Product References
Association of PTTG1 expression with invasiveness of non-functioning pituitary adenomas.
Journal of pathology and translational medicine
Kum SJ,Lee HW,Kim SG,Park H,Hwang I,Kim SP
34-1500 was used in Immunohistochemistry to evaluate the usefulness of PTTG1, PITX2, and galectin-3 as predictive biomarkers for invasive non-functioning pituitary adenomas (NFPAs) by determining the relationship between the expressions of these three proteins and the invasiveness of the NFPAs and investigate whether PTTG1, E-cadherin, and Ki-67, which are known to be related to each other, show a correlation with NFPA features.
Sat Jan 01 00:00:00 EST 2022
Protein stabilization by RSUME accounts for PTTG pituitary tumor abundance and oncogenicity.
Endocrine-related cancer
Fuertes M,Sapochnik M,Tedesco L,Senin S,Attorresi A,Ajler P,Carrizo G,Cervio A,Sevlever G,Bonfiglio JJ,Stalla GK,Arzt E
34-1500 was used in Western Blotting to show that PTTG high protein steady state levels account for PTTG tumor abundance and demonstrate a critical role of RSUME in this process in pituitary tumor cells.
Fri Jun 01 00:00:00 EDT 2018
mTOR promotes pituitary tumor development through activation of PTTG1.
Oncogene
Chen R,Duan J,Li L,Ma Q,Sun Q,Ma J,Li C,Zhou X,Chen H,Jing Y,Zhao S,Wu X,Zhang H
341500 was used in immunohistochemistry and western blot to show that pituitary tumor transforming gene 1 expression is upregulated in an mammalian/mechanistic target of rapamycin complex 1-dependent manner
Thu Feb 16 00:00:00 EST 2017
Apratoxin A Shows Novel Pancreas-Targeting Activity through the Binding of Sec 61.
Molecular cancer therapeutics
Huang KC,Chen Z,Jiang Y,Akare S,Kolber-Simonds D,Condon K,Agoulnik S,Tendyke K,Shen Y,Wu KM,Mathieu S,Choi HW,Zhu X,Shimizu H,Kotake Y,Gerwick WH,Uenaka T,Woodall-Jappe M,Nomoto K
34-1500 was used in immunoprecipitation to characterize novel pancreas-targeting activity through the binding of Sec 61 by Apratoxin A
Wed Jun 01 00:00:00 EDT 2016
Inhibition of PTTG1 expression by microRNA suppresses proliferation and induces apoptosis of malignant glioma cells.
Oncology letters
Su X,Chen J,Ni L,Shi W,Shi J,Liu X,Zhang Y,Gong P,Zhu H,Huang Q
34-1500 was used in Western Blotting to investigate the role of pituitary tumour-transforming gene 1 in the proliferation, invasion and apoptosis of human malignant glioma U251 cells.
Tue Nov 01 00:00:00 EDT 2016
Inhibition of PTTG1 expression by microRNA suppresses proliferation and induces apoptosis of malignant glioma cells.
Oncology letters
Su X,Chen J,Ni L,Shi W,Shi J,Liu X,Zhang Y,Gong P,Zhu H,Huang Q
34-1500 was used in Western Blotting to investigate the role of pituitary tumour-transforming gene 1 in the proliferation, invasion and apoptosis of human malignant glioma U251 cells.
Tue Nov 01 00:00:00 EDT 2016
Inhibition of PTTG1 expression by microRNA suppresses proliferation and induces apoptosis of malignant glioma cells.
Oncology letters
Su X,Chen J,Ni L,Shi W,Shi J,Liu X,Zhang Y,Gong P,Zhu H,Huang Q
34-1500 was used in Western Blotting to investigate the role of pituitary tumour-transforming gene 1 in the proliferation, invasion and apoptosis of human malignant glioma U251 cells.
Tue Nov 01 00:00:00 EDT 2016
Nek2A destruction marks APC/C activation at the prophase-to-prometaphase transition by spindle-checkpoint-restricted Cdc20.
Journal of cell science
Boekhout M,Wolthuis R
34-1500 was used in western blot to explore how Nek2 isoform A affects anaphase-promoting complex/cyclosome containing Cdc20.
