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STAR Polyclonal Antibody

STAR Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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STAR Antibody (12225-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded mouse testis tissue slide using 12225-1-AP (STAR Antibody) at dilution of 1:200 (under 40x lens).

STAR Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

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Product Details

12225-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 24 publications 24 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:200

Immunocytochemistry (ICC/IF)

View 4 publications 4 publications

Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

STAR Fusion Protein Ag2862 (1-285 aa encoded by BC010550)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.34 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MLLATFKLC AGSSYRHMRN MKGLRQQAVM AISQELNRRA LGGPTPSTWI NQVRRRSSLL GSRLEETLYS DQELAYLQQG EEAMQKALGI LSNQEGWKKE SQQDNGDKVM SKVVPDVGKV FRLEVVVDQP MERLYEELVE RMEAMGEWNP NVKEIKVLQK IGKDTFITHE LAAEAAGNLV GPRDFVSVRC AKRRGSTCVL AGMATDFGNM PEQKGVIRAE HGPTCMVLHP LAGSPSKTKL TWLLSIDLKG WLPKSIINQV LSQTQVDFAN HLRKRLESHP ASEARC (1-285 aa encoded by B C010550)

Target Information

Steroidogenic acute regulatory protein (StAR) plays a significant role in cholesterol transport from the cytoplasmic outer membrane to the inner mitochondrial membrane. The 37 kDa precursor is cleaved to generate an active 28 kDa protein capable of facilitating cholesterol metabolism into pregnenolone. StAR is prevalently expressed in mitochondria of steroid-producing adrenal and gonadal tissue. Abnormalities in StAR gene expression are impacted in autosomal Lipoid Congenial Adrenal Hyperplasia (LCAH) resulting in defects in pregnenolone and cortisol synthesis. The mechanism of cholesterol binding to StAR has yet to be elucidated.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Prepubertal exposure to copper oxide nanoparticles induces Leydig cell injury with steroidogenesis disorders in mouse testes.

Biochemical and biophysical research communications

Zheng X,Chen J,Kang L,Wei Y,Wu Y,Hong Y,Wang X,Li D,Shen L,Long C,Wei G,Wu S

Sun Apr 30 00:00:00 EDT 2023

Clinical and functional analyses of the novel STAR c.558C>A in a patient with classic lipoid congenital adrenal hyperplasia.

Frontiers in genetics

Liu J,Dai HM,Guang GP,Hu WM,Jin P

Sat Feb 04 00:00:00 EST 2023

Casein Kinase 1α Regulates Testosterone Synthesis and Testis Development in Adult Mice.

Endocrinology

Guo H,Zhang D,Zhou Y,Sun L,Li C,Luo X,Liu J,Cui S

Mon Mar 13 00:00:00 EDT 2023

Exosomes derived from BMSCs ameliorate cyclophosphamide-induced testosterone deficiency by enhancing the autophagy of Leydig cells via the AMPK-mTOR signaling pathway.

Asian journal of andrology

Liang HY,Peng F,Pan MJ,Liao SL,Wei C,Wei GY,Xie X,Xue KY,Chen MK,Yang JK,Guo WB,Liu CD,Zhou QZ

Fri Jul 21 00:00:00 EDT 2023

Bisphenol S induces oxidative stress-mediated impairment of testosterone synthesis by inhibiting the Nrf2/HO-1 signaling pathway.

Journal of biochemical and molecular toxicology

Wang YX,Dai W,Li YZ,Wu ZY,Kan YQ,Zeng HC,He QZ

Wed Mar 01 00:00:00 EST 2023

HE4 overexpression in mice leads to leydig cell hyperplasia and spermatogensis impairment: Pathological implications for oligospermia.

Molecular and cellular endocrinology

Ling P,Tang L,Lin M,Bu C,Yin Y,Wang F,Chen D,Jiang SW

Thu Jun 01 00:00:00 EDT 2023

Expression Analysis of Lipocalin 2 (LCN2) in Reproductive and Non-Reproductive Tissues of Esr1-Deficient Mice.

International journal of molecular sciences

Kessel JC,Weiskirchen R,Schröder SK

Thu May 25 00:00:00 EDT 2023

Expression Analysis of Lipocalin 2 (LCN2) in Reproductive and Non-Reproductive Tissues of Esr1-Deficient Mice.

International journal of molecular sciences

Kessel JC,Weiskirchen R,Schröder SK

Thu May 25 00:00:00 EDT 2023

Mixed-Culture Propagation of Uterine-Tissue-Resident Macrophages and Their Expression Properties of Steroidogenic Molecules.

Biomedicines

Ogawa K,Tanida T

Wed Mar 22 00:00:00 EDT 2023

Lactoferrin Restores the Deoxynivalenol-Impaired Spermatogenesis and Blood-Testis Barrier Integrity via Improving the Antioxidant Capacity and Modifying the Cell Adhesion and Inflammatory Response.

