Product References
Neurodegeneration and astrogliosis in the entorhinal cortex in Alzheimer's disease: Stereological layer-specific assessment and proteomic analysis.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Astillero-Lopez V,Gonzalez-Rodriguez M,Villar-Conde S,Flores-Cuadrado A,Martinez-Marcos A,Ubeda-Banon I,Saiz-Sanchez D
Thu Dec 01 00:00:00 EST 2022
Neurodegeneration and astrogliosis in the entorhinal cortex in Alzheimer's disease: Stereological layer-specific assessment and proteomic analysis.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Astillero-Lopez V,Gonzalez-Rodriguez M,Villar-Conde S,Flores-Cuadrado A,Martinez-Marcos A,Ubeda-Banon I,Saiz-Sanchez D
Thu Dec 01 00:00:00 EST 2022
Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models.
Autophagy
Prieto Huarcaya S,Drobny A,Marques ARA,Di Spiezio A,Dobert JP,Balta D,Werner C,Rizo T,Gallwitz L,Bub S,Stojkovska I,Belur NR,Fogh J,Mazzulli JR,Xiang W,Fulzele A,Dejung M,Sauer M,Winner B,Rose-John S,Arnold P,Saftig P,Zunke F
A-6442 was used in Immunocytochemistry-immunofluorescence to indicate that cathepsin D is critical for SNCA clearance and function.
Sun May 01 00:00:00 EDT 2022
Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models.
Autophagy
Prieto Huarcaya S,Drobny A,Marques ARA,Di Spiezio A,Dobert JP,Balta D,Werner C,Rizo T,Gallwitz L,Bub S,Stojkovska I,Belur NR,Fogh J,Mazzulli JR,Xiang W,Fulzele A,Dejung M,Sauer M,Winner B,Rose-John S,Arnold P,Saftig P,Zunke F
A-6442 was used in Immunocytochemistry-immunofluorescence to indicate that cathepsin D is critical for SNCA clearance and function.
Sun May 01 00:00:00 EDT 2022
Engineered neuronal microtissue provides exogenous axons for delayed nerve fusion and rapid neuromuscular recovery in rats.
Bioactive materials
Burrell JC,Das S,Laimo FA,Katiyar KS,Browne KD,Shultz RB,Tien VJ,Vu PT,Petrov D,Ali ZS,Rosen JM,Cullen DK
A-6442 was used in Immunocytochemistry to show that TE-NMIs provide the potential to improve functional recovery following delayed nerve repair.
Thu Dec 01 00:00:00 EST 2022
Oncogenic UBE3C promotes breast cancer progression by activating Wnt/β-catenin signaling.
Cancer cell international
Hang C,Zhao S,Wang T,Zhang Y
Published figure using Synapsin 1 polyclonal antibody (Product # A-6442) in Immunocytochemistry
Wed Jan 06 00:00:00 EST 2021
Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Nature communications
Inak G,Rybak-Wolf A,Lisowski P,Pentimalli TM,Jüttner R,Glažar P,Uppal K,Bottani E,Brunetti D,Secker C,Zink A,Meierhofer D,Henke MT,Dey M,Ciptasari U,Mlody B,Hahn T,Berruezo-Llacuna M,Karaiskos N,Di Virgilio M,Mayr JA,Wortmann SB,Priller J,Gotthardt M,Jones DP,Mayatepek E,Stenzel W,Diecke S,Kühn R,Wanker EE,Rajewsky N,Schuelke M,Prigione A
A-6442 was used in Immunocytochemistry to provide mechanistic insights and suggest potential interventional strategies for a rare mitochondrial disease.
Fri Mar 26 00:00:00 EDT 2021
Neuronal MT1-MMP mediates ECM clearance and Lrp4 cleavage for agrin deposition and signaling in presynaptic development.
Journal of cell science
Oentaryo MJ,Tse AC,Lee CW
A-6442 was used in Immunocytochemistry to report that the proteolytic activity of neuronal membrane-type 1 matrix metalloproteinase (MT1-MMP; also known as MMP14) facilitates agrin deposition and signaling during presynaptic development at NMJs.
Wed Aug 05 00:00:00 EDT 2020
Decreased synthesis of ribosomal proteins in tauopathy revealed by non-canonical amino acid labelling.
The EMBO journal
Evans HT,Benetatos J,van Roijen M,Bodea LG,Götz J
A-6442 was used in Western Blotting to present a potential pathomechanism by which pathological tau interferes with cellular functions through the dysregulation of ribosomal protein synthesis.
Mon Jul 01 00:00:00 EDT 2019
Redundant and nonredundant organismal functions of EPS15 and EPS15L1.
