Invitrogen

Somatostatin Monoclonal Antibody (YC7)

Somatostatin Antibody in Immunocytochemistry, Immunohistochemistry (ICC/IF, IHC)

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Somatostatin Antibody (MA5-16987) in ICC/IF, IHC

Life science alliance 2020 - Figure S4. Specificity of pancreatic ductal adenocarcinoma-driven beta-cell depletion. (A, B, C, D) Formalin-fixed paraffin-embedded sections from control, pancreatitis (PPT), HFD-fed (HFD), or KC mice (n = 6) were immunostained with antibodies to insulin, glucagon, somatostatin, or PP and revealed by immunofluorescence. Representative pictures of normal or remnant islets are shown (left). INS+, GCG+, SST+,... View More

Somatostatin Antibody in Immunocytochemistry (ICC/IF)

Somatostatin Antibody in Immunohistochemistry, Immunohistochemistry (Paraffin) (IHC, IHC (P))

Somatostatin Antibody in Immunohistochemistry (IHC)

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Product Details

MA5-16987

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent

View 1 publication 1 publication

Immunohistochemistry (PFA fixed) (IHC (PFA))

View 1 publication 1 publication

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Flow Cytometry (Flow)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Guinea pig, Human, Mouse, Pig, Rat

Published species

Human, Mouse

Host/Isotype

Rat / IgG2b

Class

Monoclonal

Type

Antibody

Clone

YC7

Immunogen

Somatostatin conjugated to thyroglobulin.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

tissue culture supernatant

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2538460

Target Information

The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A spatiotemporal steroidogenic regulatory network in human fetal adrenal glands and gonads.

Frontiers in endocrinology

Wang Y,Guo B,Guo Y,Qi N,Lv Y,Ye Y,Huang Y,Long X,Chen H,Su C,Zhang L,Zhang Q,Li M,Liao J,Yan Y,Mao X,Zeng Y,Jiang J,Chen Z,Guo Y,Gao S,Cheng J,Jiang Y,Mo Z

MA5-16987 was used in Flow Cytometry to study human fetal adrenal glands through single-cell transcriptome techniques, revealing their role in steroid synthesis and sexual differentiation during early gestational weeks.

Tue Dec 06 00:00:00 EST 2022

A spatiotemporal steroidogenic regulatory network in human fetal adrenal glands and gonads.

Frontiers in endocrinology

Wang Y,Guo B,Guo Y,Qi N,Lv Y,Ye Y,Huang Y,Long X,Chen H,Su C,Zhang L,Zhang Q,Li M,Liao J,Yan Y,Mao X,Zeng Y,Jiang J,Chen Z,Guo Y,Gao S,Cheng J,Jiang Y,Mo Z

Tue Dec 06 00:00:00 EST 2022

Heterogeneous Development of β-Cell Populations in Diabetes-Resistant and -Susceptible Mice.

Diabetes

Gottmann P,Speckmann T,Stadion M,Zuljan E,Aga H,Sterr M,Büttner M,Santos PM,Jähnert M,Bornstein SR,Theis FJ,Lickert H,Schürmann A

MA5-16987 was used in Immunohistochemistry-immunofluorescence to identify six β-cell clusters with similar abundance in both strains.

Thu Sep 01 00:00:00 EDT 2022

A point mutation in the Pdia6 gene results in loss of pancreatic β-cell identity causing overt diabetes.

Molecular metabolism

Chhabra NF,Amend AL,Bastidas-Ponce A,Sabrautzki S,Tarquis-Medina M,Sachs S,Rubey M,Lorenz-Depiereux B,Feuchtinger A,Bakhti M,Lickert H,Przemeck GKH,Hrabě de Angelis M

MA5-16987 was used in Immunohistochemistry (PFA fixed) to demonstrate that a global Pdia6 mutation renders mice hypoinsulinemic and hyperglycemic due to loss of pancreatic β-cell function and identity.

