7TM Antibodies

SST5, Somatostatin Receptor 5 Polyclonal Antibody

SST5, Somatostatin Receptor 5 Antibody in Immunocytochemistry (ICC/IF)

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SST5, Somatostatin Receptor 5 Antibody (7TM0359N-IC) in ICC/IF

Immunocytochemical identification of Somatostatin Receptor 5 in transfected HEK293 cells. Native HEK293 cells (MOCK) or HEK293 cells stably expressing the Somatostatin Receptor 5 (SST5) were immunocytochemically stained with anti-SST5 (Somatostatin Receptor 5) antibody (7TM0359N-IC) at a dilution of 1:200. Note, SST5 receptors were confined to the plasma membrane in transfected cells.

SST5, Somatostatin Receptor 5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SST5, Somatostatin Receptor 5 Antibody in Western Blot (WB)

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Product Details

7TM0359N-IC

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:200

View 4 publications 4 publications

Not applicable (N/A)

View 9 publications 9 publications

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide with sequence QEATPPAHRAAANGLMQTSKL corresponds to amino acids 344 - 364 of human SST5.

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

Dulbecco's PBS, pH 7.4

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice (domestic); Dry ice (international)

Target Information

Somatostatin is a multifunctional protein affecting exocrine and endocrine protein secretion, neurotransmission, and neuronal modulation and regulating cell proliferation. All these functions of Somatostatin are executed through a class of GPCR protein family members called somatostatin receptor. Till date, 6 classes of somatostatin receptors have been discovered out of which SSTR5, 364A.A protein, is a receptor subtype expressed predominantly in the pituitary and hypothalamus region of brain. Studies revealed that SSTR5 contains seven transmembrane regions and undergoes homodimerization and also heterodimerizes with SSTR1. Although the specific functions of SSTR5 are still elusive, the studies indicate that it complements SSTR2 regulation of ACTH secretion. Polymorphisms in SSTR5 gene have been observed in patients with acromegaly.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

In situ visualization of opioid and cannabinoid drug effects using phosphosite-specific GPCR antibodies.

Communications biology

Fritzwanker S,Nagel F,Kliewer A,Stammer V,Schulz S

Sat Apr 15 00:00:00 EDT 2023

Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization.

Science signaling

Miess E,Gondin AB,Yousuf A,Steinborn R,Mösslein N,Yang Y,Göldner M,Ruland JG,Bünemann M,Krasel C,Christie MJ,Halls ML,Schulz S,Canals M

Tue Jul 17 00:00:00 EDT 2018

Role of Phosphorylation Sites in Desensitization of µ-Opioid Receptor.

Molecular pharmacology

Yousuf A,Miess E,Sianati S,Du YP,Schulz S,Christie MJ

Thu Oct 01 00:00:00 EDT 2015

Heterologous regulation of agonist-independent μ-opioid receptor phosphorylation by protein kinase C.

British journal of pharmacology

Illing S,Mann A,Schulz S

Sat Mar 01 00:00:00 EST 2014

Loss of morphine reward and dependence in mice lacking G protein-coupled receptor kinase 5.

Biological psychiatry

Glück L,Loktev A,Moulédous L,Mollereau C,Law PY,Schulz S

Sat Nov 15 00:00:00 EST 2014

Phosphorylation of threonine 333 regulates trafficking of the human sst5 somatostatin receptor.

Molecular endocrinology (Baltimore, Md.)

Petrich A,Mann A,Kliewer A,Nagel F,Strigli A,Märtens JC,Pöll F,Schulz S

Mon Apr 01 00:00:00 EDT 2013

Phosphorylation of threonine 333 regulates trafficking of the human sst5 somatostatin receptor.

Molecular endocrinology (Baltimore, Md.)

Petrich A,Mann A,Kliewer A,Nagel F,Strigli A,Märtens JC,Pöll F,Schulz S

Mon Apr 01 00:00:00 EDT 2013

Differentiation of opioid drug effects by hierarchical multi-site phosphorylation.

Molecular pharmacology

Just S,Illing S,Trester-Zedlitz M,Lau EK,Kotowski SJ,Miess E,Mann A,Doll C,Trinidad JC,Burlingame AL,von Zastrow M,Schulz S

Fri Mar 01 00:00:00 EST 2013

Expression of SSTR2a, but not of SSTRs 1, 3, or 5 in somatotroph adenomas assessed by monoclonal antibodies was reduced by octreotide and correlated with the acute and long-term effects of octreotide.

The Journal of clinical endocrinology and metabolism

Casar-Borota O,Heck A,Schulz S,Nesland JM,Ramm-Pettersen J,Lekva T,Alafuzoff I,Bollerslev J

Fri Nov 01 00:00:00 EDT 2013

The Journal of clinical endocrinology and metabolism

Casar-Borota O,Heck A,Schulz S,Nesland JM,Ramm-Pettersen J,Lekva T,Alafuzoff I,Bollerslev J

Fri Nov 01 00:00:00 EDT 2013

Deciphering µ-opioid receptor phosphorylation and dephosphorylation in HEK293 cells.

