7TM Antibodies

SST2, Somatostatin Receptor 2 Polyclonal Antibody

SST2, Somatostatin Receptor 2 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 7

SST2, Somatostatin Receptor 2 Antibody (7TM0356N-IC) in ICC/IF

Immunocytochemical identification of Somatostatin Receptor 2 in transfected HEK293 cells. HEK293 cells stably expressing the Somatostatin Receptor 2 (SST2) were either not exposed or exposed to 1 µM SRIF (somatotropin release inhibiting factor) for 30 min and immunocytochemically stained with anti-SST2 (Somatostatin Receptor 2) antibody (7TM0356N-IC) at a dilution of 1:200. Note, SST2 receptors were confine... View More

SST2, Somatostatin Receptor 2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SST2, Somatostatin Receptor 2 Antibody in Western Blot (WB)

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Product Details

7TM0356N-IC

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:100

View 1 publication 1 publication

Immunohistochemistry (PFA fixed) (IHC (PFA))

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:200

View 7 publications 7 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to residues 335-369 of human, mouse and rat SST2.

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

Dulbecco's PBS, pH 7.4

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice (domestic); Dry ice (international)

Target Information

SSTR2 (somatostatin receptor 2) is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in the cerebrum and kidney. Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The receptor is coupled via pertussis toxin sensitive G proteins to inhibit adenylyl cyclase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Carboxyl-terminal receptor domains control the differential dephosphorylation of somatostatin receptors by protein phosphatase 1 isoforms.

PloS one

Lehmann A,Kliewer A,Märtens JC,Nagel F,Schulz S

Tue Jan 06 00:00:00 EST 2015

Carboxyl-terminal receptor domains control the differential dephosphorylation of somatostatin receptors by protein phosphatase 1 isoforms.

PloS one

Lehmann A,Kliewer A,Märtens JC,Nagel F,Schulz S

Tue Jan 06 00:00:00 EST 2015

Carboxyl-terminal multi-site phosphorylation regulates internalization and desensitization of the human sst2 somatostatin receptor.

Molecular and cellular endocrinology

Lehmann A,Kliewer A,Schütz D,Nagel F,Stumm R,Schulz S

Fri Apr 25 00:00:00 EDT 2014

Carboxyl-terminal multi-site phosphorylation regulates internalization and desensitization of the human sst2 somatostatin receptor.

Molecular and cellular endocrinology

Lehmann A,Kliewer A,Schütz D,Nagel F,Stumm R,Schulz S

Fri Apr 25 00:00:00 EDT 2014

Somatostatin and its 2A receptor in dorsal root ganglia and dorsal horn of mouse and human: expression, trafficking and possible role in pain.

Molecular pain

Shi TJ,Xiang Q,Zhang MD,Barde S,Kai-Larsen Y,Fried K,Josephson A,Glück L,Deyev SM,Zvyagin AV,Schulz S,Hökfelt T

Thu Feb 13 00:00:00 EST 2014

Somatostatin and its 2A receptor in dorsal root ganglia and dorsal horn of mouse and human: expression, trafficking and possible role in pain.

Molecular pain

Shi TJ,Xiang Q,Zhang MD,Barde S,Kai-Larsen Y,Fried K,Josephson A,Glück L,Deyev SM,Zvyagin AV,Schulz S,Hökfelt T

Thu Feb 13 00:00:00 EST 2014

A transplantable phosphorylation probe for direct assessment of G protein-coupled receptor activation.

PloS one

Kliewer A,Mann A,Petrich A,Pöll F,Schulz S

Fri Nov 30 00:00:00 EST 2012

A transplantable phosphorylation probe for direct assessment of G protein-coupled receptor activation.

PloS one

Kliewer A,Mann A,Petrich A,Pöll F,Schulz S

Fri Nov 30 00:00:00 EST 2012

Structural determinants of agonist-selective signaling at the sst(2A) somatostatin receptor.

Molecular endocrinology (Baltimore, Md.)

Nagel F,Doll C,Pöll F,Kliewer A,Schröder H,Schulz S

Sun May 01 00:00:00 EDT 2011

Structural determinants of agonist-selective signaling at the sst(2A) somatostatin receptor.

Molecular endocrinology (Baltimore, Md.)

Nagel F,Doll C,Pöll F,Kliewer A,Schröder H,Schulz S

Sun May 01 00:00:00 EDT 2011

Pasireotide and octreotide stimulate distinct patterns of sst2A somatostatin receptor phosphorylation.

