Invitrogen

SOX2 Polyclonal Antibody

Advanced Verification

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

19 Published Figures

42 References

View all (90) SOX2 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

SOX2 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 26

SOX2 Antibody (48-1400) in ICC/IF

Immunofluorescence analysis of SOX2 was performed using 70% confluent log phase NTERA-2 cl.D1 cells. The cells were fixed with 4% paraformaldehyde for 5 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for overnight at room temperature. The cells were labeled with SOX2 Polyclonal Antibody (Product # 48-1400) at 1:200 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product # A... View More

SOX2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SOX2 Antibody in Immunocytochemistry, Immunohistochemistry (ICC/IF, IHC)

SOX2 Antibody in Immunohistochemistry (IHC)

SOX2 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

Product Image Gallery

SOX2 Antibody — Antibody specificity was demonstrated by detection of differential basal expression of the target across Cell line tested owing to their inherent genetic constitution. Relative expression of SOX2 was observed in NTERA2 and NCCIT in comparision to HeLa using Anti-SOX2 Polyclonal Antibody (Product # 48-1400) in Western Blot. {RE}

Product Details

48-1400

Applications

Tested Dilution

Publications

Western Blot (WB)

1-3 µg/mL

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 10 publications 10 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20

Immunohistochemistry (PFA fixed) (IHC (PFA))

View 1 publication 1 publication

Immunohistochemistry (Frozen) (IHC (F))

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

2-3 µg/mL

View 15 publications 15 publications

Flow Cytometry (Flow)

View 3 publications 3 publications

Immunoprecipitation (IP)

5 µg

ChIP assay (ChIP)

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Chicken, Fruit fly, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide derived from the N-terminal region of the human SOX2 protein

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2533841

Target Information

SOX2 is an intronless gene encoding a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of the SOX2 gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. The SOX2 gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). Further, SOX2 protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation, optic nerve hypoplasia and syndromic microphthalmia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Single-nucleus transcriptomics of IDH1- and TP53-mutant glioma stem cells displays diversified commitment on invasive cancer progenitors.

Scientific reports

Gulaia V,Shmelev M,Romanishin A,Shved N,Farniev V,Goncharov N,Biktimirov A,Vargas IL,Khodosevich K,Kagansky A,Kumeiko V

48-1400 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunohistochemistry (Frozen) to perform single-nucleus transcriptomics of mutant and wild-type glioma samples sorted for Sox2 stem cell marker.

Tue Nov 08 00:00:00 EST 2022

Generation of three induced pluripotent stem cells lines from patients with esophageal atresia/tracheoesophageal fistula type C.

Stem cell research

Raad S,David A,Chung W,Faure C

48-1400 was used in Immunohistochemistry-immunofluorescence to generate three iPSC cell lines using peripheral blood mononuclear cells (PBMCs) from EA/TEF type C patients.

Fri Apr 01 00:00:00 EDT 2022

Metabolic-imaging of human glioblastoma live tumors: A new precision-medicine approach to predict tumor treatment response early.

Frontiers in oncology

Morelli M,Lessi F,Barachini S,Liotti R,Montemurro N,Perrini P,Santonocito OS,Gambacciani C,Snuderl M,Pieri F,Aquila F,Farnesi A,Naccarato AG,Viacava P,Cardarelli F,Ferri G,Mulholland P,Ottaviani D,Paiar F,Liberti G,Pasqualetti F,Menicagli M,Aretini P,Signore G,Franceschi S,Mazzanti CM

48-1400 was used in Immunohistochemistry to develop a novel functional precision medicine approach to test the response to anticancer treatments in organoids derived from the resected tumors of glioblastoma patients.

Sat Sep 24 00:00:00 EDT 2022

Dbnl and β-catenin promote pro-N-cadherin processing to maintain apico-basal polarity.

The Journal of cell biology

Herrera A,Menendez A,Torroba B,Ochoa A,Pons S

Published figure using SOX2 polyclonal antibody (Product # 48-1400) in Immunocytochemistry

Mon Jun 07 00:00:00 EDT 2021

Stemness-Associated Markers Are Expressed in Extracranial Arteriovenous Malformation.

Frontiers in surgery

Luke Krishnan CS,Brasch HD,Patel J,Bockett N,Paterson E,Davis PF,Tan ST

48-1400 was used in Western Blot to study the presence and expression pattern of OCT4, SOX2, NANOG, KLF4, and c-MYC in extracranial arteriovenous malformation.

