Invitrogen

SNAP25 Polyclonal Antibody

SNAP25 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SNAP25 Antibody (PA1-9102) in IHC (P)

Immunohistochemistry analysis of SNAP25 in human brain, cortex. Samples were incubated with SNAP25 polyclonal antibody (Product # PA1-9102) using a dilution of 5 µg/mL. Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

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Product Details

PA1-9102

Applications

Tested Dilution

Publications

Western Blot (WB)

0.005-0.01 µg/mL

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to the C terminus amino acids DEANQRATKMLGSG.

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Ammonium sulfate precipitation

Storage buffer

TBS, pH 7.3, with 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2270688

Product Specific Information

This antibody is predicted to react with canine and rat based on sequence homology.

This antibody is tested in Peptide ELISA: antibody detection limit dilution 64,000.

Target Information

SNAP25 is a t-SNARE involved in the molecular regulation of neurotransmitter release. It may play a role in the synaptic function of specific neuronal systems. SNAP25 associates with proteins involved in vesicle docking and membrane fusion. It also regulates plasma membrane recycling through its interaction with CENPF. Mutations in the gene can results in myasthenic syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

KHSRP loss increases neuronal growth and synaptic transmission and alters memory consolidation through RNA stabilization.

Communications biology

Olguin SL,Patel P,Buchanan CN,Dell'Orco M,Gardiner AS,Cole R,Vaughn LS,Sundararajan A,Mudge J,Allan AM,Ortinski P,Brigman JL,Twiss JL,Perrone-Bizzozero NI

PA1-9102 was used in Western Blotting to test functions of KH-type splicing regulatory protein in vivo.

Thu Jul 07 00:00:00 EDT 2022

Traumatic stress history interacts with sex and chronic peripheral inflammation to alter mitochondrial function of synaptosomes.

Brain, behavior, and immunity

Shaw GA,Hyer MM,Targett I,Council KR,Dyer SK,Turkson S,Burns CM,Neigh GN

PA1-9102 was used in Western Blotting to highlight that different mechanisms are likely in play between the sexes and that sex differences in neural outcomes may be precipitated by sex-specific effects of life experiences on mitochondrial function in the synapse.

Sat Aug 01 00:00:00 EDT 2020

Bioinformatics

Protein Aliases: ALMS1; blind drunk; CG17676; CG17884; CG40452; Dmel CG40452; Dmel_CG40452; FLJ23079; HGNC:11132; resistance to inhibitors of cholinesterase 4 homolog; SNAP 25; SNAP-25; snp25; SUP; Super protein; Synaptosomal-associated 25 kDa protein; Synaptosomal-associated protein 25; synaptosomal-associated protein, 25 kDa; synaptosomal-associated protein, 25kDa; synaptosome associated protein 25kDa

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Gene Aliases: bA416N4.2; Bdr; CMS18; dJ1068F16.2; GENA70; RIC-4; RIC4; SEC9; SNAP; SNAP-25; SNAP-25a; SNAP-25B; SNAP25; sp; SUP

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UniProt ID: (Human) P60880, (Rat) P60881, (Mouse) P60879

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Entrez Gene ID: (Human) 6616, (Rat) 25012, (Mouse) 20614

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Function(s)

SNAP receptor activity protein binding syntaxin-1 binding calcium-dependent protein binding SNARE binding voltage-gated potassium channel activity myosin binding protein domain specific binding protein N-terminus binding ion channel binding SNARE protein

Process(es)

neurotransmitter uptake chemical synaptic transmission neurotransmitter secretion locomotory behavior associative learning regulation of neuron projection development glutamate secretion synaptic vesicle exocytosis synaptic vesicle docking synaptic vesicle priming synaptic vesicle fusion to presynaptic active zone membrane regulation of insulin secretion long-term synaptic potentiation exocytosis axonogenesis long-term memory endosomal transport growth hormone secretion sleep positive regulation of insulin secretion positive regulation of hormone secretion calcium ion-regulated exocytosis of neurotransmitter regulation of synapse assembly regulation of establishment of protein localization potassium ion transmembrane transport regulation of ion transmembrane transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SNAP25 Polyclonal Antibody

SNAP25 Antibody (PA1-9102) in IHC (P)

Product Details

PA1-9102

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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