Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
11839-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Surfactant protein D Fusion Protein Ag2461 (21-375 aa encoded by BC022318)
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: AGMKTYSHR TMPSACTLVM CSSVESGLPG RDGRDGREGP RGEKGDPGLP GAAGQAGMPG QAGPVGPKGD NGSVGEPGPK GDTGPSGPPG PPGVPGPAGR EGPLGKQGNI GPQGKPGPKG EAGPKGEVGA PGMQGSAGAR GLAGPKGERG VPGERGVPGN TGAAGSAGAM GPQGSPGARG PPGLKGDKGI PGDKGAKGES GLPDVASLRQ QVEALQGQVQ HLQAAFSQYK KVELFPNGQS VGEKIFKTAG FVKPFTEAQL LCTQAGGQLA SPRSAAENAA LQQLVVAKNE AAFLSMTDSK TEGKFTYPTG ESLVYSNWAP GKPNDDGGSE DCVEIFTNGK WNDRACGEKR LVVCEF (21-375 aa encoded by BC022318)
Target Information
Surfactant protein D (SP-D) is synthesized and secreted by lung epithelial cells. It belongs to group III of the family of C-type lectins and members of this group has overall structure consisting of multiple globular 'head' regions linked by triple-helical, collagen-like, strands. This group also includes SP-A and the serum proteins mannan-binding protein, conglutinin and collectin-43, all of which have been shown to bind to the C1q receptor found on a wide variety of cells. Both SP-D and SP-A have been shown to enhance oxygen radical production by alveolar macrophages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Collectin-7; Collectin7; CP4; Lung surfactant protein D; PSP-D; PSP-D Surfactant protein D; pulmonary surfactant apoprotein; Pulmonary surfactant associated protein PSP-D; pulmonary surfactant protein D; Pulmonary surfactant-associated protein D; SFTP 4; surfactant associated protein D; Surfactant associated protein pulmonary 4; surfactant, pulmonary-associated protein D; surfactant-associated protein, pulmonary 4
Gene Aliases: AI573415; COLEC7; PSP-D; PSPD; SFTP4; SFTPD; SP-D; SPD
UniProt ID: (Human) P35247, (Rat) P35248, (Mouse) P50404
Entrez Gene ID: (Human) 6441, (Rat) 25350, (Mouse) 20390
regulation of cytokine production
receptor-mediated endocytosis
respiratory gaseous exchange
negative regulation of T cell proliferation
defense response to bacterium
surfactant homeostasis
cellular protein metabolic process
negative regulation of interleukin-2 biosynthetic process
innate immune response
macrophage chemotaxis
lung alveolus development
positive regulation of phagocytosis
regulation of immune response
reactive oxygen species metabolic process
opsonization
response to corticosteroid
negative regulation of interleukin-2 production
negative regulation of phagocytosis
regulation of liquid surface tension
response to glucocorticoid
response to hyperoxia
response to growth factor
immune system process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support