Proteintech

Sestrin 2 Polyclonal Antibody

Sestrin 2 Antibody in Immunocytochemistry (ICC/IF)

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Sestrin 2 Antibody (10795-1-AP) in ICC/IF

Immunofluorescent analysis of Hela cells, using SESN2 antibody 10795-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

Sestrin 2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Sestrin 2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10795-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 165 publications 165 publications

Immunohistochemistry (IHC)

View 14 publications 14 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:800

Immunocytochemistry (ICC/IF)

1:10-1:100

View 21 publications 21 publications

Flow Cytometry (Flow)

Assay-dependent

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 13 publications 13 publications

Miscellaneous PubMed (Misc)

View 3 publications 3 publications

Not applicable (N/A)

View 8 publications 8 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Sestrin 2 Fusion Protein Ag1247 (132-480 aa encoded by BC013304)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.48 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: HMAEFLQTG GDPEWLLGLH RAPEKLRKLS EINKLLAHRP WLITKEHIQA LLKTGEHTWS LAELIQALVL LTHCHSLSSF VFGCGILPEG DADGSPAPQA PTPPSEQSSP PSRDPLNNSG GFESARDVEA LMERMQQLQE SLLRDEGTSQ EEMESRFELE KSESLLVTPS ADILEPSPHP DMLCFVEDPT FGYEDFTRRG AQAPPTFRAQ DYTWEDHGYS LIQRLYPEGG QLLDEKFQAA YSLTYNTIAM HSGVDTSVLR RAIWNYIHCV FGIRYDDYDY GEVNQLLERN LKVYIKTVAC YPEKTTRRMY NLFWRHFRHS EKVHVNLLLL EARMQAALLY ALRAITRYMT (132-480 aa encoded by BC013304)

Target Information

This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Activation of Sestrin2 accelerates deep second-degree burn wound healing through PI3K/AKT pathway.

Archives of biochemistry and biophysics

Wang K,Shen K,Han F,Bai X,Fang Z,Jia Y,Zhang J,Li Y,Cai W,Wang X,Luo L,Guo K,Wang H,Yang X,Wang H,Hu D

Sat Jul 15 00:00:00 EDT 2023

Activation of Sestrin2 accelerates deep second-degree burn wound healing through PI3K/AKT pathway.

Archives of biochemistry and biophysics

Wang K,Shen K,Han F,Bai X,Fang Z,Jia Y,Zhang J,Li Y,Cai W,Wang X,Luo L,Guo K,Wang H,Yang X,Wang H,Hu D

Sat Jul 15 00:00:00 EDT 2023

Activation of Sestrin2 accelerates deep second-degree burn wound healing through PI3K/AKT pathway.

Archives of biochemistry and biophysics

Wang K,Shen K,Han F,Bai X,Fang Z,Jia Y,Zhang J,Li Y,Cai W,Wang X,Luo L,Guo K,Wang H,Yang X,Wang H,Hu D

Sat Jul 15 00:00:00 EDT 2023

Activation of Sestrin2 accelerates deep second-degree burn wound healing through PI3K/AKT pathway.

Archives of biochemistry and biophysics

Wang K,Shen K,Han F,Bai X,Fang Z,Jia Y,Zhang J,Li Y,Cai W,Wang X,Luo L,Guo K,Wang H,Yang X,Wang H,Hu D

Sat Jul 15 00:00:00 EDT 2023

Activation of Sestrin2 accelerates deep second-degree burn wound healing through PI3K/AKT pathway.

Archives of biochemistry and biophysics

Wang K,Shen K,Han F,Bai X,Fang Z,Jia Y,Zhang J,Li Y,Cai W,Wang X,Luo L,Guo K,Wang H,Yang X,Wang H,Hu D

Sat Jul 15 00:00:00 EDT 2023

Activation of Sestrin2 accelerates deep second-degree burn wound healing through PI3K/AKT pathway.

Archives of biochemistry and biophysics

Wang K,Shen K,Han F,Bai X,Fang Z,Jia Y,Zhang J,Li Y,Cai W,Wang X,Luo L,Guo K,Wang H,Yang X,Wang H,Hu D

Sat Jul 15 00:00:00 EDT 2023

Sestrin2 Mediates Metformin Rescued the Age-Related Cardiac Dysfunctions of Cardiorenal Syndrome Type 3.

Cells

Iglesias M,Wang H,Krause-Hauch M,Ren D,Zoungrana LI,Li Z,Zhang J,Wei J,Yadav N,Patel K,Fatmi MK,Liu R,Lesnefsky EJ,Li J

Wed Mar 08 00:00:00 EST 2023

Sesn2 Serves as a Regulator between Mitochondrial Unfolded Protein Response and Mitophagy in Intervertebral Disc Degeneration.

International journal of biological sciences

Xu WN,Liu C,Zheng HL,Xu HX,Yang RZ,Jiang SD,Zhu LX

Thu Feb 09 00:00:00 EST 2023

Sesn2 Serves as a Regulator between Mitochondrial Unfolded Protein Response and Mitophagy in Intervertebral Disc Degeneration.

International journal of biological sciences

Xu WN,Liu C,Zheng HL,Xu HX,Yang RZ,Jiang SD,Zhu LX

Thu Feb 09 00:00:00 EST 2023

Sesn2 Serves as a Regulator between Mitochondrial Unfolded Protein Response and Mitophagy in Intervertebral Disc Degeneration.

International journal of biological sciences

Xu WN,Liu C,Zheng HL,Xu HX,Yang RZ,Jiang SD,Zhu LX

Thu Feb 09 00:00:00 EST 2023

Sesn2 Serves as a Regulator between Mitochondrial Unfolded Protein Response and Mitophagy in Intervertebral Disc Degeneration.

International journal of biological sciences

Xu WN,Liu C,Zheng HL,Xu HX,Yang RZ,Jiang SD,Zhu LX

Thu Feb 09 00:00:00 EST 2023

NRF3 activates mTORC1 arginine-dependently for cancer cell viability.

iScience

Hirose S,Waku T,Tani M,Masuda H,Endo K,Ashitani S,Aketa I,Kitano H,Nakada S,Wada A,Hatanaka A,Osawa T,Soga T,Kobayashi A

Fri Feb 17 00:00:00 EST 2023

Ring domains are essential for GATOR2-dependent mTORC1 activation.

Molecular cell

Jiang C,Dai X,He S,Zhou H,Fang L,Guo J,Liu S,Zhang T,Pan W,Yu H,Fu T,Li D,Inuzuka H,Wang P,Xiao J,Wei W

Thu Jan 05 00:00:00 EST 2023

Farnesoid X Receptor (FXR) Regulates mTORC1 Signaling and Autophagy by Inhibiting SESN2 Expression.

Molecular nutrition & food research

Wang G,Chen L,Qin S,Geng H,Xia C,Zheng Y,Lei X,Zhang J,Wu S,Yao J,Deng L

Wed Mar 01 00:00:00 EST 2023

CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth.

Cell reports

Yin S,Liu L,Ball LE,Wang Y,Bedford MT,Duncan SA,Wang H,Gan W

Tue Apr 25 00:00:00 EDT 2023

Sestrin2 prevents neonatal incision pain and re-incision enhanced hyperalgesia in adult rats.

Brain research

Shi X,Wang C,Zhao T,Gu M,Yang J,Sun N,Huang Y,Yao Y,Yu L,Yan M

Sat Apr 15 00:00:00 EDT 2023

Sestrin2 prevents neonatal incision pain and re-incision enhanced hyperalgesia in adult rats.

Brain research

Shi X,Wang C,Zhao T,Gu M,Yang J,Sun N,Huang Y,Yao Y,Yu L,Yan M

Sat Apr 15 00:00:00 EDT 2023

A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy.

EMBO molecular medicine

Southwell N,Primiano G,Nadkarni V,Attarwala N,Beattie E,Miller D,Alam S,Liparulo I,Shurubor YI,Valentino ML,Carelli V,Servidei S,Gross SS,Manfredi G,Chen Q,D'Aurelio M

Mon Jul 10 00:00:00 EDT 2023

Sirtuin 6 is required for the integrated stress response and resistance to inhibition of transcriptional cyclin-dependent kinases.

Science translational medicine

Kartha N,Gianopulos JE,Schrank Z,Cavender SM,Dobersch S,Kynnap BD,Wallace-Povirk A,Wladyka CL,Santana JF,Kim JC,Yu A,Bridgwater CM,Fuchs K,Dysinger S,Lampano AE,Notta F,Price DH,Hsieh AC,Hingorani SR,Kugel S

Wed May 03 00:00:00 EDT 2023

SESN2-Mediated AKT/GSK-3β/NRF2 Activation to Ameliorate Adriamycin Cardiotoxicity in High-Fat Diet-Induced Obese Mice.

Antioxidants & redox signaling

Gao T,Wang B J,Xiao M,Wang A J,Wang S,Tang Y,Zhang J,Lu G,Guo H,Guo Y,Liu Q,Li J,Gu J

Thu Aug 03 00:00:00 EDT 2023

Effects of Leucine Ingestion and Contraction on the Sestrin/GATOR2 Pathway and mTORC1 Activation in Rat Fast-Twitch muscle.

The Journal of nutrition

Kanzaki K,Wada M

Tue Aug 01 00:00:00 EDT 2023

Effects of Leucine Ingestion and Contraction on the Sestrin/GATOR2 Pathway and mTORC1 Activation in Rat Fast-Twitch muscle.

The Journal of nutrition

Kanzaki K,Wada M

Tue Aug 01 00:00:00 EDT 2023

Oxidative stress from DGAT1 oncoprotein inhibition in melanoma suppresses tumor growth when ROS defenses are also breached.

Cell reports

Wilcock DJ,Badrock AP,Wong CW,Owen R,Guerin M,Southam AD,Johnston H,Telfer BA,Fullwood P,Watson J,Ferguson H,Ferguson J,Lloyd GR,Jankevics A,Dunn WB,Wellbrock C,Lorigan P,Ceol C,Francavilla C,Smith MP,Hurlstone AFL

Tue Jun 21 00:00:00 EDT 2022

KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity.

Autophagy

Yan G,Li X,Zheng Z,Gao W,Chen C,Wang X,Cheng Z,Yu J,Zou G,Farooq MZ,Zhu X,Zhu W,Zhong Q,Yan X

Thu Dec 01 00:00:00 EST 2022

SESN2/NRF2 signaling activates as a direct downstream regulator of the PERK pathway against endoplasmic reticulum stress to improve the in vitro maturation of porcine oocytes.

Free radical biology & medicine

Park HJ,Yang SG,Koo DB

Sat Jan 01 00:00:00 EST 2022

SESN2/NRF2 signaling activates as a direct downstream regulator of the PERK pathway against endoplasmic reticulum stress to improve the in vitro maturation of porcine oocytes.

Free radical biology & medicine

Park HJ,Yang SG,Koo DB

Sat Jan 01 00:00:00 EST 2022

Specific amino acids regulate Sestrin2 mRNA and protein levels in an ATF4-dependent manner in C2C12 myocytes.

Biochimica et biophysica acta. General subjects

Sawa R,Ohnishi A,Ohno M,Nagata M,Wake I,Okimura Y

Thu Sep 01 00:00:00 EDT 2022

Exercise protects intestinal epithelial barrier from high fat diet- induced permeabilization through SESN2/AMPKα1/HIF-1α signaling.

The Journal of nutritional biochemistry

Yu C,Liu S,Niu Y,Fu L

Thu Sep 01 00:00:00 EDT 2022

Cajaninstilbene Acid Ameliorates Acetaminophen-Induced Liver Injury Through Enhancing Sestrin2/AMPK-Mediated Mitochondrial Quality Control.

Frontiers in pharmacology

Yan M,Jin S,Liu Y,Wang L,Wang Z,Xia T,Chang Q

Fri Apr 01 00:00:00 EDT 2022

Sestrin2 overexpression attenuates osteoarthritis pain via induction of AMPK/PGC-1α-mediated mitochondrial biogenesis and suppression of neuroinflammation.

Brain, behavior, and immunity

Sun J,Song FH,Wu JY,Zhang LQ,Li DY,Gao SJ,Liu DQ,Zhou YQ,Mei W

Sun May 01 00:00:00 EDT 2022

ZFP36L2 suppresses mTORc1 through a P53-dependent pathway to prevent peripartum cardiomyopathy in mice.

The Journal of clinical investigation

Kouzu H,Tatekoshi Y,Chang HC,Shapiro JS,McGee WA,De Jesus A,Ben-Sahra I,Arany Z,Leor J,Chen C,Blackshear PJ,Ardehali H

Mon May 16 00:00:00 EDT 2022

Cell Type-Specific Metabolic Response to Amino Acid Starvation Dictates the Role of Sestrin2 in Regulation of mTORC1.

