Product References
Mechanism of action of hepatitis B virus S antigen transport-inhibiting oligonucleotide polymer, STOPS, molecules.
Molecular therapy. Nucleic acids
Kao CC,Nie Y,Ren S,De Costa NTTS,Pandey RK,Hong J,Smith DB,Symons JA,Beigelman L,Blatt LM
32-4600 was used in Western Blot to show that the STOPS inhibition of HBsAg levels in HBV-infected cells occurs by sequestering cellular proteins needed for proper expression and folding of HBsAg.
Tue Mar 08 00:00:00 EST 2022
Mechanism of action of hepatitis B virus S antigen transport-inhibiting oligonucleotide polymer, STOPS, molecules.
Molecular therapy. Nucleic acids
Kao CC,Nie Y,Ren S,De Costa NTTS,Pandey RK,Hong J,Smith DB,Symons JA,Beigelman L,Blatt LM
32-4600 was used in Western Blot to show that the STOPS inhibition of HBsAg levels in HBV-infected cells occurs by sequestering cellular proteins needed for proper expression and folding of HBsAg.
Tue Mar 08 00:00:00 EST 2022
RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer.
Nature communications
Hall AE,Pohl SÖ,Cammareri P,Aitken S,Younger NT,Raponi M,Billard CV,Carrancio AB,Bastem A,Freile P,Haward F,Adams IR,Caceres JF,Preyzner P,von Kriegsheim A,Dunlop MG,Din FV,Myant KB
32-4600 was used in Immunohistochemistry to identify dysregulated RNA splicing as a key driver of tumour cell dedifferentiation in colorectal cancer.
Thu May 19 00:00:00 EDT 2022
Nuclear speckle integrity and function require TAO2 kinase.
Proceedings of the National Academy of Sciences of the United States of America
Gao S,Esparza M,Dehghan I,Aksenova V,Zhang K,Batten K,Ferretti MB,Begg BE,Cagatay T,Shay JW,García-Sastre A,Goldsmith EJ,Chen ZJ,Dasso M,Lynch KW,Cobb MH,Fontoura BMA
32-4600 was used in Western Blotting to find that a nuclear pool of TAO2 is localized at nuclear speckles and interacts with nuclear speckle factors involved in RNA splicing and nuclear export, including SRSF1 and Aly/Ref.
Tue Jun 21 00:00:00 EDT 2022
Nuclear speckle integrity and function require TAO2 kinase.
Proceedings of the National Academy of Sciences of the United States of America
Gao S,Esparza M,Dehghan I,Aksenova V,Zhang K,Batten K,Ferretti MB,Begg BE,Cagatay T,Shay JW,García-Sastre A,Goldsmith EJ,Chen ZJ,Dasso M,Lynch KW,Cobb MH,Fontoura BMA
32-4600 was used in Western Blotting to find that a nuclear pool of TAO2 is localized at nuclear speckles and interacts with nuclear speckle factors involved in RNA splicing and nuclear export, including SRSF1 and Aly/Ref.
Tue Jun 21 00:00:00 EDT 2022
Nuclear speckle integrity and function require TAO2 kinase.
Proceedings of the National Academy of Sciences of the United States of America
Gao S,Esparza M,Dehghan I,Aksenova V,Zhang K,Batten K,Ferretti MB,Begg BE,Cagatay T,Shay JW,García-Sastre A,Goldsmith EJ,Chen ZJ,Dasso M,Lynch KW,Cobb MH,Fontoura BMA
32-4600 was used in Western Blotting to find that a nuclear pool of TAO2 is localized at nuclear speckles and interacts with nuclear speckle factors involved in RNA splicing and nuclear export, including SRSF1 and Aly/Ref.
Tue Jun 21 00:00:00 EDT 2022
BRD4 prevents the accumulation of R-loops and protects against transcription-replication collision events and DNA damage.
Nature communications
Lam FC,Kong YW,Huang Q,Vu Han TL,Maffa AD,Kasper EM,Yaffe MB
32-4600 was used in Western Blotting to report that deregulated transcription following BRD4 loss in cancer cells leads to the accumulation of RNA:DNA hybrids (R-loops) and collisions with the replication machinery causing replication stress and DNA damage.
Fri Aug 14 00:00:00 EDT 2020
Splicing events in the control of genome integrity: role of SLU7 and truncated SRSF3 proteins.
Nucleic acids research
Jiménez M,Urtasun R,Elizalde M,Azkona M,Latasa MU,Uriarte I,Arechederra M,Alignani D,Bárcena-Varela M,Álvarez-Sola G,Colyn L,Santamaría E,Sangro B,Rodriguez-Ortigosa C,Fernández-Barrena MG,Ávila MA,Berasain C
32-4600 was used in Western Blotting to identify the splicing regulator SLU7 as a key mediator of genome stability.
