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Sestrin 2 Polyclonal Antibody

Sestrin 2 Antibody in Immunocytochemistry (ICC/IF)

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Sestrin 2 Antibody (21346-1-AP) in ICC/IF

Immunofluorescent analysis of Hela cells, using SESN2 antibody 21346-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

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Product Details

21346-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 9 publications 9 publications

Immunocytochemistry (ICC/IF)

1:10-1:100

View 5 publications 5 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Sestrin 2 Fusion Protein Ag15669 (1-117 aa encoded by NM_031459)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MIVADSECR AELKDYLRFA PGGVGDSGPG EEQRESRARR GPRGPSAFIP VEEVLREGAE SLEQHLGLEA LMSSGRVDNL AVVMGLHPDY FTSFWRLHYL LLHTDGPLAS SWRHYIAI (1-117 aa encoded by NM_031459 )

Target Information

This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Sestrin2 Mediates Metformin Rescued the Age-Related Cardiac Dysfunctions of Cardiorenal Syndrome Type 3.

Cells

Iglesias M,Wang H,Krause-Hauch M,Ren D,Zoungrana LI,Li Z,Zhang J,Wei J,Yadav N,Patel K,Fatmi MK,Liu R,Lesnefsky EJ,Li J

Wed Mar 08 00:00:00 EST 2023

Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer's Disease.

International journal of molecular sciences

Lopes CR,Silva JS,Santos J,Rodrigues MS,Madeira D,Oliveira A,Moreira-de-Sá A,Lourenço VS,Gonçalves FQ,Silva HB,Simões AP,Rolo AP,Canas PM,Tomé ÂR,Palmeira CM,Lopes JP,Cunha RA,Agostinho P,Ferreira SG

Sun Apr 09 00:00:00 EDT 2023

Sestrin2 contributes to BRAF inhibitor resistance via reducing redox vulnerability of melanoma cells.

Journal of dermatological science

Guo S,Yue Q,Wang S,Wang H,Ye Z,Zhang W,Shi Q,Gao T,Li C,Zhu G

Wed Feb 01 00:00:00 EST 2023

Sestrin2 contributes to BRAF inhibitor resistance via reducing redox vulnerability of melanoma cells.

Journal of dermatological science

Guo S,Yue Q,Wang S,Wang H,Ye Z,Zhang W,Shi Q,Gao T,Li C,Zhu G

Wed Feb 01 00:00:00 EST 2023

Sestrin2 provides cerebral protection through activation of Nrf2 signaling in microglia following subarachnoid hemorrhage.

Frontiers in immunology

Yang Y,Ding H,Yang C,Wu J,Bao Y,Lan S,Zhou L,Zhou L,Liu B,Hong T,Wan X,Wu X

Mon Feb 13 00:00:00 EST 2023

Sestrin2 provides cerebral protection through activation of Nrf2 signaling in microglia following subarachnoid hemorrhage.

Frontiers in immunology

Yang Y,Ding H,Yang C,Wu J,Bao Y,Lan S,Zhou L,Zhou L,Liu B,Hong T,Wan X,Wu X

Mon Feb 13 00:00:00 EST 2023

Metastatic Melanoma Cells Rely on Sestrin2 to Acquire Anoikis Resistance via Detoxifying Intracellular ROS.

The Journal of investigative dermatology

Zhu G,Xu P,Guo S,Yi X,Wang H,Yang Y,Liu L,Shi Q,Gao T,Li C

Sun Mar 01 00:00:00 EST 2020

Metastatic Melanoma Cells Rely on Sestrin2 to Acquire Anoikis Resistance via Detoxifying Intracellular ROS.

The Journal of investigative dermatology

Zhu G,Xu P,Guo S,Yi X,Wang H,Yang Y,Liu L,Shi Q,Gao T,Li C

Sun Mar 01 00:00:00 EST 2020

p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors.

Cancer cell

Carugo A,Minelli R,Sapio L,Soeung M,Carbone F,Robinson FS,Tepper J,Chen Z,Lovisa S,Svelto M,Amin S,Srinivasan S,Del Poggetto E,Loponte S,Puca F,Dey P,Malouf GG,Su X,Li L,Lopez-Terrada D,Rakheja D,Lazar AJ,Netto GJ,Rao P,Sgambato A,Maitra A,Tripathi DN,Walker CL,Karam JA,Heffernan TP,Viale A,Roberts CWM,Msaouel P,Tannir NM,Draetta GF,Genovese G

Mon Feb 11 00:00:00 EST 2019

MiR-4756 promotes albumin-induced renal tubular epithelial cell epithelial-to-mesenchymal transition and endoplasmic reticulum stress via targeting Sestrin2.

