Proteintech

SNAP25 Polyclonal Antibody

SNAP25 Antibody in Immunocytochemistry (ICC/IF)

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SNAP25 Antibody (14903-1-AP) in ICC/IF

Immunofluorescent analysis of PC-12 cells using 14903-1-AP (SNAP25 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

SNAP25 Antibody in Immunoprecipitation (IP)

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Product Details

14903-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 13 publications 13 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:10-1:100

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SNAP25 Fusion Protein Ag6695 (1-206 aa encoded by BC010647)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.48 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAEDADMRN ELEEMQRRAD QLADESLEST RRMLQLVEES KDAGIRTLVM LDEQGEQLDR VEEGMNHINQ DMKEAEKNLK DLGKCCGLFI CPCNKLKSSD AYKKAWGNNQ DGVVASQPAR VVDEREQMAI SGGFIRRVTN DARENEMDEN LEQVSGIIGN LRHMALDMGN EIDTQNRQID RIMEKADSNK TRIDEANQRA TKMLGSG (1-206 aa encoded by BC010647)

Target Information

SNAP25 is a t-SNARE involved in the molecular regulation of neurotransmitter release. It may play a role in the synaptic function of specific neuronal systems. SNAP25 associates with proteins involved in vesicle docking and membrane fusion. It also regulates plasma membrane recycling through its interaction with CENPF. Mutations in the gene can results in myasthenic syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Chen XQ,Zuo X,Becker A,Head E,Mobley WC

Mon May 01 00:00:00 EDT 2023

RUNDC3A regulates SNAP25-mediated chemotherapy resistance by binding AKT in gastric neuroendocrine carcinoma (GNEC).

Cell death discovery

Chen P,Wang W,Wong SW,Li J,Wu Q,Zhang SD,Lin Y,Kwok HF

Sat Jun 25 00:00:00 EDT 2022

Chrysin alleviates lipopolysaccharide-induced neuron damage and behavioral deficits in mice through inhibition of Fyn.

International immunopharmacology

Wang Q,Yang Z,Wu X,Zhang X,Geng F,Wang Q,Geng Z,Yu C,Li Z

Sat Oct 01 00:00:00 EDT 2022

METTL3-mediated m⁶A RNA methylation regulates dorsal lingual epithelium homeostasis.

International journal of oral science

Xiong Q,Liu C,Zheng X,Zhou X,Lei K,Zhang X,Wang Q,Lin W,Tong R,Xu R,Yuan Q

Tue May 17 00:00:00 EDT 2022

Rabphilin 3A binds the N-peptide of SNAP-25 to promote SNARE complex assembly in exocytosis.

eLife

Li T,Cheng Q,Wang S,Ma C

Thu Sep 29 00:00:00 EDT 2022

Neuromodulation Induced by Sitagliptin: A New Strategy for Treating Diabetic Retinopathy.

Biomedicines

Ramos H,Bogdanov P,Sabater D,Huerta J,Valeri M,Hernández C,Simó R

Fri Nov 26 00:00:00 EST 2021

Neuromodulation Induced by Sitagliptin: A New Strategy for Treating Diabetic Retinopathy.

Biomedicines

Ramos H,Bogdanov P,Sabater D,Huerta J,Valeri M,Hernández C,Simó R

Fri Nov 26 00:00:00 EST 2021

Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing.

Molecular neurodegeneration

Zhang Q,Zhang J,Ye J,Li X,Liu H,Ma X,Wang C,He K,Zhang W,Yuan J,Zhao Y,Xu H,Liu Q

Wed Sep 22 00:00:00 EDT 2021

Chronic hepatitis C virus infection impairs insulin secretion by regulation of p38δ MAPK-dependent exocytosis in pancreatic β-cells.

Clinical science (London, England : 1979)

Chen J,Wang F,Zhou Y,Jiang J,Ksimu S,Zhang X,Li JZ,Niu J,Wang Q

Fri Mar 13 00:00:00 EDT 2020

SNAP25/syntaxin4/VAMP2/Munc18-1 Complexes in Spinal Dorsal Horn Contributed to Inflammatory Pain.

Neuroscience

Duan XL,Guo Z,He YT,Li YX,Liu YN,Bai HH,Li HL,Hu XD,Suo ZW

Sun Mar 01 00:00:00 EST 2020

SNAP25/syntaxin4/VAMP2/Munc18-1 Complexes in Spinal Dorsal Horn Contributed to Inflammatory Pain.

Neuroscience

Duan XL,Guo Z,He YT,Li YX,Liu YN,Bai HH,Li HL,Hu XD,Suo ZW

Sun Mar 01 00:00:00 EST 2020

miR‑153 promotes neural differentiation in the mouse hippocampal HT‑22 cell line and increases the expression of neuron‑specific enolase.

