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Immunogen sequence: MAGGGGDLS TRRLNECISP VANEMNHLPA HSHDLQRMFT EDQGVDDRLL YDIVFKHFKR NKVEISNAIK KTFPFLEGLR DRDLITNKMF EDSQDSCRNL VPVQRVVYNV LSELEKTFNL PVLEALFSDV NMQEYPDLIH IYKGFENVIH DKLPLQESEE EEREERSGLQ LSLEQGTGEN SFRSLTWPPS GSPSHAGTTP PENGLSEHPC ETEQINAKRK DTTSDKDDSL GSQQTNEQCA QKAEPTESCE QIAVQVNNGD AGREMPCPLP CDEESPEAEL HNHGIQINSC SVRLVDIKKE KPFSNSKVEC QAQARTHHNQ ASDIIVIS (1-327 aa encoded by BC011562)
This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DKFZp686E07254; FLJ00340; FLJ34579; Nuclear autoantigen Sp-100; Nuclear dot-associated Sp100 protein; SP 100; SP100-HMG nuclear autoantigen; Speckled 100 kDa
Gene Aliases: lysp100b; SP100
UniProt ID: (Human) P23497
Entrez Gene ID: (Human) 6672
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