Cells

Blagojevic B,Almouhanna F,Poschet G,Wölfl S

Wed Nov 30 00:00:00 EST 2022

Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine.

Science (New York, N.Y.)

Cangelosi AL,Puszynska AM,Roberts JM,Armani A,Nguyen TP,Spinelli JB,Kunchok T,Wang B,Chan SH,Lewis CA,Comb WC,Bell GW,Helman A,Sabatini DM

Fri Jul 01 00:00:00 EDT 2022

Deubiquitinase OTUD5 modulates mTORC1 signaling to promote bladder cancer progression.

Cell death & disease

Hou T,Dan W,Liu T,Liu B,Wei Y,Yue C,Que T,Ma B,Lei Y,Wang Z,Zeng J,Fan Y,Li L

Fri Sep 09 00:00:00 EDT 2022

Deubiquitinase OTUD5 modulates mTORC1 signaling to promote bladder cancer progression.

Cell death & disease

Hou T,Dan W,Liu T,Liu B,Wei Y,Yue C,Que T,Ma B,Lei Y,Wang Z,Zeng J,Fan Y,Li L

Fri Sep 09 00:00:00 EDT 2022

Deubiquitinase OTUD5 modulates mTORC1 signaling to promote bladder cancer progression.

Cell death & disease

Hou T,Dan W,Liu T,Liu B,Wei Y,Yue C,Que T,Ma B,Lei Y,Wang Z,Zeng J,Fan Y,Li L

Fri Sep 09 00:00:00 EDT 2022

Deubiquitinase OTUD5 modulates mTORC1 signaling to promote bladder cancer progression.

Cell death & disease

Hou T,Dan W,Liu T,Liu B,Wei Y,Yue C,Que T,Ma B,Lei Y,Wang Z,Zeng J,Fan Y,Li L

Fri Sep 09 00:00:00 EDT 2022

Leucine retention in lysosomes is regulated by starvation.

Proceedings of the National Academy of Sciences of the United States of America

Bandyopadhyay U,Todorova P,Pavlova NN,Tada Y,Thompson CB,Finley LWS,Overholtzer M

Tue Feb 08 00:00:00 EST 2022

Calycosin induces autophagy and apoptosis via Sestrin2/AMPK/mTOR in human papillary thyroid cancer cells.

Frontiers in pharmacology

Qu N,Qu J,Huang N,Zhang K,Ye T,Shi J,Chen B,Kan C,Zhang J,Han F,Hou N,Sun X,Pan R

Tue Jan 03 00:00:00 EST 2023

Sestrins' Expression in the Liver Is Not Altered by Short-Term Calorie Restriction in Young and Old Rats.

Gerontology

Wrońska A,Zubrzycki A,Kmieć Z

Wed Jul 06 00:00:00 EDT 2022

Selection-free endogenous tagging of cell lines by bicistronic co-expression of the surface antigen NGFR.

MethodsX

Seibert M,Kurrle N,Stolp V,Nürnberger H,Tzschentke S,Börner L,Wempe F,Serve H,Schnütgen F

Fri Dec 02 00:00:00 EST 2022

Selection-free endogenous tagging of cell lines by bicistronic co-expression of the surface antigen NGFR.

MethodsX

Seibert M,Kurrle N,Stolp V,Nürnberger H,Tzschentke S,Börner L,Wempe F,Serve H,Schnütgen F

Fri Dec 02 00:00:00 EST 2022

Selection-free endogenous tagging of cell lines by bicistronic co-expression of the surface antigen NGFR.

MethodsX

Seibert M,Kurrle N,Stolp V,Nürnberger H,Tzschentke S,Börner L,Wempe F,Serve H,Schnütgen F

Fri Dec 02 00:00:00 EST 2022

O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine.

Nature communications

Kim K,Yoo HC,Kim BG,Kim S,Sung Y,Yoon I,Yu YC,Park SJ,Kim JH,Myung K,Hwang KY,Kim S,Han JM

Wed May 25 00:00:00 EDT 2022

Sestrin2 remedies podocyte injury via orchestrating TSP-1/TGF-β1/Smad3 axis in diabetic kidney disease.

Cell death & disease

Song S,Shi C,Bian Y,Yang Z,Mu L,Wu H,Duan H,Shi Y

Sat Jul 30 00:00:00 EDT 2022

Sestrin2 remedies podocyte injury via orchestrating TSP-1/TGF-β1/Smad3 axis in diabetic kidney disease.

Cell death & disease

Song S,Shi C,Bian Y,Yang Z,Mu L,Wu H,Duan H,Shi Y

Sat Jul 30 00:00:00 EDT 2022

Sestrin2 remedies podocyte injury via orchestrating TSP-1/TGF-β1/Smad3 axis in diabetic kidney disease.

Cell death & disease

Song S,Shi C,Bian Y,Yang Z,Mu L,Wu H,Duan H,Shi Y

Sat Jul 30 00:00:00 EDT 2022

Sestrin2 remedies podocyte injury via orchestrating TSP-1/TGF-β1/Smad3 axis in diabetic kidney disease.

Cell death & disease

Song S,Shi C,Bian Y,Yang Z,Mu L,Wu H,Duan H,Shi Y

Sat Jul 30 00:00:00 EDT 2022

Sestrin2 remedies podocyte injury via orchestrating TSP-1/TGF-β1/Smad3 axis in diabetic kidney disease.

Cell death & disease

Song S,Shi C,Bian Y,Yang Z,Mu L,Wu H,Duan H,Shi Y

Sat Jul 30 00:00:00 EDT 2022

Sestrin2 remedies podocyte injury via orchestrating TSP-1/TGF-β1/Smad3 axis in diabetic kidney disease.

Cell death & disease

Song S,Shi C,Bian Y,Yang Z,Mu L,Wu H,Duan H,Shi Y

Sat Jul 30 00:00:00 EDT 2022

Quercus acuta Thunb. Suppresses LPS-Induced Neuroinflammation in BV2 Microglial Cells via Regulating MAPK/NF-κB and Nrf2/HO-1 Pathway.

Antioxidants (Basel, Switzerland)

Kim JK,Yang HJ,Go Y

Tue Sep 20 00:00:00 EDT 2022

Sestrin2 protects against cholestatic liver injury by inhibiting endoplasmic reticulum stress and NLRP3 inflammasome-mediated pyroptosis.

Experimental & molecular medicine

Han D,Kim H,Kim S,Le QA,Han SY,Bae J,Shin HW,Kang HG,Han KH,Shin J,Park HW

Tue Mar 01 00:00:00 EST 2022

Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2.

Redox biology

Wang A J,Tang Y,Zhang J,Wang B J,Xiao M,Lu G,Li J,Liu Q,Guo Y,Gu J

Wed Jun 01 00:00:00 EDT 2022

Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2.

Redox biology

Wang A J,Tang Y,Zhang J,Wang B J,Xiao M,Lu G,Li J,Liu Q,Guo Y,Gu J

Wed Jun 01 00:00:00 EDT 2022

Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2.

Redox biology

Wang A J,Tang Y,Zhang J,Wang B J,Xiao M,Lu G,Li J,Liu Q,Guo Y,Gu J

Wed Jun 01 00:00:00 EDT 2022

Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2.

Redox biology

Wang A J,Tang Y,Zhang J,Wang B J,Xiao M,Lu G,Li J,Liu Q,Guo Y,Gu J

Wed Jun 01 00:00:00 EDT 2022

SESN2 Knockdown Increases Betulinic Acid-Induced Radiosensitivity of Hypoxic Breast Cancer Cells.

Cells

Güttler A,Weinholdt C,Ruff E,Reidt J,Darnstaedt E,Wildemann A,Petrenko M,Keßler J,Kappler M,Grosse I,Vordermark D,Bache M

Sat Dec 31 00:00:00 EST 2022

E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression.

Molecular cell

Wang D,Xu C,Yang W,Chen J,Ou Y,Guan Y,Guan J,Liu Y

Thu Feb 17 00:00:00 EST 2022

E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression.

Molecular cell

Wang D,Xu C,Yang W,Chen J,Ou Y,Guan Y,Guan J,Liu Y

Thu Feb 17 00:00:00 EST 2022

Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling.

Molecular cell

Fiore A,Zeitler L,Russier M,Groß A,Hiller MK,Parker JL,Stier L,Köcher T,Newstead S,Murray PJ

Thu Mar 03 00:00:00 EST 2022

Sestrin2 reduces cancer stemness via Wnt/β-catenin signaling in colorectal cancer.

Cancer cell international

Wei J,Zheng X,Li W,Li X,Fu Z

Fri Feb 11 00:00:00 EST 2022

Sestrin2 reduces cancer stemness via Wnt/β-catenin signaling in colorectal cancer.

Cancer cell international

Wei J,Zheng X,Li W,Li X,Fu Z

Fri Feb 11 00:00:00 EST 2022

Sestrin2 reduces cancer stemness via Wnt/β-catenin signaling in colorectal cancer.

Cancer cell international

Wei J,Zheng X,Li W,Li X,Fu Z

Fri Feb 11 00:00:00 EST 2022

Sestrin2 reduces cancer stemness via Wnt/β-catenin signaling in colorectal cancer.

Cancer cell international

Wei J,Zheng X,Li W,Li X,Fu Z

Fri Feb 11 00:00:00 EST 2022

Pharmacokinetic Analysis of Carnosic Acid and Carnosol in Standardized Rosemary Extract and the Effect on the Disease Activity Index of DSS-Induced Colitis.

Nutrients

Veenstra JP,Vemu B,Tocmo R,Nauman MC,Johnson JJ

Sat Feb 27 00:00:00 EST 2021

Prolyl endopeptidase disruption reduces hepatic inflammation and oxidative stress in methionine-choline-deficient diet-induced steatohepatitis.

Life sciences

Zhang J,Jiang D,Lin S,Cheng Y,Pan J,Ding W,Chen Y,Fan J

Thu Apr 01 00:00:00 EDT 2021

SAR1B senses leucine levels to regulate mTORC1 signalling.

Nature

Chen J,Ou Y,Luo R,Wang J,Wang D,Guan J,Li Y,Xia P,Chen PR,Liu Y

Sun Aug 01 00:00:00 EDT 2021

CERKL, a retinal dystrophy gene, regulates mitochondrial function and dynamics in the mammalian retina.

Neurobiology of disease

Mirra S,García-Arroyo R,B Domènech E,Gavaldà-Navarro A,Herrera-Úbeda C,Oliva C,Garcia-Fernàndez J,Artuch R,Villarroya F,Marfany G

Sun Aug 01 00:00:00 EDT 2021

CERKL, a retinal dystrophy gene, regulates mitochondrial function and dynamics in the mammalian retina.

Neurobiology of disease

Mirra S,García-Arroyo R,B Domènech E,Gavaldà-Navarro A,Herrera-Úbeda C,Oliva C,Garcia-Fernàndez J,Artuch R,Villarroya F,Marfany G

Sun Aug 01 00:00:00 EDT 2021

Sestrin2 protects against traumatic brain injury by reinforcing the activation of Nrf2 signaling.

Human & experimental toxicology

Liu X,Li M,Zhu J,Huang W,Song J

Thu Jul 01 00:00:00 EDT 2021

p53 induces a survival transcriptional response after nucleolar stress.

Molecular biology of the cell

Liao H,Gaur A,Mauvais C,Denicourt C

Fri Oct 01 00:00:00 EDT 2021

Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation.

Molecular cell

Kim SH,Choi JH,Wang P,Go CD,Hesketh GG,Gingras AC,Jafarnejad SM,Sonenberg N

Thu Jan 21 00:00:00 EST 2021

Daily protein supplementation attenuates immobilization-induced blunting of postabsorptive muscle mTORC1 activation in middle-aged men.

American journal of physiology. Cell physiology

Zeng N,D'Souza RF,MacRae CL,Figueiredo VC,Pileggi CA,Markworth JF,Merry TL,Cameron-Smith D,Mitchell CJ

Thu Apr 01 00:00:00 EDT 2021

Effect of Aerobic Exercise on Oxidative Stress and Inflammatory Response During Particulate Matter Exposure in Mouse Lungs.

Frontiers in physiology

So B,Park J,Jang J,Lim W,Imdad S,Kang C

Wed Feb 23 00:00:00 EST 2022

Study of the Mechanism by Which Curcumin Cooperates with Sestrin2 to Inhibit the Growth of Pancreatic Cancer.

Gastroenterology research and practice

Fu H,Ni X,Ni F,Li D,Sun H,Kong H,Shan Y,Dai S

Mon Apr 25 00:00:00 EDT 2022

Sestrin2 Regulates Osteoclastogenesis via the p62-TRAF6 Interaction.

Frontiers in cell and developmental biology

Oh SY,Kang N,Kang JY,Kim KW,Choi JH,Yang YM,Shin DM

Tue Apr 13 00:00:00 EDT 2021

The involvement of Sestrin2 in the effect of IGF-I and leucine on mTROC1 activity in C2C12 and L6 myocytes.

