Invitrogen

SOX2 Polyclonal Antibody

Advanced Verification

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

42 Published Figures

43 References

View all (90) SOX2 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

SOX2 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 62

SOX2 Antibody (PA1-094) in ICC/IF

Immunofluorescent analysis of SOX2 using anti-SOX2 polyclonal antibody (Product # PA1-094) shows specific expression in human embryonal carcinoma NTERA-2 cells (shown in green) but not in negative control HeLa cells. Formalin fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 10 minutes at room temperature. Cells were blocked with 1% Blocker BSA (Product # 37525) for 15 minutes at room temperature. Cells were probed with a rabbit polyclonal antibody recognizing SOX2 (Product # PA1-094), at a dilution of 1:200 for at least 1 h... View More

SOX2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SOX2 Antibody in Immunoprecipitation (IP)

SOX2 Antibody in Immunohistochemistry (Frozen) (IHC (F))

SOX2 Antibody in Immunohistochemistry, Immunohistochemistry (Paraffin) (IHC, IHC (P))

SOX2 Antibody in Immunohistochemistry (IHC)

SOX2 Antibody in Immunohistochemistry, In Situ Hybridization (ISH) (IHC, ISH)

Product Image Gallery

SOX2 Antibody — The specificity of anti-SOX2 polyclonal antibody (Product # PA1-094) was demonstrated by the immunofluorescence detection of specific expression of Sox2 in human embryonal carcinoma NTERA-2 cells (shown in green) but not in negative control HeLa cells. {RE}

Product Details

PA1-094

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 23 publications 23 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

View 6 publications 6 publications

Immunohistochemistry (Frozen) (IHC (F))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:100-1:500

View 6 publications 6 publications

Flow Cytometry (Flow)

1:100

View 2 publications 2 publications

Immunoprecipitation (IP)

5 µg, 1:1,000

In Situ Hybridization (ISH) (ISH)

View 1 publication 1 publication

CUT&RUN (C&R)

1:100

Product Specifications

Species Reactivity

Fish, Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Full-length human recombinant protein expressed in bacteria

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS with 1mg/mL BSA, 30% glycerol

Contains

0.05% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2539862

Target Information

SOX2 is an intronless gene encoding a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of the SOX2 gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. The SOX2 gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). Further, SOX2 protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation, optic nerve hypoplasia and syndromic microphthalmia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The role of Eya1 and Eya2 in the taste system of mice from embryonic stage to adulthood.

Frontiers in cell and developmental biology

Zhang T,Xu PX

PA1-094 was used in Immunohistochemistry to report that Eya1 is not expressed during embryonic tongue development but that Eya1-expressing progenitors in somites or pharyngeal endoderm give rise to tongue musculature or taste organs, respectively.

Sat Nov 04 00:00:00 EDT 2023

Loss of miR-6844 alters stemness/self-renewal and cancer hallmark(s) markers through CD44-JAK2-STAT3 signaling axis in breast cancer stem-like cells.

Journal of cellular biochemistry

Prajapati KS,Kumar S

PA1-094 was used in Western Blotting to explore the functional role of loss of miR-6844 in breast cancer cells derived mammosphere.

Tue Aug 01 00:00:00 EDT 2023

PSEN1 E280A Cholinergic-like Neurons and Cerebral Spheroids Derived from Mesenchymal Stromal Cells and from Induced Pluripotent Stem Cells Are Neuropathologically Equivalent.

International journal of molecular sciences

Mendivil-Perez M,Velez-Pardo C,Lopera F,Kosik KS,Jimenez-Del-Rio M

PA1-094 was used in Immunocytochemistry to determine whether 2D and 3D MenSCs- and umbilical-cord Wharton Jelly’s MSCs-derived PSEN1 E280A ChLNs and CSs were neuropathologically equivalent to PSEN1 E280A ChLNs and CSs resulting from iPSC-derived neural progenitor cells.

Thu May 18 00:00:00 EDT 2023

Establishment of the iPSC line CUIMCi005-A from a patient with Stargardt disease for retinal organoid culture.

