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Product Details
13913-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Arthropod
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SODD/BAG4 Fusion Protein Ag4905 (107-457 aa encoded by BC038505)
Conjugate
Form
Liquid
Concentration
0.51 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody detects 66-70 kDa full-length BAG4 protein and 45 kDa, 60 kDa C-terminal fragments.
Immunogen sequence: ARSRAPYPS TYPVRPELQG QSLNSYTNGA YGPTYPPGPG ANTASYSGAY YAPGYTQTSY STEVPSTYRS SGNSPTPVSR WIYPQQDCQT EAPPLRGQVP GYPPSQNPGM TLPHYPYGDG NRSVPQSGPT VRPQEDAWAS PGAYGMGGRY PWPSSAPSAP PGNLYMTEST SPWPSSGSPQ SPPSPPVQQP KDSSYPYSQS DQSMNRHNFP CSVHQYESSG TVNNDDSDLL DSQVQYSAEP QLYGNATSDH PNNQDQSSSL PEECVPSDES TPPSIKKIIH VLEKVQYLEQ EVEEFVGKKT DKAYWLLEEM LTKELLELDS VETGGQDSVR QARKEAVCKI QAILEKLEKK GL (107-457 aa encoded by BC038505)
Target Information
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BAG family molecular chaperone regulator 4; BAG-4; BAG-family molecular chaperone regulator-4; Bcl-2-associated athanogene 4; BCL2-associated athanogene 4; Silencer of death domains
Gene Aliases: BAG-4; BAG4; SODD
UniProt ID: (Human) O95429
Entrez Gene ID: (Human) 9530
protein folding
positive regulation of fibroblast migration
positive regulation of actin filament polymerization
positive regulation of peptidyl-serine phosphorylation
tumor necrosis factor-mediated signaling pathway
negative regulation of apoptotic process
positive regulation of cell adhesion
positive regulation of stress fiber assembly
positive regulation of protein kinase B signaling
cellular response to tumor necrosis factor
cellular response to epidermal growth factor stimulus
protein localization to plasma membrane
ruffle assembly
regulation of cellular response to heat
negative regulation of protein targeting to mitochondrion
negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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