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Product Details
MA5-15791
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
6D2
Immunogen
Purified recombinant fragment of human SNAI1 expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_11154780
Product Specific Information
MA5-15791 targets SNAI1 in indirect ELISA, WB applications and shows reactivity with Human samples.
The MA5-15791 immunogen is purified recombinant fragment of human SNAI1 expressed in E. Coli.
MA5-15791 detects SNAI1 which has a predicted molecular weight of approximately 29kDa.
Target Information
Zinc finger protein SNAI1 (SNAIL)is a zinc finger transcriptional repressor which down regulates the expression of the ectodermal gene within the mesoderm and functions to form the mesoderm and neural crest. It is reported that SNAI1 acts as an important factor of tumor invasion as evidenced by its role in E-cadherin down-regulation and induction of epithelial-mesenchymal transition (EMT). In human breast cancer, the expression of SNAI1 and/or the homologous SNAI2 (Slug) has been associated with E-cadherin repression, local or distant metastasis, tumor recurrence, or poor prognosis in different tumor series. It is also reported that Snail 1 protein in the stromamay be anew putative prognosis marker for colon tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protein sna; Protein snail homolog 1; Sna protein; snai; snail 1; snail 1 homolog; snail 1 zinc finger protein; snail 1, zinc finger protein; snail family zinc finger 1; snail homolog 1; Zinc finger protein SNAI1
Gene Aliases: dJ710H13.1; SLUGH2; SNA; SNAH; SNAI1; SNAIL; SNAIL1
UniProt ID: (Human) O95863
Entrez Gene ID: (Human) 6615
negative regulation of transcription from RNA polymerase II promoter
osteoblast differentiation
mesoderm formation
epithelial to mesenchymal transition
epithelial to mesenchymal transition involved in endocardial cushion formation
positive regulation of epithelial to mesenchymal transition
negative regulation of vitamin D biosynthetic process
cell migration
positive regulation of cell migration
hair follicle morphogenesis
negative regulation of DNA damage response, signal transduction by p53 class mediator
positive regulation of transcription, DNA-templated
palate development
cartilage morphogenesis
trophoblast giant cell differentiation
negative regulation of cell differentiation involved in embryonic placenta development
left/right pattern formation
Notch signaling involved in heart development
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
regulation of bicellular tight junction assembly
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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