Wed Apr 15 00:00:00 EDT 2015
MASTL promotes cyclin B1 destruction by enforcing Cdc20-independent binding of cyclin B1 to the APC/C.
Biology open
Voets E,Wolthuis R
Published figure using Securin polyclonal antibody (Product # 34-1500) in Western Blot
Fri Mar 06 00:00:00 EST 2015
LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C.
PloS one
Masuda K,Chiyoda T,Sugiyama N,Segura-Cabrera A,Kabe Y,Ueki A,Banno K,Suematsu M,Aoki D,Ishihama Y,Saya H,Kuninaka S
34-1500 was used in western blot to study CDC26 phosphorylation and its effect on the tetratricopeptide repeat subcomplex of APC/C
Mon Jan 18 00:00:00 EST 2016
The role of lipolysis stimulated lipoprotein receptor in breast cancer and directing breast cancer cell behavior.
PloS one
Reaves DK,Fagan-Solis KD,Dunphy K,Oliver SD,Scott DW,Fleming JM
34-1500 was used in western blot to investigate the role of lipolysis stimulated lipoprotein receptor in aggressive breast cancer behavior
Tue Jan 13 00:00:00 EST 2015
Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules.
Proceedings of the National Academy of Sciences of the United States of America
Wu JM,Chen CT,Coumar MS,Lin WH,Chen ZJ,Hsu JT,Peng YH,Shiao HY,Lin WH,Chu CY,Wu JS,Lin CT,Chen CP,Hsueh CC,Chang KY,Kao LP,Huang CY,Chao YS,Wu SY,Hsieh HP,Chi YH
34-1500 was used in western blot to identify and test Aurora kinases inhibitors for anti-tumor activity.
Tue May 07 00:00:00 EDT 2013
Human pituitary tumor-transforming gene 1 overexpression reinforces oncogene-induced senescence through CXCR2/p21 signaling in breast cancer cells.
Breast cancer research : BCR
Ruan JW,Liao YC,Lua I,Li MH,Hsu CY,Chen JH
34-1500 was used in immunohistochemistry and western blot to examine the role of hPTTG in breast cancer development.
Thu Jul 12 00:00:00 EDT 2012
Human pituitary tumor-transforming gene 1 overexpression reinforces oncogene-induced senescence through CXCR2/p21 signaling in breast cancer cells.
Breast cancer research : BCR
Ruan JW,Liao YC,Lua I,Li MH,Hsu CY,Chen JH
34-1500 was used in immunohistochemistry and western blot to examine the role of hPTTG in breast cancer development.
Thu Jul 12 00:00:00 EDT 2012
PTTG1 oncogene promotes tumor malignancy via epithelial to mesenchymal transition and expansion of cancer stem cell population.
The Journal of biological chemistry
Yoon CH,Kim MJ,Lee H,Kim RK,Lim EJ,Yoo KC,Lee GH,Cui YH,Oh YS,Gye MC,Lee YY,Park IC,An S,Hwang SG,Park MJ,Suh Y,Lee SJ
Published figure using Securin polyclonal antibody (Product # 34-1500) in Immunocytochemistry
Fri Jun 01 00:00:00 EDT 2012
PTTG1 oncogene promotes tumor malignancy via epithelial to mesenchymal transition and expansion of cancer stem cell population.
The Journal of biological chemistry
Yoon CH,Kim MJ,Lee H,Kim RK,Lim EJ,Yoo KC,Lee GH,Cui YH,Oh YS,Gye MC,Lee YY,Park IC,An S,Hwang SG,Park MJ,Suh Y,Lee SJ
Published figure using Securin polyclonal antibody (Product # 34-1500) in Immunocytochemistry
Fri Jun 01 00:00:00 EDT 2012
PTTG1 oncogene promotes tumor malignancy via epithelial to mesenchymal transition and expansion of cancer stem cell population.
The Journal of biological chemistry
Yoon CH,Kim MJ,Lee H,Kim RK,Lim EJ,Yoo KC,Lee GH,Cui YH,Oh YS,Gye MC,Lee YY,Park IC,An S,Hwang SG,Park MJ,Suh Y,Lee SJ
Published figure using Securin polyclonal antibody (Product # 34-1500) in Immunocytochemistry
Fri Jun 01 00:00:00 EDT 2012
PTTG1 oncogene promotes tumor malignancy via epithelial to mesenchymal transition and expansion of cancer stem cell population.