Tue Apr 23 00:00:00 EDT 2019
SAMMSON fosters cancer cell fitness by concertedly enhancing mitochondrial and cytosolic translation.
Nature structural & molecular biology
Vendramin R,Verheyden Y,Ishikawa H,Goedert L,Nicolas E,Saraf K,Armaos A,Delli Ponti R,Izumikawa K,Mestdagh P,Lafontaine DLJ,Tartaglia GG,Takahashi N,Marine JC,Leucci E
32-4600 was used in Western Blotting to highlight how a single oncogenic lncRNA can simultaneously modulate RNA-protein complex formation in two distinct cellular compartments to promote cell growth.
Thu Nov 01 00:00:00 EDT 2018
5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m5C reader.
Cell research
Yang X,Yang Y,Sun BF,Chen YS,Xu JW,Lai WY,Li A,Wang X,Bhattarai DP,Xiao W,Sun HY,Zhu Q,Ma HL,Adhikari S,Sun M,Hao YJ,Zhang B,Huang CM,Huang N,Jiang GB,Zhao YL,Wang HL,Sun YP,Yang YG
Published figure using SRSF1 monoclonal antibody (Product # 32-4600) in Immunofluorescence
Mon May 01 00:00:00 EDT 2017
Human satellite-III non-coding RNAs modulate heat-shock-induced transcriptional repression.
Journal of cell science
Goenka A,Sengupta S,Pandey R,Parihar R,Mohanta GC,Mukerji M,Ganesh S
324600 was used in western blot to clarify the regulatory role of Sat3 transcripts in heat-shock-dependent transcriptional repression
Sat Oct 01 00:00:00 EDT 2016
Comparative expression patterns and diagnostic efficacies of SR splicing factors and HNRNPA1 in gastric and colorectal cancer.
BMC cancer
Park WC,Kim HR,Kang DB,Ryu JS,Choi KH,Lee GO,Yun KJ,Kim KY,Park R,Yoon KH,Cho JH,Lee YJ,Chae SC,Park MC,Park DS
32-4600 was used in immunohistochemistry - paraffin section and western blot to compare colorectal and gastric cancer and their expression patterns and diagnostic efficacies of SR splicing factors and HNRNPA1
Fri Jun 10 00:00:00 EDT 2016
Comparative expression patterns and diagnostic efficacies of SR splicing factors and HNRNPA1 in gastric and colorectal cancer.
BMC cancer
Park WC,Kim HR,Kang DB,Ryu JS,Choi KH,Lee GO,Yun KJ,Kim KY,Park R,Yoon KH,Cho JH,Lee YJ,Chae SC,Park MC,Park DS
32-4600 was used in immunohistochemistry - paraffin section and western blot to compare colorectal and gastric cancer and their expression patterns and diagnostic efficacies of SR splicing factors and HNRNPA1
Fri Jun 10 00:00:00 EDT 2016
Splicing factor SRSF1 negatively regulates alternative splicing of MDM2 under damage.
Nucleic acids research
Comiskey DF,Jacob AG,Singh RK,Tapia-Santos AS,Chandler DS
324600 was used in western blot to study the splicing regulation of the MDM2 oncogene.
Thu Apr 30 00:00:00 EDT 2015
Regulation of gene expression via retrotransposon insertions and the noncoding RNA 4.5S RNAH.
Genes to cells : devoted to molecular & cellular mechanisms
Ishida K,Miyauchi K,Kimura Y,Mito M,Okada S,Suzuki T,Nakagawa S
32-4600 was used in immunohistochemistry to investigate how the 4.5SH cluster regulates SINE B1
Sun Nov 01 00:00:00 EDT 2015
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.
Nature chemical biology
Liu J,Yue Y,Han D,Wang X,Fu Y,Zhang L,Jia G,Yu M,Lu Z,Deng X,Dai Q,Chen W,He C
32-4600 was used in immunocytochemistry to characterize mammalian nuclear RNA N6-adenosine methylation mediation by a METTL3-METTL14 complex
Sat Feb 01 00:00:00 EST 2014
RRP1B is a metastasis modifier that regulates the expression of alternative mRNA isoforms through interactions with SRSF1.
Oncogene
Lee M,Dworkin AM,Gildea D,Trivedi NS,Moorhead GB,Crawford NP
Thu Apr 03 00:00:00 EDT 2014
RRP1B is a metastasis modifier that regulates the expression of alternative mRNA isoforms through interactions with SRSF1.
Oncogene
Lee M,Dworkin AM,Gildea D,Trivedi NS,Moorhead GB,Crawford NP
Thu Apr 03 00:00:00 EDT 2014
RRP1B is a metastasis modifier that regulates the expression of alternative mRNA isoforms through interactions with SRSF1.
