Proteintech

Sortilin Polyclonal Antibody

Sortilin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 10

Sortilin Antibody (12369-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human brain tissue slide using 12369-1-AP ( Sortilin antibody at dilution of 1:100 (under 40x lens).

Sortilin Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

Sortilin Antibody in Flow Cytometry (Flow)

Sortilin Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12369-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:5,000

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:400

Immunocytochemistry (ICC/IF)

View 4 publications 4 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Sortilin Fusion Protein Ag2997 (481-831 aa encoded by BC023542)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: EPNAVGIVI AHGSVGDAIS VMVPDVYISD DGGYSWTKML EGPHYYTILD SGGIIVAIEH SSRPINVIKF STDEGQCWQT YTFTRDPIYF TGLASEPGAR SMNISIWGFT ESFLTSQWVS YTIDFKDILE RNCEEKDYTI WLAHSTDPED YEDGCILGYK EQFLRLRKSS VCQNGRDYVV TKQPSICLCS LEDFLCDFGY YRPENDSKCV EQPELKGHDL EFCLYGREEH LTTNGYRKIP GDKCQGGVNP VREVKDLKKK CTSNFLSPEK QNSKSNSVPI ILAIVGLMLV TVVAGVLIVK KYVCGGRFLV HRYSVLQQHA EANGVDGVDA LDTASHTNKS GYHDDSDEDL LE (481-831 aa encoded by BC023542)

Target Information

Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Sortilin is required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). It is also required for protein transport from the Golgi apparatus to the endosomes. Sortilin promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also, Sortilin acts as a receptor for neurotensin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Time-resolved single-cell transcriptomics reveals the landscape and dynamics of hepatic cells in sepsis-induced acute liver dysfunction.

JHEP reports : innovation in hepatology

Chen G,Ren C,Xiao Y,Wang Y,Yao R,Wang Q,You G,Lu M,Yan S,Zhang X,Zhang J,Yao Y,Zhou H

Thu Jun 01 00:00:00 EDT 2023

Experimental and therapeutic medicine

Obata H,Naito K,Kikui A,Nakamura S,Suzuki K,Kawakita S,Suzuki T,Goto K,Nagura N,Sugiyama Y,Nagaoka I,Ishijima M

Tue Nov 01 00:00:00 EDT 2022

Knockout of syntaxin-4 in 3T3-L1 adipocytes reveals new insight into GLUT4 trafficking and adiponectin secretion.

Journal of cell science

Black HL,Livingstone R,Mastick CC,Al Tobi M,Taylor H,Geiser A,Stirrat L,Kioumourtzoglou D,Petrie JR,Boyle JG,Bryant NJ,Gould GW

Thu Dec 01 00:00:00 EST 2022

CHC22 clathrin mediates traffic from early secretory compartments for human GLUT4 pathway biogenesis.

The Journal of cell biology

Camus SM,Camus MD,Figueras-Novoa C,Boncompain G,Sadacca LA,Esk C,Bigot A,Gould GW,Kioumourtzoglou D,Perez F,Bryant NJ,Mukherjee S,Brodsky FM

Mon Jan 06 00:00:00 EST 2020

CHC22 clathrin mediates traffic from early secretory compartments for human GLUT4 pathway biogenesis.

The Journal of cell biology

Camus SM,Camus MD,Figueras-Novoa C,Boncompain G,Sadacca LA,Esk C,Bigot A,Gould GW,Kioumourtzoglou D,Perez F,Bryant NJ,Mukherjee S,Brodsky FM

Mon Jan 06 00:00:00 EST 2020

Neurotensin contributes to pediatric intestinal failure-associated liver disease via regulating intestinal bile acids uptake.

EBioMedicine

Xiao Y,Yan W,Lu Y,Zhou K,Cai W

Sat Sep 01 00:00:00 EDT 2018

Neurotensin contributes to pediatric intestinal failure-associated liver disease via regulating intestinal bile acids uptake.