Stem cell research

Su PY,Lee W,Zernant J,Tsang SH,Nagasaki T,Corneo B,Allikmets R

PA1-094 was used in Immunocytochemistry-immunofluorescence to establish an induced pluripotent stem cell line for retinal organoid research from a patient with mild disease features who is compound heterozygous for the frequent c.5882G>A (p.Gly1961Glu) missense variant and a c.4947delC (p.Glu1650Argfs*12) frameshift variant.

Thu Dec 01 00:00:00 EST 2022

Cathepsins B, D, and G Are Expressed in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma.

Frontiers in oncology

Humphries F,Chang-McDonald B,Patel J,Bockett N,Paterson E,Davis PF,Tan ST

PA1-094 was used in Immunohistochemistry-immunofluorescence to investigate the expression and localization of cathepsins B, D, and G in relation to CSC subpopulations within mHNcSCC.

Wed Apr 27 00:00:00 EDT 2022

Cathepsins B, D, and G Are Expressed in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma.

Frontiers in oncology

Humphries F,Chang-McDonald B,Patel J,Bockett N,Paterson E,Davis PF,Tan ST

PA1-094 was used in Immunohistochemistry-immunofluorescence to investigate the expression and localization of cathepsins B, D, and G in relation to CSC subpopulations within mHNcSCC.

Wed Apr 27 00:00:00 EDT 2022

Latent Tri-lineage Potential of Human Menstrual Blood-Derived Mesenchymal Stromal Cells Revealed by Specific In Vitro Culture Conditions.

Molecular neurobiology

Quintero-Espinosa D,Soto-Mercado V,Quintero-Quinchia C,Mendivil-Perez M,Velez-Pardo C,Jimenez-Del-Rio M

PA1-094 was used in Western Blot to show that MenSCs are a reliable source to obtain functional neurogenic cells to further investigate the neurobiology of neurologic disorders.

Fri Oct 01 00:00:00 EDT 2021

Stemness-Associated Markers Are Expressed in Extracranial Arteriovenous Malformation.

Frontiers in surgery

Luke Krishnan CS,Brasch HD,Patel J,Bockett N,Paterson E,Davis PF,Tan ST

PA1-094 was used in Immunohistochemistry to study the presence and expression pattern of OCT4, SOX2, NANOG, KLF4, and c-MYC in extracranial arteriovenous malformation.

Tue Apr 06 00:00:00 EDT 2021

Stemness-Associated Markers Are Expressed in Extracranial Arteriovenous Malformation.

Frontiers in surgery

Luke Krishnan CS,Brasch HD,Patel J,Bockett N,Paterson E,Davis PF,Tan ST

PA1-094 was used in Immunohistochemistry to study the presence and expression pattern of OCT4, SOX2, NANOG, KLF4, and c-MYC in extracranial arteriovenous malformation.

Tue Apr 06 00:00:00 EDT 2021

Close relationship between TAZhigh/SOX2high co-localization and metastasis in oral squamous cell carcinoma.

Polish journal of pathology : official journal of the Polish Society of Pathologists

Stasikowska-Kanicka O,Woskowicz M,Ulewicz K,Danilewicz M,Wągrowska-Danilewicz M

PA1-094 was used in Immunohistochemistry to suggest that SOX2 and TAZ could potentially cooperate and contribute to process of metastasis, especially in cases with TAZ high /SOX2 high expression.

Fri Jan 21 00:00:00 EST 2022

Cell Populations Expressing Stemness-Associated Markers in Lung Adenocarcinoma.

Life (Basel, Switzerland)

Paterson C,Kilmister EJ,Brasch HD,Bockett N,Patel J,Paterson E,Purdie G,Galvin S,Davis PF,Itinteang T,Tan ST

Published figure using SOX2 polyclonal antibody (Product # PA1-094) in Immunohistochemistry

Mon Oct 18 00:00:00 EDT 2021

Cell Populations Expressing Stemness-Associated Markers in Lung Adenocarcinoma.