Oncogene
Lee M,Dworkin AM,Gildea D,Trivedi NS,Moorhead GB,Crawford NP
Thu Apr 03 00:00:00 EDT 2014
RRP1B is a metastasis modifier that regulates the expression of alternative mRNA isoforms through interactions with SRSF1.
Oncogene
Lee M,Dworkin AM,Gildea D,Trivedi NS,Moorhead GB,Crawford NP
Thu Apr 03 00:00:00 EDT 2014
The adipogenic transcriptional cofactor ZNF638 interacts with splicing regulators and influences alternative splicing.
Journal of lipid research
Du C,Ma X,Meruvu S,Hugendubler L,Mueller E
32-4600 was used in immunocytochemistry to investigate the interaction of adipogenic transcriptional cofactor ZNF638 with splicing regulators and its effect on alternative splicing
Mon Sep 01 00:00:00 EDT 2014
The adipogenic transcriptional cofactor ZNF638 interacts with splicing regulators and influences alternative splicing.
Journal of lipid research
Du C,Ma X,Meruvu S,Hugendubler L,Mueller E
32-4600 was used in immunocytochemistry to investigate the interaction of adipogenic transcriptional cofactor ZNF638 with splicing regulators and its effect on alternative splicing
Mon Sep 01 00:00:00 EDT 2014
The splicing factor FUBP1 is required for the efficient splicing of oncogene MDM2 pre-mRNA.
The Journal of biological chemistry
Jacob AG,Singh RK,Mohammad F,Bebee TW,Chandler DS
Published figure using SRSF1 monoclonal antibody (Product # 32-4600) in Western Blot
Fri Jun 20 00:00:00 EDT 2014
The splicing factor FUBP1 is required for the efficient splicing of oncogene MDM2 pre-mRNA.
The Journal of biological chemistry
Jacob AG,Singh RK,Mohammad F,Bebee TW,Chandler DS
Published figure using SRSF1 monoclonal antibody (Product # 32-4600) in Western Blot
Fri Jun 20 00:00:00 EDT 2014
Nuclear ARVCF protein binds splicing factors and contributes to the regulation of alternative splicing.
The Journal of biological chemistry
Rappe U,Schlechter T,Aschoff M,Hotz-Wagenblatt A,Hofmann I
Published figure using SRSF1 monoclonal antibody (Product # 32-4600) in Immunocytochemistry
Fri May 02 00:00:00 EDT 2014
Nuclear ARVCF protein binds splicing factors and contributes to the regulation of alternative splicing.
The Journal of biological chemistry
Rappe U,Schlechter T,Aschoff M,Hotz-Wagenblatt A,Hofmann I
Published figure using SRSF1 monoclonal antibody (Product # 32-4600) in Immunocytochemistry
Fri May 02 00:00:00 EDT 2014
Nuclear ARVCF protein binds splicing factors and contributes to the regulation of alternative splicing.
The Journal of biological chemistry
Rappe U,Schlechter T,Aschoff M,Hotz-Wagenblatt A,Hofmann I
Published figure using SRSF1 monoclonal antibody (Product # 32-4600) in Immunocytochemistry
Fri May 02 00:00:00 EDT 2014
Nuclear ARVCF protein binds splicing factors and contributes to the regulation of alternative splicing.
The Journal of biological chemistry
Rappe U,Schlechter T,Aschoff M,Hotz-Wagenblatt A,Hofmann I
Published figure using SRSF1 monoclonal antibody (Product # 32-4600) in Immunocytochemistry
Fri May 02 00:00:00 EDT 2014
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.
Molecular cell
Zheng G,Dahl JA,Niu Y,Fedorcsak P,Huang CM,Li CJ,Vågbø CB,Shi Y,Wang WL,Song SH,Lu Z,Bosmans RP,Dai Q,Hao YJ,Yang X,Zhao WM,Tong WM,Wang XJ,Bogdan F,Furu K,Fu Y,Jia G,Zhao X,Liu J,Krokan HE,Klungland A,Yang YG,He C
Published figure using SRSF1 monoclonal antibody (Product # 32-4600) in Immunocytochemistry
Thu Jan 10 00:00:00 EST 2013
CTD serine-2 plays a critical role in splicing and termination factor recruitment to RNA polymerase II in vivo.
Nucleic acids research
Gu B,Eick D,Bensaude O
32-4600 was used in immunocytochemistry to study the mechanism for RNA splicing and termination factor recruitment to RNA polymerase II in vivo
Fri Feb 01 00:00:00 EST 2013
Malat1 is not an essential component of nuclear speckles in mice.
RNA (New York, N.Y.)
Nakagawa S,Ip JY,Shioi G,Tripathi V,Zong X,Hirose T,Prasanth KV
32-4600 was used in western blot to characterize Malat-knockout mice.
Wed Aug 01 00:00:00 EDT 2012
Malat1 is not an essential component of nuclear speckles in mice.
