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Product Details
200-4191-0100
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Superoxide Dismutase [Bovine erythrocytes]
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Ion-exchange chromatography
Storage buffer
0.02M potassium phosphate, pH 7.2, with 0.15M NaCl
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
Product Specific Information
Store vial at 4° C prior to restoration. For extended storage aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Anti-SUPEROXIDE DISMUTASE (SOD) is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated above. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum as well as purified and partially purified Superoxide Dismutase [Bovine erythrocytes]. Cross reactivity against Superoxide Dismutase from other tissues and species may occur but have not been specifically determined.
Target Information
SOD1 (superoxide dismutase) binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. This isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Amyotrophic lateral sclerosis 1 (ALS1); Cu-Zn superoxide dismutase; Cu/Zn SOD; Cu/Zn superoxide dismutase; epididymis secretory protein Li 44; HGNC:11179; hSod1; indophenoloxidase A; Indophenoloxidase A (IPOA); SOD, soluble; superoxide dismutase; Superoxide dismutase 1; Superoxide Dismutase 1 (SOD1); superoxide dismutase 1, soluble; Superoxide dismutase [Cu-Zn]; superoxide dismutase, cystolic
Gene Aliases: ALS; ALS1; HEL-S-44; homodimer; hSod1; IPOA; SOD; SOD1; SOD1L1
UniProt ID: (Bovine) P00442, (Human) P00441
Entrez Gene ID: (Bovine) 281495, (Human) 6647
activation of MAPK activity
protein polyubiquitination
response to superoxide
ovarian follicle development
regulation of cytokine production
positive regulation of cytokine production
retina homeostasis
myeloid cell homeostasis
glutathione metabolic process
superoxide metabolic process
cellular iron ion homeostasis
spermatogenesis
embryo implantation
cell aging
sensory perception of sound
locomotory behavior
regulation of blood pressure
response to heat
response to organic substance
transmission of nerve impulse
removal of superoxide radicals
peripheral nervous system myelin maintenance
regulation of multicellular organism growth
response to drug
response to hydrogen peroxide
positive regulation of catalytic activity
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of neuron apoptotic process
interspecies interaction between organisms
response to ethanol
negative regulation of cholesterol biosynthetic process
regulation of protein kinase activity
muscle cell cellular homeostasis
response to axon injury
hydrogen peroxide biosynthetic process
positive regulation of nitric-oxide synthase biosynthetic process
regulation of mitochondrial membrane potential
oxidation-reduction process
heart contraction
neurofilament cytoskeleton organization
relaxation of vascular smooth muscle
auditory receptor cell stereocilium organization
reactive oxygen species metabolic process
response to reactive oxygen species
placenta development
response to amphetamine
platelet degranulation
anterograde axonal transport
retrograde axonal transport
response to nutrient levels
positive regulation of superoxide anion generation
regulation of T cell differentiation in thymus
response to carbon monoxide
cellular response to potassium ion
superoxide anion generation
positive regulation of apoptotic process
regulation of GTPase activity
regulation of organ growth
response to antibiotic
response to copper ion
thymus development
cellular response to cadmium ion
cellular response to ATP
response to antipsychotic drug
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
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