Life (Basel, Switzerland)

Paterson C,Kilmister EJ,Brasch HD,Bockett N,Patel J,Paterson E,Purdie G,Galvin S,Davis PF,Itinteang T,Tan ST

Published figure using SOX2 polyclonal antibody (Product # PA1-094) in Immunohistochemistry

Mon Oct 18 00:00:00 EDT 2021

Cytosine and adenosine base editing in human pluripotent stem cells using transient reporters for editing enrichment.

Nature protocols

Tekel SJ,Brookhouser N,Standage-Beier K,Wang X,Brafman DA

PA1-094 was used in CUT&RUN, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to facilitate the highly efficient single-base editing of human cells at precise genomic loci.

Thu Jul 01 00:00:00 EDT 2021

Evidence of disrupted rhombic lip development in the pathogenesis of Dandy-Walker malformation.

Acta neuropathologica

Haldipur P,Bernardo S,Aldinger KA,Sivakumar T,Millman J,Sjoboen AH,Dang D,Dubocanin D,Deng M,Timms AE,Davis BD,Plummer JT,Mankad K,Oztekin O,Manganaro L,Guimiot F,Adle-Biassette H,Russo R,Siebert JR,Kidron D,Petrilli G,Roux N,Razavi F,Glass IA,Di Gioia C,Silvestri E,Millen KJ

PA1-094 was used in Immunohistochemistry to study Dandy-Walker malformation (DWM) and Cerebellar vermis hypoplasia (CVH) in prenatal cases, revealing that DWM is characterized by disrupted development of the rhombic lip, leading to reduced proliferation and expansion of progenitors, which results in disproportionate inferior vermian hypoplasia, with the timing of insult during development distinguishing DWM from CVH.

Fri Oct 01 00:00:00 EDT 2021

Cancer Stem Cell Subpopulations Are Present Within Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma.

Frontiers in oncology

Kilmister EJ,Patel J,van Schaijik B,Bockett N,Brasch HD,Paterson E,Sim D,Davis PF,Roth IM,Itinteang T,Tan ST

Published figure using SOX2 polyclonal antibody (Product # PA1-094) in Immunohistochemistry

Mon Sep 28 00:00:00 EDT 2020

Cancer Stem Cell Subpopulations Are Present Within Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma.

Frontiers in oncology

Kilmister EJ,Patel J,van Schaijik B,Bockett N,Brasch HD,Paterson E,Sim D,Davis PF,Roth IM,Itinteang T,Tan ST

Published figure using SOX2 polyclonal antibody (Product # PA1-094) in Immunohistochemistry

Mon Sep 28 00:00:00 EDT 2020

Embryonic stem cell-like subpopulations are present within Schwannoma.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Kilmister EJ,Patel J,Bockett N,Chang-McDonald B,Sim D,Wickremesekera A,Davis PF,Tan ST

PA1-094 was used in Immunohistochemistry to identify ESC-like cells in Schwannoma using the induced-pluripotent stem cell (iPSC) markers OCT4, SOX2, NANOG, KLF4 and c-MYC.

Sun Nov 01 00:00:00 EDT 2020

Identification of Cancer Stem Cell Subpopulations in Head and Neck Metastatic Malignant Melanoma.

Cells

Yoganandarajah V,Patel J,van Schaijik B,Bockett N,Brasch HD,Paterson E,Sim D,Davis PF,Roth IM,Itinteang T,Tan ST

Published figure using SOX2 polyclonal antibody (Product # PA1-094) in Immunohistochemistry

Thu Jan 30 00:00:00 EST 2020

Long-term PM_2.5 exposure increases the risk of non-small cell lung cancer (NSCLC) progression by enhancing interleukin-17a (IL-17a)-regulated proliferation and metastasis.

Aging

Chao X,Yi L,Lan LL,Wei HY,Wei D

Published figure using SOX2 polyclonal antibody (Product # PA1-094) in Immunohistochemistry

Thu Jun 18 00:00:00 EDT 2020

Long-term PM_2.5 exposure increases the risk of non-small cell lung cancer (NSCLC) progression by enhancing interleukin-17a (IL-17a)-regulated proliferation and metastasis.

