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Product Details
TA400004
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI4A8
Immunogen
Full length human recombinant protein of human BCL10 produced in HEK293T cell.
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4° C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
BCL-10 is an N-terminal CARD (Caspase Recruitment Domain) containing protein that is involved in the adaptive immune response. It promotes apoptosis, pro-caspase-9 maturation, and activation of NF-kappa-B via NIK and IKK. BCL-10 is also an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. It is a substrate for MALT1. Mutations in the gene can lead to Immmunodeficiency 37 or Lymphoma, mucosa-associated lymphoid type.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B-cell CLL/lymphoma 10; B-cell lymphoma/leukemia 10; Bcl-10; c-E10; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; CARD-containing molecule enhancing NF-kappa-B; CARD-containing proapoptotic protein; CARD-like apoptotic protein; caspase-recruiting domain-containing protein; cCARMEN; CED-3/ICH-1 prodomain homologous E10-like regulator; Cellular homolog of vCARMEN; Cellular-E10; CIPER; hCLAP; Mamm; Mammalian CARD-containing adapter molecule E10; mE10; OTTHUMP00000011647; OTTHUMP00000036080; RP11-234D19.2
Gene Aliases: BCL10; c-E10; CARMEN; CIPER; CLAP; IMD37; mE10
UniProt ID: (Human) O95999
Entrez Gene ID: (Human) 8915
protease binding
transcription coactivator activity
protein binding
protein C-terminus binding
transcription factor binding
kinase activator activity
enzyme binding
kinase binding
protein kinase binding
ubiquitin protein ligase binding
identical protein binding
ubiquitin binding
protein kinase B binding
protein self-association
NF-kappaB binding
B cell apoptotic process
neural tube closure
stimulatory C-type lectin receptor signaling pathway
toll-like receptor signaling pathway
response to molecule of bacterial origin
adaptive immune response
negative regulation of mature B cell apoptotic process
cellular defense response
I-kappaB kinase/NF-kappaB signaling
cell death
response to fungus
immunoglobulin mediated immune response
positive regulation of protein ubiquitination
response to food
positive regulation of mast cell cytokine production
Fc-epsilon receptor signaling pathway
lymphotoxin A biosynthetic process
interleukin-6 biosynthetic process
positive regulation of phosphorylation
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
innate immune response
positive regulation of interleukin-8 biosynthetic process
positive regulation of transcription, DNA-templated
T cell receptor signaling pathway
regulation of T cell receptor signaling pathway
positive regulation of T cell activation
positive regulation of NF-kappaB transcription factor activity
protein oligomerization
protein homooligomerization
protein heterooligomerization
T cell apoptotic process
cellular response to mechanical stimulus
positive regulation of extrinsic apoptotic signaling pathway
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