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society

Sawa R,Wake I,Yamamoto Y,Okimura Y

Sun Aug 01 00:00:00 EDT 2021

Sestrin 2 protects against LPS-induced acute lung injury by inducing mitophagy in alveolar macrophages.

Life sciences

Wu D,Zhang H,Wu Q,Li F,Wang Y,Liu S,Wang J

Mon Feb 15 00:00:00 EST 2021

The p53/NF-kappaB-dependent induction of sestrin2 by amyloid-beta peptides exerts antioxidative actions in neurons.

Free radical biology & medicine

Hsieh YH,Chao AC,Lin YC,Chen SD,Yang DI

Tue Jun 01 00:00:00 EDT 2021

Knockout of AMPKα2 Blocked the Protection of Sestrin2 Overexpression Against Cardiac Hypertrophy Induced by Pressure Overload.

Frontiers in pharmacology

Zhang N,Liao HH,Feng H,Mou SQ,Li WJ,Aiyasiding X,Lin Z,Ding W,Zhou ZY,Yan H,Chen S,Tang QZ

Tue Dec 07 00:00:00 EST 2021

Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction.

Proceedings of the National Academy of Sciences of the United States of America

Condon KJ,Orozco JM,Adelmann CH,Spinelli JB,van der Helm PW,Roberts JM,Kunchok T,Sabatini DM

Tue Jan 26 00:00:00 EST 2021

Upregulation Sestrin2 protects against hydrogen peroxide-induced oxidative damage bovine mammary epithelial cells via a Keap1-Nrf2/ARE pathway.

Journal of cellular physiology

Chen M,Xi Y,Chen K,Xiao P,Li S,Sun X,Han Z

Fri Jan 01 00:00:00 EST 2021

Inhibition of mTORC1 through ATF4-induced REDD1 and Sestrin2 expression by Metformin.

BMC cancer

Jang SK,Hong SE,Lee DH,Kim JY,Kim JY,Ye SK,Hong J,Park IC,Jin HO

Mon Jul 12 00:00:00 EDT 2021

Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity.

Molecular cell

Vivas-García Y,Falletta P,Liebing J,Louphrasitthiphol P,Feng Y,Chauhan J,Scott DA,Glodde N,Chocarro-Calvo A,Bonham S,Osterman AL,Fischer R,Ronai Z,García-Jiménez C,Hölzel M,Goding CR

Thu Jan 02 00:00:00 EST 2020

Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer.

The Journal of experimental medicine

Recouvreux MV,Moldenhauer MR,Galenkamp KMO,Jung M,James B,Zhang Y,Lowy A,Bagchi A,Commisso C

Mon Sep 07 00:00:00 EDT 2020

Liraglutide ameliorates obesity-related nonalcoholic fatty liver disease by regulating Sestrin2-mediated Nrf2/HO-1 pathway.

Biochemical and biophysical research communications

Han X,Ding C,Zhang G,Pan R,Liu Y,Huang N,Hou N,Han F,Xu W,Sun X

Thu May 14 00:00:00 EDT 2020

Sestrin2 promotes angiogenesis to alleviate brain injury by activating Nrf2 through regulating the interaction between p62 and Keap1 following photothrombotic stroke in rats.

Brain research

Li Y,Wu J,Yu S,Zhu J,Zhou Y,Wang P,Li L,Zhao Y

Thu Oct 15 00:00:00 EDT 2020

ATF4-Mediated Upregulation of REDD1 and Sestrin2 Suppresses mTORC1 Activity during Prolonged Leucine Deprivation.

The Journal of nutrition

Xu D,Dai W,Kutzler L,Lacko HA,Jefferson LS,Dennis MD,Kimball SR

Fri May 01 00:00:00 EDT 2020

Sestrin2 modulates cardiac inflammatory response through maintaining redox homeostasis during ischemia and reperfusion.

Redox biology

Ren D,Quan N,Fedorova J,Zhang J,He Z,Li J

Wed Jul 01 00:00:00 EDT 2020

mTOR-Dependent Role of Sestrin2 in Regulating Tumor Progression of Human Endometrial Cancer.

Cancers

Shin J,Bae J,Park S,Kang HG,Shin SM,Won G,Kim JS,Cho SG,Choi Y,Oh SM,Shin J,Kim JS,Park HW

Fri Sep 04 00:00:00 EDT 2020

Treatment of ErbB2 breast cancer by mitochondrial targeting.

Cancer & metabolism

Eldad S,Hertz R,Vainer G,Saada A,Bar-Tana J

Fri Apr 15 00:00:00 EDT 2022

Sestrin2 overexpression alleviates hydrogen peroxide-induced apoptosis and oxidative stress in retinal ganglion cells by enhancing Nrf2 activation via Keap1 downregulation.

Chemico-biological interactions

Fan Y,Xing Y,Xiong L,Wang J

Mon Jun 01 00:00:00 EDT 2020

Sestrin2 Phosphorylation by ULK1 Induces Autophagic Degradation of Mitochondria Damaged by Copper-Induced Oxidative Stress.

International journal of molecular sciences

Kim H,Jeon BT,Kim IM,Bennett SJ,Lorch CM,Viana MP,Myers JF,Trupp CJ,Whipps ZT,Kundu M,Chung S,Sun X,Khalimonchuk O,Lee J,Ro SH

Tue Aug 25 00:00:00 EDT 2020

Sestrin2 Phosphorylation by ULK1 Induces Autophagic Degradation of Mitochondria Damaged by Copper-Induced Oxidative Stress.

International journal of molecular sciences

Kim H,Jeon BT,Kim IM,Bennett SJ,Lorch CM,Viana MP,Myers JF,Trupp CJ,Whipps ZT,Kundu M,Chung S,Sun X,Khalimonchuk O,Lee J,Ro SH

Tue Aug 25 00:00:00 EDT 2020

GCN2 regulates pancreatic β cell mass by sensing intracellular amino acid levels.

JCI insight

Kanno A,Asahara SI,Furubayashi A,Masuda K,Yoshitomi R,Suzuki E,Takai T,Kimura-Koyanagi M,Matsuda T,Bartolome A,Hirota Y,Yokoi N,Inaba Y,Inoue H,Matsumoto M,Inoue K,Abe T,Wei FY,Tomizawa K,Ogawa W,Seino S,Kasuga M,Kido Y

Thu May 07 00:00:00 EDT 2020

Systematic quantitative analysis of ribosome inventory during nutrient stress.

Nature

An H,Ordureau A,Körner M,Paulo JA,Harper JW

Wed Jul 01 00:00:00 EDT 2020

Sestrin2 Attenuates Cellular Senescence by Inhibiting NADPH Oxidase 4 Expression.

Annals of geriatric medicine and research

Hwang CY,Han YH,Lee SM,Cho SM,Yu DY,Kwon KS

Tue Dec 01 00:00:00 EST 2020

Correlation between sestrin2 expression and airway remodeling in COPD.

BMC pulmonary medicine

Zhang DW,Wei YY,Ji S,Fei GH

Mon Nov 16 00:00:00 EST 2020

5-Caffeoylquinic acid ameliorates oxidative stress-mediated cell death via Nrf2 activation in hepatocytes.

Pharmaceutical biology

Chen X,Yang JH,Cho SS,Kim JH,Xu J,Seo K,Ki SH

Tue Dec 01 00:00:00 EST 2020

Protective Effects of Combination of Radix Astragali and Radix Salviae Miltiorrhizae on Kidney of Spontaneously Hypertensive Rats and Renal Intrinsic Cells.

Chinese journal of integrative medicine

Li W,Jiang YH,Wang Y,Zhao M,Hou GJ,Hu HZ,Zhou L

Wed Jan 01 00:00:00 EST 2020

Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the Sestrins/Keap1/Nrf2 Pathway in MSG-Induced Obese Mice.

BioMed research international

Du J,He W,Zhang C,Wu J,Li Z,Wang M,Feng S,Liang G

Mon Nov 23 00:00:00 EST 2020

Sulforaphane attenuates hexavalent chromium-induced cardiotoxicity via the activation of the Sesn2/AMPK/Nrf2 signaling pathway.

Metallomics : integrated biometal science

Yang D,Han B,Baiyun R,Lv Z,Wang X,Li S,Lv Y,Xue J,Liu Y,Zhang Z

Wed Dec 23 00:00:00 EST 2020

SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.

Autophagy

Lee DH,Park JS,Lee YS,Han J,Lee DK,Kwon SW,Han DH,Lee YH,Bae SH

Sun Nov 01 00:00:00 EDT 2020

The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation.

The Journal of biological chemistry

Kowalsky AH,Namkoong S,Mettetal E,Park HW,Kazyken D,Fingar DC,Lee JH

Fri Feb 14 00:00:00 EST 2020

Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals.

Nature communications

Segalés J,Perdiguero E,Serrano AL,Sousa-Victor P,Ortet L,Jardí M,Budanov AV,Garcia-Prat L,Sandri M,Thomson DM,Karin M,Hee Lee J,Muñoz-Cánoves P

Mon Jan 13 00:00:00 EST 2020

Luteolin prevents liver from tunicamycin-induced endoplasmic reticulum stress via nuclear factor erythroid 2-related factor 2-dependent sestrin 2 induction.

Toxicology and applied pharmacology

Jegal KH,Kim EO,Kim JK,Park SM,Jung DH,Lee GH,Ki SH,Byun SH,Ku SK,Cho IJ,Kim SC

Wed Jul 15 00:00:00 EDT 2020

Luteolin prevents liver from tunicamycin-induced endoplasmic reticulum stress via nuclear factor erythroid 2-related factor 2-dependent sestrin 2 induction.

Toxicology and applied pharmacology

Jegal KH,Kim EO,Kim JK,Park SM,Jung DH,Lee GH,Ki SH,Byun SH,Ku SK,Cho IJ,Kim SC

Wed Jul 15 00:00:00 EDT 2020

Luteolin prevents liver from tunicamycin-induced endoplasmic reticulum stress via nuclear factor erythroid 2-related factor 2-dependent sestrin 2 induction.

Toxicology and applied pharmacology

Jegal KH,Kim EO,Kim JK,Park SM,Jung DH,Lee GH,Ki SH,Byun SH,Ku SK,Cho IJ,Kim SC

Wed Jul 15 00:00:00 EDT 2020

Luteolin prevents liver from tunicamycin-induced endoplasmic reticulum stress via nuclear factor erythroid 2-related factor 2-dependent sestrin 2 induction.

Toxicology and applied pharmacology

Jegal KH,Kim EO,Kim JK,Park SM,Jung DH,Lee GH,Ki SH,Byun SH,Ku SK,Cho IJ,Kim SC

Wed Jul 15 00:00:00 EDT 2020

Inhibitory mechanism of muscone in liver cancer involves the induction of apoptosis and autophagy.

Oncology reports

Qi W,Li Z,Yang C,Jiangshan Dai J,Zhang Q,Wang D,Wu C,Xia L,Xu S

Sun Mar 01 00:00:00 EST 2020

Sesn2 attenuates the damage of endothelial progenitor cells induced by angiotensin II through regulating the Keap1/Nrf2 signal pathway.

Aging

Ding S,Ma N,Liu H,Tang M,Mei J

Tue Nov 24 00:00:00 EST 2020

PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis.

Molecular cancer therapeutics

Lim JT,Singh N,Leuvano LA,Calvert VS,Petricoin EF,Teachey DT,Lock RB,Padi M,Kraft AS,Padi SKR

Tue Sep 01 00:00:00 EDT 2020

Sestrin2 regulates monocyte activation through AMPK-mTOR nexus under high-glucose and dyslipidemic conditions.

Journal of cellular biochemistry

Sundararajan S,Jayachandran I,Balasubramanyam M,Mohan V,Venkatesan B,Manickam N

Wed May 01 00:00:00 EDT 2019

Sestrin2 regulates monocyte activation through AMPK-mTOR nexus under high-glucose and dyslipidemic conditions.

Journal of cellular biochemistry

Sundararajan S,Jayachandran I,Balasubramanyam M,Mohan V,Venkatesan B,Manickam N

Wed May 01 00:00:00 EDT 2019

Cold atmospheric plasma induces apoptosis of melanoma cells via Sestrin2-mediated nitric oxide synthase signaling.

Journal of biophotonics

Xia J,Zeng W,Xia Y,Wang B,Xu D,Liu D,Kong MG,Dong Y

Tue Jan 01 00:00:00 EST 2019

Cold atmospheric plasma induces apoptosis of melanoma cells via Sestrin2-mediated nitric oxide synthase signaling.

Journal of biophotonics

Xia J,Zeng W,Xia Y,Wang B,Xu D,Liu D,Kong MG,Dong Y

Tue Jan 01 00:00:00 EST 2019

Evidence for a role for Sestrin1 in mediating leucine-induced activation of mTORC1 in skeletal muscle.

