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Product Details
PA5-53712
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SQLE. Recombinant protein control fragment (Product #RP-91198).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2647903
Product Specific Information
Immunogen sequence: DGRKVTVIER DLKEPDRIVG EFLQPGGYHV LKDLGLGDTV EGLDAQVVNG YMIHDQESKS EVQIPYPLSE NNQVQSGRAF HHGRFIMSLR KAAMAEPNAK FIEGVVLQLL EEDDVVMG
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 81%.
Target Information
SQLE, also named as ERG1, SE and SM, belongs to the squalene monooxygenase family. It catalyzes the first oxygenation step in cholesterol synthesis, acting on squalene before cyclization into the basic steroid structure. SQLE may serve as a flux-controlling enzyme beyond 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR, considered as rate limiting). It is also post translationally regulated by cholesterol-dependent proteasomal degradation. The MW of SQLE is about 64 kDa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ30795; SE; Squalene epoxidase; Squalene monooxygenase
Gene Aliases: ERG1; SQLE
UniProt ID: (Human) Q14534
Entrez Gene ID: (Human) 6713
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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