Tue Apr 06 00:00:00 EDT 2021

Generation of two induced pluripotent stem cell lines from a patient with recessive inherited retinal disease caused by compound heterozygous mutations in SNRNP200.

Stem cell research

Zhang D,McLenachan S,Chen SC,Zaw K,Alziyadat Y,Zhang X,Lamey TM,Thompson JA,McLaren TL,Mellough C,De Roach JN,Chen FK

48-1400 was used in Immunocytochemistry, Flow Cytometry to generate human iPSC line from a a patient with inherited retinal disease caused by compound heterozygous mutations in the SNRNP200 gene (c.[1792C>T];[3341T>C]), which demonstrate trilineage differentiation potential.

Mon Mar 01 00:00:00 EST 2021

Generation of two induced pluripotent stem cell lines from a patient with recessive inherited retinal disease caused by compound heterozygous mutations in SNRNP200.

Stem cell research

Zhang D,McLenachan S,Chen SC,Zaw K,Alziyadat Y,Zhang X,Lamey TM,Thompson JA,McLaren TL,Mellough C,De Roach JN,Chen FK

Mon Mar 01 00:00:00 EST 2021

The Effect of Fluid Flow Shear Stress and Substrate Stiffness on Yes-Associated Protein (YAP) Activity and Osteogenesis in Murine Osteosarcoma Cells.

Cancers

Coughlin TR,Sana A,Voss K,Gadi A,Basu-Roy U,Curtin CM,Mansukhani A,Kennedy OD

48-1400 was used in Immunocytochemistry-immunofluorescence to suggest that modulation of fluid movement through, or stiffness levels within, OS tumors could represent a novel consideration in the development of new treatments to prevent their progression.

Wed Jun 23 00:00:00 EDT 2021

The Effect of Fluid Flow Shear Stress and Substrate Stiffness on Yes-Associated Protein (YAP) Activity and Osteogenesis in Murine Osteosarcoma Cells.

Cancers

Coughlin TR,Sana A,Voss K,Gadi A,Basu-Roy U,Curtin CM,Mansukhani A,Kennedy OD

Wed Jun 23 00:00:00 EDT 2021

Anti-oncogenic activities exhibited by paracrine factors of MSCs can be mediated by modulation of KITLG and DKK1 genes in glioma SCs in vitro.

Molecular therapy oncolytics

Aslam N,Abusharieh E,Abuarqoub D,Ali D,Al-Hattab D,Wehaibi S,Al-Kurdi B,Jamali F,Alshaer W,Jafar H,Awidi AS

48-1400 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to conclude that different types of mesenchymal stem cells possess antitumor properties and their paracrine factors, in combination with anti-immune modalities, can provide practical therapeutic targets for glioblastoma treatment.

Fri Mar 26 00:00:00 EDT 2021

Anti-oncogenic activities exhibited by paracrine factors of MSCs can be mediated by modulation of KITLG and DKK1 genes in glioma SCs in vitro.

Molecular therapy oncolytics

Aslam N,Abusharieh E,Abuarqoub D,Ali D,Al-Hattab D,Wehaibi S,Al-Kurdi B,Jamali F,Alshaer W,Jafar H,Awidi AS

Fri Mar 26 00:00:00 EDT 2021

Cell Populations Expressing Stemness-Associated Markers in Lung Adenocarcinoma.

Life (Basel, Switzerland)

Paterson C,Kilmister EJ,Brasch HD,Bockett N,Patel J,Paterson E,Purdie G,Galvin S,Davis PF,Itinteang T,Tan ST

48-1400 was used in Western Blot to suggest that the expression of the stemness-associated markers OCT4, SOX2, NANOG, KFL4 and c-MYC by LA at the mRNA and protein level, and the unique expression patterns suggest a putative presence of CSC subpopulations within LA, which may be a novel therapeutic target for this cancer.

Mon Oct 18 00:00:00 EDT 2021

Cancer Stem Cell Subpopulations Are Present Within Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma.

Frontiers in oncology

Kilmister EJ,Patel J,van Schaijik B,Bockett N,Brasch HD,Paterson E,Sim D,Davis PF,Roth IM,Itinteang T,Tan ST

Published figure using SOX2 polyclonal antibody (Product # 48-1400) in Western Blot

Mon Sep 28 00:00:00 EDT 2020

Cancer Stem Cell Subpopulations Are Present Within Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma.