Antioxidants (Basel, Switzerland)

Li Z,Zhao Y,Zong Q,Hu P,Bao W,Liu HY,Cai D

Mon Jan 09 00:00:00 EST 2023

A Short Promoter Region Containing Conserved Regulatory Motifs Is Required for Steroidogenic Acute Regulatory Protein (Star) Gene Expression in the Mouse Testis.

International journal of molecular sciences

Bouchard MF,Picard J,Tremblay JJ,Viger RS

Sun Oct 09 00:00:00 EDT 2022

A Short Promoter Region Containing Conserved Regulatory Motifs Is Required for Steroidogenic Acute Regulatory Protein (Star) Gene Expression in the Mouse Testis.

International journal of molecular sciences

Bouchard MF,Picard J,Tremblay JJ,Viger RS

Sun Oct 09 00:00:00 EDT 2022

Paternal cadmium exposure affects testosterone synthesis by reducing the testicular cholesterol pool in offspring mice.

Ecotoxicology and environmental safety

Zhou J,Zhang Y,Zeng L,Wang X,Mu H,Wang M,Pan H,Su P

Thu Sep 01 00:00:00 EDT 2022

Astragalus polysaccharide protects sepsis model rats after cecum ligation and puncture.

Frontiers in bioengineering and biotechnology

Li J,Zhao J,Chai Y,Li W,Liu X,Chen Y

Tue Nov 08 00:00:00 EST 2022

Progesterone Induces Apoptosis and Steroidogenesis in Porcine Placental Trophoblasts.

Animals : an open access journal from MDPI

Liu Y,Ding H,Yang Y,Liu Y,Cao X,Feng T

Sat Oct 08 00:00:00 EDT 2022

Chronic exposure to propylparaben at the humanly relevant dose triggers ovarian aging in adult mice.

Ecotoxicology and environmental safety

Yan W,Li M,Guo Q,Li X,Zhou S,Dai J,Zhang J,Wu M,Tang W,Wen J,Xue L,Jin Y,Luo A,Wang S

Fri Apr 15 00:00:00 EDT 2022

Transcriptomic analysis of MA-10 tumor Leydig cells treated with adipose derived hormones adiponectin and resistin.

Reproductive biology

Nguyen HT,Martin LJ

Tue Mar 01 00:00:00 EST 2022

Effects of Bushen Yiyuan recipe on testosterone synthesis in Leydig cells of rats with exercise-induced low serum testosterone levels.

Pharmaceutical biology

Wang Y,Peng X,Zhou Z,Tang C,Liu W

Thu Dec 01 00:00:00 EST 2022

Effects of 4-vinylcyclohexene diepoxide on the cell cycle, apoptosis, and steroid hormone secretion of goat ovarian granulosa cells.

In vitro cellular & developmental biology. Animal

Miao Y,Wan W,Zhu K,Pan M,Zhao X,Ma B,Wei Q

Tue Mar 01 00:00:00 EST 2022

Single-cell RNA-seq analysis of testicular somatic cell development in pigs.

Journal of genetics and genomics = Yi chuan xue bao

Zhang L,Guo M,Liu Z,Liu R,Zheng Y,Yu T,Lv Y,Lu H,Zeng W,Zhang T,Pan C

Tue Nov 01 00:00:00 EDT 2022

Isorhamnetin Promotes Estrogen Biosynthesis and Proliferation in Porcine Granulosa Cells via the PI3K/Akt Signaling Pathway.

Journal of agricultural and food chemistry

Li X,Chen H,Zhang Z,Xu D,Duan J,Li X,Yang L,Hua R,Cheng J,Li Q

Wed Jun 16 00:00:00 EDT 2021

Propylparaben concentrations in the urine of women and adverse effects on ovarian function in mice in vivo and ovarian cells in vitro.

Journal of applied toxicology : JAT

Jiao L,Li S,Zhai J,Wang D,Li H,Chu W,Geng X,Du Y

Mon Nov 01 00:00:00 EDT 2021

Cyclin-dependent kinase inhibitor 1B acts as a novel molecule to mediate testosterone synthesis and secretion in mouse Leydig cells by luteinizing hormone (LH) signaling pathway.

In vitro cellular & developmental biology. Animal

Guo H,Luo X,Sun L,Li J,Cui S

Sun Aug 01 00:00:00 EDT 2021

Effect of luteinizing hormone concentration on transcriptome and subcellular organelle phenotype of ovarian granulosa cells.

Journal of assisted reproduction and genetics

Wan YT,Liu S,Zhao SK,Luo YY,Lv YS,Qu DN,Liu MH,Li Y

Thu Apr 01 00:00:00 EDT 2021

Prenatal exposure to propylparaben at human-relevant doses accelerates ovarian aging in adult mice.