American journal of physiology. Endocrinology and metabolism

Xu D,Shimkus KL,Lacko HA,Kutzler L,Jefferson LS,Kimball SR

Wed May 01 00:00:00 EDT 2019

Inhibitory Effect of Sestrin 2 on Hepatic Stellate Cell Activation and Liver Fibrosis.

Antioxidants & redox signaling

Yang JH,Kim KM,Cho SS,Shin SM,Ka SO,Na CS,Park BH,Jegal KH,Kim JK,Ku SK,Lee HJ,Park SG,Cho IJ,Ki SH

Sat Jul 20 00:00:00 EDT 2019

Repositioning of niclosamide ethanolamine (NEN), an anthelmintic drug, for the treatment of lipotoxicity.

Free radical biology & medicine

Park JS,Lee YS,Lee DH,Bae SH

Sat Jun 01 00:00:00 EDT 2019

Protective effect of sestrin2 against iron overload and ferroptosis-induced liver injury.

Toxicology and applied pharmacology

Park SJ,Cho SS,Kim KM,Yang JH,Kim JH,Jeong EH,Yang JW,Han CY,Ku SK,Cho IJ,Ki SH

Sun Sep 15 00:00:00 EDT 2019

Ginseng metabolite Protopanaxadiol induces Sestrin2 expression and AMPK activation through GCN2 and PERK.

Cell death & disease

Jin HR,Du CH,Wang CZ,Yuan CS,Du W

Fri Apr 05 00:00:00 EDT 2019

p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis.

Oncotarget

Ding B,Haidurov A,Chawla A,Parmigiani A,van de Kamp G,Dalina A,Yuan F,Lee JH,Chumakov PM,Grossman SR,Budanov AV

Tue Dec 10 00:00:00 EST 2019

Cardioprotective roles of sestrin 1 and sestrin 2 against doxorubicin cardiotoxicity.

American journal of physiology. Heart and circulatory physiology

Li R,Huang Y,Semple I,Kim M,Zhang Z,Lee JH

Mon Jul 01 00:00:00 EDT 2019

Methionine restriction activates the integrated stress response in triple-negative breast cancer cells by a GCN2- and PERK-independent mechanism.

American journal of cancer research

Rajanala SH,Ringquist R,Cryns VL

Thu Oct 01 00:00:00 EDT 2020

Sestrin2 overexpression attenuates focal cerebral ischemic injury in rat by increasing Nrf2/HO-1 pathway-mediated angiogenesis.

Neuroscience

Wang P,Zhao Y,Li Y,Wu J,Yu S,Zhu J,Li L,Zhao Y

Mon Jul 01 00:00:00 EDT 2019

Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer.

Free radical biology & medicine

Shin D,Kim EH,Lee J,Roh JL

Sat Dec 01 00:00:00 EST 2018

Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer.

Free radical biology & medicine

Shin D,Kim EH,Lee J,Roh JL

Sat Dec 01 00:00:00 EST 2018

Exercise improves glucose uptake in murine myotubes through the AMPKα2-mediated induction of Sestrins.

Biochimica et biophysica acta. Molecular basis of disease

Wang T,Niu Y,Liu S,Yuan H,Liu X,Fu L

Mon Oct 01 00:00:00 EDT 2018

Exercise improves glucose uptake in murine myotubes through the AMPKα2-mediated induction of Sestrins.

Biochimica et biophysica acta. Molecular basis of disease

Wang T,Niu Y,Liu S,Yuan H,Liu X,Fu L

Mon Oct 01 00:00:00 EDT 2018

Epimedium koreanum Ameliorates Oxidative Stress-Mediated Liver Injury by Activating Nuclear Factor Erythroid 2-Related Factor 2.

The American journal of Chinese medicine

Jung JY,Park SM,Ko HL,Lee JR,Park CA,Byun SH,Ku SK,Cho IJ,Kim SC

Fri Aug 03 00:00:00 EDT 2018

Epimedium koreanum Ameliorates Oxidative Stress-Mediated Liver Injury by Activating Nuclear Factor Erythroid 2-Related Factor 2.

The American journal of Chinese medicine

Jung JY,Park SM,Ko HL,Lee JR,Park CA,Byun SH,Ku SK,Cho IJ,Kim SC

Fri Aug 03 00:00:00 EDT 2018

Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway.

Journal of molecular and cellular cardiology

Quan N,Wang L,Chen X,Luckett C,Cates C,Rousselle T,Zheng Y,Li J

Thu Feb 01 00:00:00 EST 2018

Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway.

Journal of molecular and cellular cardiology

Quan N,Wang L,Chen X,Luckett C,Cates C,Rousselle T,Zheng Y,Li J

Thu Feb 01 00:00:00 EST 2018

Hemistepsin A ameliorates acute inflammation in macrophages via inhibition of nuclear factor-κB and activation of nuclear factor erythroid 2-related factor 2.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Kim JK,Lee JE,Jung EH,Jung JY,Jung DH,Ku SK,Cho IJ,Kim SC

Mon Jan 01 00:00:00 EST 2018

Hemistepsin A ameliorates acute inflammation in macrophages via inhibition of nuclear factor-κB and activation of nuclear factor erythroid 2-related factor 2.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Kim JK,Lee JE,Jung EH,Jung JY,Jung DH,Ku SK,Cho IJ,Kim SC

Mon Jan 01 00:00:00 EST 2018

The influence of retinoic acid-induced differentiation on the radiation response of male germline stem cells.

DNA repair

Zheng Y,Lei Q,Jongejan A,Mulder CL,van Daalen SKM,Mastenbroek S,Hwang G,Jordan PW,Repping S,Hamer G

Mon Oct 01 00:00:00 EDT 2018

The influence of retinoic acid-induced differentiation on the radiation response of male germline stem cells.

DNA repair

Zheng Y,Lei Q,Jongejan A,Mulder CL,van Daalen SKM,Mastenbroek S,Hwang G,Jordan PW,Repping S,Hamer G

Mon Oct 01 00:00:00 EDT 2018

RBX1-mediated ubiquitination of SESN2 promotes cell death upon prolonged mitochondrial damage in SH-SY5Y neuroblastoma cells.

Molecular and cellular biochemistry

Kumar A,Shaha C

Sat Sep 01 00:00:00 EDT 2018

RBX1-mediated ubiquitination of SESN2 promotes cell death upon prolonged mitochondrial damage in SH-SY5Y neuroblastoma cells.

Molecular and cellular biochemistry

Kumar A,Shaha C

Sat Sep 01 00:00:00 EDT 2018

The putative leucine sensor Sestrin2 is hyperphosphorylated by acute resistance exercise but not protein ingestion in human skeletal muscle.

European journal of applied physiology

Zeng N,D'Souza RF,Sorrenson B,Merry TL,Barnett MPG,Mitchell CJ,Cameron-Smith D

Fri Jun 01 00:00:00 EDT 2018

The putative leucine sensor Sestrin2 is hyperphosphorylated by acute resistance exercise but not protein ingestion in human skeletal muscle.

European journal of applied physiology

Zeng N,D'Souza RF,Sorrenson B,Merry TL,Barnett MPG,Mitchell CJ,Cameron-Smith D

Fri Jun 01 00:00:00 EDT 2018

Sestrin2 facilitates glutamine-dependent transcription of PGC-1α and survival of liver cancer cells under glucose limitation.

The FEBS journal

Kumar A,Giri S,Shaha C

Sun Apr 01 00:00:00 EDT 2018

Synergistic AML Cell Death Induction by Marine Cytotoxin (+)-1(R), 6(S), 1'(R), 6'(S), 11(R), 17(S)-Fistularin-3 and Bcl-2 Inhibitor Venetoclax.

Marine drugs

Florean C,Kim KR,Schnekenburger M,Kim HJ,Moriou C,Debitus C,Dicato M,Al-Mourabit A,Han BW,Diederich M

Wed Dec 19 00:00:00 EST 2018

Synergistic AML Cell Death Induction by Marine Cytotoxin (+)-1(R), 6(S), 1'(R), 6'(S), 11(R), 17(S)-Fistularin-3 and Bcl-2 Inhibitor Venetoclax.

Marine drugs

Florean C,Kim KR,Schnekenburger M,Kim HJ,Moriou C,Debitus C,Dicato M,Al-Mourabit A,Han BW,Diederich M

Wed Dec 19 00:00:00 EST 2018

SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation.

Scientific reports

Kumar A,Shaha C

Fri Jan 12 00:00:00 EST 2018

SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation.

Scientific reports

Kumar A,Shaha C

Fri Jan 12 00:00:00 EST 2018

Sestrin 2 confers primary resistance to sorafenib by simultaneously activating AKT and AMPK in hepatocellular carcinoma.

Cancer medicine

Dai J,Huang Q,Niu K,Wang B,Li Y,Dai C,Chen Z,Tao K,Dai J

Thu Nov 01 00:00:00 EDT 2018

Sestrin 2 confers primary resistance to sorafenib by simultaneously activating AKT and AMPK in hepatocellular carcinoma.

Cancer medicine

Dai J,Huang Q,Niu K,Wang B,Li Y,Dai C,Chen Z,Tao K,Dai J

Thu Nov 01 00:00:00 EDT 2018

Sestrin 2 confers primary resistance to sorafenib by simultaneously activating AKT and AMPK in hepatocellular carcinoma.

Cancer medicine

Dai J,Huang Q,Niu K,Wang B,Li Y,Dai C,Chen Z,Tao K,Dai J

Thu Nov 01 00:00:00 EDT 2018

Sestrin 2 confers primary resistance to sorafenib by simultaneously activating AKT and AMPK in hepatocellular carcinoma.

Cancer medicine

Dai J,Huang Q,Niu K,Wang B,Li Y,Dai C,Chen Z,Tao K,Dai J

Thu Nov 01 00:00:00 EDT 2018

Sestrins are differentially expressed with age in the skeletal muscle of men: A cross-sectional analysis.

Experimental gerontology

Zeng N,D'Souza RF,Mitchell CJ,Cameron-Smith D

Sat Sep 01 00:00:00 EDT 2018

SZT2 dictates GATOR control of mTORC1 signalling.

Nature

Peng M,Yin N,Li MO

Thu Mar 16 00:00:00 EDT 2017

SZT2 dictates GATOR control of mTORC1 signalling.

Nature

Peng M,Yin N,Li MO

Thu Mar 16 00:00:00 EDT 2017

Ltbp4 regulates Pdgfrβ expression via TGFβ-dependent modulation of Nrf2 transcription factor function.

Matrix biology : journal of the International Society for Matrix Biology

Tomasovic A,Kurrle N,Wempe F,De-Zolt S,Scheibe S,Koli K,Serchinger M,Schnütgen F,Sürün D,Sterner-Kock A,Weissmann N,von Melchner H

Mon May 01 00:00:00 EDT 2017

Ltbp4 regulates Pdgfrβ expression via TGFβ-dependent modulation of Nrf2 transcription factor function.

Matrix biology : journal of the International Society for Matrix Biology

Tomasovic A,Kurrle N,Wempe F,De-Zolt S,Scheibe S,Koli K,Serchinger M,Schnütgen F,Sürün D,Sterner-Kock A,Weissmann N,von Melchner H

Mon May 01 00:00:00 EDT 2017

Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway.

Free radical biology & medicine

Kim HJ,Joe Y,Kim SK,Park SU,Park J,Chen Y,Kim J,Ryu J,Cho GJ,Surh YJ,Ryter SW,Kim UH,Chung HT

Fri Sep 01 00:00:00 EDT 2017

Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway.

Free radical biology & medicine

Kim HJ,Joe Y,Kim SK,Park SU,Park J,Chen Y,Kim J,Ryu J,Cho GJ,Surh YJ,Ryter SW,Kim UH,Chung HT

Fri Sep 01 00:00:00 EDT 2017

5-Fluorouracil inhibits cell migration by induction of Sestrin2 in colon cancer cells.

Archives of pharmacal research

Seo K,Ki SH,Park EY,Shin SM

Wed Feb 01 00:00:00 EST 2017

5-Fluorouracil inhibits cell migration by induction of Sestrin2 in colon cancer cells.

Archives of pharmacal research

Seo K,Ki SH,Park EY,Shin SM

Wed Feb 01 00:00:00 EST 2017

Sestrin2 protects against acetaminophen-induced liver injury.

Chemico-biological interactions

Kim SJ,Kim KM,Yang JH,Cho SS,Kim JY,Park SJ,Lee SK,Ku SK,Cho IJ,Ki SH

Mon May 01 00:00:00 EDT 2017

Sestrin2 protects against acetaminophen-induced liver injury.

Chemico-biological interactions

Kim SJ,Kim KM,Yang JH,Cho SS,Kim JY,Park SJ,Lee SK,Ku SK,Cho IJ,Ki SH

Mon May 01 00:00:00 EDT 2017

Activating transcription factor 6-dependent sestrin 2 induction ameliorates ER stress-mediated liver injury.