Life science alliance
Milesi C,Alberici P,Pozzi B,Oldani A,Beznoussenko GV,Raimondi A,Soppo BE,Amodio S,Caldieri G,Malabarba MG,Bertalot G,Confalonieri S,Parazzoli D,Mironov AA,Tacchetti C,Di Fiore PP,Sigismund S,Offenhäuser N
A-6442 was used in Western Blotting to characterise the redundant and nonredundant functions of EPS15 and EPS15L1.
Fri Feb 01 00:00:00 EST 2019
Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide.
Neuron
Zunke F,Moise AC,Belur NR,Gelyana E,Stojkovska I,Dzaferbegovic H,Toker NJ,Jeon S,Fredriksen K,Mazzulli JR
A-6442 was used in Western Blotting to determine the mechanism of glycosphin-golipid-induced aggregation.
Wed Jan 03 00:00:00 EST 2018
Two-Dimensional Ti3C2 MXene for High-Resolution Neural Interfaces.
ACS nano
Driscoll N,Richardson AG,Maleski K,Anasori B,Adewole O,Lelyukh P,Escobedo L,Cullen DK,Lucas TH,Gogotsi Y,Vitale F
A-6442 was used in Immunocytochemistry-immunoflourescence to indicate that Ti3C2 MXene microelectrodes have the potential to become a powerful platform technology for high-resolution biological interfaces.
Tue Oct 23 00:00:00 EDT 2018
TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss.
Neuron
Paolicelli RC,Jawaid A,Henstridge CM,Valeri A,Merlini M,Robinson JL,Lee EB,Rose J,Appel S,Lee VM,Trojanowski JQ,Spires-Jones T,Schulz PE,Rajendran L
Published figure using Synapsin 1 polyclonal antibody (Product # A-6442) in Western Blot
Wed Jul 19 00:00:00 EDT 2017
Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Mazzulli JR,Zunke F,Tsunemi T,Toker NJ,Jeon S,Burbulla LF,Patnaik S,Sidransky E,Marugan JJ,Sue CM,Krainc D
Published figure using Synapsin 1 polyclonal antibody (Product # A-6442) in Immunofluorescence
Wed Jul 20 00:00:00 EDT 2016
Innervation of Cochlear Hair Cells by Human Induced Pluripotent Stem Cell-Derived Neurons In Vitro.
Stem cells international
Gunewardene N,Crombie D,Dottori M,Nayagam BA
A-6442 was used in immunocytochemistry and immunohistochemistry to investigate human induced pluripotent stem cell-derived neurons in vitro and their innervation of cochlear hair cells
Fri Mar 11 00:00:00 EST 2016
Rebuilding Brain Circuitry with Living Micro-Tissue Engineered Neural Networks.
Tissue engineering. Part A
Struzyna LA,Wolf JA,Mietus CJ,Adewole DO,Chen HI,Smith DH,Cullen DK
A-6442 was used in immunohistochemistry - frozen section to create and characterize micro-tissue engineered neural networks
Sun Nov 01 00:00:00 EDT 2015
A protocol for concurrent high-quality immunohistochemical and biochemical analyses in adult mouse central nervous system.
The European journal of neuroscience
Notter T,Panzanelli P,Pfister S,Mircsof D,Fritschy JM
A-6442 was used in immunohistochemistry to identify a method for simultaneous use of both biochemistry and immunohistochemistry in regards to the same tissue
Wed Jan 01 00:00:00 EST 2014
A protocol for concurrent high-quality immunohistochemical and biochemical analyses in adult mouse central nervous system.
The European journal of neuroscience
Notter T,Panzanelli P,Pfister S,Mircsof D,Fritschy JM
A-6442 was used in immunohistochemistry to identify a method for simultaneous use of both biochemistry and immunohistochemistry in regards to the same tissue
Wed Jan 01 00:00:00 EST 2014
An in vitro model of developmental synaptogenesis using cocultures of human neural progenitors and cochlear explants.
Stem cells and development
Nayagam BA,Edge AS,Needham K,Hyakumura T,Leung J,Nayagam DA,Dottori M
A-6442 was used in immunocytochemistry to characterize differentiated hESC-derived neural progenitors.
Fri Mar 15 00:00:00 EDT 2013
Reelin immunoreactivity in neuritic varicosities in the human hippocampal formation of non-demented subjects and Alzheimer's disease patients.
Acta neuropathologica communications
Notter T,Knuesel I
Published figure using Synapsin 1 polyclonal antibody (Product # A-6442) in Immunohistochemistry
Wed Jun 26 00:00:00 EDT 2013
α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Lim Y,Kehm VM,Lee EB,Soper JH,Li C,Trojanowski JQ,Lee VM
A-6442 was used in immunohistochemistry - paraffin section to study an inducible alpha-syn transgenic mouse model of dementia with Lewy body disease
Wed Jul 06 00:00:00 EDT 2011
Regional differentiation of retinoic acid-induced human pluripotent embryonic carcinoma stem cell neurons.