Frontiers in oncology

Kilmister EJ,Patel J,van Schaijik B,Bockett N,Brasch HD,Paterson E,Sim D,Davis PF,Roth IM,Itinteang T,Tan ST

Published figure using SOX2 polyclonal antibody (Product # 48-1400) in Western Blot

Mon Sep 28 00:00:00 EDT 2020

The master transcription factor SOX2, mutated in anophthalmia/microphthalmia, is post-transcriptionally regulated by the conserved RNA-binding protein RBM24 in vertebrate eye development.

Human molecular genetics

Dash S,Brastrom LK,Patel SD,Scott CA,Slusarski DC,Lachke SA

48-1400 was used in Immunocytochemistry to investigate whether the conserved RNA-binding motif protein, RBM24, positively controls Sox2 mRNA stability and is necessary for optimal SOX2 mRNA and protein levels in development, perturbation of which causes ocular defects, including microphthalmia and anophthalmia.

Fri Mar 13 00:00:00 EDT 2020

Generation of three induced pluripotent stem cell lines from a patient with Usher syndrome caused by biallelic c.949C > A and c.1256G > T mutations in the USH2A gene.

Stem cell research

Zaw K,Wong EYM,Zhang X,Zhang D,Chen SC,Thompson JA,Lamey T,McLaren T,De Roach JN,Wilton SD,Fletcher S,Mitrpant C,Atlas MD,Chen FK,McLenachan S

48-1400 was used in Immunocytochemistry to describe the generation of three induced pluripotent stem cell lines from dermal fibroblasts derived from a patient carrying biallelic c.949C > A and c.1256G > T variants in the USH2A gene, using episomal reprogramming plasmids expressing OCT4, SOX2, KLF4, MYCL, LIN28, mir302/367 and shRNA targeting TP53.

Wed Dec 16 00:00:00 EST 2020

Maternal Immune Activation Alters Fetal Brain Development and Enhances Proliferation of Neural Precursor Cells in Rats.

Frontiers in immunology

Baines KJ,Hillier DM,Haddad FL,Rajakumar N,Schmid S,Renaud SJ

48-1400 was used in Immunohistochemistry-immunofluorescence to suggest that MIA elicits rapid gene expression changes within the conceptus, including repression of neurodevelopmental pathways, resulting in profound alterations in fetal brain development.

Fri Apr 02 00:00:00 EDT 2021

Maternal Immune Activation Alters Fetal Brain Development and Enhances Proliferation of Neural Precursor Cells in Rats.

Frontiers in immunology

Baines KJ,Hillier DM,Haddad FL,Rajakumar N,Schmid S,Renaud SJ

Fri Apr 02 00:00:00 EDT 2021

Colon adenocarcinoma-derived cells that express induced-pluripotent stem cell markers possess stem cell function.

PloS one

Munro MJ,Peng L,Wickremesekera SK,Tan ST

48-1400 was used in Western Blotting to investigate the expression of a panel of induced pluripotent stem cell (iPSC) markers in primary colon adenocarcinoma (CA)-derived cell lines.

Fri Jul 31 00:00:00 EDT 2020

Colon adenocarcinoma-derived cells that express induced-pluripotent stem cell markers possess stem cell function.

PloS one

Munro MJ,Peng L,Wickremesekera SK,Tan ST

48-1400 was used in Western Blotting to investigate the expression of a panel of induced pluripotent stem cell (iPSC) markers in primary colon adenocarcinoma (CA)-derived cell lines.

Fri Jul 31 00:00:00 EDT 2020

Reprogramming and Differentiation of Cutaneous Squamous Cell Carcinoma Cells in Recessive Dystrophic Epidermolysis Bullosa.

International journal of molecular sciences

Rami A,Łaczmański Ł,Jacków-Nowicka J,Jacków J

Published figure using SOX2 polyclonal antibody (Product # 48-1400) in Immunocytochemistry

Tue Dec 29 00:00:00 EST 2020

Identification of Cancer Stem Cell Subpopulations in Head and Neck Metastatic Malignant Melanoma.

