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Product Details
MA5-48412
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
5E9H10
Immunogen
Purified recombinant fragment of human SCARB1 (AA: Extra(33-232)) expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_3090850
Target Information
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BI binds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by a distinct mechanism. In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD36; CD36 and LIMPII analogous 1; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; CD36 antigen-like 1; CLA-1; Collagen type I receptor, thrombospondin receptor-like 1; scavenger receptor b1; Scavenger receptor class B member 1; scavenger receptor class B type III; scavenger receptor class B, member 1; SR-BI; SRB1
Gene Aliases: CD36L1; CLA-1; CLA1; HDLQTL6; SCARB1; SR-BI; SRB1
UniProt ID: (Human) Q8WTV0
Entrez Gene ID: (Human) 949
lipopolysaccharide binding
virus receptor activity
phosphatidylserine binding
lipopolysaccharide receptor activity
transporter activity
protein binding
1-phosphatidylinositol binding
high-density lipoprotein particle binding
low-density lipoprotein particle binding
apolipoprotein binding
apolipoprotein A-I binding
protein homodimerization activity
high-density lipoprotein particle receptor activity
membrane trafficking regulatory protein
endothelial cell proliferation
androgen biosynthetic process
cholesterol catabolic process
receptor-mediated endocytosis
positive regulation of endothelial cell migration
positive regulation of triglyceride biosynthetic process
positive regulation of cholesterol storage
regulation of phosphatidylcholine catabolic process
phospholipid transport
lipopolysaccharide transport
lipopolysaccharide-mediated signaling pathway
detection of lipopolysaccharide
cholesterol efflux
high-density lipoprotein particle remodeling
low-density lipoprotein particle clearance
high-density lipoprotein particle clearance
vitamin transmembrane transport
wound healing
lipoprotein metabolic process
cholesterol homeostasis
blood vessel endothelial cell migration
recognition of apoptotic cell
reverse cholesterol transport
adhesion of symbiont to host
viral entry into host cell
regulation of phagocytosis
intestinal absorption
positive regulation of nitric-oxide synthase activity
triglyceride homeostasis
cholesterol import
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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