PloS one
Coyle DE,Li J,Baccei M
A-6442 was used in immunocytochemistry to identify the transcription factors that determine the rostocaudal and dorsoventral identity of NT2N derived from a monolayer differentiation model.
Thu Jan 20 00:00:00 EST 2011
Synapse-to-neuron ratio is inversely related to neuronal density in mature neuronal cultures.
Brain research
Cullen DK,Gilroy ME,Irons HR,Laplaca MC
A-6442 was used in immunocytochemistry to use an in vitro model to study the influence of cell density and neuronal maturity on synapse number and distribution
Thu Nov 04 00:00:00 EDT 2010
Synapse-to-neuron ratio is inversely related to neuronal density in mature neuronal cultures.
Brain research
Cullen DK,Gilroy ME,Irons HR,Laplaca MC
A-6442 was used in immunocytochemistry to use an in vitro model to study the influence of cell density and neuronal maturity on synapse number and distribution
Thu Nov 04 00:00:00 EDT 2010
Proteomics analysis reveals overlapping functions of clustered protocadherins.
Molecular & cellular proteomics : MCP
Han MH,Lin C,Meng S,Wang X
A-6442 was used in western blot to delineate the composition of PCDH-gamma complexes and its role in neural development.
Fri Jan 01 00:00:00 EST 2010
Chronic CXCL10 alters neuronal properties in rat hippocampal culture.
Journal of neuroimmunology
Cho J,Nelson TE,Bajova H,Gruol DL
A-6442 was used in western blot to ascertain the effects of chronic exposure to CXCL10 on neuronal function
Sun Feb 15 00:00:00 EST 2009
Cutting edge: MHC class I-Ly49 interaction regulates neuronal function.
Journal of immunology (Baltimore, Md. : 1950)
Zohar O,Reiter Y,Bennink JR,Lev A,Cavallaro S,Paratore S,Pick CG,Brooker G,Yewdell JW
Published figure using Synapsin 1 polyclonal antibody (Product # A-6442) in Immunohistochemistry
Thu May 15 00:00:00 EDT 2008
Three-dimensional neural constructs: a novel platform for neurophysiological investigation.
Journal of neural engineering
Irons HR,Cullen DK,Shapiro NP,Lambert NA,Lee RH,Laplaca MC
A-6442 was used in immunocytochemistry to develop an electrophysiologically active 3D neural construct with neurons and astrocytes encased in a bioactive extracellular matrix-based scaffold
Mon Sep 01 00:00:00 EDT 2008
Chronic interleukin-6 alters the level of synaptic proteins in hippocampus in culture and in vivo.
The European journal of neuroscience
Vereyken EJ,Bajova H,Chow S,de Graan PN,Gruol DL
A-6442 was used in western blot to characterize cultured hippocampal neurons chronically exposed to IL-6
Fri Jun 01 00:00:00 EDT 2007
Protein fucosylation regulates synapsin Ia/Ib expression and neuronal morphology in primary hippocampal neurons.
Proceedings of the National Academy of Sciences of the United States of America
Murrey HE,Gama CI,Kalovidouris SA,Luo WI,Driggers EM,Porton B,Hsieh-Wilson LC
Published figure using Synapsin 1 polyclonal antibody (Product # A-6442) in Western Blot
Tue Jan 03 00:00:00 EST 2006
Protein fucosylation regulates synapsin Ia/Ib expression and neuronal morphology in primary hippocampal neurons.
Proceedings of the National Academy of Sciences of the United States of America
Murrey HE,Gama CI,Kalovidouris SA,Luo WI,Driggers EM,Porton B,Hsieh-Wilson LC
Published figure using Synapsin 1 polyclonal antibody (Product # A-6442) in Western Blot
Tue Jan 03 00:00:00 EST 2006
Viral induction of central nervous system innate immune responses.
Journal of virology
Rempel JD,Quina LA,Blakely-Gonzales PK,Buchmeier MJ,Gruol DL
A-6442 was used in western blot to assess the ability of the central nervous system to generate innate immune responses
Fri Apr 01 00:00:00 EST 2005
Homeostatic control of presynaptic release is triggered by postsynaptic membrane depolarization.
Neuron
Paradis S,Sweeney ST,Davis GW
A-6442 was used in immunohistochemistry to show that a monitor of muscle membrane depolarization is sufficient to initiate synaptic homeostatic compensation
Fri Jun 01 00:00:00 EDT 2001
Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein.