Cells

Yoganandarajah V,Patel J,van Schaijik B,Bockett N,Brasch HD,Paterson E,Sim D,Davis PF,Roth IM,Itinteang T,Tan ST

48-1400 was used in Western Blotting to identifiy and characterize cancer stem cells in head and neck metastatic malignant melanoma to regional lymph nodes using induced pluripotent stem cell markers.

Thu Jan 30 00:00:00 EST 2020

Generation of two induced pluripotent stem cell lines from a patient with dominant PRPF31 mutation and a related non-penetrant carrier.

Stem cell research

McLenachan S,Zhang D,Zhang X,Chen SC,Lamey T,Thompson JA,McLaren T,De Roach JN,Fletcher S,Chen FK

48-1400 was used in Immunocytochemistry, Flow Cytometry to report the generation of the human iPSC line LEIi008-A from a patient with retinitis pigmentosa-11 caused by a dominant nonsense mutation in the PRPF31 gene (NM_015629.3:c.1205C > A p.(Ser402Ter)).

Tue Jan 01 00:00:00 EST 2019

Generation of two induced pluripotent stem cell lines from a patient with dominant PRPF31 mutation and a related non-penetrant carrier.

Stem cell research

McLenachan S,Zhang D,Zhang X,Chen SC,Lamey T,Thompson JA,McLaren T,De Roach JN,Fletcher S,Chen FK

Tue Jan 01 00:00:00 EST 2019

Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle.

eLife

Friman ET,Deluz C,Meireles-Filho AC,Govindan S,Gardeux V,Deplancke B,Suter DM

Published figure using SOX2 polyclonal antibody (Product # 48-1400) in ChIP assay

Tue Dec 03 00:00:00 EST 2019

Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle.

eLife

Friman ET,Deluz C,Meireles-Filho AC,Govindan S,Gardeux V,Deplancke B,Suter DM

Published figure using SOX2 polyclonal antibody (Product # 48-1400) in ChIP assay

Tue Dec 03 00:00:00 EST 2019

Endogenous fluctuations of OCT4 and SOX2 bias pluripotent cell fate decisions.

Molecular systems biology

Strebinger D,Deluz C,Friman ET,Govindan S,Alber AB,Suter DM

Published figure using SOX2 polyclonal antibody (Product # 48-1400) in Western Blot

Sun Sep 01 00:00:00 EDT 2019

Endogenous fluctuations of OCT4 and SOX2 bias pluripotent cell fate decisions.

Molecular systems biology

Strebinger D,Deluz C,Friman ET,Govindan S,Alber AB,Suter DM

Published figure using SOX2 polyclonal antibody (Product # 48-1400) in Western Blot

Sun Sep 01 00:00:00 EDT 2019

Site-specific phosphorylation and caspase cleavage of GFAP are new markers of Alexander disease severity.

eLife

Battaglia RA,Beltran AS,Delic S,Dumitru R,Robinson JA,Kabiraj P,Herring LE,Madden VJ,Ravinder N,Willems E,Newman RA,Quinlan RA,Goldman JE,Perng MD,Inagaki M,Snider NT

Published figure using SOX2 polyclonal antibody (Product # 48-1400) in Immunocytochemistry

Mon Nov 04 00:00:00 EST 2019

Generation of a human iPSC line, INMi002-A, carrying the most prevalent USH2A variant associated with Usher syndrome type 2.

Stem cell research

Sanjurjo-Soriano C,Erkilic N,Manes G,Dubois G,Hamel CP,Meunier I,Kalatzis V

48-1400 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to generate an induced pluripotent stem cell (iPSC) line using dermal fibroblasts from a patient with Usher syndrome type 2 (USH2).

Sat Dec 01 00:00:00 EST 2018

The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells.

Nature cell biology

Donato V,Bonora M,Simoneschi D,Sartini D,Kudo Y,Saraf A,Florens L,Washburn MP,Stadtfeld M,Pinton P,Pagano M

Published figure using SOX2 polyclonal antibody (Product # 48-1400) in Western Blot

Sat Apr 01 00:00:00 EDT 2017

Human limbal neurospheres prevent photoreceptor cell death in a rat model of retinal degeneration.

Clinical & experimental ophthalmology

McLenachan S,Zhang D,Hao E,Zhang L,Chen SC,Chen FK

48-1400 was used in Immunocytochemistry-immunofluorescence to examine undifferentiated cultured adult human limbal neurospheres as donor cells for retinal cell therapies by transplantation into a rat model of retinal degeneration.