Biochimica et biophysica acta. Molecular cell research

Jegal KH,Park SM,Cho SS,Byun SH,Ku SK,Kim SC,Ki SH,Cho IJ

Sat Jul 01 00:00:00 EDT 2017

Activating transcription factor 6-dependent sestrin 2 induction ameliorates ER stress-mediated liver injury.

Biochimica et biophysica acta. Molecular cell research

Jegal KH,Park SM,Cho SS,Byun SH,Ku SK,Kim SC,Ki SH,Cho IJ

Sat Jul 01 00:00:00 EDT 2017

Sestrin 2 induces autophagy and attenuates insulin resistance by regulating AMPK signaling in C2C12 myotubes.

Experimental cell research

Li H,Liu S,Yuan H,Niu Y,Fu L

Mon May 01 00:00:00 EDT 2017

Sestrin 2 induces autophagy and attenuates insulin resistance by regulating AMPK signaling in C2C12 myotubes.

Experimental cell research

Li H,Liu S,Yuan H,Niu Y,Fu L

Mon May 01 00:00:00 EDT 2017

Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea.

Neuroscience

Zhang C,Sun W,Li J,Xiong B,Frye MD,Ding D,Salvi R,Kim MJ,Someya S,Hu BH

Wed Oct 11 00:00:00 EDT 2017

Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea.

Neuroscience

Zhang C,Sun W,Li J,Xiong B,Frye MD,Ding D,Salvi R,Kim MJ,Someya S,Hu BH

Wed Oct 11 00:00:00 EDT 2017

Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea.

Neuroscience

Zhang C,Sun W,Li J,Xiong B,Frye MD,Ding D,Salvi R,Kim MJ,Someya S,Hu BH

Wed Oct 11 00:00:00 EDT 2017

Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea.

Neuroscience

Zhang C,Sun W,Li J,Xiong B,Frye MD,Ding D,Salvi R,Kim MJ,Someya S,Hu BH

Wed Oct 11 00:00:00 EDT 2017

Distinct Role of Sesn2 in Response to UVB-Induced DNA Damage and UVA-Induced Oxidative Stress in Melanocytes.

Photochemistry and photobiology

Zhao B,Shah P,Qiang L,He TC,Budanov A,He YY

Sun Jan 01 00:00:00 EST 2017

Effects of Gui Zhu Yi Kun formula on the P53/AMPK pathway of autophagy in granulosa cells of rats with polycystic ovary syndrome.

Experimental and therapeutic medicine

Xing Y,Liu YX,Liu X,Wang SL,Li P,Lin XH,Sui CL,Xu C,Qi B,Tong Q

Thu Jun 01 00:00:00 EDT 2017

Effects of Gui Zhu Yi Kun formula on the P53/AMPK pathway of autophagy in granulosa cells of rats with polycystic ovary syndrome.

Experimental and therapeutic medicine

Xing Y,Liu YX,Liu X,Wang SL,Li P,Lin XH,Sui CL,Xu C,Qi B,Tong Q

Thu Jun 01 00:00:00 EDT 2017

A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells.

Cell reports

Byun JK,Choi YK,Kim JH,Jeong JY,Jeon HJ,Kim MK,Hwang I,Lee SY,Lee YM,Lee IK,Park KG

Tue Jul 18 00:00:00 EDT 2017

A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells.

Cell reports

Byun JK,Choi YK,Kim JH,Jeong JY,Jeon HJ,Kim MK,Hwang I,Lee SY,Lee YM,Lee IK,Park KG

Tue Jul 18 00:00:00 EDT 2017

A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells.

Cell reports

Byun JK,Choi YK,Kim JH,Jeong JY,Jeon HJ,Kim MK,Hwang I,Lee SY,Lee YM,Lee IK,Park KG

Tue Jul 18 00:00:00 EDT 2017

A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells.

Cell reports

Byun JK,Choi YK,Kim JH,Jeong JY,Jeon HJ,Kim MK,Hwang I,Lee SY,Lee YM,Lee IK,Park KG

Tue Jul 18 00:00:00 EDT 2017

A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells.

Cell reports

Byun JK,Choi YK,Kim JH,Jeong JY,Jeon HJ,Kim MK,Hwang I,Lee SY,Lee YM,Lee IK,Park KG

Tue Jul 18 00:00:00 EDT 2017

A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells.

Cell reports

Byun JK,Choi YK,Kim JH,Jeong JY,Jeon HJ,Kim MK,Hwang I,Lee SY,Lee YM,Lee IK,Park KG

Tue Jul 18 00:00:00 EDT 2017

Sesn2 gene ablation enhances susceptibility to gentamicin-induced hair cell death via modulation of AMPK/mTOR signaling.

Cell death discovery

Ebnoether E,Ramseier A,Cortada M,Bodmer D,Levano-Huaman S

Tue Sep 29 00:00:00 EDT 2020

Sesn2 gene ablation enhances susceptibility to gentamicin-induced hair cell death via modulation of AMPK/mTOR signaling.

Cell death discovery

Ebnoether E,Ramseier A,Cortada M,Bodmer D,Levano-Huaman S

Tue Sep 29 00:00:00 EDT 2020

Sesn2 gene ablation enhances susceptibility to gentamicin-induced hair cell death via modulation of AMPK/mTOR signaling.

Cell death discovery

Ebnoether E,Ramseier A,Cortada M,Bodmer D,Levano-Huaman S

Tue Sep 29 00:00:00 EDT 2020

Sesn2 gene ablation enhances susceptibility to gentamicin-induced hair cell death via modulation of AMPK/mTOR signaling.

Cell death discovery

Ebnoether E,Ramseier A,Cortada M,Bodmer D,Levano-Huaman S

Tue Sep 29 00:00:00 EDT 2020

Acute resistance exercise induces Sestrin2 phosphorylation and p62 dephosphorylation in human skeletal muscle.

Physiological reports

Zeng N,D'Souza RF,Figueiredo VC,Markworth JF,Roberts LA,Peake JM,Mitchell CJ,Cameron-Smith D

Fri Dec 01 00:00:00 EST 2017

Acute resistance exercise induces Sestrin2 phosphorylation and p62 dephosphorylation in human skeletal muscle.

Physiological reports

Zeng N,D'Souza RF,Figueiredo VC,Markworth JF,Roberts LA,Peake JM,Mitchell CJ,Cameron-Smith D

Fri Dec 01 00:00:00 EST 2017

Sestrin2 prevents age-related intolerance to ischemia and reperfusion injury by modulating substrate metabolism.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Quan N,Sun W,Wang L,Chen X,Bogan JS,Zhou X,Cates C,Liu Q,Zheng Y,Li J

Fri Sep 01 00:00:00 EDT 2017

Stem cell function and stress response are controlled by protein synthesis.

Nature

Blanco S,Bandiera R,Popis M,Hussain S,Lombard P,Aleksic J,Sajini A,Tanna H,Cortés-Garrido R,Gkatza N,Dietmann S,Frye M

Thu Jun 16 00:00:00 EDT 2016

SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages.

Autophagy

Kim MJ,Bae SH,Ryu JC,Kwon Y,Oh JH,Kwon J,Moon JS,Kim K,Miyawaki A,Lee MG,Shin J,Kim YS,Kim CH,Ryter SW,Choi AM,Rhee SG,Ryu JH,Yoon JH

Tue Aug 02 00:00:00 EDT 2016

SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages.

Autophagy

Kim MJ,Bae SH,Ryu JC,Kwon Y,Oh JH,Kwon J,Moon JS,Kim K,Miyawaki A,Lee MG,Shin J,Kim YS,Kim CH,Ryter SW,Choi AM,Rhee SG,Ryu JH,Yoon JH

Tue Aug 02 00:00:00 EDT 2016

Sestrin2 inhibits hypoxia-inducible factor-1α accumulation via AMPK-mediated prolyl hydroxylase regulation.

Free radical biology & medicine

Seo K,Seo S,Ki SH,Shin SM

Thu Dec 01 00:00:00 EST 2016

Sestrin2 inhibits hypoxia-inducible factor-1α accumulation via AMPK-mediated prolyl hydroxylase regulation.

Free radical biology & medicine

Seo K,Seo S,Ki SH,Shin SM

Thu Dec 01 00:00:00 EST 2016

p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb.

Molecular cancer research : MCR

Agarwal S,Bell CM,Taylor SM,Moran RG

Fri Jan 01 00:00:00 EST 2016

p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb.

Molecular cancer research : MCR

Agarwal S,Bell CM,Taylor SM,Moran RG

Fri Jan 01 00:00:00 EST 2016

p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb.

Molecular cancer research : MCR

Agarwal S,Bell CM,Taylor SM,Moran RG

Fri Jan 01 00:00:00 EST 2016

p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb.

Molecular cancer research : MCR

Agarwal S,Bell CM,Taylor SM,Moran RG

Fri Jan 01 00:00:00 EST 2016

Nuclear Factor-kappaB-Dependent Sestrin2 Induction Mediates the Antioxidant Effects of BDNF Against Mitochondrial Inhibition in Rat Cortical Neurons.

Molecular neurobiology

Wu CL,Chen SD,Yin JH,Hwang CS,Yang DI

Mon Aug 01 00:00:00 EDT 2016

Nuclear Factor-kappaB-Dependent Sestrin2 Induction Mediates the Antioxidant Effects of BDNF Against Mitochondrial Inhibition in Rat Cortical Neurons.

Molecular neurobiology

Wu CL,Chen SD,Yin JH,Hwang CS,Yang DI

Mon Aug 01 00:00:00 EDT 2016

Eupatilin induces Sestrin2-dependent autophagy to prevent oxidative stress.

Apoptosis : an international journal on programmed cell death

Jegal KH,Ko HL,Park SM,Byun SH,Kang KW,Cho IJ,Kim SC

Sun May 01 00:00:00 EDT 2016

Eupatilin induces Sestrin2-dependent autophagy to prevent oxidative stress.

Apoptosis : an international journal on programmed cell death

Jegal KH,Ko HL,Park SM,Byun SH,Kang KW,Cho IJ,Kim SC

Sun May 01 00:00:00 EDT 2016

Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation.

Cellular signalling

Kimball SR,Gordon BS,Moyer JE,Dennis MD,Jefferson LS

Mon Aug 01 00:00:00 EDT 2016

Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation.

Cellular signalling

Kimball SR,Gordon BS,Moyer JE,Dennis MD,Jefferson LS

Mon Aug 01 00:00:00 EDT 2016

Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation.

Cellular signalling

Kimball SR,Gordon BS,Moyer JE,Dennis MD,Jefferson LS

Mon Aug 01 00:00:00 EDT 2016

Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation.

Cellular signalling

Kimball SR,Gordon BS,Moyer JE,Dennis MD,Jefferson LS

Mon Aug 01 00:00:00 EDT 2016

Cardiac-Specific Deletion of the Pdha1 Gene Sensitizes Heart to Toxicological Actions of Ischemic Stress.

Toxicological sciences : an official journal of the Society of Toxicology

Sun W,Quan N,Wang L,Yang H,Chu D,Liu Q,Zhao X,Leng J,Li J

Sun May 01 00:00:00 EDT 2016

Cardiac-Specific Deletion of the Pdha1 Gene Sensitizes Heart to Toxicological Actions of Ischemic Stress.

Toxicological sciences : an official journal of the Society of Toxicology

Sun W,Quan N,Wang L,Yang H,Chu D,Liu Q,Zhao X,Leng J,Li J

Sun May 01 00:00:00 EDT 2016

Compound C Increases Sestrin2 Expression via Mitochondria-Dependent ROS Production.

Biological & pharmaceutical bulletin

Seo K,Seo S,Ki SH,Shin SM

Fri Jan 27 00:00:00 EST 2017

Compound C Increases Sestrin2 Expression via Mitochondria-Dependent ROS Production.

Biological & pharmaceutical bulletin

Seo K,Seo S,Ki SH,Shin SM

Fri Jan 27 00:00:00 EST 2017

Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis.

eLife

Ro SH,Xue X,Ramakrishnan SK,Cho CS,Namkoong S,Jang I,Semple IA,Ho A,Park HW,Shah YM,Lee JH

Thu Feb 25 00:00:00 EST 2016

Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis.

eLife

Ro SH,Xue X,Ramakrishnan SK,Cho CS,Namkoong S,Jang I,Semple IA,Ho A,Park HW,Shah YM,Lee JH

Thu Feb 25 00:00:00 EST 2016

Sestrin2 Silencing Exacerbates Cerebral Ischemia/Reperfusion Injury by Decreasing Mitochondrial Biogenesis through the AMPK/PGC-1α Pathway in Rats.

