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Product Details
X1637P
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide derived from the sphingosine 1-phosphate phosphatase 2 protein.
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
whole serum
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive Control: Human brain lysate. Western blot: tissue lysate should be used at 10-50 µg/lane.
Target Information
Sphingosine 1-phosphate (S1P) is a highly bioactive lipid that has a myriad of biological effects both intracellularly as a second messenger and extracellularly by binding to the S1P(1-5)/Gprotein- coupled receptors of the endothelial differentiation gene family. Intracellularly, at least two enzymes, sphingosine kinase (1 and 2) and S1P phosphatase, regulate the activity of S1P by governing the phosphorylation of S1P. SPPase2 is localized to the endoplasmic reticulum. The enzymatic activity and localization of SPPase2 are similar to SPPase1. The tissue expression of SPPase2 was different from that of SPPase1. SPPase2 is an important member of the SPPase family whichplay a role in attenuating intracellular S1P signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ39004; sphingosine 1-phosphate phosphohydrolase 2; Sphingosine-1-phosphatase 2; Sphingosine-1-phosphate phosphatase 2; sphingosine-1-phosphate phosphotase 2; SPPase2
Gene Aliases: SGPP2; SPP2; SPPase2
UniProt ID: (Human) Q8IWX5
Entrez Gene ID: (Human) 130367
Performance Guarantee
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