Wed Dec 01 00:00:00 EST 2021

A point mutation in the Pdia6 gene results in loss of pancreatic β-cell identity causing overt diabetes.

Molecular metabolism

Chhabra NF,Amend AL,Bastidas-Ponce A,Sabrautzki S,Tarquis-Medina M,Sachs S,Rubey M,Lorenz-Depiereux B,Feuchtinger A,Bakhti M,Lickert H,Przemeck GKH,Hrabě de Angelis M

Wed Dec 01 00:00:00 EST 2021

Pancreatic cancer triggers diabetes through TGF-β-mediated selective depletion of islet β-cells.

Life science alliance

Parajuli P,Nguyen TL,Prunier C,Razzaque MS,Xu K,Atfi A

Published figure using Somatostatin monoclonal antibody (Product # MA5-16987) in Immunohistochemistry

Mon Jun 01 00:00:00 EDT 2020

Pancreatic cancer triggers diabetes through TGF-β-mediated selective depletion of islet β-cells.

Life science alliance

Parajuli P,Nguyen TL,Prunier C,Razzaque MS,Xu K,Atfi A

Published figure using Somatostatin monoclonal antibody (Product # MA5-16987) in Immunohistochemistry

Mon Jun 01 00:00:00 EDT 2020

Pancreatic cancer triggers diabetes through TGF-β-mediated selective depletion of islet β-cells.

Life science alliance

Parajuli P,Nguyen TL,Prunier C,Razzaque MS,Xu K,Atfi A

Published figure using Somatostatin monoclonal antibody (Product # MA5-16987) in Immunohistochemistry

Mon Jun 01 00:00:00 EDT 2020

Point mutations in the PDX1 transactivation domain impair human β-cell development and function.

Molecular metabolism

Wang X,Sterr M,Burtscher I,Böttcher A,Beckenbauer J,Siehler J,Meitinger T,Häring HU,Staiger H,Cernilogar FM,Schotta G,Irmler M,Beckers J,Wright CVE,Bakhti M,Lickert H

MA5-16987 was used in Immunocytochemistry-immunoflourescence to reveal mechanistic details of how common coding mutations in PDX1 impair human pancreatic endocrine lineage formation and Β-cell function and contribute to the predisposition for diabetes.

Sat Jun 01 00:00:00 EDT 2019

Point mutations in the PDX1 transactivation domain impair human β-cell development and function.

Molecular metabolism

Wang X,Sterr M,Burtscher I,Böttcher A,Beckenbauer J,Siehler J,Meitinger T,Häring HU,Staiger H,Cernilogar FM,Schotta G,Irmler M,Beckers J,Wright CVE,Bakhti M,Lickert H

Sat Jun 01 00:00:00 EDT 2019

Bioinformatics

Protein Aliases: Growth hormone release-inhibiting factor; prepro-somatostatin; preprosomatostatin; Somatostatin; somatostatin 28; somatostatin-14; somatostatin-28; somatotropin release-inhibiting factor; SRIF

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Gene Aliases: SMST; SOM; SRIF; SS; SS-14; SS-28; SST

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UniProt ID: (Human) P61278, (Pig) P01168, (Mouse) P60041, (Rat) P60042

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Entrez Gene ID: (Human) 6750, (Pig) 494469, (Mouse) 20604, (Guinea pig) 100730851, (Rat) 24797

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Function(s)

hormone activity peptide hormone

Process(es)

hyperosmotic response cell surface receptor signaling pathway G-protein coupled receptor signaling pathway cell-cell signaling chemical synaptic transmission response to nutrient digestion negative regulation of cell proliferation hormone-mediated apoptotic signaling pathway response to heat response to acidic pH regulation of cell migration response to drug response to amino acid response to steroid hormone signal transduction response to organonitrogen compound

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Somatostatin Monoclonal Antibody (YC7)

Somatostatin Antibody (MA5-16987) in ICC/IF, IHC

Product Details

MA5-16987

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunohistochemistry (Frozen) (IHC (F))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Target Information

Bioinformatics

Performance Guarantee

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