Aging

Chao X,Yi L,Lan LL,Wei HY,Wei D

Published figure using SOX2 polyclonal antibody (Product # PA1-094) in Immunohistochemistry

Thu Jun 18 00:00:00 EDT 2020

SOX2 Expression and Transcriptional Activity Identifies a Subpopulation of Cancer Stem Cells in Sarcoma with Prognostic Implications.

Cancers

Menendez ST,Rey V,Martinez-Cruzado L,Gonzalez MV,Morales-Molina A,Santos L,Blanco V,Alvarez C,Estupiñan O,Allonca E,Rodrigo JP,García-Castro J,Garcia-Pedrero JM,Rodriguez R

PA1-094 was used in Flow cytometry/Cell sorting to demonstrates that SOX2 is a pro-tumorigenic factor with prognostic potential in sarcoma.

Mon Apr 13 00:00:00 EDT 2020

SOX2 Expression and Transcriptional Activity Identifies a Subpopulation of Cancer Stem Cells in Sarcoma with Prognostic Implications.

Cancers

Menendez ST,Rey V,Martinez-Cruzado L,Gonzalez MV,Morales-Molina A,Santos L,Blanco V,Alvarez C,Estupiñan O,Allonca E,Rodrigo JP,García-Castro J,Garcia-Pedrero JM,Rodriguez R

PA1-094 was used in Flow cytometry/Cell sorting to demonstrates that SOX2 is a pro-tumorigenic factor with prognostic potential in sarcoma.

Mon Apr 13 00:00:00 EDT 2020

SOX2 Expression and Transcriptional Activity Identifies a Subpopulation of Cancer Stem Cells in Sarcoma with Prognostic Implications.

Cancers

Menendez ST,Rey V,Martinez-Cruzado L,Gonzalez MV,Morales-Molina A,Santos L,Blanco V,Alvarez C,Estupiñan O,Allonca E,Rodrigo JP,García-Castro J,Garcia-Pedrero JM,Rodriguez R

PA1-094 was used in Flow cytometry/Cell sorting to demonstrates that SOX2 is a pro-tumorigenic factor with prognostic potential in sarcoma.

Mon Apr 13 00:00:00 EDT 2020

Expression of Components of the Renin-Angiotensin System in Pyogenic Granuloma.

Frontiers in surgery

Papali'i-Curtin JC,Brasch HD,van Schaijik B,de Jongh J,Marsh RW,Tan ST,Itinteang T

PA1-094 was used in Immunohistochemistry to investigate the expression of components of the renin-angiotensin system in relation to a putative embryonic stem cell-like population within pyogenic granuloma.

Thu Oct 01 00:00:00 EDT 2020

Cancer stem cell subpopulations in moderately differentiated head and neck cutaneous squamous cell carcinoma.

Heliyon

Koh SP,Brasch HD,de Jongh J,Itinteang T,Tan ST

Published figure using SOX2 polyclonal antibody (Product # PA1-094) in Immunohistochemistry

Thu Aug 01 00:00:00 EDT 2019

Persistent motor dysfunction despite homeostatic rescue of cerebellar morphogenesis in the Car8 waddles mutant mouse.

Neural development

Miterko LN,White JJ,Lin T,Brown AM,O'Donovan KJ,Sillitoe RV

PA1-094 was used in Immunohistochemistry-immunofluorescence to study how the loss of carbonic anhydrase 8, a regulator of IP3R1 Ca2+ signalling in Purkinje cells, alters cerebellar development in Car8wdl mice.

Tue Mar 12 00:00:00 EDT 2019

PI3K-Yap activity drives cortical gyrification and hydrocephalus in mice.

eLife

Roy A,Murphy RM,Deng M,MacDonald JW,Bammler TK,Aldinger KA,Glass IA,Millen KJ

PA1-094 was used in Immunohistochemistry to study the mechanisms driving the initiation of brain folding.