Scientific reports

Li L,Xiao L,Hou Y,He Q,Zhu J,Li Y,Wu J,Zhao J,Yu S,Zhao Y

Mon Jul 25 00:00:00 EDT 2016

Sestrin2 Silencing Exacerbates Cerebral Ischemia/Reperfusion Injury by Decreasing Mitochondrial Biogenesis through the AMPK/PGC-1α Pathway in Rats.

Scientific reports

Li L,Xiao L,Hou Y,He Q,Zhu J,Li Y,Wu J,Zhao J,Yu S,Zhao Y

Mon Jul 25 00:00:00 EDT 2016

p62/SQSTM1 is required for the protection against endoplasmic reticulum stress-induced apoptotic cell death.

Free radical research

Park JS,Oh SY,Lee DH,Lee YS,Sung SH,Ji HW,Lee MJ,Lee YH,Rhee SG,Bae SH

Thu Dec 01 00:00:00 EST 2016

p62/SQSTM1 is required for the protection against endoplasmic reticulum stress-induced apoptotic cell death.

Free radical research

Park JS,Oh SY,Lee DH,Lee YS,Sung SH,Ji HW,Lee MJ,Lee YH,Rhee SG,Bae SH

Thu Dec 01 00:00:00 EST 2016

JNK1 ablation in mice confers long-term metabolic protection from diet-induced obesity at the cost of moderate skin oxidative damage.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Becattini B,Zani F,Breasson L,Sardi C,D'Agostino VG,Choo MK,Provenzani A,Park JM,Solinas G

Thu Sep 01 00:00:00 EDT 2016

Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency.

Cell reports

Reddy K,Cusack CL,Nnah IC,Khayati K,Saqcena C,Huynh TB,Noggle SA,Ballabio A,Dobrowolski R

Tue Mar 08 00:00:00 EST 2016

Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency.

Cell reports

Reddy K,Cusack CL,Nnah IC,Khayati K,Saqcena C,Huynh TB,Noggle SA,Ballabio A,Dobrowolski R

Tue Mar 08 00:00:00 EST 2016

The Expression of the Endogenous mTORC1 Inhibitor Sestrin 2 Is Induced by UVB and Balanced with the Expression Level of Sestrin 1.

PloS one

Mlitz V,Gendronneau G,Berlin I,Buchberger M,Eckhart L,Tschachler E

Mon Jun 26 00:00:00 EDT 2017

The Expression of the Endogenous mTORC1 Inhibitor Sestrin 2 Is Induced by UVB and Balanced with the Expression Level of Sestrin 1.

PloS one

Mlitz V,Gendronneau G,Berlin I,Buchberger M,Eckhart L,Tschachler E

Mon Jun 26 00:00:00 EDT 2017

Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death.

Scientific reports

Ding B,Parmigiani A,Divakaruni AS,Archer K,Murphy AN,Budanov AV

Wed Mar 02 00:00:00 EST 2016

Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death.

Scientific reports

Ding B,Parmigiani A,Divakaruni AS,Archer K,Murphy AN,Budanov AV

Wed Mar 02 00:00:00 EST 2016

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.

Genes & development

Ye J,Palm W,Peng M,King B,Lindsten T,Li MO,Koumenis C,Thompson CB

Sun Nov 15 00:00:00 EST 2015

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.

Genes & development

Ye J,Palm W,Peng M,King B,Lindsten T,Li MO,Koumenis C,Thompson CB

Sun Nov 15 00:00:00 EST 2015

Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling.

Diabetes

Tao R,Xiong X,Liangpunsakul S,Dong XC

Wed Apr 01 00:00:00 EDT 2015

Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling.

Diabetes

Tao R,Xiong X,Liangpunsakul S,Dong XC

Wed Apr 01 00:00:00 EDT 2015

Role of sestrin2 in the regulation of proinflammatory signaling in macrophages.

Free radical biology & medicine

Yang JH,Kim KM,Kim MG,Seo KH,Han JY,Ka SO,Park BH,Shin SM,Ku SK,Cho IJ,Ki SH

Thu Jan 01 00:00:00 EST 2015

Role of sestrin2 in the regulation of proinflammatory signaling in macrophages.

Free radical biology & medicine

Yang JH,Kim KM,Kim MG,Seo KH,Han JY,Ka SO,Park BH,Shin SM,Ku SK,Cho IJ,Ki SH

Thu Jan 01 00:00:00 EST 2015

Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Morrison A,Chen L,Wang J,Zhang M,Yang H,Ma Y,Budanov A,Lee JH,Karin M,Li J

Sun Feb 01 00:00:00 EST 2015

Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Morrison A,Chen L,Wang J,Zhang M,Yang H,Ma Y,Budanov A,Lee JH,Karin M,Li J

Sun Feb 01 00:00:00 EST 2015

Sestrin2 facilitates death receptor-induced apoptosis in lung adenocarcinoma cells through regulation of XIAP degradation.

Cell cycle (Georgetown, Tex.)

Ding B,Parmigiani A,Yang C,Budanov AV

Thu Aug 18 00:00:00 EDT 2016

Sestrin2 facilitates death receptor-induced apoptosis in lung adenocarcinoma cells through regulation of XIAP degradation.

Cell cycle (Georgetown, Tex.)

Ding B,Parmigiani A,Yang C,Budanov AV

Thu Aug 18 00:00:00 EDT 2016

Sestrin2-AMPK activation protects mitochondrial function against glucose deprivation-induced cytotoxicity.

Cellular signalling

Seo K,Ki SH,Shin SM

Wed Jul 01 00:00:00 EDT 2015

Sestrin2-AMPK activation protects mitochondrial function against glucose deprivation-induced cytotoxicity.

Cellular signalling

Seo K,Ki SH,Shin SM

Wed Jul 01 00:00:00 EDT 2015

Nck1 deficiency improves pancreatic β cell survival to diabetes-relevant stresses by modulating PERK activation and signaling.

Cellular signalling

Yamani L,Li B,Larose L

Tue Dec 01 00:00:00 EST 2015

Nck1 deficiency improves pancreatic β cell survival to diabetes-relevant stresses by modulating PERK activation and signaling.

Cellular signalling

Yamani L,Li B,Larose L

Tue Dec 01 00:00:00 EST 2015

Amino Acid-Induced Activation of mTORC1 in Rat Liver Is Attenuated by Short-Term Consumption of a High-Fat Diet.

The Journal of nutrition

Kimball SR,Ravi S,Gordon BS,Dennis MD,Jefferson LS

Sun Nov 01 00:00:00 EDT 2015

Amino Acid-Induced Activation of mTORC1 in Rat Liver Is Attenuated by Short-Term Consumption of a High-Fat Diet.

The Journal of nutrition

Kimball SR,Ravi S,Gordon BS,Dennis MD,Jefferson LS

Sun Nov 01 00:00:00 EDT 2015

Insulin Increases Sestrin 2 Content by Reducing Its Degradation through the PI 3 K/mTOR Signaling Pathway.

International journal of endocrinology

Chai D,Wang G,Zhou Z,Yang H,Yu Z

Fri Mar 20 00:00:00 EDT 2015

Insulin Increases Sestrin 2 Content by Reducing Its Degradation through the PI 3 K/mTOR Signaling Pathway.

International journal of endocrinology

Chai D,Wang G,Zhou Z,Yang H,Yu Z

Fri Mar 20 00:00:00 EDT 2015

Regulation of Toll-like receptor-mediated Sestrin2 induction by AP-1, Nrf2, and the ubiquitin-proteasome system in macrophages.

Toxicological sciences : an official journal of the Society of Toxicology

Kim MG,Yang JH,Kim KM,Jang CH,Jung JY,Cho IJ,Shin SM,Ki SH

Wed Apr 01 00:00:00 EDT 2015

Regulation of Toll-like receptor-mediated Sestrin2 induction by AP-1, Nrf2, and the ubiquitin-proteasome system in macrophages.

Toxicological sciences : an official journal of the Society of Toxicology

Kim MG,Yang JH,Kim KM,Jang CH,Jung JY,Cho IJ,Shin SM,Ki SH

Wed Apr 01 00:00:00 EDT 2015

Regulation of Toll-like receptor-mediated Sestrin2 induction by AP-1, Nrf2, and the ubiquitin-proteasome system in macrophages.

Toxicological sciences : an official journal of the Society of Toxicology

Kim MG,Yang JH,Kim KM,Jang CH,Jung JY,Cho IJ,Shin SM,Ki SH

Wed Apr 01 00:00:00 EDT 2015

Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains.

Nature communications

Kim H,An S,Ro SH,Teixeira F,Park GJ,Kim C,Cho CS,Kim JS,Jakob U,Lee JH,Cho US

Fri Nov 27 00:00:00 EST 2015

Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains.

Nature communications

Kim H,An S,Ro SH,Teixeira F,Park GJ,Kim C,Cho CS,Kim JS,Jakob U,Lee JH,Cho US

Fri Nov 27 00:00:00 EST 2015

The chalcone compound isosalipurposide (ISPP) exerts a cytoprotective effect against oxidative injury via Nrf2 activation.

Toxicology and applied pharmacology

Han JY,Cho SS,Yang JH,Kim KM,Jang CH,Park DE,Bang JS,Jung YS,Ki SH

Sat Aug 15 00:00:00 EDT 2015

Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions.

The Journal of biological chemistry

Tomasovic A,Kurrle N,Sürün D,Heidler J,Husnjak K,Poser I,Schnütgen F,Scheibe S,Seimetz M,Jaksch P,Hyman A,Weissmann N,von Melchner H

Fri Apr 10 00:00:00 EDT 2015

Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions.

The Journal of biological chemistry

Tomasovic A,Kurrle N,Sürün D,Heidler J,Husnjak K,Poser I,Schnütgen F,Scheibe S,Seimetz M,Jaksch P,Hyman A,Weissmann N,von Melchner H

Fri Apr 10 00:00:00 EDT 2015

Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions.

The Journal of biological chemistry

Tomasovic A,Kurrle N,Sürün D,Heidler J,Husnjak K,Poser I,Schnütgen F,Scheibe S,Seimetz M,Jaksch P,Hyman A,Weissmann N,von Melchner H

Fri Apr 10 00:00:00 EDT 2015

Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions.

The Journal of biological chemistry

Tomasovic A,Kurrle N,Sürün D,Heidler J,Husnjak K,Poser I,Schnütgen F,Scheibe S,Seimetz M,Jaksch P,Hyman A,Weissmann N,von Melchner H

Fri Apr 10 00:00:00 EDT 2015

Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions.

The Journal of biological chemistry

Tomasovic A,Kurrle N,Sürün D,Heidler J,Husnjak K,Poser I,Schnütgen F,Scheibe S,Seimetz M,Jaksch P,Hyman A,Weissmann N,von Melchner H

Fri Apr 10 00:00:00 EDT 2015

Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions.

The Journal of biological chemistry

Tomasovic A,Kurrle N,Sürün D,Heidler J,Husnjak K,Poser I,Schnütgen F,Scheibe S,Seimetz M,Jaksch P,Hyman A,Weissmann N,von Melchner H

Fri Apr 10 00:00:00 EDT 2015

Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.

Cell

Peng M,Yin N,Li MO

Thu Sep 25 00:00:00 EDT 2014

Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.

Cell

Peng M,Yin N,Li MO

Thu Sep 25 00:00:00 EDT 2014

Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species.

Proceedings of the National Academy of Sciences of the United States of America

Ro SH,Nam M,Jang I,Park HW,Park H,Semple IA,Kim M,Kim JS,Park H,Einat P,Damari G,Golikov M,Feinstein E,Lee JH

Tue May 27 00:00:00 EDT 2014

Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species.

Proceedings of the National Academy of Sciences of the United States of America

Ro SH,Nam M,Jang I,Park HW,Park H,Semple IA,Kim M,Kim JS,Park H,Einat P,Damari G,Golikov M,Feinstein E,Lee JH

Tue May 27 00:00:00 EDT 2014

Sestrin2 decreases renal oxidative stress, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of reactive oxygen species production.

Hypertension (Dallas, Tex. : 1979)

Yang Y,Cuevas S,Yang S,Villar VA,Escano C,Asico L,Yu P,Jiang X,Weinman EJ,Armando I,Jose PA

Wed Oct 01 00:00:00 EDT 2014

Sestrin2 decreases renal oxidative stress, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of reactive oxygen species production.

Hypertension (Dallas, Tex. : 1979)

Yang Y,Cuevas S,Yang S,Villar VA,Escano C,Asico L,Yu P,Jiang X,Weinman EJ,Armando I,Jose PA

Wed Oct 01 00:00:00 EDT 2014

Sestrin2 decreases renal oxidative stress, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of reactive oxygen species production.

Hypertension (Dallas, Tex. : 1979)

Yang Y,Cuevas S,Yang S,Villar VA,Escano C,Asico L,Yu P,Jiang X,Weinman EJ,Armando I,Jose PA

Wed Oct 01 00:00:00 EDT 2014

Sestrin2 decreases renal oxidative stress, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of reactive oxygen species production.

