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Product Details
SGCA-101AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 654-704 on rat Guanylyl cyclase alpha 1 subunit protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a 130 kDa precursor form present in the endoplasmic reticulum and a 145 kDa form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heatstable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 4.6.1.2; alpha 1 sGC; GC-S-alpha-1; GCS-alpha-1; GCS-alpha-3; GCS-alpha1; GCSalpha1; guanylate cyclase 1, soluble, alpha 3; Guanylate cyclase soluble alpha 1 (GTP pyrophosphate - lyase); Guanylate cyclase soluble subunit alpha-1; Guanylate cyclase soluble subunit alpha-3; Guanylate cyclase, soluble, alpha 1 (GTP pyrophosphate - lyase); GUCY1A1; Soluble guanylate cyclase large subunit
Gene Aliases: 1200016O07Rik; GC-SA3; GUC1A3; GUCA3; GUCSA3; GUCY1A1; GUCY1A3; MYMY6; SGC; sGC-alpha1
UniProt ID: (Human) Q02108, (Mouse) Q9ERL9
Entrez Gene ID: (Human) 2982, (Mouse) 60596, (Rat) 497757
cGMP biosynthetic process
nitric oxide mediated signal transduction
blood circulation
regulation of blood pressure
response to herbicide
response to organic cyclic compound
positive regulation of cGMP biosynthetic process
response to defense-related host nitric oxide production
relaxation of vascular smooth muscle
cyclic nucleotide biosynthetic process
intracellular signal transduction
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