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SOX1 Antibody (PA5-23370) in WB
Western blot analysis of SOX1 in human brain lysate in the 1) absence and 2) presence of immunizing peptide and 3) mouse brain lysate. Samples were incubated in SOX1 polyclonal antibody (Product # PA5-23370) using a dilution of 0.5 µg/mL, 0.5 µg/mL, and 2 µg/mL respectively..
Product Details
PA5-23370
Product Specifications
Species Reactivity
Dog,
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A portion of amino acids 350-391 of human SOX1
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2540893
Target Information
SOX1, also known as SRY (sex determining region Y)-box 1, is a transcription factor belonging to the SRY-related HMG box family of transcription factors with a HMG box DNA-binding domain. SOX1 works through multiple independent pathways to promote neuronal cell fate determination and differentiation. This nuclear protein acts as a modulator of LINE retroposons promoter activity and is also involved in the development of the central nervous system, mainly neural and lens development. Transcriptional activator SOX1 binds directly to the HES1 promoter and suppresses HES1 transcription, thus attenuating Notch signaling. It also binds to beta-catenin and suppresses beta-catenin-mediated TCF/LEF signaling, thus potentially attenuating the WNT signaling pathway. Expression of SOX1 is seen mostly in embryonic tissues and moderately in brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: SRY (sex determining region Y)-box 1; SRY box 1; SRY-box 1; SRY-box containing gene 1; SRY-related HMG-box gene 1; Transcription factor SOX-1
Gene Aliases: BB176347; Sox-1; SOX1
UniProt ID: (Human) O00570, (Mouse) P53783
Entrez Gene ID: (Human) 6656, (Dog) 607464, (Mouse) 20664
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
HMG box transcription factor
neuron migration
lens morphogenesis in camera-type eye
chromatin organization
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
ventral spinal cord interneuron specification
forebrain neuron development
positive regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
forebrain neuron differentiation
forebrain development
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