Hypertension (Dallas, Tex. : 1979)

Yang Y,Cuevas S,Yang S,Villar VA,Escano C,Asico L,Yu P,Jiang X,Weinman EJ,Armando I,Jose PA

Wed Oct 01 00:00:00 EDT 2014

Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1.

The FEBS journal

Ro SH,Semple IA,Park H,Park H,Park HW,Kim M,Kim JS,Lee JH

Mon Sep 01 00:00:00 EDT 2014

Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1.

The FEBS journal

Ro SH,Semple IA,Park H,Park H,Park HW,Kim M,Kim JS,Lee JH

Mon Sep 01 00:00:00 EDT 2014

Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1.

The FEBS journal

Ro SH,Semple IA,Park H,Park H,Park HW,Kim M,Kim JS,Lee JH

Mon Sep 01 00:00:00 EDT 2014

Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1.

The FEBS journal

Ro SH,Semple IA,Park H,Park H,Park HW,Kim M,Kim JS,Lee JH

Mon Sep 01 00:00:00 EDT 2014

Induction of sestrin2 as an endogenous protective mechanism against amyloid beta-peptide neurotoxicity in primary cortical culture.

Experimental neurology

Chen YS,Chen SD,Wu CL,Huang SS,Yang DI

Sat Mar 01 00:00:00 EST 2014

Induction of sestrin2 as an endogenous protective mechanism against amyloid beta-peptide neurotoxicity in primary cortical culture.

Experimental neurology

Chen YS,Chen SD,Wu CL,Huang SS,Yang DI

Sat Mar 01 00:00:00 EST 2014

Induction of sestrin2 as an endogenous protective mechanism against amyloid beta-peptide neurotoxicity in primary cortical culture.

Experimental neurology

Chen YS,Chen SD,Wu CL,Huang SS,Yang DI

Sat Mar 01 00:00:00 EST 2014

Induction of sestrin2 as an endogenous protective mechanism against amyloid beta-peptide neurotoxicity in primary cortical culture.

Experimental neurology

Chen YS,Chen SD,Wu CL,Huang SS,Yang DI

Sat Mar 01 00:00:00 EST 2014

Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner.

International journal of molecular medicine

Kim GT,Lee SH,Kim JI,Kim YM

Tue Apr 01 00:00:00 EDT 2014

Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner.

International journal of molecular medicine

Kim GT,Lee SH,Kim JI,Kim YM

Tue Apr 01 00:00:00 EDT 2014

Autophagy and senescence, stress responses induced by the DNA-damaging mycotoxin alternariol.

Toxicology

Solhaug A,Torgersen ML,Holme JA,Lagadic-Gossmann D,Eriksen GS

Thu Dec 04 00:00:00 EST 2014

Autophagy and senescence, stress responses induced by the DNA-damaging mycotoxin alternariol.

Toxicology

Solhaug A,Torgersen ML,Holme JA,Lagadic-Gossmann D,Eriksen GS

Thu Dec 04 00:00:00 EST 2014

Expression of a novel stress-inducible protein, sestrin 2, in rat glomerular parietal epithelial cells.

American journal of physiology. Renal physiology

Hamatani H,Hiromura K,Sakairi T,Takahashi S,Watanabe M,Maeshima A,Ohse T,Pippin JW,Shankland SJ,Nojima Y

Mon Sep 15 00:00:00 EDT 2014

Expression of a novel stress-inducible protein, sestrin 2, in rat glomerular parietal epithelial cells.

American journal of physiology. Renal physiology

Hamatani H,Hiromura K,Sakairi T,Takahashi S,Watanabe M,Maeshima A,Ohse T,Pippin JW,Shankland SJ,Nojima Y

Mon Sep 15 00:00:00 EDT 2014

Expression of a novel stress-inducible protein, sestrin 2, in rat glomerular parietal epithelial cells.

American journal of physiology. Renal physiology

Hamatani H,Hiromura K,Sakairi T,Takahashi S,Watanabe M,Maeshima A,Ohse T,Pippin JW,Shankland SJ,Nojima Y

Mon Sep 15 00:00:00 EDT 2014

Expression of a novel stress-inducible protein, sestrin 2, in rat glomerular parietal epithelial cells.

American journal of physiology. Renal physiology

Hamatani H,Hiromura K,Sakairi T,Takahashi S,Watanabe M,Maeshima A,Ohse T,Pippin JW,Shankland SJ,Nojima Y

Mon Sep 15 00:00:00 EDT 2014

Sestrins inhibit mTORC1 kinase activation through the GATOR complex.

Cell reports

Parmigiani A,Nourbakhsh A,Ding B,Wang W,Kim YC,Akopiants K,Guan KL,Karin M,Budanov AV

Thu Nov 20 00:00:00 EST 2014

Sestrins inhibit mTORC1 kinase activation through the GATOR complex.

Cell reports

Parmigiani A,Nourbakhsh A,Ding B,Wang W,Kim YC,Akopiants K,Guan KL,Karin M,Budanov AV

Thu Nov 20 00:00:00 EST 2014

Sestrins inhibit mTORC1 kinase activation through the GATOR complex.

Cell reports

Parmigiani A,Nourbakhsh A,Ding B,Wang W,Kim YC,Akopiants K,Guan KL,Karin M,Budanov AV

Thu Nov 20 00:00:00 EST 2014

Sestrins inhibit mTORC1 kinase activation through the GATOR complex.

Cell reports

Parmigiani A,Nourbakhsh A,Ding B,Wang W,Kim YC,Akopiants K,Guan KL,Karin M,Budanov AV

Thu Nov 20 00:00:00 EST 2014

p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage.

The Journal of biological chemistry

Cam M,Bid HK,Xiao L,Zambetti GP,Houghton PJ,Cam H

Fri Feb 14 00:00:00 EST 2014

p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage.

The Journal of biological chemistry

Cam M,Bid HK,Xiao L,Zambetti GP,Houghton PJ,Cam H

Fri Feb 14 00:00:00 EST 2014

Sestrin2 protein positively regulates AKT enzyme signaling and survival in human squamous cell carcinoma and melanoma cells.

The Journal of biological chemistry

Zhao B,Shah P,Budanov AV,Qiang L,Ming M,Aplin A,Sims DM,He YY

Fri Dec 26 00:00:00 EST 2014

Sestrin2 protein positively regulates AKT enzyme signaling and survival in human squamous cell carcinoma and melanoma cells.

The Journal of biological chemistry

Zhao B,Shah P,Budanov AV,Qiang L,Ming M,Aplin A,Sims DM,He YY

Fri Dec 26 00:00:00 EST 2014

Sestrin2 protein positively regulates AKT enzyme signaling and survival in human squamous cell carcinoma and melanoma cells.

The Journal of biological chemistry

Zhao B,Shah P,Budanov AV,Qiang L,Ming M,Aplin A,Sims DM,He YY

Fri Dec 26 00:00:00 EST 2014

Sestrin2 protein positively regulates AKT enzyme signaling and survival in human squamous cell carcinoma and melanoma cells.

The Journal of biological chemistry

Zhao B,Shah P,Budanov AV,Qiang L,Ming M,Aplin A,Sims DM,He YY

Fri Dec 26 00:00:00 EST 2014

Hepatoprotective role of Sestrin2 against chronic ER stress.

Nature communications

Park HW,Park H,Ro SH,Jang I,Semple IA,Kim DN,Kim M,Nam M,Zhang D,Yin L,Lee JH

Fri Jun 20 00:00:00 EDT 2014

Hepatoprotective role of Sestrin2 against chronic ER stress.

Nature communications

Park HW,Park H,Ro SH,Jang I,Semple IA,Kim DN,Kim M,Nam M,Zhang D,Yin L,Lee JH

Fri Jun 20 00:00:00 EDT 2014

Hepatoprotective role of Sestrin2 against chronic ER stress.

Nature communications

Park HW,Park H,Ro SH,Jang I,Semple IA,Kim DN,Kim M,Nam M,Zhang D,Yin L,Lee JH

Fri Jun 20 00:00:00 EDT 2014

Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.

Cell metabolism

Bae SH,Sung SH,Oh SY,Lim JM,Lee SK,Park YN,Lee HE,Kang D,Rhee SG

Tue Jan 08 00:00:00 EST 2013

Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.

Cell metabolism

Bae SH,Sung SH,Oh SY,Lim JM,Lee SK,Park YN,Lee HE,Kang D,Rhee SG

Tue Jan 08 00:00:00 EST 2013

Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.

Cell metabolism

Bae SH,Sung SH,Oh SY,Lim JM,Lee SK,Park YN,Lee HE,Kang D,Rhee SG

Tue Jan 08 00:00:00 EST 2013

Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.

Cell metabolism

Bae SH,Sung SH,Oh SY,Lim JM,Lee SK,Park YN,Lee HE,Kang D,Rhee SG

Tue Jan 08 00:00:00 EST 2013

The degree of liver injury determines the role of p21 in liver regeneration and hepatocarcinogenesis in mice.

Hepatology (Baltimore, Md.)

Buitrago-Molina LE,Marhenke S,Longerich T,Sharma AD,Boukouris AE,Geffers R,Guigas B,Manns MP,Vogel A

Sun Sep 01 00:00:00 EDT 2013

The degree of liver injury determines the role of p21 in liver regeneration and hepatocarcinogenesis in mice.

Hepatology (Baltimore, Md.)

Buitrago-Molina LE,Marhenke S,Longerich T,Sharma AD,Boukouris AE,Geffers R,Guigas B,Manns MP,Vogel A

Sun Sep 01 00:00:00 EDT 2013

Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death.

Cell death and differentiation

Ben-Sahra I,Dirat B,Laurent K,Puissant A,Auberger P,Budanov A,Tanti JF,Bost F

Mon Apr 01 00:00:00 EDT 2013

Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death.

Cell death and differentiation

Ben-Sahra I,Dirat B,Laurent K,Puissant A,Auberger P,Budanov A,Tanti JF,Bost F

Mon Apr 01 00:00:00 EDT 2013

Antioxidant activity of sestrin 2 controls neuropathic pain after peripheral nerve injury.

Antioxidants & redox signaling

Kallenborn-Gerhardt W,Lu R,Syhr KM,Heidler J,von Melchner H,Geisslinger G,Bangsow T,Schmidtko A

Tue Dec 10 00:00:00 EST 2013

Antioxidant activity of sestrin 2 controls neuropathic pain after peripheral nerve injury.

Antioxidants & redox signaling

Kallenborn-Gerhardt W,Lu R,Syhr KM,Heidler J,von Melchner H,Geisslinger G,Bangsow T,Schmidtko A

Tue Dec 10 00:00:00 EST 2013

The tumor suppressor p53 fine-tunes reactive oxygen species levels and neurogenesis via PI3 kinase signaling.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Forsberg K,Wuttke A,Quadrato G,Chumakov PM,Wizenmann A,Di Giovanni S

Wed Sep 04 00:00:00 EDT 2013

The tumor suppressor p53 fine-tunes reactive oxygen species levels and neurogenesis via PI3 kinase signaling.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Forsberg K,Wuttke A,Quadrato G,Chumakov PM,Wizenmann A,Di Giovanni S

Wed Sep 04 00:00:00 EDT 2013

The tumor suppressor p53 fine-tunes reactive oxygen species levels and neurogenesis via PI3 kinase signaling.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Forsberg K,Wuttke A,Quadrato G,Chumakov PM,Wizenmann A,Di Giovanni S

Wed Sep 04 00:00:00 EDT 2013

The tumor suppressor p53 fine-tunes reactive oxygen species levels and neurogenesis via PI3 kinase signaling.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Forsberg K,Wuttke A,Quadrato G,Chumakov PM,Wizenmann A,Di Giovanni S

Wed Sep 04 00:00:00 EDT 2013

Resveratrol inhibits LXRα-dependent hepatic lipogenesis through novel antioxidant Sestrin2 gene induction.

Toxicology and applied pharmacology

Jin SH,Yang JH,Shin BY,Seo K,Shin SM,Cho IJ,Ki SH

Thu Aug 15 00:00:00 EDT 2013

Resveratrol inhibits LXRα-dependent hepatic lipogenesis through novel antioxidant Sestrin2 gene induction.

Toxicology and applied pharmacology

Jin SH,Yang JH,Shin BY,Seo K,Shin SM,Cho IJ,Ki SH

Thu Aug 15 00:00:00 EDT 2013

Regulatory effects of sestrin 3 (SESN3) in BCR-ABL expressing cells.

PloS one

Vakana E,Arslan AD,Szilard A,Altman JK,Platanias LC

Mon Jul 07 00:00:00 EDT 2014

Regulatory effects of sestrin 3 (SESN3) in BCR-ABL expressing cells.

PloS one

Vakana E,Arslan AD,Szilard A,Altman JK,Platanias LC

Mon Jul 07 00:00:00 EDT 2014

Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD.

