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Product Details
13154-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ST3GAL6 Fusion Protein Ag3782 (25-331 aa encoded by BC023312)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: GTNVYWVAP VEMKRRNKIQ PCLSKPAFAS LLRFHQFHPF LCAADFRKIA SLYGSDKFDL PYGMRTSAEY FRLALSKLQS CDLFDEFDNI PCKKCVVVGN GGVLKNKTLG EKIDSYDVII RMNNGPVLGH EEEVGRRTTF RLFYPESVFS DPIHNDPNTT VILTAFKPHD LRWLLELLMG DKINTNGFWK KPALNLIYKP YQIRILDPFI IRTAAYELLH FPKVFPKNQK PKHPTTGIIA ITLAFYICHE VHLAGFKYNF SDLKSPLHYY GNATMSLMNK NAYHNVTAEQ LFLKDIIEKN LVINLTQD (25-331 aa encoded by BC023312 )
Target Information
Sialyltransferases catalyze the transfer of sialic acid from cytidine 5-prime monophospho-N-acetylneuraminic acid (CMP-NeuAc) to terminal positions of glycoprotein and glycolipid carbohydrate groups. Terminal NeuAc residues are key determinants of carbohydrate structures, such as the sialyl-Lewis X determinants, and are widely distributed in many cell types. However, cancer cells often express more heavily sialylated glycans on their cell surface and this feature sometimes correlates with invasiveness. In contrast, expression of ST3gal6, a member of the sialyltransferase family that sialylates type II lactosamine structures on glycoproteins and glycolipids, was found to be significantly decreased by hypermethylation of the gene in gastrointestinal cancer. At least three isoforms of ST3gal6 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alpha-2,3-sialyltransferase VI; alpha2,3-sialyltransferase ST3Gal VI; CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI; sia10; Sialyltransferase 10; sialyltransferase 10 (alpha-2,3-sialyltransferase VI); ST3Gal VI; ST3GalVI; Type 2 lactosamine alpha-2,3-sialyltransferase
Gene Aliases: 1700023B24Rik; AI930218; AW552396; SIAT10; ST3GAL6; ST3GALVI
UniProt ID: (Human) Q9Y274, (Mouse) Q8VIB3
Entrez Gene ID: (Human) 10402, (Rat) 304023, (Mouse) 54613
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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