Tue Aug 01 00:00:00 EDT 2017

The miR-20-Rest-Wnt signaling axis regulates neural progenitor cell differentiation.

Scientific reports

Cui Y,Han J,Xiao Z,Chen T,Wang B,Chen B,Liu S,Han S,Fang Y,Wei J,Wang X,Ma X,Dai J

48-1400 was used in immunocytochemistry to analyze regulation of neural progenitor cell differentiation by the miR-20-Rest-Wnt signaling axis

Mon Mar 21 00:00:00 EDT 2016

The miR-20-Rest-Wnt signaling axis regulates neural progenitor cell differentiation.

Scientific reports

Cui Y,Han J,Xiao Z,Chen T,Wang B,Chen B,Liu S,Han S,Fang Y,Wei J,Wang X,Ma X,Dai J

48-1400 was used in immunocytochemistry to analyze regulation of neural progenitor cell differentiation by the miR-20-Rest-Wnt signaling axis

Mon Mar 21 00:00:00 EDT 2016

A Branching Process to Characterize the Dynamics of Stem Cell Differentiation.

Scientific reports

Míguez DG

48-1400 was used in immunohistochemistry to create a mathematical model that predicts the average rates of proliferative and differentiative divisions in stem cell population

Wed Aug 19 00:00:00 EDT 2015

A Branching Process to Characterize the Dynamics of Stem Cell Differentiation.

Scientific reports

Míguez DG

48-1400 was used in immunohistochemistry to create a mathematical model that predicts the average rates of proliferative and differentiative divisions in stem cell population

Wed Aug 19 00:00:00 EDT 2015

The miR-7 identified from collagen biomaterial-based three-dimensional cultured cells regulates neural stem cell differentiation.

Stem cells and development

Cui Y,Xiao Z,Chen T,Wei J,Chen L,Liu L,Chen B,Wang X,Li X,Dai J

Published figure using SOX2 polyclonal antibody (Product # 48-1400) in Immunofluorescence

Sat Feb 15 00:00:00 EST 2014

Sustained Wnt/β-catenin signalling causes neuroepithelial aberrations through the accumulation of aPKC at the apical pole.

Nature communications

Herrera A,Saade M,Menendez A,Marti E,Pons S

48-1400 was used in immunohistochemistry to report that beta-catenin controls the cell fate and polarity of neuroblasts by modulating the expression and localization of aPKC.

Thu Jun 19 00:00:00 EDT 2014

Cellular characterization of human pluripotent stem cells.

Methods in molecular biology (Clifton, N.J.)

Quintanilla RH

Thu Sep 19 00:00:00 EDT 2013

Novel developmental biology-based protocol of embryonic stem cell differentiation to morphologically sound and functional yet immature hepatocytes.

Liver international : official journal of the International Association for the Study of the Liver

Bukong TN,Lo T,Szabo G,Dolganiuc A

48-1400 was used in flow cytometry to describe a method to generate mature hepatocytes from embryonic stem cells.

Tue May 01 00:00:00 EDT 2012

Genome-wide analysis reveals that Smad3 and JMJD3 HDM co-activate the neural developmental program.

Development (Cambridge, England)

Estarás C,Akizu N,García A,Beltrán S,de la Cruz X,Martínez-Balbás MA

48-1400 was used in immunohistochemistry to report that neurogenesis is promoted by an interplay between the TGFβ pathway and JMJD3.

Wed Aug 01 00:00:00 EDT 2012

MiR-125b orchestrates cell proliferation, differentiation and migration in neural stem/progenitor cells by targeting Nestin.

BMC neuroscience

Cui Y,Xiao Z,Han J,Sun J,Ding W,Zhao Y,Chen B,Li X,Dai J

48-1400 was used in immunocytochemistry to investigate the role of miR-125b in neural stem/progenitor cells

Fri Sep 28 00:00:00 EDT 2012

MiR-125b orchestrates cell proliferation, differentiation and migration in neural stem/progenitor cells by targeting Nestin.

BMC neuroscience

Cui Y,Xiao Z,Han J,Sun J,Ding W,Zhao Y,Chen B,Li X,Dai J

48-1400 was used in immunocytochemistry to investigate the role of miR-125b in neural stem/progenitor cells

Fri Sep 28 00:00:00 EDT 2012

Sorting live stem cells based on Sox2 mRNA expression.

