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Product Details
PA5-145098
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 99-185. Recombinant protein control fragment (Product #RP-110186).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_3092046
Product Specific Information
Immunogen sequence: RISMLYMAKL GPDVITEEIN IDDEDSTTDT DGAAETCVSV QCQKQIKELR DQIVSVQEEK KILAIELENL KSKLVEVIEE VNKVKQE
Antigen sequence identity: Mouse 92%; Rat 91%
Target Information
SHTN1 is a protein coding gene involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Shootin-1; Shootin1; shot1
Gene Aliases: KIAA1598; SHTN1
UniProt ID: (Human) A0MZ66
Entrez Gene ID: (Human) 57698
substrate-dependent cell migration, cell extension
Ras protein signal transduction
axonogenesis
Cdc42 protein signal transduction
netrin-activated signaling pathway
positive regulation of axon extension
neuron projection morphogenesis
cytoplasmic actin-based contraction involved in cell motility
endoplasmic reticulum polarization
actin filament bundle retrograde transport
cell-cell adhesion
regulation of establishment of cell polarity
positive regulation of neuron migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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