Thu May 16 00:00:00 EDT 2019

Embryonic Stem Cell-like Population within Venous Malformation Expresses the Renin-Angiotensin System.

Plastic and reconstructive surgery. Global open

Tan EMS,Brasch HD,Davis PF,Itinteang T,Tan ST

PA1-094 was used in Immunohistochemistry-immunofluorescence to discover (through immunofluorescence immunohistochemical staining) the expression of the Renin-Angiotensin System in Embryonic Stem Cell-like Population within Venous Malformation (VM), thus revealing a new theraputic target for VM.

Mon Apr 01 00:00:00 EDT 2019

Epigenetic alterations mediate iPSC-induced normalization of DNA repair gene expression and TNR stability in Huntington's disease cells.

Journal of cell science

Mollica PA,Zamponi M,Reid JA,Sharma DK,White AE,Ogle RC,Bruno RD,Sachs PC

PA1-094 was used in Immunocytochemistry-immunoflourescence to study the mechanisms underlying Huntington's disease associated cellular dysfunction in pluripotency and neurodevelopment.

Fri Jul 06 00:00:00 EDT 2018

3D bioprinter applied picosecond pulsed electric fields for targeted manipulation of proliferation and lineage specific gene expression in neural stem cells.

Journal of neural engineering

Petrella RA,Mollica PA,Zamponi M,Reid JA,Xiao S,Bruno RD,Sachs PC

PA1-094 was used in Immunocytochemistry-immunoflourescence to describe the potential of psPEF in directing neural stem cells (NSCs) gene expression, metabolism, and proliferation. As a comparison mesenchymal stem cells (MSCs) were also tested.

Mon Oct 01 00:00:00 EDT 2018

Expression of Embryonic Stem Cell Markers on the Microvessels of WHO Grade I Meningioma.

Frontiers in surgery

Shivapathasundram G,Wickremesekera AC,Brasch HD,Marsh R,Tan ST,Itinteang T

Published figure using SOX2 polyclonal antibody (Product # PA1-094) in Immunohistochemistry

Wed Sep 30 00:00:00 EDT 2020

Characterization of Cancer Stem Cells in Colon Adenocarcinoma Metastasis to the Liver.

Frontiers in surgery

Humphries HN,Wickremesekera SK,Marsh RW,Brasch HD,Mehrotra S,Tan ST,Itinteang T

Published figure using SOX2 polyclonal antibody (Product # PA1-094) in Immunohistochemistry

Mon Mar 21 00:00:00 EDT 2022

The Identification of Three Cancer Stem Cell Subpopulations within Moderately Differentiated Lip Squamous Cell Carcinoma.

Frontiers in surgery

Ram R,Brasch HD,Dunne JC,Davis PF,Tan ST,Itinteang T

Published figure using SOX2 polyclonal antibody (Product # PA1-094) in Immunofluorescence

Tue Sep 29 00:00:00 EDT 2020

The Identification of Three Cancer Stem Cell Subpopulations within Moderately Differentiated Lip Squamous Cell Carcinoma.

Frontiers in surgery

Ram R,Brasch HD,Dunne JC,Davis PF,Tan ST,Itinteang T

Published figure using SOX2 polyclonal antibody (Product # PA1-094) in Immunofluorescence

Tue Sep 29 00:00:00 EDT 2020

Cancer Stem Cells in Moderately Differentiated Lip Squamous Cell Carcinoma Express Components of the Renin-Angiotensin System.

Frontiers in surgery

Ram RS,Brasch HD,Dunne JC,Davis PF,Tan ST,Itinteang T

Published figure using SOX2 polyclonal antibody (Product # PA1-094) in Immunofluorescence

Mon Mar 21 00:00:00 EDT 2022

Cancer Stem Cells in Moderately Differentiated Lip Squamous Cell Carcinoma Express Components of the Renin-Angiotensin System.

Frontiers in surgery

Ram RS,Brasch HD,Dunne JC,Davis PF,Tan ST,Itinteang T

Published figure using SOX2 polyclonal antibody (Product # PA1-094) in Immunofluorescence

Mon Mar 21 00:00:00 EDT 2022

Six1 is essential for differentiation and patterning of the mammalian auditory sensory epithelium.