The Journal of biological chemistry
Yoon CH,Kim MJ,Lee H,Kim RK,Lim EJ,Yoo KC,Lee GH,Cui YH,Oh YS,Gye MC,Lee YY,Park IC,An S,Hwang SG,Park MJ,Suh Y,Lee SJ
Published figure using Securin polyclonal antibody (Product # 34-1500) in Immunocytochemistry
Fri Jun 01 00:00:00 EDT 2012
PTTG1 oncogene promotes tumor malignancy via epithelial to mesenchymal transition and expansion of cancer stem cell population.
The Journal of biological chemistry
Yoon CH,Kim MJ,Lee H,Kim RK,Lim EJ,Yoo KC,Lee GH,Cui YH,Oh YS,Gye MC,Lee YY,Park IC,An S,Hwang SG,Park MJ,Suh Y,Lee SJ
Published figure using Securin polyclonal antibody (Product # 34-1500) in Immunocytochemistry
Fri Jun 01 00:00:00 EDT 2012
PTTG1 oncogene promotes tumor malignancy via epithelial to mesenchymal transition and expansion of cancer stem cell population.
The Journal of biological chemistry
Yoon CH,Kim MJ,Lee H,Kim RK,Lim EJ,Yoo KC,Lee GH,Cui YH,Oh YS,Gye MC,Lee YY,Park IC,An S,Hwang SG,Park MJ,Suh Y,Lee SJ
Published figure using Securin polyclonal antibody (Product # 34-1500) in Immunocytochemistry
Fri Jun 01 00:00:00 EDT 2012
PTTG1 oncogene promotes tumor malignancy via epithelial to mesenchymal transition and expansion of cancer stem cell population.
The Journal of biological chemistry
Yoon CH,Kim MJ,Lee H,Kim RK,Lim EJ,Yoo KC,Lee GH,Cui YH,Oh YS,Gye MC,Lee YY,Park IC,An S,Hwang SG,Park MJ,Suh Y,Lee SJ
Published figure using Securin polyclonal antibody (Product # 34-1500) in Immunocytochemistry
Fri Jun 01 00:00:00 EDT 2012
The C-terminus of PARK2 is required for its self-interaction, solubility and role in the spindle assembly checkpoint.
Biochimica et biophysica acta
Chen Y,Fang ST,Yeh PC,Yang HH,Chen SY,Chang CJ,Zhai WJ,Chen YC,Juang YL
34-1500 was used in western blot to study PARK2 expression and localization during the cell cycle
Sun Apr 01 00:00:00 EDT 2012
Securin and separase modulate membrane traffic by affecting endosomal acidification.
Traffic (Copenhagen, Denmark)
Bacac M,Fusco C,Planche A,Santodomingo J,Demaurex N,Leemann-Zakaryan R,Provero P,Stamenkovic I
34-1500 was used in immunocytochemistry and western blot to study the contribution of securin and separase in membrane traffic and protein secretion.
Sun May 01 00:00:00 EDT 2011
Securin and separase modulate membrane traffic by affecting endosomal acidification.
Traffic (Copenhagen, Denmark)
Bacac M,Fusco C,Planche A,Santodomingo J,Demaurex N,Leemann-Zakaryan R,Provero P,Stamenkovic I
34-1500 was used in immunocytochemistry and western blot to study the contribution of securin and separase in membrane traffic and protein secretion.
Sun May 01 00:00:00 EDT 2011
Thyroid hormone receptors are tumor suppressors in a mouse model of metastatic follicular thyroid carcinoma.
Oncogene
Zhu XG,Zhao L,Willingham MC,Cheng SY
34-1500 was used in Western Blotting to identify that thyroid hormone receptors could function as tumour suppressors in a mouse model of metastatic follicular thyroid cancer.
Thu Apr 01 00:00:00 EDT 2010
Substrate degradation by the anaphase promoting complex occurs during mitotic slippage.
Cell cycle (Georgetown, Tex.)
