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Invitrogen
STAT5 beta Polyclonal Antibody
Advanced Verification
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 16
STAT5 beta Antibody (71-2500) in IHC (P)
Immunohistochemistry analysis of STAT5B showing staining in the cytoplasm and nucleus of paraffin-embedded mouse spleen tissue (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at room te... View More
Product Details
71-2500
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide corresponding to the C-terminus of murine Stat5b coupled to protein carrier
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2533980
Target Information
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: mammary gland factor STAT5B; Signal transducer and activator of transcription 5a; Signal transducer and activator of transcription 5B; STA5B; STAT; transcription factor STAT5B
Gene Aliases: STAT5; STAT5B
UniProt ID: (Human) P51692, (Rat) P52632, (Mouse) Q541Q5
Entrez Gene ID: (Human) 6777, (Rat) 25126, (Mouse) 20851
RNA polymerase II core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein tyrosine kinase activity
signal transducer activity
protein binding
protein phosphatase binding
glucocorticoid receptor binding
protein dimerization activity
DNA binding
double-stranded DNA binding
sequence-specific DNA binding
DNA-binding transcription factor
allantoin metabolic process
luteinization
response to hypoxia
natural killer cell differentiation
liver development
citrate metabolic process
2-oxoglutarate metabolic process
succinate metabolic process
oxaloacetate metabolic process
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
isoleucine metabolic process
valine metabolic process
creatine metabolic process
fatty acid metabolic process
acute-phase response
JAK-STAT cascade
female pregnancy
lactation
peptidyl-tyrosine phosphorylation
regulation of steroid metabolic process
taurine metabolic process
lipid storage
regulation of epithelial cell differentiation
response to estradiol
response to lipopolysaccharide
positive regulation of natural killer cell proliferation
positive regulation of natural killer cell differentiation
cellular response to hormone stimulus
T cell differentiation in thymus
prolactin signaling pathway
regulation of multicellular organism growth
positive regulation of multicellular organism growth
positive regulation of activated T cell proliferation
progesterone metabolic process
T cell homeostasis
negative regulation of apoptotic process
positive regulation of interleukin-2 biosynthetic process
response to ethanol
positive regulation of B cell differentiation
positive regulation of gamma-delta T cell differentiation
negative regulation of erythrocyte differentiation
positive regulation of erythrocyte differentiation
positive regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
positive regulation of natural killer cell mediated cytotoxicity
creatinine metabolic process
development of secondary female sexual characteristics
development of secondary male sexual characteristics
Peyer's patch development
positive regulation of smooth muscle cell proliferation
positive regulation of inflammatory response
positive regulation of cellular component movement
JAK-STAT cascade involved in growth hormone signaling pathway
response to interleukin-2
response to interleukin-4
response to interleukin-15
cellular response to growth factor stimulus
cellular response to epidermal growth factor stimulus
mast cell migration
regulation of transcription, DNA-templated
signal transduction
sex differentiation
positive regulation of cell proliferation
cytokine-mediated signaling pathway
regulation of cell adhesion
response to peptide hormone
positive regulation of lymphocyte differentiation
transcription, DNA-templated
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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