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Product Details
PA5-63999
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human STOML2. Recombinant protein control fragment (Product #RP-103428).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2648030
Product Specific Information
Immunogen sequence: RESLNASIVD AINQAADCWG IRCLRYEIKD IHVPPRVKES MQMQVEAERR KRATVLESEG TRESAINVAE G
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.
Target Information
Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EPB72-like 2; EPB72-like protein 2; Paraprotein target 7; Paratarg-7; SLP-2; stomatin (EPB72)-like 2; stomatin-like 2; Stomatin-like protein 2, mitochondrial
Gene Aliases: HSPC108; SLP-2; SLP2; STOML2
UniProt ID: (Human) Q9UJZ1
Entrez Gene ID: (Human) 30968
mitochondrial calcium ion transport
cellular calcium ion homeostasis
mitochondrion organization
lipid localization
positive regulation of mitochondrial membrane potential
interleukin-2 production
mitochondrial protein processing
CD4-positive, alpha-beta T cell activation
mitochondrial ATP synthesis coupled proton transport
T cell receptor signaling pathway
protein oligomerization
positive regulation of mitochondrial DNA replication
positive regulation of cardiolipin metabolic process
stress-induced mitochondrial fusion
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