Lee J,Kim JA,Margolis RL,Fotedar R
Published figure using Securin polyclonal antibody (Product # 34-1500) in Western Blot
Sat May 01 00:00:00 EDT 2010
Tumor suppressor activity of KLF6 mediated by downregulation of the PTTG1 oncogene.
FEBS letters
Lee UE,Ghiassi-Nejad Z,Paris AJ,Yea S,Narla G,Walsh M,Friedman SL
Published figure using Securin polyclonal antibody (Product # 34-1500) in ChIP assay
Fri Mar 05 00:00:00 EST 2010
Tumor suppressor activity of KLF6 mediated by downregulation of the PTTG1 oncogene.
FEBS letters
Lee UE,Ghiassi-Nejad Z,Paris AJ,Yea S,Narla G,Walsh M,Friedman SL
Published figure using Securin polyclonal antibody (Product # 34-1500) in ChIP assay
Fri Mar 05 00:00:00 EST 2010
DNA damage triggers p21WAF1-dependent Emi1 down-regulation that maintains G2 arrest.
Molecular biology of the cell
Lee J,Kim JA,Barbier V,Fotedar A,Fotedar R
34-1500 was used in western blot to assess the role of p21(WAF1) in G2-M phase checkpoint control and in prevention of polyploidy after DNA damage
Wed Apr 01 00:00:00 EDT 2009
S100A1 deficiency results in prolonged ventricular repolarization in response to sympathetic activation.
General physiology and biophysics
Ackermann GE,Domenighetti AA,Deten A,Bonath I,Marenholz I,Pedrazzini T,Erne P,Heizmann CW
34-1500 was used in western blot to use knockout mice to study the contribution of S100A1 in various heart functions.
Sun Jun 01 00:00:00 EDT 2008
Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone beta receptor inhibits mitotic progression.
The Journal of clinical investigation
Ying H,Furuya F,Zhao L,Araki O,West BL,Hanover JA,Willingham MC,Cheng SY
Published figure using Securin polyclonal antibody (Product # 34-1500) in Western Blot
Wed Nov 01 00:00:00 EST 2006
Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone beta receptor inhibits mitotic progression.
The Journal of clinical investigation
Ying H,Furuya F,Zhao L,Araki O,West BL,Hanover JA,Willingham MC,Cheng SY
Published figure using Securin polyclonal antibody (Product # 34-1500) in Western Blot
Wed Nov 01 00:00:00 EST 2006
Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone beta receptor inhibits mitotic progression.
The Journal of clinical investigation
Ying H,Furuya F,Zhao L,Araki O,West BL,Hanover JA,Willingham MC,Cheng SY
Published figure using Securin polyclonal antibody (Product # 34-1500) in Western Blot
Wed Nov 01 00:00:00 EST 2006
Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone beta receptor inhibits mitotic progression.
The Journal of clinical investigation
Ying H,Furuya F,Zhao L,Araki O,West BL,Hanover JA,Willingham MC,Cheng SY
Published figure using Securin polyclonal antibody (Product # 34-1500) in Western Blot
Wed Nov 01 00:00:00 EST 2006
p53-regulated transcriptional program associated with genotoxic stress-induced apoptosis.
The Journal of biological chemistry
Kho PS,Wang Z,Zhuang L,Li Y,Chew JL,Ng HH,Liu ET,Yu Q
Fri May 14 00:00:00 EDT 2004
Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells.
Endocrinology
Yu R,Lu W,Chen J,McCabe CJ,Melmed S
Sat Nov 01 00:00:00 EST 2003
DNA damage-induced inhibition of securin expression is mediated by p53.
The Journal of biological chemistry
Zhou Y,Mehta KR,Choi AP,Scolavino S,Zhang X
34-1500 was used in Western Blotting to demonstrate that securin is a p53 target gene, and may play a role in the p53-mediated cellular response to DNA damage.
Fri Jan 03 00:00:00 EST 2003
DNA damage-induced inhibition of securin expression is mediated by p53.
The Journal of biological chemistry
Zhou Y,Mehta KR,Choi AP,Scolavino S,Zhang X
34-1500 was used in Western Blotting to demonstrate that securin is a p53 target gene, and may play a role in the p53-mediated cellular response to DNA damage.
Fri Jan 03 00:00:00 EST 2003