EBioMedicine

Xiao Y,Yan W,Lu Y,Zhou K,Cai W

Sat Sep 01 00:00:00 EDT 2018

Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice.

Proceedings of the National Academy of Sciences of the United States of America

Johnson NR,Condello C,Guan S,Oehler A,Becker J,Gavidia M,Carlson GA,Giles K,Prusiner SB

Tue Dec 19 00:00:00 EST 2017

Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice.

Proceedings of the National Academy of Sciences of the United States of America

Johnson NR,Condello C,Guan S,Oehler A,Becker J,Gavidia M,Carlson GA,Giles K,Prusiner SB

Tue Dec 19 00:00:00 EST 2017

Prions amplify through degradation of the VPS10P sorting receptor sortilin.

PLoS pathogens

Uchiyama K,Tomita M,Yano M,Chida J,Hara H,Das NR,Nykjaer A,Sakaguchi S

Thu Jun 01 00:00:00 EDT 2017

Prions amplify through degradation of the VPS10P sorting receptor sortilin.

PLoS pathogens

Uchiyama K,Tomita M,Yano M,Chida J,Hara H,Das NR,Nykjaer A,Sakaguchi S

Thu Jun 01 00:00:00 EDT 2017

Prions amplify through degradation of the VPS10P sorting receptor sortilin.

PLoS pathogens

Uchiyama K,Tomita M,Yano M,Chida J,Hara H,Das NR,Nykjaer A,Sakaguchi S

Thu Jun 01 00:00:00 EDT 2017

Prions amplify through degradation of the VPS10P sorting receptor sortilin.

PLoS pathogens

Uchiyama K,Tomita M,Yano M,Chida J,Hara H,Das NR,Nykjaer A,Sakaguchi S

Thu Jun 01 00:00:00 EDT 2017

Mapping of the N-linked glycoproteome of human spermatozoa.

Journal of proteome research

Wang G,Wu Y,Zhou T,Guo Y,Zheng B,Wang J,Bi Y,Liu F,Zhou Z,Guo X,Sha J

Fri Dec 06 00:00:00 EST 2013

Mapping of the N-linked glycoproteome of human spermatozoa.

Journal of proteome research

Wang G,Wu Y,Zhou T,Guo Y,Zheng B,Wang J,Bi Y,Liu F,Zhou Z,Guo X,Sha J

Fri Dec 06 00:00:00 EST 2013

Bioinformatics

Protein Aliases: 100 kDa NT receptor; Glycoprotein 110; Glycoprotein 95; Gp110; Gp95; mNTR3; Neurotensin receptor 3; NT3; NTR3; Sortilin

View more View less

Gene Aliases: 2900053A11Rik; AI852375; Gp95; LDLCQ6; NT3; NTR3; Nts3; Ntsr3; SORT1

View more View less

UniProt ID: (Human) Q99523, (Mouse) Q6PHU5, (Rat) O54861

View more View less

Entrez Gene ID: (Human) 6272, (Mouse) 20661, (Rat) 83576

View more View less

Function(s)

protein binding nerve growth factor receptor activity enzyme binding neurotensin receptor activity, non-G-protein coupled nerve growth factor binding G-protein coupled neurotensin receptor activity membrane traffic protein

Process(es)

ossification Golgi to endosome transport endocytosis G-protein coupled receptor signaling pathway neuropeptide signaling pathway multicellular organism development endosome to lysosome transport extrinsic apoptotic signaling pathway via death domain receptors regulation of gene expression myotube differentiation vesicle organization endosome transport via multivesicular body sorting pathway response to insulin nerve growth factor signaling pathway negative regulation of fat cell differentiation glucose import neurotrophin TRK receptor signaling pathway plasma membrane to endosome transport negative regulation of lipoprotein lipase activity positive regulation of epithelial cell apoptotic process transport cell differentiation intracellular protein transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

Sortilin Polyclonal Antibody

Sortilin Antibody (12369-1-AP) in IHC (P)

Product Details

12369-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!