Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
FIGURE: 1 / 4
SSTR5 Antibody (MA5-35700) in IHC (P)
Immunohistochemistry analysis of SSTR5 in paraffin-embedded human lung cancer. Samples were incubated with SSTR5 Monoclonal antibody (Product # MA5-35700) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Product Details
MA5-35700
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
ARC1282
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SSTR5 (P35346)
Conjugate
Form
Liquid
Concentration
0.28 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2849600
Product Specific Information
Immunogen sequence: MEPLFPASTP SWNASSPGAA SGGGDNRTLV GPAPSAGARA VLVPVLYLLV CAAGLGGNTL VIYVVLRFAK MKTVTNIYIL NLAVADVLYM LGLPFLATQN
Target Information
Somatostatin is a multifunctional protein affecting exocrine and endocrine protein secretion, neurotransmission, and neuronal modulation and regulating cell proliferation. All these functions of Somatostatin are executed through a class of GPCR protein family members called somatostatin receptor. Till date, 6 classes of somatostatin receptors have been discovered out of which SSTR5, 364A.A protein, is a receptor subtype expressed predominantly in the pituitary and hypothalamus region of brain. Studies revealed that SSTR5 contains seven transmembrane regions and undergoes homodimerization and also heterodimerizes with SSTR1. Although the specific functions of SSTR5 are still elusive, the studies indicate that it complements SSTR2 regulation of ACTH secretion. Polymorphisms in SSTR5 gene have been observed in patients with acromegaly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: somatostatin receptor; Somatostatin receptor subtype 5; Somatostatin receptor type 5; SS-5-R; SS5-R; SS5R
Gene Aliases: Smstr5; Somato; SS-5-R; sst5; SSTR5
UniProt ID: (Human) P35346, (Mouse) O08858
Entrez Gene ID: (Human) 6755, (Rat) 25354, (Mouse) 20609
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
chemical synaptic transmission
negative regulation of cell proliferation
positive regulation of cytokinesis
somatostatin signaling pathway
glucose homeostasis
regulation of insulin secretion
cellular response to glucocorticoid stimulus
neuropeptide signaling pathway
cellular response to estradiol stimulus
signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support