Disease models & mechanisms

Heidler J,Fysikopoulos A,Wempe F,Seimetz M,Bangsow T,Tomasovic A,Veit F,Scheibe S,Pichl A,Weisel F,Lloyd KC,Jaksch P,Klepetko W,Weissmann N,von Melchner H

Fri Nov 01 00:00:00 EDT 2013

Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD.

Disease models & mechanisms

Heidler J,Fysikopoulos A,Wempe F,Seimetz M,Bangsow T,Tomasovic A,Veit F,Scheibe S,Pichl A,Weisel F,Lloyd KC,Jaksch P,Klepetko W,Weissmann N,von Melchner H

Fri Nov 01 00:00:00 EDT 2013

Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD.

Disease models & mechanisms

Heidler J,Fysikopoulos A,Wempe F,Seimetz M,Bangsow T,Tomasovic A,Veit F,Scheibe S,Pichl A,Weisel F,Lloyd KC,Jaksch P,Klepetko W,Weissmann N,von Melchner H

Fri Nov 01 00:00:00 EDT 2013

Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD.

Disease models & mechanisms

Heidler J,Fysikopoulos A,Wempe F,Seimetz M,Bangsow T,Tomasovic A,Veit F,Scheibe S,Pichl A,Weisel F,Lloyd KC,Jaksch P,Klepetko W,Weissmann N,von Melchner H

Fri Nov 01 00:00:00 EDT 2013

Quercetin Regulates Sestrin 2-AMPK-mTOR Signaling Pathway and Induces Apoptosis via Increased Intracellular ROS in HCT116 Colon Cancer Cells.

Journal of cancer prevention

Kim GT,Lee SH,Kim YM

Sun Sep 01 00:00:00 EDT 2013

Quercetin Regulates Sestrin 2-AMPK-mTOR Signaling Pathway and Induces Apoptosis via Increased Intracellular ROS in HCT116 Colon Cancer Cells.

Journal of cancer prevention

Kim GT,Lee SH,Kim YM

Sun Sep 01 00:00:00 EDT 2013

Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3.

Cell metabolism

Lee JH,Budanov AV,Talukdar S,Park EJ,Park HL,Park HW,Bandyopadhyay G,Li N,Aghajan M,Jang I,Wolfe AM,Perkins GA,Ellisman MH,Bier E,Scadeng M,Foretz M,Viollet B,Olefsky J,Karin M

Wed Sep 05 00:00:00 EDT 2012

Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3.

Cell metabolism

Lee JH,Budanov AV,Talukdar S,Park EJ,Park HL,Park HW,Bandyopadhyay G,Li N,Aghajan M,Jang I,Wolfe AM,Perkins GA,Ellisman MH,Bier E,Scadeng M,Foretz M,Viollet B,Olefsky J,Karin M

Wed Sep 05 00:00:00 EDT 2012

Nrf2-ARE pathway regulates induction of Sestrin-2 expression.

Free radical biology & medicine

Shin BY,Jin SH,Cho IJ,Ki SH

Wed Aug 15 00:00:00 EDT 2012

Nrf2-ARE pathway regulates induction of Sestrin-2 expression.

Free radical biology & medicine

Shin BY,Jin SH,Cho IJ,Ki SH

Wed Aug 15 00:00:00 EDT 2012

Nrf2-ARE pathway regulates induction of Sestrin-2 expression.

Free radical biology & medicine

Shin BY,Jin SH,Cho IJ,Ki SH

Wed Aug 15 00:00:00 EDT 2012

Antioxidant sestrin-2 redistribution to neuronal soma in human immunodeficiency virus-associated neurocognitive disorders.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology

Soontornniyomkij V,Soontornniyomkij B,Moore DJ,Gouaux B,Masliah E,Tung S,Vinters HV,Grant I,Achim CL

Sat Sep 01 00:00:00 EDT 2012

Antioxidant sestrin-2 redistribution to neuronal soma in human immunodeficiency virus-associated neurocognitive disorders.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology

Soontornniyomkij V,Soontornniyomkij B,Moore DJ,Gouaux B,Masliah E,Tung S,Vinters HV,Grant I,Achim CL

Sat Sep 01 00:00:00 EDT 2012

Antioxidant sestrin-2 redistribution to neuronal soma in human immunodeficiency virus-associated neurocognitive disorders.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology

Soontornniyomkij V,Soontornniyomkij B,Moore DJ,Gouaux B,Masliah E,Tung S,Vinters HV,Grant I,Achim CL

Sat Sep 01 00:00:00 EDT 2012

Down-regulation of the PTTG1 proto-oncogene contributes to the melanoma suppressive effects of the cyclin-dependent kinase inhibitor PHA-848125.

Biochemical pharmacology

Caporali S,Alvino E,Levati L,Esposito AI,Ciomei M,Brasca MG,Del Bufalo D,Desideri M,Bonmassar E,Pfeffer U,D'Atri S

Sat Sep 01 00:00:00 EDT 2012

Down-regulation of the PTTG1 proto-oncogene contributes to the melanoma suppressive effects of the cyclin-dependent kinase inhibitor PHA-848125.

Biochemical pharmacology

Caporali S,Alvino E,Levati L,Esposito AI,Ciomei M,Brasca MG,Del Bufalo D,Desideri M,Bonmassar E,Pfeffer U,D'Atri S

Sat Sep 01 00:00:00 EDT 2012

Highly reactive meso-like positions of dipyrihexaphyrin.

Chemical communications (Cambridge, England)

Setsune J,Yamato K

Fri May 11 00:00:00 EDT 2012

Highly reactive meso-like positions of dipyrihexaphyrin.

Chemical communications (Cambridge, England)

Setsune J,Yamato K

Fri May 11 00:00:00 EDT 2012

Mechanisms involved in alternariol-induced cell cycle arrest.

Mutation research

Solhaug A,Vines LL,Ivanova L,Spilsberg B,Holme JA,Pestka J,Collins A,Eriksen GS

Tue Feb 26 00:00:00 EST 2013

Mechanisms involved in alternariol-induced cell cycle arrest.

Mutation research

Solhaug A,Vines LL,Ivanova L,Spilsberg B,Holme JA,Pestka J,Collins A,Eriksen GS

Tue Feb 26 00:00:00 EST 2013

Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells.

PloS one

Sanli T,Linher-Melville K,Tsakiridis T,Singh G

Fri Jun 29 00:00:00 EDT 2012

Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells.

PloS one

Sanli T,Linher-Melville K,Tsakiridis T,Singh G

Fri Jun 29 00:00:00 EDT 2012

Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells.

PloS one

Sanli T,Linher-Melville K,Tsakiridis T,Singh G

Fri Jun 29 00:00:00 EDT 2012

Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells.

PloS one

Sanli T,Linher-Melville K,Tsakiridis T,Singh G

Fri Jun 29 00:00:00 EDT 2012

Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine.

American journal of physiology. Endocrinology and metabolism

Lang CH,Frost RA,Bronson SK,Lynch CJ,Vary TC

Tue Jun 01 00:00:00 EDT 2010

Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine.

American journal of physiology. Endocrinology and metabolism

Lang CH,Frost RA,Bronson SK,Lynch CJ,Vary TC

Tue Jun 01 00:00:00 EDT 2010

Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD.

Disease models & mechanisms

Wempe F,De-Zolt S,Koli K,Bangsow T,Parajuli N,Dumitrascu R,Sterner-Kock A,Weissmann N,Keski-Oja J,von Melchner H

Wed May 26 00:00:00 EDT 2010

Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD.

Disease models & mechanisms

Wempe F,De-Zolt S,Koli K,Bangsow T,Parajuli N,Dumitrascu R,Sterner-Kock A,Weissmann N,Keski-Oja J,von Melchner H

Wed May 26 00:00:00 EDT 2010

Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD.

Disease models & mechanisms

Wempe F,De-Zolt S,Koli K,Bangsow T,Parajuli N,Dumitrascu R,Sterner-Kock A,Weissmann N,Keski-Oja J,von Melchner H

Wed May 26 00:00:00 EDT 2010

Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD.

Disease models & mechanisms

Wempe F,De-Zolt S,Koli K,Bangsow T,Parajuli N,Dumitrascu R,Sterner-Kock A,Weissmann N,Keski-Oja J,von Melchner H

Wed May 26 00:00:00 EDT 2010

Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD.

Disease models & mechanisms

Wempe F,De-Zolt S,Koli K,Bangsow T,Parajuli N,Dumitrascu R,Sterner-Kock A,Weissmann N,Keski-Oja J,von Melchner H

Wed May 26 00:00:00 EDT 2010

Artemis is a negative regulator of p53 in response to oxidative stress.

Oncogene

Zhang X,Zhu Y,Geng L,Wang H,Legerski RJ

Thu Jun 04 00:00:00 EDT 2009

Artemis is a negative regulator of p53 in response to oxidative stress.

Oncogene

Zhang X,Zhu Y,Geng L,Wang H,Legerski RJ

Thu Jun 04 00:00:00 EDT 2009

Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins.

Antioxidants & redox signaling

Woo HA,Bae SH,Park S,Rhee SG

Wed Apr 01 00:00:00 EDT 2009

Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins.

Antioxidants & redox signaling

Woo HA,Bae SH,Park S,Rhee SG

Wed Apr 01 00:00:00 EDT 2009

Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins.

Antioxidants & redox signaling

Woo HA,Bae SH,Park S,Rhee SG

Wed Apr 01 00:00:00 EDT 2009

Rosiglitazone acts as a neuroprotectant in retinal cells via up-regulation of sestrin-1 and SOD-2.

Journal of neurochemistry

Doonan F,Wallace DM,O'Driscoll C,Cotter TG

Wed Apr 01 00:00:00 EDT 2009

Rosiglitazone acts as a neuroprotectant in retinal cells via up-regulation of sestrin-1 and SOD-2.

Journal of neurochemistry

Doonan F,Wallace DM,O'Driscoll C,Cotter TG

Wed Apr 01 00:00:00 EDT 2009

Role of sestrin2 in peroxide signaling in macrophages.

FEBS letters

Essler S,Dehne N,Brüne B

Tue Nov 03 00:00:00 EST 2009

Role of sestrin2 in peroxide signaling in macrophages.

FEBS letters

Essler S,Dehne N,Brüne B

Tue Nov 03 00:00:00 EST 2009

A novel antioxidant function for the tumor-suppressor gene p53 in the retinal ganglion cell.

Investigative ophthalmology & visual science

O'Connor JC,Wallace DM,O'Brien CJ,Cotter TG

Wed Oct 01 00:00:00 EDT 2008

A novel antioxidant function for the tumor-suppressor gene p53 in the retinal ganglion cell.

Investigative ophthalmology & visual science

O'Connor JC,Wallace DM,O'Brien CJ,Cotter TG

Wed Oct 01 00:00:00 EDT 2008

Role of p53 in antioxidant defense of HPV-positive cervical carcinoma cells following H2O2 exposure.

Journal of cell science

Ding B,Chi SG,Kim SH,Kang S,Cho JH,Kim DS,Cho NH

Sun Jul 01 00:00:00 EDT 2007

Role of p53 in antioxidant defense of HPV-positive cervical carcinoma cells following H2O2 exposure.

Journal of cell science

Ding B,Chi SG,Kim SH,Kang S,Cho JH,Kim DS,Cho NH

Sun Jul 01 00:00:00 EDT 2007

Bioinformatics

Protein Aliases: hypoxia induced gene 95; hypoxia-induced; Hypoxia-induced gene; Sestrin-2

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Gene Aliases: HI95; RGD1566319; SES2; SESN2; SEST2

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UniProt ID: (Human) P58004, (Mouse) P58043

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Entrez Gene ID: (Human) 83667, (Rat) 502988, (Mouse) 230784

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Function(s)

protein binding oxidoreductase activity, acting on peroxide as acceptor sulfiredoxin activity leucine binding peroxidase

Process(es)

regulation of protein phosphorylation fatty acid beta-oxidation autophagy response to glucose positive regulation of macroautophagy negative regulation of cell growth DNA damage response, signal transduction by p53 class mediator mitochondrial DNA metabolic process response to insulin cellular response to oxidative stress positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress protein kinase B signaling glucose import triglyceride homeostasis cellular response to amino acid stimulus cellular response to leucine reactive oxygen species metabolic process regulation of gluconeogenesis involved in cellular glucose homeostasis cellular oxidant detoxification positive regulation of protein localization to nucleus regulation of response to reactive oxygen species negative regulation of translation in response to endoplasmic reticulum stress negative regulation of TORC1 signaling regulation of cAMP-dependent protein kinase activity mitochondrion organization glucose homeostasis

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Sestrin 2 Polyclonal Antibody

Sestrin 2 Antibody (10795-1-AP) in ICC/IF

Product Details

10795-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

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Published species

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Immunogen

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