Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Immunogen sequence: DCSRLFDNDL PDGWEERRTA SGRIQYLNHI TRTTQWERPT RPASEYSSPG RPLSCFVDEN TPISGTNGAT CGQSSDPRLA ERRVRSQRHR NYMSRTHLHT P; Positive Samples: SW480; Cellular Location: Cell membrane, Cytoplasm, Membrane raft, Nucleus
SMURF2 is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein interacts with SMAD1, SMAD2 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. It enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.
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Protein Aliases: E3 ubiquitin ligase SMURF2; E3 ubiquitin-protein ligase SMURF2; HECT-type E3 ubiquitin transferase SMURF2; hSMURF2; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2
Gene Aliases: SMURF2
UniProt ID: (Human) Q9HAU4
Entrez Gene ID: (Human) 64750
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