Invitrogen

Synaptophysin Monoclonal Antibody (SYP02)

Synaptophysin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 6

Synaptophysin Antibody (MA5-11575) in IHC (P)

Immunohistochemistry analysis of Synaptophysin showing staining in the cytoplasm of paraffin-embedded human pancreas tissue (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at room tempe... View More

Synaptophysin Antibody in Western Blot (WB)

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Product Details

MA5-11575

Applications

Tested Dilution

Publications

Western Blot (WB)

1:250

Immunohistochemistry (IHC)

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

SYP02

Immunogen

A synthetic peptide encoding a region near the C-terminal end of the synaptophysin protein

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

tissue culture supernatant

Contains

0.09% sodium azide

Storage conditions

4° C

Shipping conditions

Wet ice

RRID

AB_10982708

Product Specific Information

MA5-11575 targets Synaptophysin in IHC (P) applications and shows reactivity with Human and Rat samples.

The MA5-11575 immunogen is a synthetic peptide encoding a region near the C-terminal end of the synaptophysin protein.

Target Information

Synaptophysin is a calcium-binding and integral membrane glycoprotein present in presynaptic vesicles in almost all neurons. Synaptophysin has four transmembrane domains and it forms a complex with dynamin at high calcium concentrations suggesting an involvement in synaptic vesicle endocytosis. It is also involved in the regulation of short-term and long-term synaptic plasticity. Synaptophysin is currently the most widely used marker for nerve terminals and for differentiating neuroendocrine tumors. Mutations in the gene can result in mental retardation, X-linked 96.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Papillary glioneuronal tumor--a rare entity: report of four cases and brief review of literature.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

Agarwal S,Sharma MC,Singh G,Suri V,Sarkar C,Garg A,Kumar R,Chandra PS

MA5-11575 was used in immunohistochemistry to report on four cases of papillary glioneuronal tumor

Thu Nov 01 00:00:00 EDT 2012

Invasive lobular carcinoma with extracellular mucin as a distinct variant of lobular carcinoma: a case report.

Diagnostic pathology

Haltas H,Bayrak R,Yenidunya S,Kosehan D,Sen M,Akin K

MA5-11575 was used in immunohistochemistry to report on a case of invasive lobular carcinoma with extracellular mucin

Mon Aug 06 00:00:00 EDT 2012

Desmoplastic small round cell tumor of the submandibular gland--a rare but distinctive primary salivary gland neoplasm.

Human pathology

Yin WH,Guo SP,Yang HY,Chan JK

MA5-11575 was used in immunohistochemistry to report on a case of desmoplastic small round cell tumor of the submandibular gland

Mon Mar 01 00:00:00 EST 2010

Primary signet-ring cell carcinoma of the cervix: case report and review of the literature.

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists

Balci S,Saglam A,Usubutun A

MA5-11575 was used in immunohistochemistry to report on a case of primary signet-ring cell carcinoma of the cervix

Mon Mar 01 00:00:00 EST 2010

Carcinoid-like pattern in melanoma: report of 4 cases.

The American Journal of dermatopathology

Kacerovska D,Michal M,Sosna B,Cempirkova D,Ambrus M,Richtr P,Danis D,Zelger B,Kazakov DV

MA5-11575 was used in immunohistochemistry to report on four cases of carcinoid-like pattern in melanoma

Sat Aug 01 00:00:00 EDT 2009

Cerebellar liponeurocytoma/lipidized medulloblastoma.

Journal of neuro-oncology

Aker FV,Ozkara S,Eren P,Peker O,Armağan S,Hakan T

MA5-11575 was used in immunohistochemistry to report on a case of cerebellar liponeurocytoma/lipidized medulloblastoma

Sat Jan 01 00:00:00 EST 2005

Generation of structures formed by lens and retinal cells differentiating from embryonic stem cells.

Developmental dynamics : an official publication of the American Association of Anatomists

Hirano M,Yamamoto A,Yoshimura N,Tokunaga T,Motohashi T,Ishizaki K,Yoshida H,Okazaki K,Yamazaki H,Hayashi S,Kunisada T

MA5-11575 was used in immunocytochemistry to develop a culture system in which lens, neural retina and pigmented retina structures can be induced from embryonic stem cells

Mon Dec 01 00:00:00 EST 2003

Bioinformatics

Protein Aliases: BM89 antigen; Major synaptic vesicle protein p38; Synaptophysin; Syp I

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Gene Aliases: A230093K24Rik; AI848995; MRX96; MRXSYP; p38; Syn; SYP; Syp1

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UniProt ID: (Human) P08247, (Rat) P07825, (Mouse) Q62277

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Entrez Gene ID: (Human) 6855, (Rat) 24804, (Mouse) 20977

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Function(s)

transporter activity cholesterol binding SH2 domain binding identical protein binding protein self-association protein binding syntaxin-1 binding protein domain specific binding protein complex binding membrane trafficking regulatory protein

Process(es)

endocytosis synaptic vesicle maturation regulation of neuronal synaptic plasticity regulation of long-term neuronal synaptic plasticity regulation of short-term neuronal synaptic plasticity synaptic vesicle membrane organization cellular response to organic substance regulation of opioid receptor signaling pathway transport chemical synaptic transmission

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Synaptophysin Monoclonal Antibody (SYP02)

Synaptophysin Antibody (MA5-11575) in IHC (P)

Product Details

MA5-11575

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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