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SR-BI Antibody (PA5-90750) in WB
Western blot analysis of SR-BI in extracts of various cell lines. Samples were incubated with SR-BI Polyclonal antibody (Product # PA5-90750) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-90750
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SR-BI (NP_0054964)
Conjugate
Form
Liquid
Concentration
0.28 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2806221
Product Specific Information
Immunogen sequence: MGCSAKARWA AGALGVAGLL CAVLGAVMIV MVPSLIKQQV LKNVRIDPSS LSFNMWKEIP IPFYLSVYFF DVMNPSEILK GEKPQVRERG PYVYREFRHK; Positive Samples: Rat ovary; Cellular Location: Cell membrane, Membrane, Multi-pass membrane protein, caveola
Target Information
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BI binds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by a distinct mechanism. In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD36; CD36 and LIMPII analogous 1; CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1 (scavanger receptor class B type 1); CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; CD36 antigen-like 1; CLA-1; Collagen type I receptor, thrombospondin receptor-like 1; HDL QTL 1; scavanger receptor class B type 1; scavenger receptor b1; Scavenger receptor class B member 1; scavenger receptor class B type I; scavenger receptor class B type III; scavenger receptor class B, member 1; scavenger receptor class B1; SR-BI; SRB1
Gene Aliases: AI120173; CD36; CD36L1; CLA-1; CLA1; D5Ertd460e; Hdlq1; HDLQTL6; Hlb398; mSR-BI; SCARB1; SR-B1; SR-BI; SRB1; SRBI
UniProt ID: (Human) Q8WTV0, (Rat) P97943, (Mouse) D3Z2V4
Entrez Gene ID: (Human) 949, (Rat) 25073, (Mouse) 20778
lipopolysaccharide binding
virus receptor activity
phosphatidylserine binding
lipopolysaccharide receptor activity
transporter activity
protein binding
1-phosphatidylinositol binding
high-density lipoprotein particle binding
low-density lipoprotein particle binding
apolipoprotein binding
apolipoprotein A-I binding
protein homodimerization activity
high-density lipoprotein particle receptor activity
lipid transporter activity
membrane trafficking regulatory protein
endothelial cell proliferation
androgen biosynthetic process
cholesterol catabolic process
receptor-mediated endocytosis
positive regulation of endothelial cell migration
positive regulation of triglyceride biosynthetic process
positive regulation of cholesterol storage
regulation of phosphatidylcholine catabolic process
phospholipid transport
lipopolysaccharide transport
lipopolysaccharide-mediated signaling pathway
detection of lipopolysaccharide
cholesterol efflux
high-density lipoprotein particle remodeling
low-density lipoprotein particle clearance
high-density lipoprotein particle clearance
vitamin transmembrane transport
wound healing
lipoprotein metabolic process
cholesterol homeostasis
blood vessel endothelial cell migration
recognition of apoptotic cell
reverse cholesterol transport
adhesion of symbiont to host
viral entry into host cell
regulation of phagocytosis
intestinal absorption
positive regulation of nitric-oxide synthase activity
triglyceride homeostasis
cholesterol import
steroid biosynthetic process
lipid transport
phagocytosis, recognition
cell adhesion
cholesterol transport
pattern recognition receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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