Proceedings of the National Academy of Sciences of the United States of America
Galvin JE,Uryu K,Lee VM,Trojanowski JQ
A-6442 was used in immunohistochemistry - paraffin section to investigate the contribution of beta-synuclein and gamma-synuclein to Parkinson's disease and dementia with Lewy bodies
Tue Nov 09 00:00:00 EST 1999
Subtle neuronal death in striatum after short forebrain ischemia in rats detected by in situ end-labeling for DNA damage.
Stroke
Schmidt-Kastner R,Fliss H,Hakim AM
A-6442 was used in immunohistochemistry to compare apoptosis in the hippocampus and striatum after ischemic injury.
Wed Jan 01 00:00:00 EST 1997
Synaptotagmin I is present mainly in autonomic and sensory neurons of the rat peripheral nervous system.
Neuroscience
Li JY,Jahn R,Dahlström A
A-6442 was used in immunohistochemistry - frozen section to determine the distribution of synaptotagmin I in the rat peripheral nervous system
Thu Dec 01 00:00:00 EST 1994
Development of the principal sensory nucleus of the trigeminal nerve of the rat and evidence for a transient synaptic field in the trigeminal sensory tract.
The Journal of comparative neurology
al-Ghoul WM,Miller MW
A-6442 was used in immunohistochemistry to evaluate if the spatiotemporal patterns of synaptogenesis coincide with patterns in neuronal generation, migration, and death
Thu Apr 22 00:00:00 EDT 1993
Cytosolic rat brain synapsin I is a diacylglycerol kinase.
Proceedings of the National Academy of Sciences of the United States of America
Kahn DW,Besterman JM
A-6442 was used in western blot to propose that rat brain synapsin functions as a diacyglycerol kinase
Mon Jul 15 00:00:00 EDT 1991
The distribution of synapsin I and synaptophysin in hippocampal neurons developing in culture.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Fletcher TL,Cameron P,De Camilli P,Banker G
A-6442 was used in immunocytochemistry and western blot to study the sorting of synaptic vesicle proteins in neurons
Sat Jun 01 00:00:00 EDT 1991
Redistribution of synaptophysin and synapsin I during alpha-latrotoxin-induced release of neurotransmitter at the neuromuscular junction.
The Journal of cell biology
Torri-Tarelli F,Villa A,Valtorta F,De Camilli P,Greengard P,Ceccarelli B
A-6442 was used in immunohistochemistry and western blot to examine synaptic vesicle-specific phosphoproteins synaptophysin and synapsin I distribution during intense quantal secretion
Thu Feb 01 00:00:00 EST 1990
Developmental changes of synapsin I subcellular localization in rat cerebellar neurons.
Cell structure and function
Harada A,Sobue K,Hirokawa N
A-6442 was used in immunohistochemistry to determine the subcellular localization of synapsin I during the development of rat cerebellar cortices
Sat Dec 01 00:00:00 EST 1990
The cytoskeletal architecture of the presynaptic terminal and molecular structure of synapsin 1.
The Journal of cell biology
Hirokawa N,Sobue K,Kanda K,Harada A,Yorifuji H
A-6442 was used in western blot to study the cytoskeletal architecture and its relationship with synaptic vesicles in synapses
Sun Jan 01 00:00:00 EST 1989
Synapsin I: an actin-bundling protein under phosphorylation control.
The Journal of cell biology
Petrucci TC,Morrow JS
A-6442 was used in western blot to study the interactions between synapsin I and tubulin and actin filaments
Tue Sep 01 00:00:00 EDT 1987
Presence of synapsin I in afferent and efferent nerve endings of vestibular sensory epithelia.
Brain research
Favre D,Scarfone E,Di Gioia G,De Camilli P,Dememes D
A-6442 was used in immunohistochemistry to study expression and localization of synapsin I in the cat vestibular epithelium
Wed Oct 08 00:00:00 EDT 1986
Characterization of synapsin I binding to small synaptic vesicles.
The Journal of biological chemistry
Schiebler W,Jahn R,Doucet JP,Rothlein J,Greengard P
A-6442 was used in western blot to isolate synapsin I and study its binding to small synaptic vesicles
Wed Jun 25 00:00:00 EDT 1986
Synapsin I in nerve terminals: selective association with small synaptic vesicles.
Science (New York, N.Y.)
Navone F,Greengard P,De Camilli P
A-6442 was used in immunocytochemistry to examine the localization of synapsin I
Fri Dec 07 00:00:00 EST 1984
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.jpg?time=20240507?time=20240507 "Synapsin 1 Antibody (A-6442) in IHC")
