Invitrogen

SSTR2 Polyclonal Antibody

5 Published Figures

8 References

View all (34) SSTR2 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (2)
Published Figures (5)

SSTR2 Antibody in Immunohistochemistry (IHC)

FIGURE: 1 / 7

SSTR2 Antibody (PA3-109) in IHC

Immunohistochemical staining of SSTR2A in human pancreatic islands using Product # PA3-109.

SSTR2 Antibody in Immunohistochemistry, Immunohistochemistry (Paraffin) (IHC, IHC (P))

Product Image Gallery

Product Details

PA3-109

Applications

Tested Dilution

Publications

Western Blot (WB)

1:250

View 2 publications 2 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:2500

View 1 publication 1 publication

Immunohistochemistry (PFA fixed) (IHC (PFA))

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:5,000

Product Specifications

Species Reactivity

Human, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues E(355) T Q R T L L N G D L Q T S I(369) of human SSTR2A.

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2196063

Product Specific Information

PA3-109 detects Somatostatin Receptor 2A in human and rat samples.

PA3-109 has been used successfully in Western blot, immunocytochemistry, and immunohistochemistry procedures. In Western blot analysis of SSTR2A transfected HEK-293 cells this antibody detects a ~62-72 kDa protein representing SSTR2A.

The PA3-109 immunogen is a synthetic peptide corresponding to residues E(355) T Q R T L L N G D L Q T S I(369) of human SSTR2A.

Target Information

SSTR2 (somatostatin receptor 2) is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in the cerebrum and kidney. Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The receptor is coupled via pertussis toxin sensitive G proteins to inhibit adenylyl cyclase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The Wnt pathway protein Dvl1 targets somatostatin receptor 2 for lysosome-dependent degradation.

The Journal of biological chemistry

Carr HS,Zuo Y,Frost JA

Published figure using SSTR2 polyclonal antibody (Product # PA3-109) in Western Blot

Mon May 01 00:00:00 EDT 2023

p53-Mediated Radiosensitization of ¹⁷⁷Lu-DOTATATE in Neuroblastoma Tumor Spheroids.

Biomolecules

Lundsten S,Berglund H,Jha P,Krona C,Hariri M,Nelander S,Lane DP,Nestor M

PA3-109 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that VIP116 inhibited neuroblastoma cell growth, potentiated 177Lu-DOTATATE treatment and could, therefore, be a feasible treatment option for neuroblastoma.

Mon Nov 15 00:00:00 EST 2021

Pituispheres Contain Genetic Variants Characteristic to Pituitary Adenoma Tumor Tissue.

Frontiers in endocrinology

Peculis R,Mandrika I,Petrovska R,Dortane R,Megnis K,Nazarovs J,Balcere I,Stukens J,Konrade I,Pirags V,Klovins J,Rovite V

PA3-109 was used in Immunohistochemistry to trace the origin of sphere-forming and adherent pituitary cell cultures and characterize the potential use of these surgery derived cell lines as pituitary adenoma model.

Mon May 10 00:00:00 EDT 2021

Loss of IQSEC3 Disrupts GABAergic Synapse Maintenance and Decreases Somatostatin Expression in the Hippocampus.

Cell reports

Kim S,Kim H,Park D,Kim J,Hong J,Kim JS,Jung H,Kim D,Cheong E,Ko J,Um JW

PA3-109 was used in Immunohistochemistry (PFA fixed) to show that IQSEC3 knockdown (KD) reduced GABAergic synaptic density in vivo, suggesting that IQSEC3 is required for GABAergic synapse maintenance in vivo.

Tue Feb 11 00:00:00 EST 2020

Somatostatin receptor expression on von Hippel-Lindau-associated hemangioblastomas offers novel therapeutic target.

Scientific reports

Sizdahkhani S,Feldman MJ,Piazza MG,Ksendzovsky A,Edwards NA,Ray-Chaudhury A,Maric D,Merrill MJ,Pacak K,Zhuang Z,Chittiboina P

PA3-109 was used in immunohistochemistry - paraffin section to determine the expression of somatostatin receptors in Von Hippel-Lindau-associated hemangioblastomas

Tue Jan 17 00:00:00 EST 2017

Somatostatin receptor expression on von Hippel-Lindau-associated hemangioblastomas offers novel therapeutic target.

Scientific reports

Sizdahkhani S,Feldman MJ,Piazza MG,Ksendzovsky A,Edwards NA,Ray-Chaudhury A,Maric D,Merrill MJ,Pacak K,Zhuang Z,Chittiboina P

PA3-109 was used in immunohistochemistry - paraffin section to determine the expression of somatostatin receptors in Von Hippel-Lindau-associated hemangioblastomas

Tue Jan 17 00:00:00 EST 2017

SSTR2-based reporters for assessing gene transfer into non-small cell lung cancer: evaluation using an intrathoracic mouse model.

Human gene therapy

Singh SP,Han L,Murali R,Solis L,Roth J,Ji L,Wistuba I,Kundra V

Published figure using SSTR2 polyclonal antibody (Product # PA3-109) in Immunohistochemistry

Sat Jan 01 00:00:00 EST 2011

Tumor-induced hypophosphatemic rickets in an adolescent boy--clinical presentation, diagnosis, and histological findings in growth plate and muscle tissue.

The Journal of clinical endocrinology and metabolism

Haeusler G,Freilinger M,Dominkus M,Egerbacher M,Amann G,Kolb A,Schlegel W,Raimann A,Staudenherz A

PA3-109 was used in immunohistochemistry to investigate a case of tumor-induced hypophosphatemic rickets

Fri Oct 01 00:00:00 EDT 2010

Bioinformatics

Protein Aliases: somatostatin receptor; somatostatin receptor 2a; somatostatin receptor subtype 2; Somatostatin receptor type 2; somatotropin release-inhibiting factor receptor; SRIF-1; SS-2-R; SS2-R; SS2R; SSR2; SSTR2A

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Gene Aliases: Smstr2; SSTR2

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UniProt ID: (Human) P30874, (Rat) P30680

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Entrez Gene ID: (Human) 6752, (Rat) 54305

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Function(s)

somatostatin receptor activity protein binding PDZ domain binding neuropeptide binding G-protein coupled receptor transmembrane signal receptor

Process(es)

regulation of muscle contraction G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway neuropeptide signaling pathway cell-cell signaling chemical synaptic transmission spermatogenesis response to nutrient digestion negative regulation of cell proliferation cerebellum development peristalsis forebrain development somatostatin signaling pathway response to starvation cellular response to glucocorticoid stimulus cellular response to estradiol stimulus G-protein coupled receptor signaling pathway

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SSTR2 Polyclonal Antibody

SSTR2 Antibody (PA3-109) in IHC

Product Details

PA3-109

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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