Molecular endocrinology (Baltimore, Md.)

Pöll F,Lehmann D,Illing S,Ginj M,Jacobs S,Lupp A,Stumm R,Schulz S

Mon Feb 01 00:00:00 EST 2010

Pasireotide and octreotide stimulate distinct patterns of sst2A somatostatin receptor phosphorylation.

Molecular endocrinology (Baltimore, Md.)

Pöll F,Lehmann D,Illing S,Ginj M,Jacobs S,Lupp A,Stumm R,Schulz S

Mon Feb 01 00:00:00 EST 2010

Differential effects of octreotide and pasireotide on somatostatin receptor internalization and trafficking in vitro.

The Journal of clinical endocrinology and metabolism

Lesche S,Lehmann D,Nagel F,Schmid HA,Schulz S

Sun Feb 01 00:00:00 EST 2009

Differential effects of octreotide and pasireotide on somatostatin receptor internalization and trafficking in vitro.

The Journal of clinical endocrinology and metabolism

Lesche S,Lehmann D,Nagel F,Schmid HA,Schulz S

Sun Feb 01 00:00:00 EST 2009

Indium-111-pentetreotide scintigraphy and somatostatin receptor subtype 2 expression: new prognostic factors for malignant well-differentiated endocrine tumors.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Asnacios A,Courbon F,Rochaix P,Bauvin E,Cances-Lauwers V,Susini C,Schulz S,Boneu A,Guimbaud R,Buscail L

Wed Feb 20 00:00:00 EST 2008

Indium-111-pentetreotide scintigraphy and somatostatin receptor subtype 2 expression: new prognostic factors for malignant well-differentiated endocrine tumors.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Asnacios A,Courbon F,Rochaix P,Bauvin E,Cances-Lauwers V,Susini C,Schulz S,Boneu A,Guimbaud R,Buscail L

Wed Feb 20 00:00:00 EST 2008

Reassessment of sst2 somatostatin receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-1.

The Journal of clinical endocrinology and metabolism

Fischer T,Doll C,Jacobs S,Kolodziej A,Stumm R,Schulz S

Sat Nov 01 00:00:00 EDT 2008

Reassessment of sst2 somatostatin receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-1.

The Journal of clinical endocrinology and metabolism

Fischer T,Doll C,Jacobs S,Kolodziej A,Stumm R,Schulz S

Sat Nov 01 00:00:00 EDT 2008

Immunohistochemical determination of five somatostatin receptors in meningioma reveals frequent overexpression of somatostatin receptor subtype sst2A.

Clinical cancer research : an official journal of the American Association for Cancer Research

Schulz S,Pauli SU,Schulz S,Händel M,Dietzmann K,Firsching R,Höllt V

Mon May 01 00:00:00 EDT 2000

Immunohistochemical determination of five somatostatin receptors in meningioma reveals frequent overexpression of somatostatin receptor subtype sst2A.

Clinical cancer research : an official journal of the American Association for Cancer Research

Schulz S,Pauli SU,Schulz S,Händel M,Dietzmann K,Firsching R,Höllt V

Mon May 01 00:00:00 EDT 2000

A valve at the bladder outlet.

The Australian and New Zealand journal of surgery

O'Rourke DA

Thu Feb 01 00:00:00 EST 1973

Bioinformatics

Protein Aliases: somatostatin receptor; somatostatin receptor 2a; Somatostatin receptor type 2; SRIF-1; SS-2-R; SS2R; SSR2; SSTR2A

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Gene Aliases: SSTR2

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UniProt ID: (Human) P30874

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Entrez Gene ID: (Human) 6752

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Function(s)

somatostatin receptor activity protein binding PDZ domain binding neuropeptide binding G-protein coupled receptor transmembrane signal receptor

Process(es)

regulation of muscle contraction G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway neuropeptide signaling pathway cell-cell signaling chemical synaptic transmission spermatogenesis response to nutrient digestion negative regulation of cell proliferation cerebellum development peristalsis forebrain development somatostatin signaling pathway response to starvation cellular response to glucocorticoid stimulus cellular response to estradiol stimulus

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SST2, Somatostatin Receptor 2 Polyclonal Antibody

SST2, Somatostatin Receptor 2 Antibody (7TM0356N-IC) in ICC/IF

Product Details

7TM0356N-IC

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Target Information

Bioinformatics

Performance Guarantee

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