PloS one

Larsson HM,Lee ST,Roccio M,Velluto D,Lutolf MP,Frey P,Hubbell JA

48-1400 was used in immunocytochemistry to report how stem cells can be purified using molecular beacons.

Tue Jun 11 00:00:00 EDT 2013

The HMG-box transcription factor SoxNeuro acts with Tcf to control Wg/Wnt signaling activity.

Development (Cambridge, England)

Chao AT,Jones WM,Bejsovec A

Thu Mar 01 00:00:00 EST 2007

SOX2 is a dose-dependent regulator of retinal neural progenitor competence.

Genes & development

Taranova OV,Magness ST,Fagan BM,Wu Y,Surzenko N,Hutton SR,Pevny LH

Mon May 01 00:00:00 EDT 2006

Mutations in SOX2 cause anophthalmia.

Nature genetics

Fantes J,Ragge NK,Lynch SA,McGill NI,Collin JR,Howard-Peebles PN,Hayward C,Vivian AJ,Williamson K,van Heyningen V,FitzPatrick DR

Tue Apr 01 00:00:00 EST 2003

Vertebrate neurogenesis is counteracted by Sox1-3 activity.

Nature neuroscience

Bylund M,Andersson E,Novitch BG,Muhr J

Sat Nov 01 00:00:00 EST 2003

Bioinformatics

Protein Aliases: Delta EF2a; MCOPS3 (Microphthalmia Syndromic type 3); sex determining region Y-box 2; SOX 2; SRY (sex determining region Y) box 2; SRY (sex determining region Y)-box 2; SRY box 2; SRY related HMG box 2; SRY-box containing gene 2; SRY-related HMG-box gene 2; Transcription factor SOX-2; transcription factor SOX2

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Gene Aliases: ANOP3; lcc; MCOPS3; RGD1565646; Sox-2; SOX2; ysb

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UniProt ID: (Human) P48431, (Mouse) P48432

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Entrez Gene ID: (Human) 6657, (Rat) 499593, (Mouse) 20674

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Function(s)

transcription regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding miRNA binding sequence-specific DNA binding transcription regulatory region DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding molecular_function chromatin binding transcription factor binding protein heterodimerization activity chromatin DNA binding HMG box transcription factor

Process(es)

negative regulation of transcription from RNA polymerase II promoter osteoblast differentiation eye development endodermal cell fate specification chromatin organization regulation of transcription, DNA-templated transcription from RNA polymerase II promoter cell cycle arrest response to wounding regulation of gene expression glial cell fate commitment pituitary gland development adenohypophysis development positive regulation of cell-cell adhesion forebrain development somatic stem cell population maintenance tissue regeneration regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of MAPK cascade positive regulation of cell differentiation negative regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter inner ear development negative regulation of epithelial cell proliferation response to growth factor negative regulation of canonical Wnt signaling pathway neuronal stem cell population maintenance cell fate specification positive regulation of neuroblast proliferation regulation of transcription from RNA polymerase II promoter sensory perception of sound response to organic substance stem cell population maintenance forebrain neuron differentiation cerebral cortex development negative regulation of Wnt signaling pathway male genitalia development positive regulation of epithelial cell differentiation olfactory placode formation response to retinoic acid inner ear morphogenesis tongue development cell fate commitment negative regulation of cell differentiation positive regulation of neuron differentiation negative regulation of osteoblast differentiation positive regulation of Notch signaling pathway pigment biosynthetic process lung alveolus development embryonic organ development anatomical structure formation involved in morphogenesis neuron fate commitment diencephalon morphogenesis stem cell differentiation regulation of neurogenesis detection of mechanical stimulus involved in sensory perception of sound detection of mechanical stimulus involved in equilibrioception retina morphogenesis in camera-type eye lens induction in camera-type eye epithelial tube branching involved in lung morphogenesis transcription, DNA-templated multicellular organism development

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SOX2 Polyclonal Antibody

SOX2 Antibody (48-1400) in ICC/IF

Product Details

48-1400

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunohistochemistry (Frozen) (IHC (F))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

ChIP assay (ChIP)

Miscellaneous PubMed (Misc)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Target Information

Bioinformatics

Performance Guarantee

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