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Product Details
PA1-18309
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the C-terminal residues A(434) S T T S S F I S S P Y T S V D E Y S(452) of rat NK-3 receptor protein.
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2200909
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
Target Information
The tachykinins are a family of small peptides that include the neurotransmitters substance P, neurokinin A, and neurokinin B, which can act on three related but distinct seven transmembrane G-proteins coupled receptors, albeit at different concentrations. The NK-3 receptor (NK3R) has greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system. It is likely these signals lead to the release of vasopressin and oxytocin into the circulation. NK3R may be involved in learning and memory as mice lacking this gene expressed cognitive deficits compared to normal mice. Although it has been suggested that NK3R plays a role in the regulation of vagal afferent relay neurons, it is likely that these receptors are activated by substance P or neurokinin A, as the airway nerves do not express neurokinin B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Neurokinin B; Neurokinin B receptor; Neuromedin K receptor (Neurokinin B/Tachikin 3); Neuromedin-K receptor; NK-3 receptor; NK-3R; NK3R TAC3R; NKR; Nmk-r; tachikin receptor 3; Tachykinin receptor 3
Gene Aliases: Nkr; Nmkr; Tac3r; Tacr3
UniProt ID: (Rat) P16177
Entrez Gene ID: (Rat) 24808
tachykinin receptor signaling pathway
aging
positive regulation of heart rate
response to estradiol
regulation of dopamine metabolic process
response to cocaine
hyperosmotic salinity response
response to morphine
positive regulation of blood pressure
regulation of feeding behavior
positive regulation of uterine smooth muscle contraction
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