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The organic anion transporting polypeptides, OATP-A (also designated OATP1, OATP1A2 and SLC21A3) and OATP-C (also designated OATP2, SLC21A6 and LST1), mediate hepatic uptake of cardiac glycosides. The expression of OATP-C, but not OATP-A, is inducible by phenobarbital and pregnenolone-16a-carbonitrile, resulting in the increased capacity of the liver to extract cardiac glycosides from the plasma. OATP-A is expressed in liver and kidney and helps mediate sodium-independent uptake of the anionic steroid conjugates dehydroepiandrosterone sulfate, estradiol-17-glucuronide and prostaglandin. OATP-C is exclusively expressed in liver and is localized to the basolateral hepatocyte membrane.
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Protein Aliases: Brain digoxin carrier protein; Brain-specific organic anion transporter; OATP-1; OATP-B1; organic anion transporter 2; Organic anion-transporting polypeptide 1; SO1A2; Sodium-independent organic anion transporter 1; Sodium-independent organic anion-transporting polypeptide 1; Sodium-independent organic anion-transporting polypeptide 2; solute carrier family (organic anion transporter) member 1; solute carrier family (organic anion transporter) member 3; solute carrier family 21 (organic anion transporter), member 1; solute carrier family 21 (organic anion transporter), member 5; Solute carrier family 21 member 1; Solute carrier family 21 member 5; solute carrier family 21, member 1; Solute carrier organic anion transporter family member 1A1; Solute carrier organic anion transporter family member 1A4; solute carrier organic anion transporter family, member 1a4
Gene Aliases: A530084B21; OATP-1; Oatp1; Oatp1a1; Oatp1a4; Oatp2; Slc21a1; Slc21a3; Slc21a5; Slco1a1; Slco1a4
UniProt ID: (Mouse) Q9QXZ6, (Rat) P46720, (Rat) O35913
Entrez Gene ID: (Mouse) 28248, (Rat) 50572, (Rat) 170698
Molecular Function:
transporter
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