Proteintech

SOX17 Polyclonal Antibody

FIGURE: 1 / 3

SOX17 Antibody (24903-1-AP) in WB

Mouse embryo tissue were subjected to SDS PAGE followed by western blot with 24903-1-AP ( SOX17 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

Product Image Gallery

Product Details

24903-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 4 publications 4 publications

Immunocytochemistry (ICC/IF)

View 6 publications 6 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SOX17 Fusion Protein Ag19157 (1-66 aa encoded by BC111365)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.32 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSSPDAGYA SDDQSQTQSA LPAVMAGLGP CPWAESLSPI GDMKVKGEAP ANSGAPAGAA GRAKGES (1-66 aa encoded by B C111365)

Target Information

SOX17 (transcription factor SOX-17) belongs to the SRY-related HMB box family of transcription factors. It acts as a transcription regulator that binds target promoter DNA and bends the DNA. It binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. SOX17 modulates transcriptional regulation via WNT3A and inhibits Wnt signaling. It promotes degradation of activated CTNNB1. SOX17 plays an essential role in the regulation of embryonic development and is required for normal looping of the embryonic hear tube and for normal development of the definitive gut endoderm. Mutations in the gene can result in vesicoureteral reflux.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics.

American journal of respiratory and critical care medicine

Sangam S,Sun X,Schwantes-An TH,Yegambaram M,Lu Q,Shi Y,Cook T,Fisher A,Frump AL,Coleman A,Sun Y,Liang S,Crawford H,Lutz KA,Maun AD,Pauciulo MW,Karnes JH,Chaudhary KR,Stewart DJ,Langlais PR,Jain M,Alotaibi M,Lahm T,Jin Y,Gu H,Tang H,Nichols WC,Black SM,Desai AA

Sat Apr 15 00:00:00 EDT 2023

SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics.

American journal of respiratory and critical care medicine

Sat Apr 15 00:00:00 EDT 2023

SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics.

American journal of respiratory and critical care medicine

Sat Apr 15 00:00:00 EDT 2023

SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics.

American journal of respiratory and critical care medicine

Sat Apr 15 00:00:00 EDT 2023

Generation of a heterozygous FLNC mutation-carrying human iPSC line, USFi002-A, for modeling dilated cardiomyopathy.

Stem cell research

Argenziano MA,Burgos Angulo M,Najari Beidokhti M,Yang J,Bertalovitz AC,McDonald TV

Sat May 01 00:00:00 EDT 2021

Establishment of an arrhythmogenic right ventricular cardiomyopathy derived iPSC cell line (USFi004-A) carrying a heterozygous mutation in PKP2 (c.1799delA).

Stem cell research

Yang J,Samal E,Burgos Angulo M,Bertalovitz A,McDonald TV

Thu Jul 01 00:00:00 EDT 2021

Generation of an iPSC cell line (USFi003-A) from a patient with dilated cardiomyopathy carrying a heterozygous mutation in LMNA (p.R541C).

Stem cell research

Yang J,Burgos Angulo M,Argenziano MA,Bertalovitz A,Najari Beidokhti M,McDonald TV

Thu Jul 01 00:00:00 EDT 2021

Simultaneous and quantitative monitoring transcription factors in human embryonic stem cell differentiation using mass spectrometry-based targeted proteomics.

Analytical and bioanalytical chemistry

Xu M,Xu L,Cao J,Hu Y,Xu F,Liu Y,Chen Y

Mon Mar 01 00:00:00 EST 2021

Generation of a Friedreich's Ataxia patient-derived iPSC line USFi001-A.

Stem cell research

Angulo MB,Yang J,Argenziano MA,Bertalovitz AC,Beidokhti MN,McDonald TV

Thu Jul 01 00:00:00 EDT 2021

miR-937-5p targets SOX17 to modulate breast cancer cell cycle and cell proliferation through the Wnt signaling pathway.

Cellular signalling

Xiong X,Xu W,Gong J,Wang L,Dai M,Chen G,Yuan L

Fri Jan 01 00:00:00 EST 2021

ADNP Controls Gene Expression Through Local Chromatin Architecture by Association With BRG1 and CHD4.

Frontiers in cell and developmental biology

Sun X,Yu W,Li L,Sun Y

Mon Sep 28 00:00:00 EDT 2020

Phosphorylation of Threonine³⁴³ Is Crucial for OCT4 Interaction with SOX2 in the Maintenance of Mouse Embryonic Stem Cell Pluripotency.

Stem cell reports

Abulaiti X,Zhang H,Wang A,Li N,Li Y,Wang C,Du X,Li L

Tue Nov 14 00:00:00 EST 2017

Phosphorylation of Threonine³⁴³ Is Crucial for OCT4 Interaction with SOX2 in the Maintenance of Mouse Embryonic Stem Cell Pluripotency.

Stem cell reports

Abulaiti X,Zhang H,Wang A,Li N,Li Y,Wang C,Du X,Li L

Tue Nov 14 00:00:00 EST 2017

Bioinformatics

Protein Aliases: SRY (sex determining region Y)-box 17; SRY box 17; SRY-box containing gene 17; SRY-related HMG-box transcription factor SOX17; Transcription factor SOX-17

View more View less

Gene Aliases: Sox-17; SOX17; VUR3

View more View less

UniProt ID: (Human) Q9H6I2, (Mouse) Q61473

View more View less

Entrez Gene ID: (Human) 64321, (Mouse) 20671, (Rat) 312936

View more View less

Function(s)

transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription coactivator activity protein binding beta-catenin binding transcription factor binding sequence-specific DNA binding transcription regulatory region DNA binding protein heterodimerization activity RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding molecular_function HMG box transcription factor

Process(es)

negative regulation of transcription from RNA polymerase II promoter angiogenesis vasculogenesis endoderm formation inner cell mass cellular morphogenesis heart looping cardiogenic plate morphogenesis embryonic heart tube morphogenesis outflow tract morphogenesis negative regulation of Wnt signaling pathway involved in heart development regulation of transcription, DNA-templated spermatogenesis endodermal cell fate determination rostrocaudal neural tube patterning signal transduction involved in regulation of gene expression negative regulation of cell growth protein destabilization embryonic heart tube development cell migration involved in gastrulation negative regulation of mesodermal cell fate specification mRNA transcription from RNA polymerase II promoter positive regulation of cell differentiation positive regulation of protein catabolic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of embryonic development embryonic foregut morphogenesis positive regulation of skeletal muscle tissue development stem cell fate specification protein stabilization canonical Wnt signaling pathway endocardium formation regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification cardiac cell fate determination heart formation endocardial cell differentiation common bile duct development gall bladder development endodermal digestive tract morphogenesis renal system development regulation of stem cell proliferation negative regulation of canonical Wnt signaling pathway regulation of stem cell division regulation of cardiac cell fate specification transcription, DNA-templated transcription from RNA polymerase II promoter gastrulation endoderm development positive regulation of gene expression Wnt signaling pathway negative regulation of Wnt signaling pathway regulation of mesodermal cell fate specification regulation of cell differentiation embryonic organ development stem cell differentiation biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

SOX17 Polyclonal Antibody

SOX17 Antibody (24903-1-AP) in WB

Product Details

24903-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!