British journal of pharmacology

Doll C,Pöll F,Peuker K,Loktev A,Glück L,Schulz S

Thu Nov 01 00:00:00 EDT 2012

Agonist-selective patterns of µ-opioid receptor phosphorylation revealed by phosphosite-specific antibodies.

British journal of pharmacology

Doll C,Konietzko J,Pöll F,Koch T,Höllt V,Schulz S

Thu Sep 01 00:00:00 EDT 2011

Analgesic tolerance to high-efficacy agonists but not to morphine is diminished in phosphorylation-deficient S375A μ-opioid receptor knock-in mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Grecksch G,Just S,Pierstorff C,Imhof AK,Glück L,Doll C,Lupp A,Becker A,Koch T,Stumm R,Höllt V,Schulz S

Wed Sep 28 00:00:00 EDT 2011

Reassessment of sst(5) somatostatin receptor expression in normal and neoplastic human tissues using the novel rabbit monoclonal antibody UMB-4.

Neuroendocrinology

Lupp A,Hunder A,Petrich A,Nagel F,Doll C,Schulz S

Wed Mar 21 00:00:00 EDT 2012

Reassessment of sst(5) somatostatin receptor expression in normal and neoplastic human tissues using the novel rabbit monoclonal antibody UMB-4.

Neuroendocrinology

Lupp A,Hunder A,Petrich A,Nagel F,Doll C,Schulz S

Wed Mar 21 00:00:00 EDT 2012

Reassessment of sst(5) somatostatin receptor expression in normal and neoplastic human tissues using the novel rabbit monoclonal antibody UMB-4.

Neuroendocrinology

Lupp A,Hunder A,Petrich A,Nagel F,Doll C,Schulz S

Wed Mar 21 00:00:00 EDT 2012

Identification of somatostatin receptor subtypes 1, 2A, 3, and 5 in neuroendocrine tumours with subtype specific antibodies.

Gut

Kulaksiz H,Eissele R,Rössler D,Schulz S,Höllt V,Cetin Y,Arnold R

Tue Jan 01 00:00:00 EST 2002

Identification of somatostatin receptor subtypes 1, 2A, 3, and 5 in neuroendocrine tumours with subtype specific antibodies.

Gut

Kulaksiz H,Eissele R,Rössler D,Schulz S,Höllt V,Cetin Y,Arnold R

Tue Jan 01 00:00:00 EST 2002

Identification of somatostatin receptor subtypes 1, 2A, 3, and 5 in neuroendocrine tumours with subtype specific antibodies.

Gut

Kulaksiz H,Eissele R,Rössler D,Schulz S,Höllt V,Cetin Y,Arnold R

Tue Jan 01 00:00:00 EST 2002

Immunohistochemical determination of five somatostatin receptors in meningioma reveals frequent overexpression of somatostatin receptor subtype sst2A.

Clinical cancer research : an official journal of the American Association for Cancer Research

Schulz S,Pauli SU,Schulz S,Händel M,Dietzmann K,Firsching R,Höllt V

Mon May 01 00:00:00 EDT 2000

Immunohistochemical determination of five somatostatin receptors in meningioma reveals frequent overexpression of somatostatin receptor subtype sst2A.

Clinical cancer research : an official journal of the American Association for Cancer Research

Schulz S,Pauli SU,Schulz S,Händel M,Dietzmann K,Firsching R,Höllt V

Mon May 01 00:00:00 EDT 2000

Immunohistochemical determination of five somatostatin receptors in meningioma reveals frequent overexpression of somatostatin receptor subtype sst2A.

Clinical cancer research : an official journal of the American Association for Cancer Research

Schulz S,Pauli SU,Schulz S,Händel M,Dietzmann K,Firsching R,Höllt V

Mon May 01 00:00:00 EDT 2000

Bioinformatics

Protein Aliases: somatostatin receptor; somatostatin receptor subtype 5; Somatostatin receptor type 5; SS-5-R

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Gene Aliases: SS-5-R; SSTR5

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UniProt ID: (Human) P35346

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Entrez Gene ID: (Human) 6755

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Function(s)

somatostatin receptor activity neuropeptide binding G-protein coupled receptor transmembrane signal receptor

Process(es)

G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway chemical synaptic transmission negative regulation of cell proliferation positive regulation of cytokinesis somatostatin signaling pathway glucose homeostasis regulation of insulin secretion cellular response to glucocorticoid stimulus

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SST5, Somatostatin Receptor 5 Polyclonal Antibody

SST5, Somatostatin Receptor 5 Antibody (7TM0359N-IC) in ICC/IF

Product Details

7TM0359N-IC

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Target Information

Bioinformatics

Performance Guarantee

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