PLoS genetics

Zhang T,Xu J,Maire P,Xu PX

Published figure using SOX2 polyclonal antibody (Product # PA1-094) in Immunofluorescence

Fri Sep 01 00:00:00 EDT 2017

Six1 is essential for differentiation and patterning of the mammalian auditory sensory epithelium.

PLoS genetics

Zhang T,Xu J,Maire P,Xu PX

Published figure using SOX2 polyclonal antibody (Product # PA1-094) in Immunofluorescence

Fri Sep 01 00:00:00 EDT 2017

Embryonic Stem Cell-Like Subpopulations in Venous Malformation.

Frontiers in medicine

Tan EMS,Siljee SD,Brasch HD,Enriquez S,Tan ST,Itinteang T

Published figure using SOX2 polyclonal antibody (Product # PA1-094) in Immunofluorescence

Sat Apr 09 00:00:00 EDT 2022

Cancer stem cells in moderately differentiated oral tongue squamous cell carcinoma express components of the renin-angiotensin system.

Journal of clinical pathology

Itinteang T,Dunne JC,Chibnall AM,Brasch HD,Davis PF,Tan ST

Published figure using SOX2 polyclonal antibody (Product # PA1-094) in Immunofluorescence

Sat Oct 01 00:00:00 EDT 2016

Cancer stem cells in moderately differentiated oral tongue squamous cell carcinoma.

Journal of clinical pathology

Baillie R,Itinteang T,Yu HH,Brasch HD,Davis PF,Tan ST

PA1094 was used in immunohistochemistry - paraffin section to discuss the role of cancer stem cells in moderately differentiated oral tongue squamous cell carcinoma

Mon Aug 01 00:00:00 EDT 2016

Cancer stem cells in moderately differentiated oral tongue squamous cell carcinoma.

Journal of clinical pathology

Baillie R,Itinteang T,Yu HH,Brasch HD,Davis PF,Tan ST

PA1094 was used in immunohistochemistry - paraffin section to discuss the role of cancer stem cells in moderately differentiated oral tongue squamous cell carcinoma

Mon Aug 01 00:00:00 EDT 2016

Cancer Stem Cells in Glioblastoma Multiforme.

Frontiers in surgery

Bradshaw A,Wickremesekera A,Brasch HD,Chibnall AM,Davis PF,Tan ST,Itinteang T

Published figure using SOX2 polyclonal antibody (Product # PA1-094) in Immunohistochemistry

Mon Sep 12 00:00:00 EDT 2016

Cancer Stem Cells in Glioblastoma Multiforme.

Frontiers in surgery

Bradshaw A,Wickremesekera A,Brasch HD,Chibnall AM,Davis PF,Tan ST,Itinteang T

Published figure using SOX2 polyclonal antibody (Product # PA1-094) in Immunohistochemistry

Mon Sep 12 00:00:00 EDT 2016

Cancer Stem Cells in Moderately Differentiated Buccal Mucosal Squamous Cell Carcinoma Express Components of the Renin-Angiotensin System.

Frontiers in surgery

Featherston T,Yu HH,Dunne JC,Chibnall AM,Brasch HD,Davis PF,Tan ST,Itinteang T

PA1094 was used in immunohistochemistry - paraffin section to characterize cancer stem cell subpopulations within moderately differentiated buccal mucosal squamous cell carcinoma

Mon Mar 21 00:00:00 EDT 2022

Glioblastoma Multiforme Cancer Stem Cells Express Components of the Renin-Angiotensin System.

Frontiers in surgery

Bradshaw AR,Wickremesekera AC,Brasch HD,Chibnall AM,Davis PF,Tan ST,Itinteang T

PA1094 was used in immunohistochemistry - paraffin section to measure expression of the renin-angiotensin system in cancer stem cells

Mon Mar 21 00:00:00 EDT 2022

Aldh1 Expression and Activity Increase During Tumor Evolution in Sarcoma Cancer Stem Cell Populations.