Molecular medicine reports

Xu C,Wang C,Meng Q,Gu Y,Wang Q,Xu W,Han Y,Qin Y,Li J,Jia S,Xu J,Zhou Y

Thu Aug 01 00:00:00 EDT 2019

Structural and Functional Analysis of the CAPS SNARE-Binding Domain Required for SNARE Complex Formation and Exocytosis.

Cell reports

Zhou H,Wei Z,Wang S,Yao D,Zhang R,Ma C

Tue Mar 19 00:00:00 EDT 2019

Absence of BBSome function leads to astrocyte reactivity in the brain.

Molecular brain

Singh M,Garrison JE,Wang K,Sheffield VC

Thu May 09 00:00:00 EDT 2019

MicroRNA-210-5p Contributes to Cognitive Impairment in Early Vascular Dementia Rat Model Through Targeting Snap25.

Frontiers in molecular neuroscience

Ren Z,Yu J,Wu Z,Si W,Li X,Liu Y,Zhou J,Deng R,Chen D

Wed Sep 30 00:00:00 EDT 2020

MicroRNA-210-5p Contributes to Cognitive Impairment in Early Vascular Dementia Rat Model Through Targeting Snap25.

Frontiers in molecular neuroscience

Ren Z,Yu J,Wu Z,Si W,Li X,Liu Y,Zhou J,Deng R,Chen D

Wed Sep 30 00:00:00 EDT 2020

MicroRNA-210-5p Contributes to Cognitive Impairment in Early Vascular Dementia Rat Model Through Targeting Snap25.

Frontiers in molecular neuroscience

Ren Z,Yu J,Wu Z,Si W,Li X,Liu Y,Zhou J,Deng R,Chen D

Wed Sep 30 00:00:00 EDT 2020

MicroRNA-210-5p Contributes to Cognitive Impairment in Early Vascular Dementia Rat Model Through Targeting Snap25.

Frontiers in molecular neuroscience

Ren Z,Yu J,Wu Z,Si W,Li X,Liu Y,Zhou J,Deng R,Chen D

Wed Sep 30 00:00:00 EDT 2020

Comparison of the Expression Changes after Botulinum Toxin Type A and Minocycline Administration in Lipopolysaccharide-Stimulated Rat Microglial and Astroglial Cultures.

Frontiers in cellular and infection microbiology

Piotrowska A,Popiolek-Barczyk K,Pavone F,Mika J

Wed Dec 27 00:00:00 EST 2017

Comparison of the Expression Changes after Botulinum Toxin Type A and Minocycline Administration in Lipopolysaccharide-Stimulated Rat Microglial and Astroglial Cultures.

Frontiers in cellular and infection microbiology

Piotrowska A,Popiolek-Barczyk K,Pavone F,Mika J

Wed Dec 27 00:00:00 EST 2017

Bioinformatics

Protein Aliases: ALMS1; blind drunk; CG17676; CG17884; CG40452; Dmel CG40452; Dmel_CG40452; FLJ23079; HGNC:11132; resistance to inhibitors of cholinesterase 4 homolog; SNAP 25; SNAP-25; snp25; SUP; Super protein; Synaptosomal-associated 25 kDa protein; Synaptosomal-associated protein 25; synaptosomal-associated protein, 25 kDa; synaptosomal-associated protein, 25kDa; synaptosome associated protein 25kDa

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Gene Aliases: bA416N4.2; Bdr; CMS18; dJ1068F16.2; GENA70; RIC-4; RIC4; SEC9; SNAP; SNAP-25; SNAP-25a; SNAP-25B; SNAP25; sp; SUP

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UniProt ID: (Human) P60880, (Rat) P60881, (Mouse) P60879

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Entrez Gene ID: (Human) 6616, (Rat) 25012, (Mouse) 20614

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Function(s)

SNAP receptor activity protein binding syntaxin-1 binding calcium-dependent protein binding SNARE binding voltage-gated potassium channel activity myosin binding protein domain specific binding protein N-terminus binding ion channel binding SNARE protein

Process(es)

neurotransmitter uptake chemical synaptic transmission neurotransmitter secretion locomotory behavior associative learning regulation of neuron projection development glutamate secretion synaptic vesicle exocytosis synaptic vesicle docking synaptic vesicle priming synaptic vesicle fusion to presynaptic active zone membrane regulation of insulin secretion long-term synaptic potentiation exocytosis axonogenesis long-term memory endosomal transport growth hormone secretion sleep positive regulation of insulin secretion positive regulation of hormone secretion calcium ion-regulated exocytosis of neurotransmitter regulation of synapse assembly regulation of establishment of protein localization potassium ion transmembrane transport regulation of ion transmembrane transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SNAP25 Polyclonal Antibody

SNAP25 Antibody (14903-1-AP) in ICC/IF

Product Details

14903-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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