Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
STAT6 Polyclonal Antibody
Advanced Verification
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 1
STAT6 Antibody (PA5-81977)
Relative expression in western blot: Antibody specificity was demonstrated by detection of known differential basal expression of the target across tissue/cell models. Expression of STAT6 was observed specifically in A-549 cells and in U-251MG cells using anti-STAT6 Polyclonal Antibody (Product #PA5-81977) in western blot. The relative expression levels of STAT6 within each cell line is shown using RNA-Seq.... View More
Product Details
PA5-81977
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human STAT6. Recombinant protein control fragment (Product #RP-94781).
Conjugate
Form
Liquid
Concentration
0.15 mg/mL
Purification
Anitgen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2789138
Product Specific Information
Immunogen sequence: VYPPHSHSIP PYQGLSPEES VNVLSAFQEP HLQMPPSLGQ MSLPFDQPHP QGLLPCQPQE HAVSSPDPLL CSDVTMVEDS CLSQPVTAFP QGTWIGEDIF PPLLPPTEQD LTKLLLEGQG ESGGGSLGAQ PLLQPSHYGQ SGISMSHMDL R
Target Information
STAT6 protein is a transcription factor activated by cytokines, particularly interleukin-4 and IL13. (Stat6-/-) were found to be deficient in IL-4-mediated functions including Th2 helper T-cell differentiation, expression of cell surface markers, T-cell proliferation, immunoglobulin class switching to IgE, and partial loss of IL-4 mediated proliferation. STAT6 mRNA has been detected in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung and placenta. STAT6 is critically involved in Th2 immune response. STAT6 is crucial for IL-4-mediated biological responses, and naturally in two isoforms: STAT6a and STAT6c.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: 12S1644; IL-4 Stat; IL4 STAT; Signal transducer and activator of transcription 6; signal transducer and activator of transcription 6, interleukin-4 induced; STAT; STAT, interleukin4-induced; STAT-6; transcription factor IL-4 STAT
Gene Aliases: D12S1644; IL-4-STAT; STAT6; STAT6B; STAT6C
UniProt ID: (Human) P42226
Entrez Gene ID: (Human) 6778
negative regulation of transcription from RNA polymerase II promoter
T-helper 1 cell lineage commitment
negative regulation of type 2 immune response
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
signal transduction
positive regulation of type I interferon production
mammary gland epithelial cell proliferation
interleukin-4-mediated signaling pathway
regulation of cell proliferation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of isotype switching to IgE isotypes
mammary gland morphogenesis
cellular response to hydrogen peroxide
cellular response to reactive nitrogen species
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support