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Invitrogen
SOX10 Polyclonal Antibody
Advanced Verification
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 8
SOX10 Antibody (PA5-47001) in ICC/IF
Immunocytochemical analysis of SOX10 was detected in immersion fixed BG01V human embryonic stem cells differentiated to neural crest stem cells using Goat Anti-human SOX10 Antigen Affinity-purified Polyclonal Antibody (Product # PA5-47001) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the 557-conjugated Anti-Goat IgG Secondary Antibody (re and counterstained with DAPI (blue). Specific staining was localized to nuclei.
Product Details
PA5-47001
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant human SOX10 Met1-Ala118
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2608449
Product Specific Information
In direct ELISAs, less than 2% cross-reactivity with recombinant human (rh) SOX2, rhSOX7 and rhSOX17 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
SOX10 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. This protein may act as a transcriptional activator after forming a protein complex with other proteins. It acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: dominant megacolon, mouse, human homolog of; MGC15649; SRY; SRY (sex determining region Y)-box 10; SRY box 10; SRY-related HMG-box gene 10; Transcription factor SOX-10
Gene Aliases: DOM; PCWH; SOX10; WS2E; WS4; WS4C
UniProt ID: (Human) P56693
Entrez Gene ID: (Human) 6663
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription factor binding
chromatin binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription coactivator activity
protein binding
transcription factor binding
identical protein binding
in utero embryonic development
neural crest cell migration
positive regulation of neuroblast proliferation
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
peripheral nervous system development
anatomical structure morphogenesis
positive regulation of gliogenesis
melanocyte differentiation
lacrimal gland development
negative regulation of apoptotic process
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cell maturation
enteric nervous system development
digestive tract morphogenesis
developmental growth
oligodendrocyte differentiation
stem cell differentiation
morphogenesis of a branching epithelium
negative regulation of canonical Wnt signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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