Environmental pollution (Barking, Essex : 1987)

Li M,Zhou S,Wu Y,Li Y,Yan W,Guo Q,Xi Y,Chen Y,Li Y,Wu M,Zhang J,Wei J,Wang S

Wed Sep 15 00:00:00 EDT 2021

Induction of autophagy by Beclin-1 in granulosa cells contributes to follicular progesterone elevation in ovarian endometriosis.

Translational research : the journal of laboratory and clinical medicine

Ding Y,Zhu Q,He Y,Lu Y,Wang Y,Qi J,Wu H,Xu R,Li J,Li X,Sun Y

Fri Jan 01 00:00:00 EST 2021

Single-cell transcriptomes reveal heterogeneity of high-grade serous ovarian carcinoma.

Clinical and translational medicine

Hao Q,Li J,Zhang Q,Xu F,Xie B,Lu H,Wu X,Zhou X

Sun Aug 01 00:00:00 EDT 2021

Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells.

Cell death & disease

Jing J,Ding N,Wang D,Ge X,Ma J,Ma R,Huang X,Jueraitetibaike K,Liang K,Wang S,Cao S,Zhao AZ,Yao B

Fri Aug 14 00:00:00 EDT 2020

La₂O₃ Nanoparticles Induce Reproductive Toxicity Mediated by the Nrf-2/ARE Signaling Pathway in Kunming Mice.

International journal of nanomedicine

Yuan L,Li Q,Bai D,Shang X,Hu F,Chen Z,An T,Chen Y,Zhang X

Thu Jul 23 00:00:00 EDT 2020

The ovarian estrogen synthesis function was impaired in Y123F mouse and partly restored by exogenous FSH supplement.

Reproductive biology and endocrinology : RB&E

Tu X,Liu M,Tang J,Zhang Y,Shi Y,Yu L,Sun Z

Fri May 04 00:00:00 EDT 2018

The ovarian estrogen synthesis function was impaired in Y123F mouse and partly restored by exogenous FSH supplement.

Reproductive biology and endocrinology : RB&E

Tu X,Liu M,Tang J,Zhang Y,Shi Y,Yu L,Sun Z

Fri May 04 00:00:00 EDT 2018

The ovarian estrogen synthesis function was impaired in Y123F mouse and partly restored by exogenous FSH supplement.

Reproductive biology and endocrinology : RB&E

Tu X,Liu M,Tang J,Zhang Y,Shi Y,Yu L,Sun Z

Fri May 04 00:00:00 EDT 2018

The ovarian estrogen synthesis function was impaired in Y123F mouse and partly restored by exogenous FSH supplement.

Reproductive biology and endocrinology : RB&E

Tu X,Liu M,Tang J,Zhang Y,Shi Y,Yu L,Sun Z

Fri May 04 00:00:00 EDT 2018

STMN1 Promotes Progesterone Production Via StAR Up-regulation in Mouse Granulosa Cells.

Scientific reports

Dou YD,Zhao H,Huang T,Zhao SG,Liu XM,Yu XC,Ma ZX,Zhang YC,Liu T,Gao X,Li L,Lu G,Chan WY,Gao F,Liu HB,Chen ZJ

Wed Jun 08 00:00:00 EDT 2016

STMN1 Promotes Progesterone Production Via StAR Up-regulation in Mouse Granulosa Cells.

Scientific reports

Dou YD,Zhao H,Huang T,Zhao SG,Liu XM,Yu XC,Ma ZX,Zhang YC,Liu T,Gao X,Li L,Lu G,Chan WY,Gao F,Liu HB,Chen ZJ

Wed Jun 08 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: cholesterol trafficker; lipid transporter; Luteinizing hormone-induced protein; mitochondrial steroid acute regulatory protein; StAR; StAR related lipid transfer (START) domain containing 1; StAR-related lipid transfer (START) domain containing 1; StARD1; START domain containing 1; START domain-containing protein 1; steroid acute regulatory protein; steroidogenic acute regulator; Steroidogenic acute regulatory protein, mitochondrial; testis secretory sperm-binding protein Li 241mP

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Gene Aliases: AV363654; D8Ertd419e; STAR; STARD1

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UniProt ID: (Human) P49675, (Mouse) P51557, (Rat) P97826

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Entrez Gene ID: (Human) 6770, (Pig) 396597, (Mouse) 20845, (Rat) 25557

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Function(s)

protein binding cholesterol binding cholesterol transporter activity intermembrane cholesterol transfer activity lipid binding

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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STAR Polyclonal Antibody

STAR Antibody (12225-1-AP) in IHC (P)

Product Details

12225-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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