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Product Details
H00006272-M01
Product Specifications
Species Reactivity
Rat,
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
1B3
Immunogen
SORT1 (NP_002950, 203 a.a. approximately 299 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Tissue lysate).
Immunogen sequence: FAKNFVQTDL PFHPLTQMMY SPQNSDYLLA LSTENGLWVS KNFGGKWEEI HKAVCLAKWG SDNTIFFTTY ANGSCKADLG ALELWRTSDL GKSFKTI
Target Information
Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Sortilin is required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). It is also required for protein transport from the Golgi apparatus to the endosomes. Sortilin promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also, Sortilin acts as a receptor for neurotensin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 100 kDa NT receptor; Glycoprotein 110; Glycoprotein 95; Gp110; Gp95; Neurotensin receptor 3; NT3; NTR3; Sortilin
Gene Aliases: Gp95; LDLCQ6; NT3; NTR3; Nts3; SORT1
UniProt ID: (Human) Q99523, (Rat) O54861
Entrez Gene ID: (Human) 6272, (Rat) 83576
ossification
Golgi to endosome transport
endocytosis
G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
multicellular organism development
endosome to lysosome transport
extrinsic apoptotic signaling pathway via death domain receptors
regulation of gene expression
myotube differentiation
vesicle organization
endosome transport via multivesicular body sorting pathway
response to insulin
nerve growth factor signaling pathway
negative regulation of fat cell differentiation
glucose import
neurotrophin TRK receptor signaling pathway
plasma membrane to endosome transport
negative regulation of lipoprotein lipase activity
positive regulation of epithelial cell apoptotic process
intracellular protein transport
cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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