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Invitrogen
SUV39H1 Recombinant Rabbit Monoclonal Antibody (3H60L17)
Advanced Verification
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 6
SUV39H1 Antibody (702443) in ICC/IF
Localization of endogenous SUV39H1 with heterochromatin was observed by immunofluorescence microscopy using Anti- SUV39H1 Recombinant Rabbit Monoclonal Antibody. NIH3T3 mouse fibroblast cells were stained with Anti- SUV39H1 Recombinant Rabbit Monoclonal Antibody (Product # 702443, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows detection and localization of SUV39H1 protein in the cell nucleus (green), Panel b) is stained for ... View More
Product Details
702443
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Cynomolgus monkey,
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
3H60L17
Immunogen
Protein corresponding to human SUV39H1 (aa65-aa214)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2688312
Product Specific Information
This antibody is predicted to react with Monkey, Bovine, Sheep
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: H3-K9-HMTase 1; Histone H3-K9 methyltransferase 1; Histone-lysine N-methyltransferase SUV39H1; histone-lysine N-methyltransferase, H3 lysine-9 specific 1; Lysine N-methyltransferase 1A; Position-effect variegation 3-9 homolog; Su(var)3-9 homolog 1; Suppressor of variegation 3-9 homolog 1; Suv39h histone methyltransferase
Gene Aliases: AI852103; AL022883; DXHXS7466e; H3-K9-HMTase 1; KMT1A; MG44; mIS6; SUV39H; SUV39H1
UniProt ID: (Human) Q53G60, (Mouse) O54864
Entrez Gene ID: (Cynomolgus monkey) 102134179, (Human) 6839, (Mouse) 20937
transcription regulatory region sequence-specific DNA binding
chromatin binding
protein binding
zinc ion binding
S-adenosylmethionine-dependent methyltransferase activity
histone-lysine N-methyltransferase activity
histone methyltransferase activity
histone methyltransferase activity (H3-K9 specific)
protein N-terminus binding
RNA polymerase II regulatory region sequence-specific DNA binding
methyltransferase activity
protein methyltransferase activity
transferase activity
metal ion binding
chromatin/chromatin-binding, or -regulatory protein
histone modifying enzyme
negative regulation of transcription from RNA polymerase II promoter
chromatin silencing at rDNA
chromatin organization
transcription, DNA-templated
rRNA processing
cellular response to DNA damage stimulus
cell cycle
viral process
cell differentiation
histone H3-K9 dimethylation
histone H3-K9 trimethylation
negative regulation of circadian rhythm
negative regulation of transcription, DNA-templated
rhythmic process
cellular response to hypoxia
DNA packaging
chromatin silencing
regulation of transcription, DNA-templated
protein methylation
chromatin modification
methylation
histone lysine methylation
histone H3-K9 methylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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