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Nordic
Saccharomyces 6-Phosphogluconic dehydrogenase Polyclonal Antibody
Product Details
NE128-PAB
Product Specifications
Species Reactivity
Yeast
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Saccharomyces 6-Phosphogluconic dehydrogenase
Conjugate
Form
Lyophilized
Concentration
2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 0.5% dextran
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstituted by adding 0.5 mL sterile distilled water, spun down to remove insoluble particles, divided into small aliquots, frozen and stored at or below -20°C.
Cross-reactivities against enzymes of other sources may occur but have not been determined.
Prior to use, an aliquot is thawed slowly at ambient temperature, spun down again and used to prepare working dilutions by adding sterile phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. Working dilutions should be stored at 4°C, not refrozen, and preferably used t he same day. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance of the product.
Target Information
6-Phosphogluconic acid, also known as 6-phospho-D-gluconate or gluconate 6-phosphate, belongs to the class of organic compounds known as monosaccharide phosphates. These are monosaccharides comprising a phosphated group linked to the carbohydrate unit. 6-Phosphogluconic acid is soluble (in water) and a moderately acidic compound (based on its pKa). 6-Phosphogluconic acid has been found in human adipose tissue, epidermis and prostate tissues, and has also been detected in multiple biofluids, such as saliva and blood. Within the cell, 6-phosphogluconic acid is primarily located in the endoplasmic reticulum. 6-Phosphogluconic acid exists in all eukaryotes, ranging from yeast to humans. 6-Phosphogluconic acid participates in a number of enzymatic reactions. In particular, 6-Phosphogluconic acid can be biosynthesized from gluconolactone and water through the action of the enzyme 6-phosphogluconolactonase. In addition, 6-Phosphogluconic acid can be converted into D-ribulose 5-phosphate; which is catalyzed by the enzyme putative uncharacterized protein PGD. In humans, 6-phosphogluconic acid is involved in the pentose phosphate pathway. 6-Phosphogluconic acid is also involved in several metabolic disorders, some of which include glucose-6-phosphate dehydrogenase deficiency, ribose-5-phosphate isomerase deficiency, transaldolase deficiency, and cancer (via the Warburg effect). Outside of the human body, 6-phosphogluconic acid can be found in a number of food items such as white lupine, american pokeweed, peach, and star anise. This makes 6-phosphogluconic acid a potential biomarker for the consumption of these food products.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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