RNA (New York, N.Y.)
Nakagawa S,Ip JY,Shioi G,Tripathi V,Zong X,Hirose T,Prasanth KV
32-4600 was used in western blot to characterize Malat-knockout mice.
Wed Aug 01 00:00:00 EDT 2012
Hypoxia is a modifier of SMN2 splicing and disease severity in a severe SMA mouse model.
Human molecular genetics
Bebee TW,Dominguez CE,Samadzadeh-Tarighat S,Akehurst KL,Chandler DS
Mon Oct 01 00:00:00 EDT 2012
Hypoxia is a modifier of SMN2 splicing and disease severity in a severe SMA mouse model.
Human molecular genetics
Bebee TW,Dominguez CE,Samadzadeh-Tarighat S,Akehurst KL,Chandler DS
Mon Oct 01 00:00:00 EDT 2012
Adaptive alternative splicing correlates with less environmental risk of parkinsonism.
Neuro-degenerative diseases
Benmoyal-Segal L,Soreq L,Ben-Shaul Y,Ben-Ari S,Ben-Moshe T,Aviel S,Bergman H,Soreq H
32-4600 was used in Immunohistochemistry to show that general changes in splicing including splice shift to AChE-R, if properly functioning, can minimize the effects of MPTP.
Fri May 18 00:00:00 EDT 2012
SAM68 regulates neuronal activity-dependent alternative splicing of neurexin-1.
Cell
Iijima T,Wu K,Witte H,Hanno-Iijima Y,Glatter T,Richard S,Scheiffele P
Published figure using SRSF1 monoclonal antibody (Product # 32-4600) in Western Blot
Fri Dec 23 00:00:00 EST 2011
Cell-to-cell variability of alternative RNA splicing.
Molecular systems biology
Waks Z,Klein AM,Silver PA
Published figure using SRSF1 monoclonal antibody (Product # 32-4600) in Western Blot
Tue Jul 05 00:00:00 EDT 2011
Cell-to-cell variability of alternative RNA splicing.
Molecular systems biology
Waks Z,Klein AM,Silver PA
Published figure using SRSF1 monoclonal antibody (Product # 32-4600) in Western Blot
Tue Jul 05 00:00:00 EDT 2011
Protein kinase a-dependent phosphorylation of serine 119 in the proto-oncogenic serine/arginine-rich splicing factor 1 modulates its activity as a splicing enhancer protein.
Genes & cancer
Aksaas AK,Eikvar S,Akusjärvi G,Skålhegg BS,Kvissel AK
Published figure using SRSF1 monoclonal antibody (Product # 32-4600) in Immunofluorescence
Mon Aug 01 00:00:00 EDT 2011
Protein kinase a-dependent phosphorylation of serine 119 in the proto-oncogenic serine/arginine-rich splicing factor 1 modulates its activity as a splicing enhancer protein.
Genes & cancer
Aksaas AK,Eikvar S,Akusjärvi G,Skålhegg BS,Kvissel AK
Published figure using SRSF1 monoclonal antibody (Product # 32-4600) in Immunofluorescence
Mon Aug 01 00:00:00 EDT 2011
Protein kinase a-dependent phosphorylation of serine 119 in the proto-oncogenic serine/arginine-rich splicing factor 1 modulates its activity as a splicing enhancer protein.
Genes & cancer
Aksaas AK,Eikvar S,Akusjärvi G,Skålhegg BS,Kvissel AK
Published figure using SRSF1 monoclonal antibody (Product # 32-4600) in Immunofluorescence
Mon Aug 01 00:00:00 EDT 2011
S1-1 nuclear domains: characterization and dynamics as a function of transcriptional activity.
Biology of the cell
Inoue A,Tsugawa K,Tokunaga K,Takahashi KP,Uni S,Kimura M,Nishio K,Yamamoto N,Honda K,Watanabe T,Yamane H,Tani T
32-4600 was used in immunocytochemistry to elucidate the function of S1-1
Mon Sep 01 00:00:00 EDT 2008
Three-dimensional positioning of genes in mouse cell nuclei.
Chromosoma
Hepperger C,Mannes A,Merz J,Peters J,Dietzel S
32-4600 was used in immunocytochemistry to study the nuclear localization of several genes
Mon Dec 01 00:00:00 EST 2008
The switch in alternative splicing of cyclic AMP-response element modulator protein CREM{tau}2{alpha} (activator) to CREM{alpha} (repressor) in human myometrial cells is mediated by SRp40.
The Journal of biological chemistry
Tyson-Capper AJ,Bailey J,Krainer AR,Robson SC,Europe-Finner GN
Fri Oct 14 00:00:00 EDT 2005
F-actin-dependent insolubility of chromatin-modifying components.
The Journal of biological chemistry
Andrin C,Hendzel MJ
Fri Jun 11 00:00:00 EDT 2004