Scientific reports

Martinez-Cruzado L,Tornin J,Santos L,Rodriguez A,García-Castro J,Morís F,Rodriguez R

PA1-094 was used in immunocytochemistry and western blot to characterize an increase of Aldh1 activity and expression during tumor evolution in sarcoma cancer stem cell populations

Mon Jun 13 00:00:00 EDT 2016

Aldh1 Expression and Activity Increase During Tumor Evolution in Sarcoma Cancer Stem Cell Populations.

Scientific reports

Martinez-Cruzado L,Tornin J,Santos L,Rodriguez A,García-Castro J,Morís F,Rodriguez R

PA1-094 was used in immunocytochemistry and western blot to characterize an increase of Aldh1 activity and expression during tumor evolution in sarcoma cancer stem cell populations

Mon Jun 13 00:00:00 EDT 2016

Embryonic Stem Cell-like Population in Dupuytren's Disease.

Plastic and reconstructive surgery. Global open

Koh SP,On N,Brasch HD,Chibnall AM,Armstrong JR,Davis PF,Tan ST,Itinteang T

PA1094 was used in immunohistochemistry - paraffin section to investigate the primitive population that might be upstream of the mesenchymal stem cell population within Dupuytren's disease

Tue Nov 01 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: Delta EF2a; MCOPS3 (Microphthalmia Syndromic type 3); sex determining region Y-box 2; SOX 2; SRY (sex determining region Y) box 2; SRY (sex determining region Y)-box 2; SRY box 2; SRY related HMG box 2; SRY-box containing gene 2; SRY-related HMG-box gene 2; Transcription factor SOX-2; transcription factor SOX2

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Gene Aliases: ANOP3; lcc; MCOPS3; Sox-2; SOX2; ysb

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UniProt ID: (Human) P48431, (Mouse) P48432

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Entrez Gene ID: (Human) 6657, (Mouse) 20674

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Function(s)

transcription regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding miRNA binding sequence-specific DNA binding transcription regulatory region DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding chromatin binding transcription factor binding chromatin DNA binding protein heterodimerization activity HMG box transcription factor

Process(es)

negative regulation of transcription from RNA polymerase II promoter osteoblast differentiation eye development endodermal cell fate specification chromatin organization regulation of transcription, DNA-templated transcription from RNA polymerase II promoter cell cycle arrest response to wounding regulation of gene expression glial cell fate commitment pituitary gland development adenohypophysis development positive regulation of cell-cell adhesion forebrain development somatic stem cell population maintenance tissue regeneration regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of MAPK cascade positive regulation of cell differentiation negative regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter inner ear development negative regulation of epithelial cell proliferation response to growth factor negative regulation of canonical Wnt signaling pathway neuronal stem cell population maintenance cell fate specification positive regulation of neuroblast proliferation transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development sensory perception of sound response to organic substance stem cell population maintenance forebrain neuron differentiation cerebral cortex development negative regulation of Wnt signaling pathway male genitalia development positive regulation of epithelial cell differentiation olfactory placode formation response to retinoic acid inner ear morphogenesis tongue development cell fate commitment negative regulation of cell differentiation positive regulation of neuron differentiation negative regulation of osteoblast differentiation positive regulation of Notch signaling pathway pigment biosynthetic process lung alveolus development embryonic organ development anatomical structure formation involved in morphogenesis neuron fate commitment diencephalon morphogenesis stem cell differentiation regulation of neurogenesis detection of mechanical stimulus involved in sensory perception of sound detection of mechanical stimulus involved in equilibrioception retina morphogenesis in camera-type eye lens induction in camera-type eye epithelial tube branching involved in lung morphogenesis

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SOX2 Polyclonal Antibody

SOX2 Antibody (PA1-094) in ICC/IF

Product Details

PA1-094

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (Frozen) (IHC (F))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

In Situ Hybridization (ISH) (ISH)

CUT&RUN (C&R)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Target Information

Bioinformatics

Performance Guarantee

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