative extracellular amino terminus. Smoothened activated by b-Arrestin 2 and GRK2 acts as a receptor for Shh, the Sonic hedgehog gene product, and is a positive regulator of hedgehog signaling pathway along with the smoothened inhibitor patched protein (PTCH) and regulates vertebrate developmental processes, cellular proliferation and differentiation by activating transcription factor Gli. Smoothened mutants are known to cause sporadic basal cell carcinoma of the skin. It is known to express widely in heart and brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: frizzled family member 11; HGNC:11119; Protein Gx; Protein SMOH; Protein smoothened; seven transmembrane helix receptor; smoothened, frizzled family receptor; smoothened, seven transmembrane spanning receptor
Gene Aliases: FZD11; Gx; SMO; SMOH
UniProt ID: (Human) Q99835
Entrez Gene ID: (Human) 6608
negative regulation of transcription from RNA polymerase II promoter
vasculogenesis
osteoblast differentiation
in utero embryonic development
cell fate specification
neural crest cell migration
heart looping
positive regulation of neuroblast proliferation
positive regulation of mesenchymal cell proliferation
determination of left/right asymmetry in lateral mesoderm
type B pancreatic cell development
G-protein coupled receptor signaling pathway
smoothened signaling pathway
positive regulation of hh target transcription factor activity
ventral midline determination
midgut development
anterior/posterior pattern specification
positive regulation of gene expression
negative regulation of gene expression
dentate gyrus development
cerebellar cortex morphogenesis
thalamus development
dorsal/ventral neural tube patterning
smoothened signaling pathway involved in ventral spinal cord patterning
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
central nervous system neuron differentiation
cerebral cortex development
negative regulation of epithelial cell differentiation
hair follicle morphogenesis
protein localization to nucleus
multicellular organism growth
non-canonical Wnt signaling pathway
positive regulation of multicellular organism growth
positive regulation of protein import into nucleus
odontogenesis of dentin-containing tooth
negative regulation of apoptotic process
negative regulation of DNA binding
positive regulation of smoothened signaling pathway
positive regulation of transcription from RNA polymerase II promoter
positive regulation of organ growth
astrocyte activation
skeletal muscle fiber development
forebrain morphogenesis
homeostasis of number of cells within a tissue
positive regulation of epithelial cell proliferation
protein stabilization
myoblast migration
negative regulation of hair follicle development
canonical Wnt signaling pathway
detection of cell density by contact stimulus involved in contact inhibition
atrial septum morphogenesis
mammary gland epithelial cell differentiation
epithelial-mesenchymal cell signaling
somite development
pancreas morphogenesis
left/right axis specification
cellular response to cholesterol
renal system development
mesenchymal to epithelial transition involved in metanephric renal vesicle formation
positive regulation of branching involved in ureteric bud morphogenesis
regulation of stem cell population maintenance
regulation of heart morphogenesis
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