Journal of cellular physiology

Jia Y,Zheng Z,Yang Y,Zou M,Li J,Wang L,Guan M,Xue Y

Fri Mar 01 00:00:00 EST 2019

MiR-4756 promotes albumin-induced renal tubular epithelial cell epithelial-to-mesenchymal transition and endoplasmic reticulum stress via targeting Sestrin2.

Journal of cellular physiology

Jia Y,Zheng Z,Yang Y,Zou M,Li J,Wang L,Guan M,Xue Y

Fri Mar 01 00:00:00 EST 2019

Sestrin2, as a negative feedback regulator of mTOR, provides neuroprotection by activation AMPK phosphorylation in neonatal hypoxic-ischemic encephalopathy in rat pups.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Shi X,Xu L,Doycheva DM,Tang J,Yan M,Zhang JH

Sat Apr 01 00:00:00 EDT 2017

Sestrin2, as a negative feedback regulator of mTOR, provides neuroprotection by activation AMPK phosphorylation in neonatal hypoxic-ischemic encephalopathy in rat pups.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Shi X,Xu L,Doycheva DM,Tang J,Yan M,Zhang JH

Sat Apr 01 00:00:00 EDT 2017

Sestrin2 induced by hypoxia inducible factor1 alpha protects the blood-brain barrier via inhibiting VEGF after severe hypoxic-ischemic injury in neonatal rats.

Neurobiology of disease

Shi X,Doycheva DM,Xu L,Tang J,Yan M,Zhang JH

Tue Nov 01 00:00:00 EDT 2016

Sestrin2 induced by hypoxia inducible factor1 alpha protects the blood-brain barrier via inhibiting VEGF after severe hypoxic-ischemic injury in neonatal rats.

Neurobiology of disease

Shi X,Doycheva DM,Xu L,Tang J,Yan M,Zhang JH

Tue Nov 01 00:00:00 EDT 2016

Dynamics of mTORC1 activation in response to amino acids.

eLife

Manifava M,Smith M,Rotondo S,Walker S,Niewczas I,Zoncu R,Clark J,Ktistakis NT

Tue Oct 11 00:00:00 EDT 2016

Dynamics of mTORC1 activation in response to amino acids.

eLife

Manifava M,Smith M,Rotondo S,Walker S,Niewczas I,Zoncu R,Clark J,Ktistakis NT

Tue Oct 11 00:00:00 EDT 2016

Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation.

Molecular and cellular biology

Hou YS,Guan JJ,Xu HD,Wu F,Sheng R,Qin ZH

Sat Aug 01 00:00:00 EDT 2015

Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation.

Molecular and cellular biology

Hou YS,Guan JJ,Xu HD,Wu F,Sheng R,Qin ZH

Sat Aug 01 00:00:00 EDT 2015

Bioinformatics

Protein Aliases: hypoxia induced gene 95; hypoxia-induced; Hypoxia-induced gene; Sestrin-2

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Gene Aliases: HI95; SES2; SESN2; SEST2

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UniProt ID: (Human) P58004, (Mouse) P58043

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Entrez Gene ID: (Human) 83667, (Mouse) 230784

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Function(s)

protein binding oxidoreductase activity, acting on peroxide as acceptor sulfiredoxin activity leucine binding peroxidase

Process(es)

regulation of protein phosphorylation fatty acid beta-oxidation autophagy response to glucose positive regulation of macroautophagy negative regulation of cell growth DNA damage response, signal transduction by p53 class mediator mitochondrial DNA metabolic process response to insulin cellular response to oxidative stress positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress protein kinase B signaling glucose import triglyceride homeostasis cellular response to amino acid stimulus cellular response to leucine reactive oxygen species metabolic process regulation of gluconeogenesis involved in cellular glucose homeostasis cellular oxidant detoxification positive regulation of protein localization to nucleus regulation of response to reactive oxygen species negative regulation of translation in response to endoplasmic reticulum stress negative regulation of TORC1 signaling regulation of cAMP-dependent protein kinase activity mitochondrion organization glucose homeostasis

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Sestrin 2 Polyclonal Antibody

Sestrin 2 Antibody (21346-1-AP) in ICC/IF

Product Details

21346-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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